PT1401435E - Aplicacao topica de tiazolil-amidas - Google Patents

Aplicacao topica de tiazolil-amidas

Info

Publication number: PT1401435E
Authority: PT; Portugal
Prior art keywords: alkyl; halo; het; mono; alkoxy
Prior art date: 2001-06-22

Application number

PT02743172T

Other languages

English (en)

Inventor

Betz Ulrich

Laich Tobias

Bender Wolfgang

Fischer Ruediger

Hendrix Martin

Kleymann Gerald

Original Assignee

Aicuris Gmbh & Co Kg

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-06-22

Filing date

2002-06-10

Publication date

2006-07-31

2002-06-10 Application filed by Aicuris Gmbh & Co Kg filed Critical Aicuris Gmbh & Co Kg

2006-07-31 Publication of PT1401435E publication Critical patent/PT1401435E/pt

Links

125000000217 alkyl group Chemical group 0.000 abstract 21
125000003545 alkoxy group Chemical group 0.000 abstract 10
125000005843 halogen group Chemical group 0.000 abstract 10
125000002252 acyl group Chemical group 0.000 abstract 9
-1 3,4-methylenedioxyphenyl Chemical group 0.000 abstract 6
125000003118 aryl group Chemical group 0.000 abstract 6
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 5
125000000753 cycloalkyl group Chemical group 0.000 abstract 5
125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 4
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 4
125000004473 dialkylaminocarbonyl group Chemical group 0.000 abstract 4
125000001188 haloalkyl group Chemical group 0.000 abstract 4
125000005842 heteroatom Chemical group 0.000 abstract 4
UZFMOKQJFYMBGY-UHFFFAOYSA-N 4-hydroxy-TEMPO Chemical compound CC1(C)CC(O)CC(C)(C)N1[O] UZFMOKQJFYMBGY-UHFFFAOYSA-N 0.000 abstract 3
241000699670 Mus sp. Species 0.000 abstract 3
125000004466 alkoxycarbonylamino group Chemical group 0.000 abstract 3
125000004414 alkyl thio group Chemical group 0.000 abstract 3
125000004192 tetrahydrofuran-2-yl group Chemical group [H]C1([H])OC([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 3
HJCUTNIGJHJGCF-UHFFFAOYSA-N 9,10-dihydroacridine Chemical compound C1=CC=C2CC3=CC=CC=C3NC2=C1 HJCUTNIGJHJGCF-UHFFFAOYSA-N 0.000 abstract 2
UJOBWOGCFQCDNV-UHFFFAOYSA-N 9H-carbazole Chemical compound C1=CC=C2C3=CC=CC=C3NC2=C1 UJOBWOGCFQCDNV-UHFFFAOYSA-N 0.000 abstract 2
125000003342 alkenyl group Chemical group 0.000 abstract 2
125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 2
125000005332 alkyl sulfoxy group Chemical group 0.000 abstract 2
125000002619 bicyclic group Chemical group 0.000 abstract 2
TXCDCPKCNAJMEE-UHFFFAOYSA-N dibenzofuran Chemical compound C1=CC=C2C3=CC=CC=C3OC2=C1 TXCDCPKCNAJMEE-UHFFFAOYSA-N 0.000 abstract 2
IYYZUPMFVPLQIF-UHFFFAOYSA-N dibenzothiophene Chemical compound C1=CC=C2C3=CC=CC=C3SC2=C1 IYYZUPMFVPLQIF-UHFFFAOYSA-N 0.000 abstract 2
125000004438 haloalkoxy group Chemical group 0.000 abstract 2
125000000623 heterocyclic group Chemical group 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
125000002950 monocyclic group Chemical group 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000005389 trialkylsiloxy group Chemical group 0.000 abstract 2
SZXURXLGTQZFES-UHFFFAOYSA-N 2-phenyl-n-(5-sulfamoyl-1,3-thiazol-2-yl)acetamide Chemical class S1C(S(=O)(=O)N)=CN=C1NC(=O)CC1=CC=CC=C1 SZXURXLGTQZFES-UHFFFAOYSA-N 0.000 abstract 1
GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 abstract 1
241000700588 Human alphaherpesvirus 1 Species 0.000 abstract 1
XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 abstract 1
MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 abstract 1
229960004150 aciclovir Drugs 0.000 abstract 1
125000005236 alkanoylamino group Chemical group 0.000 abstract 1
235000001014 amino acid Nutrition 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
125000004103 aminoalkyl group Chemical group 0.000 abstract 1
IVZKZONQVYTCKC-UHFFFAOYSA-N bay 57-1293 Chemical compound N=1C(C)=C(S(N)(=O)=O)SC=1N(C)C(=O)CC(C=C1)=CC=C1C1=CC=CC=N1 IVZKZONQVYTCKC-UHFFFAOYSA-N 0.000 abstract 1
125000004985 dialkyl amino alkyl group Chemical group 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
239000003889 eye drop Substances 0.000 abstract 1
229940012356 eye drops Drugs 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
QDLAGTHXVHQKRE-UHFFFAOYSA-N lichenxanthone Natural products COC1=CC(O)=C2C(=O)C3=C(C)C=C(OC)C=C3OC2=C1 QDLAGTHXVHQKRE-UHFFFAOYSA-N 0.000 abstract 1
239000000463 material Substances 0.000 abstract 1
230000010534 mechanism of action Effects 0.000 abstract 1
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
229940068196 placebo Drugs 0.000 abstract 1
239000000902 placebo Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
150000007979 thiazole derivatives Chemical class 0.000 abstract 1
239000012873 virucide Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Inorganic Chemistry (AREA)
Organic Chemistry (AREA)
Oil, Petroleum & Natural Gas (AREA)
Virology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Dermatology (AREA)
Ophthalmology & Optometry (AREA)
Communicable Diseases (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Oncology (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Cosmetics (AREA)
Steroid Compounds (AREA)

PT02743172T 2001-06-22 2002-06-10 Aplicacao topica de tiazolil-amidas PT1401435E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE10129714A DE10129714A1 (de)	2001-06-22	2001-06-22	Topische Anwendung von Thiazolylamiden

Publications (1)

Publication Number	Publication Date
PT1401435E true PT1401435E (pt)	2006-07-31

Family

ID=7688817

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PT02743172T PT1401435E (pt)	2001-06-22	2002-06-10	Aplicacao topica de tiazolil-amidas
PT05024999T PT1629842E (pt)	2001-06-22	2002-06-10	Aplicação tópica de tiazolil-amidas

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
PT05024999T PT1629842E (pt)	2001-06-22	2002-06-10	Aplicação tópica de tiazolil-amidas

Country Status (17)

Country	Link
US (1)	US7883713B2 (pt)
EP (2)	EP1629842B1 (pt)
JP (1)	JP4342304B2 (pt)
KR (1)	KR100899491B1 (pt)
CN (1)	CN1535149B (pt)
AT (2)	ATE320253T1 (pt)
AU (1)	AU2002345023B2 (pt)
BR (1)	BRPI0210601B8 (pt)
CA (1)	CA2451552C (pt)
DE (3)	DE10129714A1 (pt)
DK (2)	DK1629842T3 (pt)
ES (2)	ES2341778T3 (pt)
IL (1)	IL159258A0 (pt)
MX (1)	MXPA03011518A (pt)
PL (1)	PL208927B1 (pt)
PT (2)	PT1401435E (pt)
WO (1)	WO2003000259A1 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10129715A1 (de) *	2001-06-22	2003-01-02	Bayer Ag	Thiazolylamide
DE102005014248A1 (de) *	2005-03-30	2006-10-05	Aicuris Gmbh & Co. Kg	Pharmazeutische Zubereitung von N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamid
CN103269593A (zh) *	2010-11-01	2013-08-28	罗马克实验室有限公司	烷基亚磺酰基取代的噻唑化物化合物
EP2573086A1 (en) *	2011-09-26	2013-03-27	AiCuris GmbH & Co. KG	N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate
EP2573085A1 (en)	2011-09-26	2013-03-27	AiCuris GmbH & Co. KG	N-[5-(aminosulfonyl)-4methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl] acetamide mesylate monohydrate having a specific particle size distribution range and a specific surface area range
JP6918823B2 (ja)	2016-04-06	2021-08-11	イノベーティブモレキュールズゲーエムベーハーＩｎｎｏｖａｔｉｖｅＭｏｌｅｃｕｌｅｓＧｍｂｈ	抗ウイルス剤として有用なアミノチアゾール誘導体
LT3544976T (lt)	2016-11-28	2021-08-10	Aicuris Gmbh & Co. Kg	N-[5-(aminosulfonil)-4-metil-1,3-tiazol-2-il]-n-metil-2-[4-(2-piridinil)-fenil]-acetamido laisvos bazės hemihidratas, jo gamybos būdai ir panaudojimai
AR110251A1 (es)	2016-11-28	2019-03-13	Aicuris Anti Infective Cures Gmbh	Una sal maleato de la base libre de n-[5-(aminosulfonil)-4-metil-1,3-tiazol-2-il]-n-metil-2-[4-(2-piridinil)-fenil]-acetamida, formulaciones farmacéuticas, métodos de fabricación y usos de la misma
AR110250A1 (es) *	2016-11-28	2019-03-13	Aicuris Anti Infective Cures Gmbh	Formulación tópica que comprende n-[5-(aminosulfonil)-4-metil-1,3-tiazol-2-il]-n-metil-2-[4-(2-piridinil)-fenil]-acetamida
WO2019068817A1 (en)	2017-10-05	2019-04-11	Innovative Molecules Gmbh	SUBSTITUTED THIAZOLEAN ENANTIOMERS AS ANTIVIRAL COMPOUNDS
EP3925595A1 (en) *	2020-06-17	2021-12-22	AiCuris GmbH & Co. KG	Ophthalmic formulation comprising n-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)phenyl] acetamide hemihydrate
CA3168721A1 (en) *	2020-03-26	2021-09-30	Jessica Redmer	Ophthalmic formulation comprising n-[5-(aminosulfonyl)-4-methyl-1,3- thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)phenyl]acetamide hemihydrate

Family Cites Families (22)

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CA984848A (en)	1970-01-16	1976-03-02	Kurt H. Pilgram	Herbicides
US3658830A (en) *	1970-01-16	1972-04-25	Shell Oil Co	5-(substituted mercapto sulfiny sulfonyl or sulfamoyl)
US3717651A (en) *	1970-04-20	1973-02-20	Shell Oil Co	Thiazoles
US3847588A (en) *	1970-04-20	1974-11-12	Shell Oil Co	Thiazoles herbicidal
GB2080682B (en) *	1980-07-30	1984-03-28	Ciba Geigy Ag	Antiherpetically active lipstick
US4556560A (en) *	1983-01-24	1985-12-03	The Procter & Gamble Company	Methods for the treatment and prophylaxis of diaper rash and diaper dermatitis
DE3319282A1 (de) *	1983-05-27	1984-11-29	Gödecke AG, 1000 Berlin	Verwendung von adenosin bei der behandlung von herpes
ES2186811T3 (es)	1995-12-29	2003-05-16	Boehringer Ingelheim Pharma	Derivados de feniltiazol con propiedades anti-virus herpes.
GB2311069A (en)	1996-03-14	1997-09-17	Merck & Co Inc	Primase isolated from human cytomegalovirus (HCMV)
US5705344A (en)	1996-03-14	1998-01-06	Tularik, Inc.	High-throughput screening assay for inhibitors of nucleic acid helicases
GB2311068A (en)	1996-03-14	1997-09-17	Merck & Co Inc	Helicase isolated from human cytomegalovirus (HCMV)
CA2223032A1 (en)	1997-02-21	1998-08-21	Smithkline Beecham Corporation	Use of hsv-1 ul-15 and vp5 in identifying anti-viral agents
DE19802437A1 (de)	1998-01-23	1999-07-29	Bayer Ag	Verwendung von substituierten Sulfonamiden als anitvirale Mittel und neue Stoffe
AU3289299A (en)	1998-02-19	1999-09-06	Tularik Inc.	Antiviral agents
NZ507032A (en)	1998-03-19	2003-06-30	Pharmacia & Upjohn	1,3,4-thiadiazoles useful for the treatment of herpes and cytomegalovirus infections
WO2000053591A1 (de) *	1999-03-08	2000-09-14	Bayer Aktiengesellschaft	Thiazolylharnstoff-derivate und ihre verwendung als antivirale mittel
DOP2000000109A (es) *	1999-12-23	2002-08-30	Gerald Kleymann	Derivados de tiazolilamida
EP1319185A1 (en) *	2000-06-15	2003-06-18	Bayer Aktiengesellschaft	Method for identifying compounds with anti-herpes activity
DE10129716A1 (de)	2001-06-22	2003-01-02	Bayer Ag	Kombinationspräparate zur Herpes-Behandlung
DE10131128A1 (de)	2001-06-28	2003-01-16	Bayer Ag	Sekundäre Sulfonamide
WO2004078163A2 (en)	2003-02-28	2004-09-16	Transform Pharmaceuticals, Inc.	Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
DE102005014248A1 (de) *	2005-03-30	2006-10-05	Aicuris Gmbh & Co. Kg	Pharmazeutische Zubereitung von N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamid

2001
- 2001-06-22 DE DE10129714A patent/DE10129714A1/de not_active Withdrawn
2002
- 2002-06-10 MX MXPA03011518A patent/MXPA03011518A/es active IP Right Grant
- 2002-06-10 US US10/481,680 patent/US7883713B2/en not_active Expired - Lifetime
- 2002-06-10 WO PCT/EP2002/006327 patent/WO2003000259A1/de not_active Ceased
- 2002-06-10 AU AU2002345023A patent/AU2002345023B2/en not_active Expired
- 2002-06-10 JP JP2003506904A patent/JP4342304B2/ja not_active Expired - Lifetime
- 2002-06-10 ES ES05024999T patent/ES2341778T3/es not_active Expired - Lifetime
- 2002-06-10 BR BRPI0210601A patent/BRPI0210601B8/pt not_active IP Right Cessation
- 2002-06-10 CN CN028125304A patent/CN1535149B/zh not_active Expired - Lifetime
- 2002-06-10 PL PL364378A patent/PL208927B1/pl unknown
- 2002-06-10 AT AT02743172T patent/ATE320253T1/de active
- 2002-06-10 PT PT02743172T patent/PT1401435E/pt unknown
- 2002-06-10 EP EP05024999A patent/EP1629842B1/de not_active Expired - Lifetime
- 2002-06-10 PT PT05024999T patent/PT1629842E/pt unknown
- 2002-06-10 ES ES02743172T patent/ES2260449T3/es not_active Expired - Lifetime
- 2002-06-10 DK DK05024999.4T patent/DK1629842T3/da active
- 2002-06-10 EP EP02743172A patent/EP1401435B1/de not_active Expired - Lifetime
- 2002-06-10 KR KR1020037016645A patent/KR100899491B1/ko not_active Expired - Fee Related
- 2002-06-10 DE DE50206084T patent/DE50206084D1/de not_active Expired - Lifetime
- 2002-06-10 DK DK02743172T patent/DK1401435T3/da active
- 2002-06-10 CA CA2451552A patent/CA2451552C/en not_active Expired - Lifetime
- 2002-06-10 IL IL15925802A patent/IL159258A0/xx active IP Right Grant
- 2002-06-10 DE DE50214378T patent/DE50214378D1/de not_active Expired - Lifetime
- 2002-06-10 AT AT05024999T patent/ATE464047T1/de active

Also Published As

Publication number	Publication date
AU2002345023B2 (en)	2007-07-12
EP1401435B1 (de)	2006-03-15
BR0210601A (pt)	2004-09-28
IL159258A0 (en)	2004-06-01
PL364378A1 (en)	2004-12-13
JP2004534818A (ja)	2004-11-18
CN1535149A (zh)	2004-10-06
BRPI0210601B1 (pt)	2016-08-23
WO2003000259A1 (de)	2003-01-03
US7883713B2 (en)	2011-02-08
ATE464047T1 (de)	2010-04-15
EP1401435A1 (de)	2004-03-31
EP1629842A1 (de)	2006-03-01
DK1401435T3 (da)	2006-07-17
MXPA03011518A (es)	2004-10-28
CA2451552A1 (en)	2003-01-03
DE50214378D1 (de)	2010-05-27
CN1535149B (zh)	2012-06-06
KR20040030689A (ko)	2004-04-09
ES2341778T3 (es)	2010-06-28
CA2451552C (en)	2011-11-08
KR100899491B1 (ko)	2009-05-26
JP4342304B2 (ja)	2009-10-14
PT1629842E (pt)	2010-05-10
ES2260449T3 (es)	2006-11-01
PL208927B1 (pl)	2011-06-30
ATE320253T1 (de)	2006-04-15
BRPI0210601B8 (pt)	2021-05-25
DK1629842T3 (da)	2010-08-02
EP1629842B1 (de)	2010-04-14
HK1069986A1 (en)	2005-06-10
US20040235917A1 (en)	2004-11-25
DE50206084D1 (de)	2006-05-11
DE10129714A1 (de)	2003-01-02

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