PT3576771T - Composições e métodos para a libertação de longo prazo de antagonistas da hormona libertadora de gonadotropina (gnrh) - Google Patents

Composições e métodos para a libertação de longo prazo de antagonistas da hormona libertadora de gonadotropina (gnrh)

Info

Publication number
PT3576771T
PT3576771T PT187475819T PT18747581T PT3576771T PT 3576771 T PT3576771 T PT 3576771T PT 187475819 T PT187475819 T PT 187475819T PT 18747581 T PT18747581 T PT 18747581T PT 3576771 T PT3576771 T PT 3576771T
Authority
PT
Portugal
Prior art keywords
ganadotropin
gnrh
antagonists
compositions
methods
Prior art date
Application number
PT187475819T
Other languages
English (en)
Original Assignee
Veru Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Veru Inc filed Critical Veru Inc
Publication of PT3576771T publication Critical patent/PT3576771T/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT187475819T 2017-01-31 2018-01-31 Composições e métodos para a libertação de longo prazo de antagonistas da hormona libertadora de gonadotropina (gnrh) PT3576771T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762452788P 2017-01-31 2017-01-31

Publications (1)

Publication Number Publication Date
PT3576771T true PT3576771T (pt) 2022-05-30

Family

ID=62976965

Family Applications (1)

Application Number Title Priority Date Filing Date
PT187475819T PT3576771T (pt) 2017-01-31 2018-01-31 Composições e métodos para a libertação de longo prazo de antagonistas da hormona libertadora de gonadotropina (gnrh)

Country Status (19)

Country Link
US (2) US20180214507A1 (pt)
EP (2) EP3576771B1 (pt)
JP (1) JP7074963B2 (pt)
KR (1) KR20190110567A (pt)
CN (1) CN110234336A (pt)
AU (1) AU2018217064A1 (pt)
CA (1) CA3052157A1 (pt)
CY (1) CY1125582T1 (pt)
DK (1) DK3576771T3 (pt)
ES (1) ES2914314T3 (pt)
HR (1) HRP20220438T1 (pt)
HU (1) HUE058207T2 (pt)
IL (1) IL268376A (pt)
LT (1) LT3576771T (pt)
MX (2) MX391306B (pt)
PL (1) PL3576771T3 (pt)
PT (1) PT3576771T (pt)
UA (1) UA127018C2 (pt)
WO (1) WO2018144603A1 (pt)

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US11690806B2 (en) 2018-05-24 2023-07-04 Celanese Eva Performance Polymers Llc Implantable device for sustained release of a macromolecular drug compound
WO2020071912A1 (en) * 2018-10-02 2020-04-09 Innocore Technologies B.V. Extended release formulations of human chorionic gonadotropin (hcg)
CN110681323B (zh) * 2019-08-26 2021-12-21 上海摩漾生物科技有限公司 具有微拓扑结构的高尔夫球型可降解微球及其制备方法
WO2021237039A1 (en) * 2020-05-21 2021-11-25 Veru Inc. Compositions and methods for long term release of gonadotropin-releasing hormone (gnrh) antagonists
CN111728957B (zh) * 2020-07-06 2022-04-19 济南大学 一种托特罗定长效缓释微球及其制备方法
BR112023022439A2 (pt) 2021-04-26 2023-12-26 Celanese Eva Performance Polymers Llc Dispositivo implantável para liberação sustentada de um composto de fármaco macromolecular
CN118201599A (zh) * 2021-12-24 2024-06-14 四川科伦药物研究院有限公司 一种可平稳释放的持续性递送制剂及其制备方法
CN119744167A (zh) * 2022-06-23 2025-04-01 G2G生物公司 含有药物和帕莫酸的缓释微球
TW202440148A (zh) * 2022-12-23 2024-10-16 大陸商長春金賽藥業有限責任公司 ＧｎＲＨ拮抗劑可注射組合物及其製備方法和用途
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Also Published As

Publication number Publication date
US20180214507A1 (en) 2018-08-02
US20180250354A1 (en) 2018-09-06
EP3576771A1 (en) 2019-12-11
IL268376A (en) 2019-09-26
WO2018144603A1 (en) 2018-08-09
AU2018217064A1 (en) 2019-08-08
ES2914314T3 (es) 2022-06-09
MX391306B (es) 2025-03-21
DK3576771T3 (da) 2022-05-30
EP3576771A4 (en) 2020-11-04
CN110234336A (zh) 2019-09-13
UA127018C2 (uk) 2023-03-15
CY1125582T1 (el) 2025-05-09
HRP20220438T1 (hr) 2022-06-10
MX2019009126A (es) 2020-01-20
RU2019123951A (ru) 2021-02-01
RU2019123951A3 (pt) 2021-08-02
JP2020506232A (ja) 2020-02-27
EP4011386A1 (en) 2022-06-15
KR20190110567A (ko) 2019-09-30
MX2022003967A (es) 2022-04-25
PL3576771T3 (pl) 2022-08-16
HUE058207T2 (hu) 2022-07-28
EP3576771B1 (en) 2022-03-09
LT3576771T (lt) 2022-04-11
JP7074963B2 (ja) 2022-05-25
CA3052157A1 (en) 2018-08-09

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