JOP20170188A1 - ثنائي النوكليوتيدات الحلقية كمنبهات ستينغ (sting) - Google Patents

ثنائي النوكليوتيدات الحلقية كمنبهات ستينغ (sting)

Info

Publication number
JOP20170188A1
JOP20170188A1 JOP/2017/0188A JOP20170188A JOP20170188A1 JO P20170188 A1 JOP20170188 A1 JO P20170188A1 JO P20170188 A JOP20170188 A JO P20170188A JO P20170188 A1 JOP20170188 A1 JO P20170188A1
Authority
JO
Jordan
Prior art keywords
sting agonists
cyclic dinucleotides
sting
compounds
formula
Prior art date
Application number
JOP/2017/0188A
Other languages
English (en)
Inventor
Zhong Minghong
Emanuel Stuart
Richter Mark
Wang Guangyi
Lu Tianbao
Bignan Gilles
Laquerre Sylvie
Connolly Peter
patrick edwards James
Beigelman Leonid
Kumar Thatikonda Santhosh
Original Assignee
Janssen Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of JOP20170188A1 publication Critical patent/JOP20170188A1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

كشف هذا الاختراع عن مركبات وتركيبات وطرق لعلاج العدوى الفيروسية أو الأمراض أو المتلازمات أو الاضطرابات التي تتأثر بتعديل STING. وتلك المركبات يتم تمثيلها بالصيغة (I) كما يلي: الصيغة (I) حيث تم تعريف R1A وR1B وR1c وB1 وR2A وR2B بهذه الوثيقة.
JOP/2017/0188A 2016-11-25 2016-11-25 ثنائي النوكليوتيدات الحلقية كمنبهات ستينغ (sting) JOP20170188A1 (ar)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662426350P 2016-11-25 2016-11-25
US201762502983P 2017-05-08 2017-05-08
US201762555232P 2017-09-07 2017-09-07

Publications (1)

Publication Number Publication Date
JOP20170188A1 true JOP20170188A1 (ar) 2019-01-30

Family

ID=60937846

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2017/0188A JOP20170188A1 (ar) 2016-11-25 2016-11-25 ثنائي النوكليوتيدات الحلقية كمنبهات ستينغ (sting)

Country Status (13)

Country Link
US (2) US11472830B2 (ar)
EP (1) EP3544989A1 (ar)
JP (2) JP7316936B2 (ar)
KR (1) KR20190085107A (ar)
CN (1) CN110291096A (ar)
AU (1) AU2017365158B2 (ar)
BR (1) BR112019010606A2 (ar)
CA (1) CA3044693A1 (ar)
JO (1) JOP20170188A1 (ar)
MX (1) MX2019006082A (ar)
TW (1) TW201831192A (ar)
UY (1) UY37495A (ar)
WO (1) WO2018098203A1 (ar)

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CN110291096A (zh) 2019-09-27
JP2022110131A (ja) 2022-07-28
US20180162899A1 (en) 2018-06-14
CA3044693A1 (en) 2018-05-31
UY37495A (es) 2018-05-31
JP7316936B2 (ja) 2023-07-28
JP2020500862A (ja) 2020-01-16
EP3544989A1 (en) 2019-10-02
AU2017365158B2 (en) 2022-02-17
US20230144627A1 (en) 2023-05-11
WO2018098203A1 (en) 2018-05-31
TW201831192A (zh) 2018-09-01
BR112019010606A2 (pt) 2019-09-17
AU2017365158A1 (en) 2019-06-06
KR20190085107A (ko) 2019-07-17
MX2019006082A (es) 2019-11-12
US11472830B2 (en) 2022-10-18

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