PT628044E - Nucleosidos terapeuticos - Google Patents

Nucleosidos terapeuticos

Info

Publication number
PT628044E
PT628044E PT93904248T PT93904248T PT628044E PT 628044 E PT628044 E PT 628044E PT 93904248 T PT93904248 T PT 93904248T PT 93904248 T PT93904248 T PT 93904248T PT 628044 E PT628044 E PT 628044E
Authority
PT
Portugal
Prior art keywords
therapeutic nucleosides
nucleosides
therapeutic
preparation
relates
Prior art date
Application number
PT93904248T
Other languages
English (en)
Portuguese (pt)
Inventor
Susan Mary Daluge
Douglas Alan Livingston
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of PT628044E publication Critical patent/PT628044E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/48—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PT93904248T 1992-02-25 1993-02-24 Nucleosidos terapeuticos PT628044E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929204015A GB9204015D0 (en) 1992-02-25 1992-02-25 Therapeutic nucleosides

Publications (1)

Publication Number Publication Date
PT628044E true PT628044E (pt) 2003-12-31

Family

ID=10711016

Family Applications (1)

Application Number Title Priority Date Filing Date
PT93904248T PT628044E (pt) 1992-02-25 1993-02-24 Nucleosidos terapeuticos

Country Status (13)

Country Link
US (5) US5641889A (fr)
EP (1) EP0628044B1 (fr)
JP (1) JP3172533B2 (fr)
KR (1) KR100282584B1 (fr)
AT (1) ATE245646T1 (fr)
AU (2) AU3571093A (fr)
CA (1) CA2130755C (fr)
DE (1) DE69333109T2 (fr)
DK (1) DK0628044T3 (fr)
ES (1) ES2203615T3 (fr)
GB (1) GB9204015D0 (fr)
PT (1) PT628044E (fr)
WO (1) WO1993017020A2 (fr)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5631370A (en) * 1988-01-20 1997-05-20 Regents Of The University Of Minnesota Optically-active isomers of dideoxycarbocyclic nucleosides
CA2001401A1 (fr) * 1988-10-25 1990-04-25 Claude Piantadosi Derives d'ether ou d'ester lipidique contenant une amine quaternaire et composes therapeutiques
GB9204015D0 (en) 1992-02-25 1992-04-08 Wellcome Found Therapeutic nucleosides
EP0702556B1 (fr) * 1993-06-10 2002-10-23 Wake Forest University (phospho)lipides contre l'infection a virus de l'hepatite b
ES2103131T3 (es) * 1993-06-21 1997-08-16 Merrell Pharma Inc Nuevos agentes de nucleosido carbociclico utiles como inhibidores selectivos de citoquinas proinflamatorias.
EP0630897A3 (fr) * 1993-06-25 1995-03-01 Bristol Myers Squibb Co 3-Hydroxy-4-hydroxyméthyl-2-methylène-cyclopentyl purines et pyrimidines.
WO1995022330A1 (fr) * 1994-02-17 1995-08-24 Commonwealth Scientific And Industrial Research Organisation Agents antiviraux
US7135584B2 (en) 1995-08-07 2006-11-14 Wake Forest University Lipid analogs for treating viral infections
EP0781138B1 (fr) 1994-08-29 2008-05-21 Wake Forest University Analogues de lipides pour le traitement d'infections virales
DE59712095D1 (de) 1996-05-30 2004-12-30 Lonza Ag Visp Verfahren zur herstellung von aminoalkoholen und derivaten davon
US5866702A (en) * 1996-08-02 1999-02-02 Cv Therapeutics, Incorporation Purine inhibitors of cyclin dependent kinase 2
SK285229B6 (sk) * 1997-05-13 2006-09-07 Lonza Ag Spôsob výroby derivátov (1R,4S)- alebo (1S,4R)-1-amino-4- (hydroxymetyl)-2-cyklopenténu a enantioméru (1R,4S)-N-butyryl-1- amino-4-(hydroxymetyl)-2-cyklopenténu
SK284594B6 (sk) 1997-11-27 2005-07-01 Lonza Ag Spôsob výroby derivátov aminoalkoholov a ich soli
US6362225B1 (en) * 1999-01-21 2002-03-26 George Andreakos Target therapies for treating common viral infections
US6514979B1 (en) 1999-03-03 2003-02-04 University Of Maryland Biotechnology Institute Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor
YU25500A (sh) 1999-05-11 2003-08-29 Pfizer Products Inc. Postupak za sintezu analoga nukleozida
ES2218225T3 (es) * 1999-09-10 2004-11-16 Stichting Rega V.Z.W. Nucleosidos carbociclicos y procedimiento para obtenerlos.
US7026469B2 (en) 2000-10-19 2006-04-11 Wake Forest University School Of Medicine Compositions and methods of double-targeting virus infections and cancer cells
WO2002032885A1 (fr) * 2000-10-18 2002-04-25 Kuraray Co., Ltd. Preparation d'esters d'acide amino-2-aza-1-oxybicyclo[3.3.0]oct-2-ene-6-carboxylique 4-n substitues et preparation de leurs produits intermediaires
US7309696B2 (en) 2000-10-19 2007-12-18 Wake Forest University Compositions and methods for targeting cancer cells
EP1399446B1 (fr) 2001-06-27 2005-08-03 Cyclacel Limited Derives de purine 2,6,9-substitues et leur utilisation dans le traitement de maladies proliferantes
EP1423976A1 (fr) 2001-08-31 2004-06-02 Thomson Licensing S.A. Compteur de sequences destine a un flux audio continu
GB0219052D0 (en) 2002-08-15 2002-09-25 Cyclacel Ltd New puring derivatives
CA2463719A1 (fr) 2003-04-05 2004-10-05 F. Hoffmann-La Roche Ag Analogues de nucleotides possedant des cycles a six chainons
GB0320738D0 (en) * 2003-09-04 2003-10-08 Glaxo Group Ltd Novel process
US7230002B2 (en) 2004-02-03 2007-06-12 Glenmark Pharmaceuticals Ltd. Dipeptidyl peptidase IV inhibitors; processes for their preparation and compositions thereof
WO2005075426A1 (fr) * 2004-02-03 2005-08-18 Glenmark Pharmaceuticals Ltd. Nouveaux inhibiteurs de dipeptidyle peptidase iv, leur procedes de preparation et compositions en comportant
US20070208042A1 (en) 2006-03-03 2007-09-06 Sherwood Services Ag Method of using vasoconstrictive agents during energy-based tissue therapy
US7767686B2 (en) * 2006-03-03 2010-08-03 Covidien Ag Method of using adenosine receptor blockers during tissue ablation
EP2178880B1 (fr) 2007-08-02 2017-10-04 Millennium Pharmaceuticals, Inc. Procédé pour la synthèse d'inhibiteurs de l'enzyme d'activation e1
JP5619743B2 (ja) 2008-08-20 2014-11-05 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． エテニル置換ピリジンおよびピリミジン誘導体およびウイルス感染の治療におけるそれらの使用
TW201020245A (en) 2008-08-20 2010-06-01 Schering Corp Ethynyl-substituted pyridine and pyrimidine derivatives and their use in treating viral infections
US8470834B2 (en) 2008-08-20 2013-06-25 Merck Sharp & Dohme Corp. AZO-substituted pyridine and pyrimidine derivatives and their use in treating viral infections
TWI409265B (zh) * 2008-08-20 2013-09-21 Merck Sharp & Dohme 經取代之吡啶及嘧啶衍生物及彼等於治療病毒感染之用途
PE20121524A1 (es) 2010-01-27 2012-12-03 Viiv Healthcare Co Combinaciones de compuestos que comprenden inhibidores de la integrasa de vih y otros agentes terapeuticos
CN103597856B (zh) 2011-04-14 2017-07-04 福纳克股份公司 听力工具
GB201513601D0 (en) * 2015-07-31 2015-09-16 Univ Liverpool Antiviral compounds
CN106220515A (zh) * 2016-08-12 2016-12-14 郸城巨鑫生物科技有限公司 一种(1r,4s)‑1‑氨基‑4‑羟甲基‑2‑环戊烯盐酸盐的合成方法
WO2018181102A1 (fr) * 2017-03-29 2018-10-04 ヤマサ醤油株式会社 Dérivé nucléosidique ou sel de celui-ci, et composition pharmaceutique le contenant

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60139653A (ja) * 1983-12-27 1985-07-24 Yoshitomi Pharmaceut Ind Ltd シクロペンテン誘導体
US4543255A (en) * 1984-05-10 1985-09-24 Southern Research Institute Carbocyclic analogs of purine 2'-deoxyribofuranosides
EP0219838A3 (fr) * 1985-10-22 1988-04-06 Takeda Chemical Industries, Ltd. Nucléosides de purine carbocycliques, leur préparation et leur utilisation
IN164556B (fr) * 1986-03-06 1989-04-08 Takeda Chemical Industries Ltd
US4734194A (en) * 1986-03-25 1988-03-29 The Upjohn Company Combined filter and valve mechanism
IN166499B (fr) * 1987-02-12 1990-05-19 Takeda Chemical Industries Ltd
GB8815265D0 (en) * 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
WO1990006671A2 (fr) * 1988-12-12 1990-06-28 Palese Peter M Procedes et compositions pour la prophylaxie et le traitement d'infections dues au virus de l'hepatite b
ATE118208T1 (de) * 1989-10-16 1995-02-15 Chiroscience Ltd Chirale azabicycloheptanone und verfahren zu ihrer herstellung.
MY104575A (en) * 1989-12-22 1994-04-30 The Wellcome Foundation Ltd Therapeutic nucleosides.
EP0471057A4 (en) * 1990-03-06 1992-11-19 Virachem, Inc. Methods and compositions for the prophylaxis and treatment of cytomegalovirus infections
GB9204015D0 (en) 1992-02-25 1992-04-08 Wellcome Found Therapeutic nucleosides

Also Published As

Publication number Publication date
CA2130755C (fr) 2004-03-30
DE69333109T2 (de) 2004-04-15
JP3172533B2 (ja) 2001-06-04
ES2203615T3 (es) 2004-04-16
KR100282584B1 (ko) 2001-02-15
US5808147A (en) 1998-09-15
US5840990A (en) 1998-11-24
US5641889A (en) 1997-06-24
GB9204015D0 (en) 1992-04-08
US20010008946A1 (en) 2001-07-19
ATE245646T1 (de) 2003-08-15
KR950700298A (ko) 1995-01-16
DE69333109D1 (de) 2003-08-28
DK0628044T3 (da) 2003-11-17
WO1993017020A2 (fr) 1993-09-02
US5919941A (en) 1999-07-06
AU3571093A (en) 1993-09-13
JPH07504185A (ja) 1995-05-11
CA2130755A1 (fr) 1993-08-26
AU2489197A (en) 1997-08-28
HK1003941A1 (en) 1998-11-13
WO1993017020A3 (fr) 1994-03-17
EP0628044A1 (fr) 1994-12-14
US6392085B2 (en) 2002-05-21
AU707075B2 (en) 1999-07-01
EP0628044B1 (fr) 2003-07-23

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