PT2247585E - Formas cristalinas de n-[2-(dietilamino)etil]-5-[(5-fluoro- 1,2-dihidro-2-oxo-3h-indol-3-ilideno)metil]-2,4-dimetil-1hpirrol- 3-carboxamida e métodos para a respetiva preparação - Google Patents

Formas cristalinas de n-[2-(dietilamino)etil]-5-[(5-fluoro- 1,2-dihidro-2-oxo-3h-indol-3-ilideno)metil]-2,4-dimetil-1hpirrol- 3-carboxamida e métodos para a respetiva preparação Download PDF

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Publication number
PT2247585E
PT2247585E PT97177729T PT09717772T PT2247585E PT 2247585 E PT2247585 E PT 2247585E PT 97177729 T PT97177729 T PT 97177729T PT 09717772 T PT09717772 T PT 09717772T PT 2247585 E PT2247585 E PT 2247585E
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PT
Portugal
Prior art keywords
ylidene
indol
carboxamide
diethylamino
pyrrole
Prior art date
Application number
PT97177729T
Other languages
English (en)
Inventor
Hans-Günter Striegel
Nesrin Mohamad
Roland Boese
Rüdiger Latz
Original Assignee
Ratiopharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ratiopharm Gmbh filed Critical Ratiopharm Gmbh
Publication of PT2247585E publication Critical patent/PT2247585E/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
PT97177729T 2008-03-06 2009-03-05 Formas cristalinas de n-[2-(dietilamino)etil]-5-[(5-fluoro- 1,2-dihidro-2-oxo-3h-indol-3-ilideno)metil]-2,4-dimetil-1hpirrol- 3-carboxamida e métodos para a respetiva preparação PT2247585E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08004143A EP2098521A1 (en) 2008-03-06 2008-03-06 Crystal forms of N-[2-(diethylamino) ethyl]-5-[fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrolle-3-carboxamide and methods for their prepparation

Publications (1)

Publication Number Publication Date
PT2247585E true PT2247585E (pt) 2014-07-17

Family

ID=39590734

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97177729T PT2247585E (pt) 2008-03-06 2009-03-05 Formas cristalinas de n-[2-(dietilamino)etil]-5-[(5-fluoro- 1,2-dihidro-2-oxo-3h-indol-3-ilideno)metil]-2,4-dimetil-1hpirrol- 3-carboxamida e métodos para a respetiva preparação

Country Status (15)

Country Link
US (1) US20110034703A1 (pt)
EP (3) EP2098521A1 (pt)
JP (1) JP2011513349A (pt)
KR (1) KR101604501B1 (pt)
CN (1) CN101965342B (pt)
AU (1) AU2009221458A1 (pt)
CA (1) CA2714441A1 (pt)
EA (1) EA020067B1 (pt)
ES (1) ES2478821T3 (pt)
IL (1) IL207984A (pt)
PL (1) PL2247585T3 (pt)
PT (1) PT2247585E (pt)
SI (1) SI2247585T1 (pt)
WO (1) WO2009109388A1 (pt)
ZA (1) ZA201005796B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2220072A2 (en) * 2007-11-21 2010-08-25 Teva Pharmaceutical Industries Ltd. Polymorphs of sunitinib base and processes for preparation thereof
KR20100135910A (ko) 2008-04-16 2010-12-27 낫코 파마 리미티드 수니티닙 염기의 신규한 다형 형태
US8153678B2 (en) 2008-06-13 2012-04-10 Medichem, S.A. Process for preparing A 3-pyrrole substituted 2-indolinone malate salt
CA2734965A1 (en) * 2008-08-25 2010-03-04 Generics [Uk] Limited Novel crystalline form and processes for its preparation
CN102197034A (zh) * 2008-08-25 2011-09-21 基因里克斯(英国)有限公司 舒尼替尼的新型多晶型物及其制备方法
EP2528913A1 (en) 2010-01-29 2012-12-05 Ranbaxy Laboratories Limited Crystalline forms of l-malic acid salt of sunitinib
WO2011100325A2 (en) 2010-02-09 2011-08-18 Sicor Inc. Polymorphs of sunitinib salts
HK1204992A1 (en) * 2012-06-25 2015-12-11 Bayer Healthcare Llc Topical ophthalmological pharmaceutical composition containing sunitinib
CN103833733B (zh) * 2012-11-21 2017-08-25 广东东阳光药业有限公司 一种替尼类药物新晶型
JP6612232B2 (ja) 2013-08-28 2019-11-27 クラウン バイオサイエンス インコーポレイテッド（タイカン） 対象のマルチキナーゼ阻害剤に対する応答性を予測する遺伝子発現シグネチャ、及びその使用
RU2567535C1 (ru) * 2014-10-01 2015-11-10 Олег Ростиславович Михайлов КРИСТАЛЛИЧЕСКАЯ ε-МОДИФИКАЦИЯ N-[2-(ДИЭТИЛАМИНО)ЭТИЛ]-5-[(Z)-(5-ФТОР-1,2-ДИГИДРО-2-ОКСО-3Н-ИНДОЛ-3-ИЛИДЕН)МЕТИЛ]-2,4-ДИМЕТИЛ-1Н-ПИРРОЛ-3-КАРБОКСАМИД МАЛАТА, СПОСОБ ЕЕ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕЕ ОСНОВЕ
CN106884206A (zh) * 2017-03-17 2017-06-23 青岛大学 一种有机非线性光学晶体用籽晶的生长方法
JP7009534B2 (ja) 2020-03-12 2022-01-25 住友理工株式会社 バッテリーパック用断熱材およびバッテリーパック

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5004392B2 (ja) 1999-12-22 2012-08-22 スージェン， インク． インドリノン化合物を用いてｃ−ｋｉｔチロシン蛋白質キナーゼ機能を調節する方法
AR034118A1 (es) * 2000-02-15 2004-02-04 Sugen Inc Compuestos de 2-indolinonas sustituidas con pirroles inhibidoras de proteinquinasas; sus composiciones farmaceuticas e intermediarios de sintesis
DK3168218T3 (en) * 2001-08-15 2019-01-14 Pharmacia & Upjohn Co Llc Crystalline comprising an L-malic acid salt of N- [2- (DIETHYLAMINO) ETHYL] -5 - [(5-FLUOR-1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDE) METHYL] -2,4 -DIMETHYL-1H-PYRROL-3-CARBOXAMIDE FOR USE AS A MEDICINE
TWI259081B (en) 2001-10-26 2006-08-01 Sugen Inc Treatment of acute myeloid leukemia with indolinone compounds
CN1308326C (zh) * 2002-02-15 2007-04-04 法马西亚和厄普乔恩公司 吲哚满酮衍生物的制备方法

Also Published As

Publication number Publication date
CN101965342B (zh) 2014-07-30
EP2604603A1 (en) 2013-06-19
ES2478821T3 (es) 2014-07-23
EP2247585A1 (en) 2010-11-10
CN101965342A (zh) 2011-02-02
US20110034703A1 (en) 2011-02-10
KR101604501B1 (ko) 2016-03-17
WO2009109388A8 (en) 2010-10-07
EA020067B1 (ru) 2014-08-29
CA2714441A1 (en) 2009-09-11
IL207984A (en) 2016-07-31
JP2011513349A (ja) 2011-04-28
SI2247585T1 (sl) 2014-08-29
WO2009109388A1 (en) 2009-09-11
IL207984A0 (en) 2010-12-30
PL2247585T3 (pl) 2014-09-30
EP2098521A1 (en) 2009-09-09
EP2247585B1 (en) 2014-04-30
KR20100125300A (ko) 2010-11-30
ZA201005796B (en) 2011-04-28
EA201001243A1 (ru) 2011-04-29
AU2009221458A1 (en) 2009-09-11

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