|
US9695212B2
(en)
|
2012-12-13 |
2017-07-04 |
Aduro Biotech, Inc. |
Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use
|
|
US9840533B2
(en)
|
2013-04-29 |
2017-12-12 |
Memorial Sloan Kettering Cancer Center |
Compositions and methods for altering second messenger signaling
|
|
PE20160080A1
(es)
|
2013-05-18 |
2016-02-21 |
Aduro Biotech Inc |
Composiciones y metodos para activar la senalizacion que depende del estimulador del gen de interferon
|
|
CR20160564A
(es)
|
2014-06-04 |
2017-01-20 |
Glaxosmithkline Ip Dev Ltd |
Dinucleótidos cíclicos como moduladores de sting
|
|
EP3546473B1
(en)
*
|
2014-12-16 |
2025-12-10 |
Kayla Therapeutics |
Fluorinated cyclic [(2',5')p(3',5')p]-dinucleotides for cytokine induction
|
|
GB201501462D0
(en)
*
|
2015-01-29 |
2015-03-18 |
Glaxosmithkline Ip Dev Ltd |
Novel compounds
|
|
EA035817B1
(ru)
|
2015-03-10 |
2020-08-14 |
Адуро Байотек, Инк. |
Композиции и способы для активации сигналинга, зависимого от "гена стимулятора интерферона"
|
|
KR102222186B1
(ko)
*
|
2015-08-13 |
2021-03-03 |
머크 샤프 앤드 돔 코포레이션 |
Sting 효능제로서 시클릭 디-뉴클레오티드 화합물
|
|
US11453697B1
(en)
|
2015-08-13 |
2022-09-27 |
Merck Sharp & Dohme Llc |
Cyclic di-nucleotide compounds as sting agonists
|
|
US10322177B2
(en)
|
2015-10-07 |
2019-06-18 |
Nant Holdings Ip, Llc |
Activation of immune-related signaling pathways in cells via optofection
|
|
CN107849084B
(zh)
|
2015-12-03 |
2021-09-14 |
葛兰素史密斯克莱知识产权发展有限公司 |
作为sting调节剂的环状嘌呤二核苷酸
|
|
KR102789862B1
(ko)
|
2016-01-11 |
2025-04-03 |
인네이트 튜머 이뮤니티, 인코포레이티드 |
Sting 활성과 연관된 상태 예컨대 암의 치료를 위한 시클릭 디뉴클레오티드
|
|
NZ746112A
(en)
*
|
2016-03-18 |
2023-01-27 |
Immune Sensor Llc |
Cyclic di-nucleotide compounds and methods of use
|
|
EP3448393A1
(en)
*
|
2016-04-25 |
2019-03-06 |
Invivogen |
Novel complexes of immunostimulatory compounds, and uses thereof
|
|
US10696985B1
(en)
|
2016-06-06 |
2020-06-30 |
Vanderbilt University |
Reversibly crosslinked endosomolytic polymer vesicles for cytosolic drug delivery
|
|
EP3507367A4
(en)
*
|
2016-07-05 |
2020-03-25 |
Aduro BioTech, Inc. |
CYCLIC DINUCLEOTID COMPOUNDS WITH INCLUDED NUCLEIC ACIDS AND USES THEREOF
|
|
IL264049B2
(en)
*
|
2016-07-06 |
2023-11-01 |
Sperovie Biosciences Inc |
Compounds, preparations and methods for treating the disease
|
|
CN109715202A
(zh)
*
|
2016-07-15 |
2019-05-03 |
斯必乐维生物科学公司 |
用于治疗疾病的化合物、组合物和方法
|
|
NL2017267B1
(en)
|
2016-07-29 |
2018-02-01 |
Aduro Biotech Holdings Europe B V |
Anti-pd-1 antibodies
|
|
NL2017270B1
(en)
|
2016-08-02 |
2018-02-09 |
Aduro Biotech Holdings Europe B V |
New anti-hCTLA-4 antibodies
|
|
US10537590B2
(en)
*
|
2016-09-30 |
2020-01-21 |
Boehringer Ingelheim International Gmbh |
Cyclic dinucleotide compounds
|
|
PT3523287T
(pt)
|
2016-10-04 |
2021-10-06 |
Merck Sharp & Dohme |
Compostos de benzo[b]tiofeno como agonistas de sting
|
|
US11001605B2
(en)
|
2016-10-07 |
2021-05-11 |
Biolog Life Science Institute Gmbh & Co. Kg |
Cyclic dinucleotides containing benzimidazole, method for the production of same, and use of same to activate stimulator of interferon genes (sting)-dependent signaling pathways
|
|
JOP20170188A1
(ar)
*
|
2016-11-25 |
2019-01-30 |
Janssen Biotech Inc |
ثنائي النوكليوتيدات الحلقية كمنبهات ستينغ (sting)
|
|
JP2018090562A
(ja)
*
|
2016-12-01 |
2018-06-14 |
武田薬品工業株式会社 |
環状ジヌクレオチド
|
|
PE20210255A1
(es)
*
|
2016-12-01 |
2021-02-10 |
Takeda Pharmaceuticals Co |
Dinucleotido ciclico como agonistas de sting (estimulador de genes de interferon)
|
|
WO2018118665A1
(en)
*
|
2016-12-20 |
2018-06-28 |
Merck Sharp & Dohme Corp. |
Cyclic dinucleotide sting agonists for cancer treatment
|
|
EA201991556A1
(ru)
*
|
2016-12-22 |
2020-01-23 |
Мавуфарма, Инк. |
Ингибиторы фосфодиэстеразы и способы лечения микробной инфекции
|
|
US20200055883A1
(en)
|
2017-02-17 |
2020-02-20 |
Eisai R&D Management Co., Ltd. |
Cyclic di-nucleotides derivative for the treatment of cancer
|
|
WO2018156625A1
(en)
*
|
2017-02-21 |
2018-08-30 |
Board Of Regents,The University Of Texas System |
Cyclic dinucleotides as agonists of stimulator of interferon gene dependent signalling
|
|
US10859566B2
(en)
|
2017-03-20 |
2020-12-08 |
Genocea Biosciences, Inc. |
Treatment methods
|
|
JOP20190218A1
(ar)
|
2017-03-22 |
2019-09-22 |
Boehringer Ingelheim Int |
مركبات ثنائية النيوكليوتيدات حلقية معدلة
|
|
KR102702926B1
(ko)
|
2017-04-13 |
2024-09-06 |
사이로파 비.브이. |
항-sirp 알파 항체
|
|
MX2019012295A
(es)
|
2017-04-14 |
2020-02-07 |
Tollnine Inc |
Polinucleotidos inmunomoduladores, conjugados de anticuerpos de los mismos y metodos para su uso.
|
|
WO2018198084A1
(en)
*
|
2017-04-27 |
2018-11-01 |
Lupin Limited |
Cyclic di-nucleotide compounds with tricyclic nucleobases
|
|
AR113224A1
(es)
|
2017-04-28 |
2020-02-19 |
Novartis Ag |
Conjugados de anticuerpo que comprenden un agonista de sting
|
|
UY37695A
(es)
|
2017-04-28 |
2018-11-30 |
Novartis Ag |
Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo
|
|
US11466047B2
(en)
|
2017-05-12 |
2022-10-11 |
Merck Sharp & Dohme Llc |
Cyclic di-nucleotide compounds as sting agonists
|
|
JP2020522495A
(ja)
|
2017-05-30 |
2020-07-30 |
ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company |
抗lag−3抗体、pd−1経路阻害剤および免疫療法剤の組み合わせを含む組成物
|
|
JP7186764B2
(ja)
*
|
2017-07-28 |
2022-12-09 |
ブリストル-マイヤーズ スクイブ カンパニー |
抗癌剤としての環状ジヌクレオチド
|
|
JP2020530838A
(ja)
|
2017-08-04 |
2020-10-29 |
メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. |
がん治療のためのベンゾ[b]チオフェンSTINGアゴニスト
|
|
RU2020109328A
(ru)
|
2017-08-04 |
2021-09-06 |
Мерк Шарп И Доум Корп. |
Комбинации антагонистов pd-1 и бензо[b]тиофеновых агонистов sting для лечения рака
|
|
MX2020002303A
(es)
*
|
2017-08-30 |
2020-09-10 |
Beijing Xuanyi Pharmasciences Co Ltd |
Dinucleotidos ciclicos como moduladores del estimulador de genes de interferon.
|
|
KR102812783B1
(ko)
*
|
2017-08-31 |
2025-05-26 |
브리스톨-마이어스 스큅 컴퍼니 |
항암제로서의 시클릭 디뉴클레오티드
|
|
US11707531B2
(en)
|
2017-09-11 |
2023-07-25 |
F-star Therapeutics, Inc. |
Compounds, compositions, and methods for the treatment of disease
|
|
US11584774B2
(en)
|
2017-09-11 |
2023-02-21 |
F-star Therapeutics, Inc. |
Compounds, compositions, and methods for the treatment of disease
|
|
EP3691640A1
(en)
*
|
2017-10-05 |
2020-08-12 |
GlaxoSmithKline Intellectual Property Development Limited |
Methods for administering sting agonists
|
|
EP3697801B1
(en)
*
|
2017-10-16 |
2024-11-20 |
Bristol-Myers Squibb Company |
Cyclic dinucleotides as anticancer agents
|
|
WO2019084060A1
(en)
|
2017-10-24 |
2019-05-02 |
Silverback Therapeutics, Inc. |
CONJUGATES AND METHODS OF USE FOR THE SELECTIVE DELIVERY OF IMMUNOMODULATORY AGENTS
|
|
KR20200098511A
(ko)
|
2017-11-10 |
2020-08-20 |
다케다 야쿠힌 고교 가부시키가이샤 |
Sting 조절제 화합물, 및 제조 및 사용 방법
|
|
EA038805B1
(ru)
*
|
2017-11-21 |
2021-10-21 |
Такеда Фармасьютикал Компани Лимитед |
Циклические динуклеотиды в качестве агонистов sting (стимулятор генов интерферона)
|
|
EP3727401A4
(en)
|
2017-12-20 |
2022-04-06 |
Merck Sharp & Dohme Corp. |
CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS
|
|
EP3728283B1
(en)
|
2017-12-20 |
2023-11-22 |
Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. |
3'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
|
|
WO2019123339A1
(en)
|
2017-12-20 |
2019-06-27 |
Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. |
2'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
|
|
EP3505527A1
(en)
|
2017-12-29 |
2019-07-03 |
Invivogen |
Cyclic dinucleotides for cytokine induction
|
|
WO2019136118A2
(en)
*
|
2018-01-04 |
2019-07-11 |
Academia Sinica |
Cell-associating immunologic adjuvants for treatment enhancement
|
|
US12220462B1
(en)
|
2018-02-13 |
2025-02-11 |
Abionyx Pharma Sa |
Complexes for delivery of cyclic dinucleotides
|
|
WO2019180683A1
(en)
|
2018-03-23 |
2019-09-26 |
Takeda Pharmaceutical Company Limited |
Sting modulator compounds with sulfamate linkages, and methods of making and using
|
|
CA3093849A1
(en)
|
2018-03-23 |
2019-09-26 |
Codiak Biosciences, Inc. |
Extracellular vesicles comprising sting-agonist
|
|
WO2019185477A1
(en)
|
2018-03-27 |
2019-10-03 |
Boehringer Ingelheim International Gmbh |
Cyclic dinucleotide compounds containing 2-aza-hypoxanthine or 6h-pytazolo[1,5-d][1,2,4]triazin-7-one as sting agonists
|
|
JP2021519279A
(ja)
|
2018-03-27 |
2021-08-10 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
修飾環式ジヌクレオチド化合物
|
|
JP7326319B2
(ja)
|
2018-04-03 |
2023-08-15 |
メルク・シャープ・アンド・ドーム・エルエルシー |
Stingアゴニストとしてのベンゾチオフェン類及び関連する化合物
|
|
EP3774765A4
(en)
|
2018-04-03 |
2021-12-29 |
Merck Sharp & Dohme Corp. |
Aza-benzothiophene compounds as sting agonists
|
|
TWI818007B
(zh)
|
2018-04-06 |
2023-10-11 |
捷克科學院有機化學與生物化學研究所 |
2'3'-環二核苷酸
|
|
TWI833744B
(zh)
|
2018-04-06 |
2024-03-01 |
捷克科學院有機化學與生物化學研究所 |
3'3'-環二核苷酸
|
|
BR112020024605A2
(pt)
|
2018-06-01 |
2021-04-06 |
Eisai R&D Management Co., Ltd. |
Métodos para o tratamento de câncer de bexiga
|
|
WO2020014127A1
(en)
|
2018-07-10 |
2020-01-16 |
Sperovie Biosciences, Inc. |
Compounds, compositions, and methods for the treatment of disease
|
|
US11691990B2
(en)
|
2018-08-16 |
2023-07-04 |
Eisai R&D Management Co., Ltd |
Salts of compounds and crystals thereof
|
|
EP3841112A1
(en)
|
2018-08-24 |
2021-06-30 |
Codiak BioSciences, Inc. |
Extracellular vesicles targeting dendritic cells and uses thereof
|
|
MX2021002764A
(es)
|
2018-09-12 |
2021-05-12 |
Silverback Therapeutics Inc |
Composiciones para el tratamiento de enfermedades con conjugados inmunoestimuladores.
|
|
EP3856258B1
(en)
|
2018-09-27 |
2024-07-31 |
Pierre Fabre Medicament |
Sulfomaleimide-based linkers and corresponding conjugates
|
|
CN112867727B
(zh)
*
|
2018-10-12 |
2024-05-17 |
上海济煜医药科技有限公司 |
环二核苷酸类化合物及其应用
|
|
WO2020092127A1
(en)
|
2018-10-29 |
2020-05-07 |
Venenum Biodesign, LLC |
Novel sting agonists
|
|
US11110106B2
(en)
|
2018-10-29 |
2021-09-07 |
Venenum Biodesign, LLC |
Sting agonists for treating bladder cancer and solid tumors
|
|
WO2020092379A1
(en)
|
2018-10-29 |
2020-05-07 |
Genocea Biosciences, Inc. |
Treatment methods
|
|
US12508233B2
(en)
|
2018-10-30 |
2025-12-30 |
Vanderbilt University |
Graft copolymers, methods of forming graft copolymers, and methods of use thereof
|
|
WO2020092617A1
(en)
|
2018-10-31 |
2020-05-07 |
Novartis Ag |
Dc-sign antibody conjugates comprising sting agonists
|
|
EP3901161B1
(en)
*
|
2019-01-10 |
2025-01-22 |
Shenzhen YING Biopharmaceutical Co., Ltd. |
Cyclic dinucleotide prodrug molecule, preparation method therefor and application thereof
|
|
CN113950486A
(zh)
|
2019-01-28 |
2022-01-18 |
罗德岛大学理事会 |
pHLIP®-介导的免疫刺激化合物的细胞内递送
|
|
EP3941607A1
(en)
|
2019-03-21 |
2022-01-26 |
Codiak BioSciences, Inc. |
Process for preparing extracellular vesicles
|
|
US20240108747A1
(en)
|
2019-03-21 |
2024-04-04 |
Lonza Sales Ag |
Extracellular vesicle conjugates and uses thereof
|
|
BR112021018694A2
(pt)
|
2019-03-21 |
2021-11-30 |
Codiak Biosciences Inc |
Vesículas extracelulares para distribuição de vacina
|
|
WO2020205688A1
(en)
|
2019-04-04 |
2020-10-08 |
Merck Sharp & Dohme Corp. |
Inhibitors of histone deacetylase-3 useful for the treatment of cancer, inflammation, neurodegeneration diseases and diabetes
|
|
WO2020227159A2
(en)
|
2019-05-03 |
2020-11-12 |
Flagship Pioneering Innovations V, Inc. |
Methods of modulating immune activity
|
|
WO2020227421A1
(en)
|
2019-05-09 |
2020-11-12 |
Aligos Therapeutics, Inc. |
Modified cyclic dinucleoside compounds as sting modulators
|
|
EP3994158A1
(en)
|
2019-07-03 |
2022-05-11 |
Codiak BioSciences, Inc. |
Extracellular vesicles targeting t cells and uses thereof
|
|
US12435104B2
(en)
|
2019-07-25 |
2025-10-07 |
Beigene, Ltd. |
Cyclic dinucleotides as sting agonists
|
|
JP7843695B2
(ja)
|
2019-08-02 |
2026-04-10 |
メルサナ セラピューティクス インコーポレイテッド |
がんの処置用のSTING(インターフェロン遺伝子刺激因子)アゴニストとしてのビス-[N-((5-カルバモイル)-1H-ベンゾ[d]イミダゾール-2-イル)-ピラゾール-5-カルボキサミド]誘導体および関連化合物
|
|
CA3149494A1
(en)
|
2019-08-12 |
2021-02-18 |
Purinomia Biotech, Inc. |
Methods and compositions for promoting and potentiating t-cell mediated immune responses through adcc targeting of cd39 expressing cells
|
|
WO2021062290A1
(en)
|
2019-09-25 |
2021-04-01 |
Codiak Biosciences, Inc. |
Methods of producing extracellular vesicles
|
|
WO2021062058A1
(en)
|
2019-09-25 |
2021-04-01 |
Codiak Biosciences, Inc. |
Sting agonist comprising exosomes for treating neuroimmunological disorders
|
|
MX2022003570A
(es)
|
2019-09-25 |
2022-07-11 |
Codiak Biosciences Inc |
Composiciones de vesícula extracelular.
|
|
KR20220094221A
(ko)
|
2019-09-25 |
2022-07-05 |
코디악 바이오사이언시즈, 인크. |
종양의 치료를 위한 il-12 디스플레잉 엑소좀과 조합된 sting 효능제 포함 엑소좀
|
|
CA3151322A1
(en)
|
2019-10-01 |
2021-04-08 |
Silverback Therapeutics, Inc. |
Combination therapy with immune stimulatory conjugates
|
|
WO2021074695A1
(en)
|
2019-10-16 |
2021-04-22 |
Avacta Life Sciences Limited |
PD-L1 INHIBITOR - TGFβ INHIBITOR BISPECIFIC DRUG MOIETIES.
|
|
EP4069683A1
(en)
|
2019-12-06 |
2022-10-12 |
Mersana Therapeutics, Inc. |
Dimeric compounds as sting agonists
|
|
JP7735291B2
(ja)
|
2020-02-21 |
2025-09-08 |
エーアールエス ファーマシューティカルズ、インコーポレイテッド |
ネクチン-4抗体コンジュゲートおよびその使用
|
|
CA3169523A1
(en)
|
2020-02-28 |
2021-09-02 |
Jaume Pons |
Transglutaminase-mediated conjugation
|
|
US20230114434A1
(en)
|
2020-03-13 |
2023-04-13 |
Codiak Biosciences, Inc. |
Extracellular vesicles for treating neurological disorders
|
|
JP2023518414A
(ja)
|
2020-03-20 |
2023-05-01 |
コディアック バイオサイエンシーズ, インコーポレイテッド |
治療のための細胞外小胞
|
|
IL296901A
(en)
|
2020-04-02 |
2022-12-01 |
Mersana Therapeutics Inc |
Antibody-drug conjugates comprising sting agonists
|
|
TW202200136A
(zh)
|
2020-04-10 |
2022-01-01 |
日商小野藥品工業股份有限公司 |
癌治療方法
|
|
US20230149560A1
(en)
|
2020-04-20 |
2023-05-18 |
Massachusetts Institute Of Technology |
Lipid compositions for delivery of sting agonist compounds and uses thereof
|
|
MX2022014110A
(es)
|
2020-05-15 |
2023-01-30 |
Immunesensor Therapeutics Inc |
Tratamientos combinados de agonistas de sting con inhibidores de puntos de control inmunitario.
|
|
WO2021237100A1
(en)
|
2020-05-21 |
2021-11-25 |
Codiak Biosciences, Inc. |
Methods of targeting extracellular vesicles to lung
|
|
WO2021252904A1
(en)
|
2020-06-11 |
2021-12-16 |
Massachusetts Institute Of Technology |
Ribonucleoprotein approach to boost the sting signaling for cancer immunotherapy
|
|
JP2023532304A
(ja)
|
2020-07-01 |
2023-07-27 |
エーアールエス ファーマシューティカルズ オペレーションズ,インク. |
抗asgr1抗体コンジュゲートおよびその使用
|
|
CN111909223A
(zh)
*
|
2020-07-17 |
2020-11-10 |
清华大学 |
环二核苷酸共价修饰物及其制备方法和应用
|
|
US20240082389A1
(en)
|
2020-09-23 |
2024-03-14 |
Lonza Sales Ag |
Methods of producing extracellular vesicles
|
|
CA3193107A1
(en)
|
2020-09-23 |
2022-03-31 |
Codiak Biosciences, Inc. |
Process for preparing extracellular vesicles
|
|
WO2022066928A2
(en)
|
2020-09-23 |
2022-03-31 |
Codiak Biosciences, Inc. |
Process for preparing extracellular vesicles
|
|
WO2022066883A1
(en)
|
2020-09-23 |
2022-03-31 |
Codiak Biosciences, Inc. |
Extracellular vesicles comprising kras antigens and uses thereof
|
|
CN115160392B
(zh)
*
|
2020-10-20 |
2026-01-30 |
泰励生物科技(上海)有限公司 |
多功能环二核苷酸及其用途
|
|
TWI901793B
(zh)
*
|
2020-10-20 |
2025-10-21 |
大陸商泰勵生物科技(上海)有限公司 |
多功能環二核苷酸及其用途
|
|
KR102466750B1
(ko)
|
2020-10-23 |
2022-11-15 |
아주대학교산학협력단 |
인돌리진 유도체를 유효성분으로 포함하는 인터페론 유전자 자극제 조성물
|
|
IL302390A
(en)
|
2020-11-09 |
2023-06-01 |
Takeda Pharmaceuticals Co |
Drug antibody conjugates
|
|
US20220211883A1
(en)
|
2020-12-17 |
2022-07-07 |
Trustees Of Tufts College |
Fap-activated radiotheranostics and uses related thereto
|
|
WO2022234003A1
(en)
|
2021-05-07 |
2022-11-10 |
Avacta Life Sciences Limited |
Cd33 binding polypeptides with stefin a protein
|
|
JP2024526874A
(ja)
|
2021-07-23 |
2024-07-19 |
イミューンセンサー セラピューティクス、インコーポレイテッド |
サイトカインとのstingアゴニスト併用療法
|
|
WO2023056468A1
(en)
|
2021-09-30 |
2023-04-06 |
Codiak Biosciences, Inc. |
Extracellular vesicle comprising cholesterol tagged sting-agonist
|
|
EP4413038A1
(en)
|
2021-10-07 |
2024-08-14 |
Avacta Life Sciences Limited |
Pd-l1 binding affimers
|
|
JP2025508076A
(ja)
|
2022-03-08 |
2025-03-21 |
アレンティス・セラピューティクス・アクチェンゲゼルシャフト |
T細胞の利用能を向上させるための抗クローディン-1抗体の使用
|
|
WO2023218243A1
(en)
|
2022-05-12 |
2023-11-16 |
Avacta Life Sciences Limited |
Lag-3/pd-l1 binding fusion proteins
|
|
GB202304385D0
(en)
|
2023-03-24 |
2023-05-10 |
Prostate Cancer Res |
Combinatorial IL-15 therapy
|
|
WO2026027944A1
(en)
|
2024-07-30 |
2026-02-05 |
Sairopa B.V. |
Anti-sirp alpha antibody formulations and uses thereof
|