|
PL2931738T3
(pl)
|
2012-12-13 |
2019-07-31 |
Aduro Biotech, Inc. |
Kompozycje zawierające cykliczne dinukleotydy purynowe o zdefiniowanej stereochemii i sposoby ich otrzymywania i zastosowania
|
|
WO2014179335A1
(en)
|
2013-04-29 |
2014-11-06 |
Memorial Sloan Kettering Cancer Center |
Compositions and methods for altering second messenger signaling
|
|
RS59500B1
(sr)
|
2013-05-18 |
2019-12-31 |
Aduro Biotech Inc |
Sastavi i metode za aktiviranje signaliziranja koje je zavisno od „stimulatora gena za interferon“
|
|
PE20170198A1
(es)
|
2014-06-04 |
2017-04-08 |
Glaxosmithkline Ip Dev Ltd |
Dinucleotidos ciclicos como moduladores de sting
|
|
EP3546473B1
(en)
*
|
2014-12-16 |
2025-12-10 |
Kayla Therapeutics |
Fluorinated cyclic [(2',5')p(3',5')p]-dinucleotides for cytokine induction
|
|
GB201501462D0
(en)
|
2015-01-29 |
2015-03-18 |
Glaxosmithkline Ip Dev Ltd |
Novel compounds
|
|
HK1248603A1
(zh)
|
2015-03-10 |
2018-10-19 |
Aduro Biotech, Inc. |
用於活化"干扰素基因的刺激剂"依懒性信号传导的组合物和方法
|
|
US11453697B1
(en)
|
2015-08-13 |
2022-09-27 |
Merck Sharp & Dohme Llc |
Cyclic di-nucleotide compounds as sting agonists
|
|
CR20180101A
(es)
|
2015-08-13 |
2018-04-12 |
Merck Sharp & Dohme |
Compuestos di-nucleóticos cíclicos como agonistas de sting
|
|
EP3359675B1
(en)
|
2015-10-07 |
2024-01-03 |
Nant Holdings IP, LLC |
Activation of immune-related signalling pathways in cells via optofection
|
|
TWI704154B
(zh)
|
2015-12-03 |
2020-09-11 |
英商葛蘭素史克智慧財產發展有限公司 |
新穎化合物
|
|
RS67188B1
(sr)
|
2016-01-11 |
2025-10-31 |
Innate Tumor Immunity Inc |
Ciklični dinukleotidi za lečenje stanja povezanih sa aktivnošću sting kao što je kancer
|
|
SG10201912074PA
(en)
*
|
2016-03-18 |
2020-02-27 |
Immune Sensor Llc |
Cyclic di-nucleotide compounds and methods of use
|
|
WO2017186711A1
(en)
*
|
2016-04-25 |
2017-11-02 |
Invivogen |
Novel complexes of immunostimulatory compounds, and uses thereof
|
|
US10696985B1
(en)
|
2016-06-06 |
2020-06-30 |
Vanderbilt University |
Reversibly crosslinked endosomolytic polymer vesicles for cytosolic drug delivery
|
|
WO2018009466A1
(en)
*
|
2016-07-05 |
2018-01-11 |
Aduro Biotech, Inc. |
Locked nucleic acid cyclic dinucleotide compounds and uses thereof
|
|
US11033569B2
(en)
*
|
2016-07-06 |
2021-06-15 |
Sperovie Biosciences, Inc. |
Compounds,Compositions, and methods for the treatment of disease
|
|
MX2019000660A
(es)
*
|
2016-07-15 |
2019-10-02 |
Sperovie Biosciences Inc |
Compuestos, composiciones y métodos para el tratamiento de enfermedades.
|
|
NL2017267B1
(en)
|
2016-07-29 |
2018-02-01 |
Aduro Biotech Holdings Europe B V |
Anti-pd-1 antibodies
|
|
NL2017270B1
(en)
|
2016-08-02 |
2018-02-09 |
Aduro Biotech Holdings Europe B V |
New anti-hCTLA-4 antibodies
|
|
US10537590B2
(en)
*
|
2016-09-30 |
2020-01-21 |
Boehringer Ingelheim International Gmbh |
Cyclic dinucleotide compounds
|
|
US10414747B2
(en)
|
2016-10-04 |
2019-09-17 |
Merck Sharp & Dohme Corp. |
Benzo[b]thiophene compounds as sting agonists
|
|
EP3523314A1
(de)
|
2016-10-07 |
2019-08-14 |
Biolog Life Science Institute Forschungslabor Und Biochemica-Vertrieb GmbH |
Benzimidazolhaltige cyclische dinukleotide, verfahren zu deren herstellung und ihre verwendung zur aktivierung von stimulator von interferongenen (sting)-abhängigen signalwegen
|
|
JOP20170188A1
(ar)
*
|
2016-11-25 |
2019-01-30 |
Janssen Biotech Inc |
ثنائي النوكليوتيدات الحلقية كمنبهات ستينغ (sting)
|
|
WO2018100558A2
(en)
*
|
2016-12-01 |
2018-06-07 |
Takeda Pharmaceutical Company Limited |
Cyclic dinucleotide
|
|
JP2018090562A
(ja)
*
|
2016-12-01 |
2018-06-14 |
武田薬品工業株式会社 |
環状ジヌクレオチド
|
|
WO2018118665A1
(en)
*
|
2016-12-20 |
2018-06-28 |
Merck Sharp & Dohme Corp. |
Cyclic dinucleotide sting agonists for cancer treatment
|
|
CN110446503A
(zh)
*
|
2016-12-22 |
2019-11-12 |
马福制药公司 |
磷酸二酯酶抑制剂及微生物治疗方法
|
|
US20200055883A1
(en)
|
2017-02-17 |
2020-02-20 |
Eisai R&D Management Co., Ltd. |
Cyclic di-nucleotides derivative for the treatment of cancer
|
|
CA3053568A1
(en)
|
2017-02-21 |
2018-08-30 |
Board Of Regents, The University Of Texas System |
Cyclic dinucleotides as agonists of stimulator of interferon gene dependent signalling
|
|
KR20190142767A
(ko)
|
2017-03-20 |
2019-12-27 |
제노세아 바이오사이언스, 인코퍼레이티드 |
치료 방법
|
|
JOP20190218A1
(ar)
|
2017-03-22 |
2019-09-22 |
Boehringer Ingelheim Int |
مركبات ثنائية النيوكليوتيدات حلقية معدلة
|
|
CN118267470A
(zh)
|
2017-04-13 |
2024-07-02 |
赛罗帕私人有限公司 |
抗SIRPα抗体
|
|
MX2019012295A
(es)
|
2017-04-14 |
2020-02-07 |
Tollnine Inc |
Polinucleotidos inmunomoduladores, conjugados de anticuerpos de los mismos y metodos para su uso.
|
|
WO2018198084A1
(en)
*
|
2017-04-27 |
2018-11-01 |
Lupin Limited |
Cyclic di-nucleotide compounds with tricyclic nucleobases
|
|
AR113224A1
(es)
|
2017-04-28 |
2020-02-19 |
Novartis Ag |
Conjugados de anticuerpo que comprenden un agonista de sting
|
|
UY37695A
(es)
|
2017-04-28 |
2018-11-30 |
Novartis Ag |
Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo
|
|
US11466047B2
(en)
|
2017-05-12 |
2022-10-11 |
Merck Sharp & Dohme Llc |
Cyclic di-nucleotide compounds as sting agonists
|
|
US20210340250A1
(en)
|
2017-05-30 |
2021-11-04 |
Bristol-Myers Squibb Company |
Compositions comprising a combination of an anti-lag-3 antibody, a pd-1 pathway inhibitor, and an immunotherapeutic agent
|
|
KR102709265B1
(ko)
*
|
2017-07-28 |
2024-09-23 |
브리스톨-마이어스 스큅 컴퍼니 |
항암제로서의 시클릭 디뉴클레오티드
|
|
US11312772B2
(en)
|
2017-08-04 |
2022-04-26 |
Merck Sharp & Dohme Corp. |
Combinations of PD-1 antagonists and benzo [b] thiophene STING agonists for cancer treatment
|
|
US11285131B2
(en)
|
2017-08-04 |
2022-03-29 |
Merck Sharp & Dohme Corp. |
Benzo[b]thiophene STING agonists for cancer treatment
|
|
WO2019043634A2
(en)
*
|
2017-08-30 |
2019-03-07 |
Beijing Xuanyi Pharmasciences Co., Ltd. |
CYCLIC DI-NUCLEOTIDES AS STIMULATORS OF INTERFERON GENE MODULATORS
|
|
US11667663B2
(en)
*
|
2017-08-31 |
2023-06-06 |
Bristol-Myers Squibb Company |
Cyclic dinucleotides as anticancer agents
|
|
WO2019051488A1
(en)
|
2017-09-11 |
2019-03-14 |
Sperovie Biosciences, Inc. |
COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING DISEASE
|
|
WO2019051489A1
(en)
|
2017-09-11 |
2019-03-14 |
Sperovie Biosciences, Inc. |
COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING DISEASE
|
|
CN111194214A
(zh)
*
|
2017-10-05 |
2020-05-22 |
葛兰素史密斯克莱知识产权发展有限公司 |
施用sting激动剂的方法
|
|
US11427610B2
(en)
*
|
2017-10-16 |
2022-08-30 |
Bristol-Myers Squibb Company |
Cyclic dinucleotides as anticancer agents
|
|
WO2019084060A1
(en)
|
2017-10-24 |
2019-05-02 |
Silverback Therapeutics, Inc. |
CONJUGATES AND METHODS OF USE FOR THE SELECTIVE DELIVERY OF IMMUNOMODULATORY AGENTS
|
|
JP7195317B2
(ja)
|
2017-11-10 |
2022-12-23 |
武田薬品工業株式会社 |
Ｓｔｉｎｇ調節剤化合物、ならびに製造及び使用する方法
|
|
EA038805B1
(ru)
*
|
2017-11-21 |
2021-10-21 |
Такеда Фармасьютикал Компани Лимитед |
Циклические динуклеотиды в качестве агонистов sting (стимулятор генов интерферона)
|
|
CN111511754B
(zh)
|
2017-12-20 |
2023-09-12 |
捷克共和国有机化学与生物化学研究所 |
活化sting转接蛋白的具有膦酸酯键的2’3’环状二核苷酸
|
|
US10966999B2
(en)
|
2017-12-20 |
2021-04-06 |
Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. |
3′3′ cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
|
|
EP3727401A4
(en)
|
2017-12-20 |
2022-04-06 |
Merck Sharp & Dohme Corp. |
CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS
|
|
EP3505527A1
(en)
|
2017-12-29 |
2019-07-03 |
Invivogen |
Cyclic dinucleotides for cytokine induction
|
|
JP7230035B2
(ja)
*
|
2018-01-04 |
2023-02-28 |
アカデミア シニカ |
治療を強化するための細胞会合免疫アジュバントならびに同アジュバントを含むキットおよび処方物
|
|
US12220462B1
(en)
|
2018-02-13 |
2025-02-11 |
Abionyx Pharma Sa |
Complexes for delivery of cyclic dinucleotides
|
|
SG11202008636YA
(en)
*
|
2018-03-23 |
2020-10-29 |
Codiak Biosciences Inc |
Extracellular vesicles comprising sting-agonist
|
|
US20210015915A1
(en)
|
2018-03-23 |
2021-01-21 |
Takeda Pharmaceutical Company Limited |
Sting modulator compounds with sulfamate linkages, and methods of making and using
|
|
CN111989338A
(zh)
|
2018-03-27 |
2020-11-24 |
勃林格殷格翰国际有限公司 |
修饰的环二核苷酸化合物
|
|
EP3774834A1
(en)
|
2018-03-27 |
2021-02-17 |
Boehringer Ingelheim International GmbH |
Cyclic dinucleotide compounds containing 2-aza-hypoxanthine or 6h-pytazolo[1,5-d][1,2,4]triazin-7-one as sting agonists
|
|
US10793557B2
(en)
|
2018-04-03 |
2020-10-06 |
Merck Sharp & Dohme Corp. |
Sting agonist compounds
|
|
US11702430B2
(en)
|
2018-04-03 |
2023-07-18 |
Merck Sharp & Dohme Llc |
Aza-benzothiophene compounds as STING agonists
|
|
TWI818007B
(zh)
|
2018-04-06 |
2023-10-11 |
捷克科學院有機化學與生物化學研究所 |
2'3'-環二核苷酸
|
|
TWI833744B
(zh)
|
2018-04-06 |
2024-03-01 |
捷克科學院有機化學與生物化學研究所 |
3'3'-環二核苷酸
|
|
MX2020012964A
(es)
|
2018-06-01 |
2021-02-16 |
Eisai R&D Man Co Ltd |
Metodos para el tratamiento de cancer de vejiga.
|
|
EP3820477A4
(en)
|
2018-07-10 |
2022-07-13 |
Sperovie Biosciences, Inc. |
COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF DISEASES
|
|
MX2020013322A
(es)
|
2018-08-16 |
2021-02-22 |
Eisai R&D Man Co Ltd |
Sales de compuestos y cristales de los mismos.
|
|
EP3841112A1
(en)
|
2018-08-24 |
2021-06-30 |
Codiak BioSciences, Inc. |
Extracellular vesicles targeting dendritic cells and uses thereof
|
|
US20200113912A1
(en)
|
2018-09-12 |
2020-04-16 |
Silverback Therapeutics, Inc. |
Methods and Compositions for the Treatment of Disease with Immune Stimulatory Conjugates
|
|
MX2021003295A
(es)
|
2018-09-27 |
2021-07-16 |
Pf Medicament |
Enlazadores basados en sulfomaleimida y sus correspondientes conjugados.
|
|
JP7492523B2
(ja)
*
|
2018-10-12 |
2024-05-29 |
シャンハイ ジェミンケア ファーマシューティカル カンパニー，リミティド |
環状ジヌクレオチド化合物及びその使用
|
|
AU2019373241A1
(en)
|
2018-10-29 |
2021-06-10 |
Genocea Biosciences, Inc. |
Treatment methods
|
|
AU2019371206A1
(en)
|
2018-10-29 |
2021-05-27 |
Venenum Biodesign, LLC |
Novel sting agonists
|
|
US11110106B2
(en)
|
2018-10-29 |
2021-09-07 |
Venenum Biodesign, LLC |
Sting agonists for treating bladder cancer and solid tumors
|
|
WO2020092633A1
(en)
|
2018-10-30 |
2020-05-07 |
Vanderbilt University |
Graft copolymers, methods of forming graft copolymers, and methods of use thereof
|
|
WO2020092617A1
(en)
|
2018-10-31 |
2020-05-07 |
Novartis Ag |
Dc-sign antibody conjugates comprising sting agonists
|
|
KR102620495B1
(ko)
*
|
2019-01-10 |
2024-01-04 |
셴젠 잉 바이오파마수티칼 씨오., 엘티디. |
시클릭 디뉴클레오티드 프로드러그 분자 및 이의 제조 방법과 응용
|
|
CN113950486A
(zh)
|
2019-01-28 |
2022-01-18 |
罗德岛大学理事会 |
pHLIP®-介导的免疫刺激化合物的细胞内递送
|
|
CN114080232A
(zh)
|
2019-03-21 |
2022-02-22 |
科迪亚克生物科学公司 |
用于疫苗递送的细胞外囊泡
|
|
KR20210141554A
(ko)
|
2019-03-21 |
2021-11-23 |
코디악 바이오사이언시즈, 인크. |
세포외 소포 접합체 및 이의 용도
|
|
WO2020191369A1
(en)
|
2019-03-21 |
2020-09-24 |
Codiak Biosciences, Inc. |
Process for preparing extracellular vesicles
|
|
US12281109B2
(en)
|
2019-04-04 |
2025-04-22 |
Merck Sharp & Dohme Llc |
Inhibitors of histone deacetylase-3 useful for the treatment of cancer, inflammation, neurodegeneration diseases and diabetes
|
|
WO2020227159A2
(en)
|
2019-05-03 |
2020-11-12 |
Flagship Pioneering Innovations V, Inc. |
Methods of modulating immune activity
|
|
JP7621974B2
(ja)
|
2019-05-09 |
2025-01-27 |
アリゴス セラピューティクス インコーポレイテッド |
Ｓｔｉｎｇモジュレータとしての修飾環状ジヌクレオシド化合物
|
|
US20220251200A1
(en)
|
2019-07-03 |
2022-08-11 |
Codiak Biosciences, Inc. |
Extracellular vesicles targeting t cells and uses thereof
|
|
WO2021013234A1
(en)
|
2019-07-25 |
2021-01-28 |
Beigene, Ltd. |
Cyclic dinucleotides as sting agonists
|
|
CA3149482A1
(en)
|
2019-08-02 |
2021-02-11 |
Mersana Therapeutics, Inc. |
Bis-[n-((5-carbamoyl)-1h-benzo[d]imidazol-2-yl)-pyrazol-5-carboxamide] derivatives and related compounds as sting (stimulator of interferon genes) agonists for the treatment of cancer
|
|
KR20220061977A
(ko)
|
2019-08-12 |
2022-05-13 |
퓨리노미아 바이오테크, 아이엔씨. |
Cd39 발현 세포의 adcc 표적화를 통해 t 세포 매개 면역 반응을 촉진 및 강화하기 위한 방법 및 조성물
|
|
US20220395465A1
(en)
|
2019-09-25 |
2022-12-15 |
Codiak Biosciences, Inc. |
Sting agonist comprising exosomes combined with il-12 displaying exosomes for treating a tumour
|
|
US20230103726A1
(en)
|
2019-09-25 |
2023-04-06 |
Codiak Biosciences, Inc. |
Methods of producing extracellular vesicles
|
|
CA3152478A1
(en)
|
2019-09-25 |
2021-04-01 |
Codiak Biosciences, Inc. |
Extracellular vesicle compositions
|
|
EP4034247A1
(en)
|
2019-09-25 |
2022-08-03 |
Codiak BioSciences, Inc. |
Sting agonist comprising exosomes for treating neuroimmunological disorders
|
|
CA3151322A1
(en)
|
2019-10-01 |
2021-04-08 |
Silverback Therapeutics, Inc. |
Combination therapy with immune stimulatory conjugates
|
|
WO2021074695A1
(en)
|
2019-10-16 |
2021-04-22 |
Avacta Life Sciences Limited |
PD-L1 INHIBITOR - TGFβ INHIBITOR BISPECIFIC DRUG MOIETIES.
|
|
WO2021113679A1
(en)
|
2019-12-06 |
2021-06-10 |
Mersana Therapeutics, Inc. |
Dimeric compounds as sting agonists
|
|
JP7735291B2
(ja)
|
2020-02-21 |
2025-09-08 |
エーアールエス ファーマシューティカルズ、インコーポレイテッド |
ネクチン－４抗体コンジュゲートおよびその使用
|
|
BR112022017136A2
(pt)
|
2020-02-28 |
2022-10-11 |
Tallac Therapeutics Inc |
Conjugação mediada por transglutaminase
|
|
WO2021184017A1
(en)
|
2020-03-13 |
2021-09-16 |
Codiak Biosciences, Inc. |
Extracellular vesicles for treating neurological disorders
|
|
JP2023518414A
(ja)
|
2020-03-20 |
2023-05-01 |
コディアック バイオサイエンシーズ， インコーポレイテッド |
治療のための細胞外小胞
|
|
WO2021202984A1
(en)
|
2020-04-02 |
2021-10-07 |
Mersana Therapeutics, Inc. |
Antibody drug conjugates comprising sting agonists
|
|
WO2021206158A1
(ja)
|
2020-04-10 |
2021-10-14 |
小野薬品工業株式会社 |
がん治療方法
|
|
WO2021216572A1
(en)
|
2020-04-20 |
2021-10-28 |
Massachusetts Institute Of Technology |
Lipid compositions for delivery of sting agonist compounds and uses thereof
|
|
JP2023533111A
(ja)
|
2020-05-15 |
2023-08-02 |
イミューンセンサー セラピューティクス、インコーポレイテッド |
免疫チェックポイント阻害剤とのｓｔｉｎｇアゴニスト併用治療
|
|
WO2021237100A1
(en)
|
2020-05-21 |
2021-11-25 |
Codiak Biosciences, Inc. |
Methods of targeting extracellular vesicles to lung
|
|
WO2021252904A1
(en)
|
2020-06-11 |
2021-12-16 |
Massachusetts Institute Of Technology |
Ribonucleoprotein approach to boost the sting signaling for cancer immunotherapy
|
|
JP2023532304A
(ja)
|
2020-07-01 |
2023-07-27 |
エーアールエス ファーマシューティカルズ オペレーションズ，インク． |
抗ａｓｇｒ１抗体コンジュゲートおよびその使用
|
|
CN111909223A
(zh)
*
|
2020-07-17 |
2020-11-10 |
清华大学 |
环二核苷酸共价修饰物及其制备方法和应用
|
|
US20230366794A1
(en)
|
2020-09-23 |
2023-11-16 |
Codiak Biosciences, Inc. |
Process for preparing extracellular vesicles
|
|
US20240241020A1
(en)
|
2020-09-23 |
2024-07-18 |
Lonza Sales Ag |
Process for preparing extracellular vesicles
|
|
WO2022066883A1
(en)
|
2020-09-23 |
2022-03-31 |
Codiak Biosciences, Inc. |
Extracellular vesicles comprising kras antigens and uses thereof
|
|
WO2022066898A2
(en)
|
2020-09-23 |
2022-03-31 |
Codiak Biosciences, Inc. |
Methods of producing extracellular vesicles
|
|
CN115160392B
(zh)
*
|
2020-10-20 |
2026-01-30 |
泰励生物科技（上海）有限公司 |
多功能环二核苷酸及其用途
|
|
AU2021363267A1
(en)
*
|
2020-10-20 |
2023-06-22 |
Tyligand Bioscience (Shanghai) Limited |
Multifunctional cyclic dinucleotide and use thereof
|
|
KR102466750B1
(ko)
|
2020-10-23 |
2022-11-15 |
아주대학교산학협력단 |
인돌리진 유도체를 유효성분으로 포함하는 인터페론 유전자 자극제 조성물
|
|
JP7397996B2
(ja)
|
2020-11-09 |
2023-12-13 |
武田薬品工業株式会社 |
抗体薬物コンジュゲート
|
|
TW202241516A
(zh)
|
2020-12-17 |
2022-11-01 |
美商杜夫特學院信託管理公司 |
經fap活化之放射性治療診斷(radiotheranostics)，與其相關用途
|
|
WO2022234003A1
(en)
|
2021-05-07 |
2022-11-10 |
Avacta Life Sciences Limited |
Cd33 binding polypeptides with stefin a protein
|
|
AU2022315305A1
(en)
|
2021-07-23 |
2024-02-01 |
Immunesensor Therapeutics, Inc. |
Sting agonist combination treatments with cytokines
|
|
WO2023056468A1
(en)
|
2021-09-30 |
2023-04-06 |
Codiak Biosciences, Inc. |
Extracellular vesicle comprising cholesterol tagged sting-agonist
|
|
TW202334196A
(zh)
|
2021-10-07 |
2023-09-01 |
英商阿法克塔生命科學有限公司 |
Pd-l1結合多肽
|
|
CN119156403A
(zh)
|
2022-03-08 |
2024-12-17 |
阿伦蒂斯治疗股份公司 |
抗紧密连接蛋白-1抗体增加t细胞可用性的用途
|
|
WO2023218243A1
(en)
|
2022-05-12 |
2023-11-16 |
Avacta Life Sciences Limited |
Lag-3/pd-l1 binding fusion proteins
|
|
GB202304385D0
(en)
|
2023-03-24 |
2023-05-10 |
Prostate Cancer Res |
Combinatorial IL-15 therapy
|
|
WO2026027944A1
(en)
|
2024-07-30 |
2026-02-05 |
Sairopa B.V. |
Anti-sirp alpha antibody formulations and uses thereof
|