PL2578595T3 - Krystaliczna lewoizowalerylospiramycyna I - Google Patents

Krystaliczna lewoizowalerylospiramycyna I

Info

Publication number
PL2578595T3
PL2578595T3 PL11786085T PL11786085T PL2578595T3 PL 2578595 T3 PL2578595 T3 PL 2578595T3 PL 11786085 T PL11786085 T PL 11786085T PL 11786085 T PL11786085 T PL 11786085T PL 2578595 T3 PL2578595 T3 PL 2578595T3
Authority
PL
Poland
Prior art keywords
levoisovalerylspiramycin
crystalline
crystalline levoisovalerylspiramycin
Prior art date
Application number
PL11786085T
Other languages
English (en)
Inventor
Yang Jiang
Yuyou Hao
Original Assignee
Shenyang Fuyang Pharmaceutical Tech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shenyang Fuyang Pharmaceutical Tech Co Ltd filed Critical Shenyang Fuyang Pharmaceutical Tech Co Ltd
Publication of PL2578595T3 publication Critical patent/PL2578595T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
PL11786085T 2010-05-25 2011-05-25 Krystaliczna lewoizowalerylospiramycyna I PL2578595T3 (pl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN201010182109 2010-05-25
CN201010182111 2010-05-25
CN201010182108 2010-05-25
PCT/CN2011/074644 WO2011147313A1 (zh) 2010-05-25 2011-05-25 左旋异戊酰螺旋霉素i、ii或iii，及其制剂、制备方法及应用
EP11786085.8A EP2578595B1 (en) 2010-05-25 2011-05-25 Crystalline levoisovalerylspiramycin i

Publications (1)

Publication Number Publication Date
PL2578595T3 true PL2578595T3 (pl) 2017-10-31

Family

ID=45003321

Family Applications (3)

Application Number Title Priority Date Filing Date
PL17166117T PL3210990T3 (pl) 2010-05-25 2011-05-25 Lewoizowalerylospiramycyna III i jej preparaty, sposoby wytwarzania i zastosowania
PL17166118T PL3210991T3 (pl) 2010-05-25 2011-05-25 Postać krystaliczna lewoizowalerylospiramycyny II oraz preparaty, sposoby wytwarzania i ich zastosowanie
PL11786085T PL2578595T3 (pl) 2010-05-25 2011-05-25 Krystaliczna lewoizowalerylospiramycyna I

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PL17166117T PL3210990T3 (pl) 2010-05-25 2011-05-25 Lewoizowalerylospiramycyna III i jej preparaty, sposoby wytwarzania i zastosowania
PL17166118T PL3210991T3 (pl) 2010-05-25 2011-05-25 Postać krystaliczna lewoizowalerylospiramycyny II oraz preparaty, sposoby wytwarzania i ich zastosowanie

Country Status (16)

Country Link
US (1) US8778896B2 (pl)
EP (3) EP2578595B1 (pl)
JP (1) JP5945868B2 (pl)
KR (2) KR20130041829A (pl)
BR (1) BR112012029913B1 (pl)
CA (3) CA2800021C (pl)
DK (3) DK2578595T3 (pl)
ES (3) ES2754614T3 (pl)
MX (1) MX340626B (pl)
MY (1) MY164231A (pl)
PH (1) PH12012502323A1 (pl)
PL (3) PL3210990T3 (pl)
PT (1) PT3210990T (pl)
RU (3) RU2647237C1 (pl)
WO (1) WO2011147313A1 (pl)
ZA (3) ZA201209738B (pl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101706519B1 (ko) * 2010-05-25 2017-02-14 쉔양 통리엔 그룹 컴패니, 리미티드 레보캐리마이신, 약학 조성물, 제조방법 및 응용
CN105497053B (zh) * 2015-12-31 2018-02-13 沈阳福洋医药科技有限公司 可利霉素在抗结核分枝杆菌感染中的应用
KR102375444B1 (ko) * 2017-07-04 2022-03-17 쉔양 푸양 파마슈티컬 테크놀로지 컴퍼니 리미티드 종양을 치료 및/또는 예방하는 약물 제조에서 이소발레릴 스피라마이신i, ii 및/또는 iii의 응용 및 약물
WO2019141256A1 (zh) 2018-01-19 2019-07-25 沈阳福洋医药科技有限公司 可利霉素或其活性成分的用途
CA3088818A1 (en) * 2018-01-19 2019-07-25 Shenyang Fuyang Pharmaceutical Technology Co., Ltd. Mtor inhibitor, pharmaceutical composition and use thereof
CA3098205A1 (en) * 2018-04-17 2019-10-24 Shanghai Tonglian Pharmaceutical Co., Ltd. Medicament for preventing and/or treating pain and/or fever, composite product and use thereof
CN110384710B (zh) * 2018-04-17 2023-01-10 沈阳福洋医药科技有限公司 一种用于预防和/或治疗疼痛的药物、组合产品及其应用
CN111939168B (zh) * 2019-05-16 2023-02-03 沈阳福洋医药科技有限公司 一种用于预防、缓解和/或治疗纤维化的药物、组合产品及其应用
CN112239483B (zh) * 2019-07-18 2023-10-27 沈阳福洋医药科技有限公司 一种化合物及药物组合物
US11351185B2 (en) 2020-03-11 2022-06-07 Asclea Corporation Use of isovalerylspiramycins as anti-cancer agents to inhibit metastasis

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5334788A (en) * 1976-09-11 1978-03-31 Sanraku Inc Antibiotics spiramycin derivatives
CN1058295C (zh) 1997-06-03 2000-11-08 中国医学科学院医药生物技术研究所 一种利用基因工程技术制造生技霉素的方法
CN1169947C (zh) * 2002-11-19 2004-10-06 中国医学科学院医药生物技术研究所 必特螺旋霉素的基因工程菌株螺旋霉素链霉菌wsj-195
CN1237976C (zh) 2003-12-23 2006-01-25 沈阳同联集团有限公司 必特螺旋霉素及其在抗感染性疾病中的应用
KR20070046917A (ko) * 2004-08-12 2007-05-03 글락소스미쓰클라인 이스트라지바치키 센타 자그레브 디.오.오. 위장관의 염증성 질환의 치료를 위한 세포-특이적컨쥬게이트의 용도
CN101054553A (zh) * 2007-04-09 2007-10-17 中国医学科学院医药生物技术研究所 异戊酰螺旋霉素i基因工程菌株的构建
CN101649325B (zh) * 2009-07-03 2011-09-07 中国医学科学院医药生物技术研究所 一种提高基因工程异戊酰螺旋霉素主组分含量的基因串连技术
CN101785778A (zh) * 2010-03-09 2010-07-28 沈阳同联集团有限公司 异戊酰螺旋霉素i的分离制备及其应用
CN101785779B (zh) * 2010-03-09 2014-03-05 沈阳同联集团有限公司 异戊酰螺旋霉素ii的分离制备
CN101773510B (zh) * 2010-03-09 2013-06-05 沈阳同联集团有限公司 异戊酰螺旋霉素iii的分离制备
KR101706519B1 (ko) * 2010-05-25 2017-02-14 쉔양 통리엔 그룹 컴패니, 리미티드 레보캐리마이신, 약학 조성물, 제조방법 및 응용

Also Published As

Publication number Publication date
CA2915236C (en) 2019-03-12
PL3210991T3 (pl) 2020-03-31
ZA201406381B (en) 2016-08-31
PT3210990T (pt) 2020-04-01
RU2647236C1 (ru) 2018-03-14
EP3210990A1 (en) 2017-08-30
EP3210991A1 (en) 2017-08-30
CA2915236A1 (en) 2011-12-01
EP3210990B1 (en) 2020-01-01
EP2578595A4 (en) 2013-11-06
MY164231A (en) 2017-11-30
MX2012013470A (es) 2013-03-18
RU2012156420A (ru) 2014-06-27
CA2915222A1 (en) 2011-12-01
EP2578595A1 (en) 2013-04-10
EP2578595B1 (en) 2017-04-19
PH12012502323A1 (en) 2023-03-10
CA2800021C (en) 2016-03-22
US8778896B2 (en) 2014-07-15
BR112012029913B1 (pt) 2021-02-02
WO2011147313A1 (zh) 2011-12-01
BR112012029913A8 (pt) 2018-01-09
MX340626B (es) 2016-07-18
JP5945868B2 (ja) 2016-07-13
KR20160017124A (ko) 2016-02-15
ES2754614T3 (es) 2020-04-20
CA2800021A1 (en) 2011-12-01
US20130065848A1 (en) 2013-03-14
ES2781425T3 (es) 2020-09-02
DK2578595T3 (en) 2017-07-10
CA2915222C (en) 2019-03-12
KR20130041829A (ko) 2013-04-25
KR101706518B1 (ko) 2017-02-14
ES2633723T3 (es) 2017-09-25
EP3210991B1 (en) 2019-08-07
BR112012029913A2 (pt) 2017-11-28
ZA201209738B (en) 2015-04-29
PL3210990T3 (pl) 2020-10-05
RU2593498C2 (ru) 2016-08-10
JP2013528166A (ja) 2013-07-08
DK3210991T3 (da) 2019-11-11
ZA201406382B (en) 2015-12-23
RU2647237C1 (ru) 2018-03-14
DK3210990T3 (da) 2020-03-23

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