PT2646457T - Síntese otimizada de ácidos biliares não polimórficos, cristalinos com tamanho de partícula definido - Google Patents

Síntese otimizada de ácidos biliares não polimórficos, cristalinos com tamanho de partícula definido

Info

Publication number
PT2646457T
PT2646457T PT117885335T PT11788533T PT2646457T PT 2646457 T PT2646457 T PT 2646457T PT 117885335 T PT117885335 T PT 117885335T PT 11788533 T PT11788533 T PT 11788533T PT 2646457 T PT2646457 T PT 2646457T
Authority
PT
Portugal
Prior art keywords
polymorphic
crystalline
pure
particle size
bile acids
Prior art date
Application number
PT117885335T
Other languages
English (en)
Inventor
Fischer Erik
Wilhelm Rudolf
Pröls Markus
Waenerlund Poulsen Heidi
Original Assignee
Dr Falk Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Falk Pharma Gmbh filed Critical Dr Falk Pharma Gmbh
Publication of PT2646457T publication Critical patent/PT2646457T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
PT117885335T 2010-11-30 2011-11-30 Síntese otimizada de ácidos biliares não polimórficos, cristalinos com tamanho de partícula definido PT2646457T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP10193143A EP2468762A1 (en) 2010-11-30 2010-11-30 Optimized synthesis of pure, non-polymorphic, crystalline bile acids with defined particle size

Publications (1)

Publication Number Publication Date
PT2646457T true PT2646457T (pt) 2016-10-18

Family

ID=44275998

Family Applications (1)

Application Number Title Priority Date Filing Date
PT117885335T PT2646457T (pt) 2010-11-30 2011-11-30 Síntese otimizada de ácidos biliares não polimórficos, cristalinos com tamanho de partícula definido

Country Status (24)

Country Link
US (2) US9512167B2 (pt)
EP (2) EP2468762A1 (pt)
JP (2) JP6276592B2 (pt)
CN (1) CN103298825B (pt)
AU (1) AU2011334928B2 (pt)
BR (1) BR112013013179B1 (pt)
CA (1) CA2818984C (pt)
CY (1) CY1118036T1 (pt)
DK (1) DK2646457T3 (pt)
EA (1) EA025586B1 (pt)
ES (1) ES2597652T3 (pt)
HR (1) HRP20161187T1 (pt)
HU (1) HUE029847T2 (pt)
IL (1) IL226616A (pt)
LT (1) LT2646457T (pt)
ME (1) ME02480B (pt)
NZ (2) NZ708988A (pt)
PL (1) PL2646457T3 (pt)
PT (1) PT2646457T (pt)
RS (1) RS55211B1 (pt)
SI (1) SI2646457T1 (pt)
UA (1) UA112764C2 (pt)
WO (1) WO2012072689A1 (pt)
ZA (1) ZA201303820B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE303399T1 (de) 2001-03-12 2005-09-15 Intercept Pharmaceuticals Inc Steroide als agonisten für fxr
EP2468762A1 (en) * 2010-11-30 2012-06-27 Dr. Falk Pharma Gmbh Optimized synthesis of pure, non-polymorphic, crystalline bile acids with defined particle size
CA3038534A1 (en) * 2016-09-30 2018-04-05 Intercept Pharmaceuticals, Inc. Crystalline forms of a bile acid derivative
EP3461485A1 (en) 2017-09-28 2019-04-03 Dr. Falk Pharma Gmbh Use of nor-ursodeoxycholic acid for reducing liver fat
WO2021130232A1 (en) 2019-12-23 2021-07-01 Medizinische Universität Wien Bile acid derivatives in the medical intervention of anxieties and/or stress symptoms
US11655240B1 (en) * 2022-05-10 2023-05-23 Beijing Grand Johamu Pharmaceutical Company, Ltd. Crystal form of compound and fumaric acid, pharmaceutical composition and method for treating coronavirus-induced diseases
CA3259229A1 (en) * 2022-07-25 2024-02-01 Shilpa Medicare Limited NOR-UDCA PHARMACEUTICAL COMPOSITIONS
WO2024245370A1 (zh) * 2023-05-31 2024-12-05 上海复宏汉霖生物技术股份有限公司 一种组合产品、盐及其用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW289020B (pt) 1993-05-08 1996-10-21 Hoechst Sktiengesellschaft
ITMI20012572A1 (it) 2001-12-06 2003-06-06 Istituto Biochimico Italiano Microgranuli di acido ursodesossicolico
PL1890705T3 (pl) * 2005-05-12 2016-05-31 Univ Graz Medizinische Zastosowanie 24-nor-UDCA do leczenia cholestatycznych chorób wątroby
CN100513415C (zh) * 2005-08-03 2009-07-15 中国人民解放军军事医学科学院毒物药物研究所 胆汁酸衍生物及其医药用途
ES2709489T3 (es) 2007-07-25 2019-04-16 Univ Graz Medizinische Uso de ácidos nor-biliares en el tratamiento de arteriosclerosis
EP2468762A1 (en) * 2010-11-30 2012-06-27 Dr. Falk Pharma Gmbh Optimized synthesis of pure, non-polymorphic, crystalline bile acids with defined particle size

Also Published As

Publication number Publication date
CN103298825B (zh) 2016-11-23
CN103298825A (zh) 2013-09-11
HUE029847T2 (en) 2017-04-28
SI2646457T1 (sl) 2016-10-28
CA2818984C (en) 2019-01-08
JP6276592B2 (ja) 2018-02-07
PL2646457T3 (pl) 2017-02-28
DK2646457T3 (en) 2016-10-10
EP2468762A1 (en) 2012-06-27
JP6594917B2 (ja) 2019-10-23
HRP20161187T1 (hr) 2016-11-04
NZ708988A (en) 2016-08-26
ZA201303820B (en) 2014-02-26
EA025586B1 (ru) 2017-01-30
EP2646457B1 (en) 2016-08-17
CY1118036T1 (el) 2017-05-17
US20140050791A1 (en) 2014-02-20
ES2597652T3 (es) 2017-01-19
HK1187351A1 (zh) 2014-04-04
RS55211B1 (sr) 2017-02-28
JP2013544267A (ja) 2013-12-12
US9512167B2 (en) 2016-12-06
BR112013013179A2 (pt) 2016-09-06
AU2011334928B2 (en) 2016-09-01
BR112013013179B1 (pt) 2021-10-13
US20170057990A1 (en) 2017-03-02
LT2646457T (lt) 2016-10-10
US10000526B2 (en) 2018-06-19
UA112764C2 (uk) 2016-10-25
CA2818984A1 (en) 2012-06-07
EA201300647A1 (ru) 2014-01-30
IL226616A (en) 2017-05-29
NZ610862A (en) 2015-07-31
ME02480B (me) 2017-02-20
JP2017081989A (ja) 2017-05-18
AU2011334928A1 (en) 2013-06-20
WO2012072689A1 (en) 2012-06-07
EP2646457A1 (en) 2013-10-09

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