PT714435E - Mutantes da pro-uroquinase - Google Patents
Mutantes da pro-uroquinaseInfo
- Publication number
- PT714435E PT714435E PT94922037T PT94922037T PT714435E PT 714435 E PT714435 E PT 714435E PT 94922037 T PT94922037 T PT 94922037T PT 94922037 T PT94922037 T PT 94922037T PT 714435 E PT714435 E PT 714435E
- Authority
- PT
- Portugal
- Prior art keywords
- pro
- mutants
- native pro
- native
- uroquinase
- Prior art date
Links
- 102000009123 Fibrin Human genes 0.000 abstract 1
- 108010073385 Fibrin Proteins 0.000 abstract 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 abstract 1
- 108010088842 Fibrinolysin Proteins 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229950003499 fibrin Drugs 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 229940012957 plasmin Drugs 0.000 abstract 1
- 230000033885 plasminogen activation Effects 0.000 abstract 1
- 108010073863 saruplase Proteins 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- 230000002537 thrombolytic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Compounds Of Unknown Constitution (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/087,163 US5472692A (en) | 1993-07-02 | 1993-07-02 | Pro-urokinase mutants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT714435E true PT714435E (pt) | 2003-08-29 |
Family
ID=22203481
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT94922037T PT714435E (pt) | 1993-07-02 | 1994-06-28 | Mutantes da pro-uroquinase |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5472692A (pt) |
| EP (2) | EP0714435B1 (pt) |
| JP (2) | JPH08511953A (pt) |
| CN (1) | CN1115412C (pt) |
| AT (1) | ATE239084T1 (pt) |
| CA (1) | CA2165977A1 (pt) |
| DE (1) | DE69432592T2 (pt) |
| ES (1) | ES2197165T3 (pt) |
| NZ (1) | NZ269061A (pt) |
| PT (1) | PT714435E (pt) |
| WO (1) | WO1995001427A1 (pt) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7544500B2 (en) * | 1999-11-13 | 2009-06-09 | Talecris Biotherapeutics, Inc. | Process for the production of a reversibly inactive acidified plasmin composition |
| US6355243B1 (en) * | 1999-11-13 | 2002-03-12 | Bayer Corporation | Method of thrombolysis by local delivery of active plasmin |
| US6964764B2 (en) * | 1999-11-13 | 2005-11-15 | Talecris Biotherapeutics, Inc. | Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin |
| US6969515B2 (en) | 1999-11-13 | 2005-11-29 | Talecris Biotherapeutics, Inc. | Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin |
| WO2002061064A2 (de) * | 2001-02-01 | 2002-08-08 | Roche Diagnostics Gmbh | Verfahren zur herstellung von rekombinantem trypsin |
| CN1311076C (zh) * | 2003-04-16 | 2007-04-18 | 普罗特奥姆技术公司 | 生产重组尿激酶的方法 |
| US7070958B2 (en) * | 2003-04-18 | 2006-07-04 | Thrombolytic Science, Inc. | Methods of making pro-urokinase mutants |
| CA2426115A1 (en) * | 2003-04-18 | 2004-10-18 | Victor Gurewich | Methods, devices, and compositions for lysis of occlusive blood clots while sparing wound sealing clots |
| GB2446550B (en) * | 2005-11-28 | 2010-12-08 | Proteomtech Inc | Methods for production of recombinant alpha1-antitrypsin |
| CN101024827B (zh) * | 2006-02-22 | 2012-05-30 | 中国科学院福建物质结构研究所 | 尿激酶催化结构域突变体的表达、纯化以及结晶 |
| CN100441683C (zh) * | 2006-03-24 | 2008-12-10 | 中国人民解放军军事医学科学院生物工程研究所 | 低分子量尿激酶突变体及其表达载体 |
| US7837992B2 (en) * | 2006-06-22 | 2010-11-23 | Beth Israel Deaconess Medical Center | C-1 inhibitor prevents non-specific plasminogen activation by a prourokinase mutant without impeding fibrin-specific fibrinolysis |
| US20070298024A1 (en) * | 2006-06-22 | 2007-12-27 | Thrombolytic Science, Inc. | C-1 inactivator inhibits two-chain urokinase mutant and limits hemostatic bleeding during thrombolysis |
| NZ596269A (en) | 2006-07-05 | 2012-12-21 | Catalyst Biosciences Inc | Protease screening methods and proteases identified thereby |
| EP1936531A1 (en) * | 2006-12-20 | 2008-06-25 | Thomson Licensing | Methods and device for secure software installation |
| WO2008103146A2 (en) * | 2007-02-23 | 2008-08-28 | Landing Biotech, Inc. | Treating atherosclerosis |
| NZ589557A (en) * | 2008-06-04 | 2012-08-31 | Talecris Biotherapeutics Inc | Immobilised streptokinase, method and kit for preparing plasmin |
| US20100143325A1 (en) * | 2008-12-09 | 2010-06-10 | Vascular Laboratory, Inc. | Composition And Methods Involving Thrombolytic Agents |
| HUE025670T2 (en) | 2009-03-03 | 2016-04-28 | Grifols Therapeutics Inc | A method for producing plasminogen |
| US20160146834A1 (en) | 2013-07-12 | 2016-05-26 | Emory University | Diagnostic assay to predict cardiovascular risk |
| RU2553533C2 (ru) * | 2013-10-23 | 2015-06-20 | Общество с ограниченной ответственностью "Международный биотехнологический центр "Генериум" ("МБЦ "Генериум") | Способ выделения и очистки рекомбинантной человеческой проурокиназы м5 |
| EP3708226A1 (en) | 2014-11-03 | 2020-09-16 | Thrombolytic Science, LLC | Methods and compositions for safe and effective thrombolysis |
| WO2018232305A1 (en) | 2017-06-16 | 2018-12-20 | Thrombolytic Science, Llc | Methods and compositions for thrombolysis |
| MX2020010091A (es) | 2018-03-27 | 2021-01-15 | Umc Utrecht Holding Bv | Trombolisis direccionada para tratamiento de trombosis microvascular. |
| US11613744B2 (en) | 2018-12-28 | 2023-03-28 | Vertex Pharmaceuticals Incorporated | Modified urokinase-type plasminogen activator polypeptides and methods of use |
| WO2020140101A1 (en) * | 2018-12-28 | 2020-07-02 | Catalyst Biosciences, Inc. | Modified urokinase-type plasminogen activator polypeptides and methods of use |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03503484A (ja) * | 1988-02-10 | 1991-08-08 | ジェンザイム コーポレーション | 糖タンパク質の治療機能の強化 |
| US5108901A (en) * | 1988-09-02 | 1992-04-28 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties |
| EP0387380A1 (en) * | 1989-03-17 | 1990-09-19 | BEHRINGWERKE Aktiengesellschaft | Mutants of urinary plasminogen activator, their production and use |
-
1993
- 1993-07-02 US US08/087,163 patent/US5472692A/en not_active Expired - Fee Related
-
1994
- 1994-06-28 CA CA002165977A patent/CA2165977A1/en not_active Abandoned
- 1994-06-28 EP EP94922037A patent/EP0714435B1/en not_active Expired - Lifetime
- 1994-06-28 WO PCT/US1994/007278 patent/WO1995001427A1/en not_active Ceased
- 1994-06-28 EP EP03009709A patent/EP1361276A1/en not_active Withdrawn
- 1994-06-28 PT PT94922037T patent/PT714435E/pt unknown
- 1994-06-28 JP JP7503598A patent/JPH08511953A/ja active Pending
- 1994-06-28 ES ES94922037T patent/ES2197165T3/es not_active Expired - Lifetime
- 1994-06-28 CN CN94193246A patent/CN1115412C/zh not_active Expired - Lifetime
- 1994-06-28 NZ NZ269061A patent/NZ269061A/en unknown
- 1994-06-28 DE DE69432592T patent/DE69432592T2/de not_active Expired - Fee Related
- 1994-06-28 AT AT94922037T patent/ATE239084T1/de not_active IP Right Cessation
-
2004
- 2004-07-07 JP JP2004200871A patent/JP2004337172A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| NZ269061A (en) | 1997-03-24 |
| CN1115412C (zh) | 2003-07-23 |
| ATE239084T1 (de) | 2003-05-15 |
| WO1995001427A1 (en) | 1995-01-12 |
| DE69432592D1 (de) | 2003-06-05 |
| JP2004337172A (ja) | 2004-12-02 |
| EP0714435B1 (en) | 2003-05-02 |
| EP1361276A1 (en) | 2003-11-12 |
| CA2165977A1 (en) | 1995-01-12 |
| EP0714435A4 (en) | 1997-08-20 |
| US5472692A (en) | 1995-12-05 |
| ES2197165T3 (es) | 2004-01-01 |
| DE69432592T2 (de) | 2004-04-01 |
| CN1130402A (zh) | 1996-09-04 |
| EP0714435A1 (en) | 1996-06-05 |
| JPH08511953A (ja) | 1996-12-17 |
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