PT81689B - Processo para a preparacao de agentes hipoglicemicos homodissacarios, designadamente, glicosidos da 2,6-imino-2,6-didesoxi-d-glicero-1-gulo-heptidol (homonojirimicina) - Google Patents

Processo para a preparacao de agentes hipoglicemicos homodissacarios, designadamente, glicosidos da 2,6-imino-2,6-didesoxi-d-glicero-1-gulo-heptidol (homonojirimicina)

Info

Publication number: PT81689B
Authority: PT; Portugal
Prior art keywords: glycosides; homonojyrymicine; heptidol; dimenson; glycero
Prior art date: 1984-12-18

Application number

PT81689A

Other languages

English (en)

Portuguese (pt)

Other versions

PT81689A (en

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-12-18

Filing date

1985-12-16

Publication date

1987-11-30

1985-12-16 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1986-01-01 Publication of PT81689A publication Critical patent/PT81689A/pt

1987-11-30 Publication of PT81689B publication Critical patent/PT81689B/pt

Links

229930182470 glycoside Natural products 0.000 title abstract 2
150000002338 glycosides Chemical class 0.000 title 1
-1 Homonojirimycin glycosides Chemical class 0.000 abstract 2
CLVUFWXGNIFGNC-QTSLKERKSA-N (2r,3s,5r,6r)-2,6-bis(hydroxymethyl)piperidine-3,4,5-triol Chemical compound OC[C@H]1N[C@H](CO)[C@H](O)C(O)[C@@H]1O CLVUFWXGNIFGNC-QTSLKERKSA-N 0.000 abstract 1
150000001720 carbohydrates Chemical class 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
102000038379 digestive enzymes Human genes 0.000 abstract 1
108091007734 digestive enzymes Proteins 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines Containing Plant Substances (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Luminescent Compositions (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PT81689A 1984-12-18 1985-12-16 Processo para a preparacao de agentes hipoglicemicos homodissacarios, designadamente, glicosidos da 2,6-imino-2,6-didesoxi-d-glicero-1-gulo-heptidol (homonojirimicina) PT81689B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/683,127 US4634765A (en)	1984-12-18	1984-12-18	Homodisaccharide hypoglycemic agents

Publications (2)

Publication Number	Publication Date
PT81689A PT81689A (en)	1986-01-01
PT81689B true PT81689B (pt)	1987-11-30

Family

ID=24742682

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT81689A PT81689B (pt)	1984-12-18	1985-12-16	Processo para a preparacao de agentes hipoglicemicos homodissacarios, designadamente, glicosidos da 2,6-imino-2,6-didesoxi-d-glicero-1-gulo-heptidol (homonojirimicina)

Country Status (20)

Country	Link
US (1)	US4634765A (fr)
EP (1)	EP0186103B1 (fr)
JP (1)	JPS61158994A (fr)
KR (1)	KR900005607B1 (fr)
CN (1)	CN1016784B (fr)
AT (1)	ATE62249T1 (fr)
AU (1)	AU574246B2 (fr)
CA (1)	CA1240989A (fr)
DE (1)	DE3582420D1 (fr)
DK (1)	DK587085A (fr)
ES (1)	ES8706164A1 (fr)
FI (1)	FI80707C (fr)
GR (1)	GR853032B (fr)
HU (1)	HU194263B (fr)
IE (1)	IE58186B1 (fr)
NO (1)	NO162387B (fr)
NZ (1)	NZ214570A (fr)
PH (1)	PH23660A (fr)
PT (1)	PT81689B (fr)
ZA (1)	ZA859573B (fr)

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GB2181729B (en) *	1985-10-12	1990-04-04	Nippon Shinyaku Co Ltd	Glucosylmoranoline derivatives and production thereof
JPS62242692A (ja) *	1986-04-15	1987-10-23	Nippon Shinyaku Co Ltd	モラノリン誘導体の製造法
EP0344383A1 (fr) *	1988-06-02	1989-12-06	Merrell Dow Pharmaceuticals Inc.	Inhibiteurs d'alpha-glucosidase
EP0345104B1 (fr) *	1988-06-02	1995-11-02	Merrell Dow Pharmaceuticals Inc.	Inhibiteurs d'alpha-glucosidase
US4880917A (en) *	1988-07-01	1989-11-14	Merrell Dow Pharmaceuticals Inc.	Process for hydrolyzing 2,6-dideoxy-2,6-iminoheptononitrile derivatives using trifluoroacetic acid and dinitrogen tetroxide
US4908439A (en) *	1988-09-16	1990-03-13	Merrell Dow Pharmaceuticals Inc.	Synthesis of intermediate useful in the preparation of nojirimycin and related compounds
US5227479A (en) *	1989-12-20	1993-07-13	Merrell Dow Pharmaceuticals Inc.	Process for the preparation of nojirimycin and related compounds
US5504078A (en) *	1990-06-08	1996-04-02	Merrell Dow Pharmaceuticals Inc.	α-glucosidase inhibitors
ATE422359T1 (de) *	1997-04-15	2009-02-15	Csir	Verbindungen und pharmazeutische zusammensetzungen mit appetitunterdrückender aktivität
GB2396815B (en) *	1999-10-27	2004-09-08	Phytopharm Plc	A composition comprising a pregnenone derivative and an NSAID
EP1181277A4 (fr)	2000-03-31	2005-08-10	Univ Michigan State	Procede de preparation de 1,5-didesoxy-1,5-imino hexitols a partir d'oximes ou d'imines
GB2363985B (en)	2000-06-30	2004-09-29	Phytopharm Plc	Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use
US7262318B2 (en) *	2004-03-10	2007-08-28	Pfizer, Inc.	Substituted heteroaryl- and phenylsulfamoyl compounds
US20050288340A1 (en) *	2004-06-29	2005-12-29	Pfizer Inc	Substituted heteroaryl- and phenylsulfamoyl compounds
AU2005308575A1 (en) *	2004-11-23	2006-06-01	Warner-Lambert Company Llc	7-(2h-pyrazol-3-yl)-3, 5-dihyroxy-heptanoic acid derivatives as HMG Co-A reductase inhibitors for the treatment of lipidemia
WO2006133447A1 (fr) *	2005-06-08	2006-12-14	Amicus Therapeutics, Inc.	Compositions de sucre cristallin et procede de production associe
US20060293508A1 (en) *	2005-06-08	2006-12-28	Michael Major	Stabilization of triflated compounds
US7973157B2 (en) *	2005-06-08	2011-07-05	Amicus Therapeutics, Inc.	Imino and amino sugar purification
US7741317B2 (en)	2005-10-21	2010-06-22	Bristol-Myers Squibb Company	LXR modulators
US7888376B2 (en)	2005-11-23	2011-02-15	Bristol-Myers Squibb Company	Heterocyclic CETP inhibitors
JP5498168B2 (ja)	2006-12-01	2014-05-21	ブリストル−マイヤーズスクイブカンパニー	アテローム性動脈硬化および循環器疾患の治療のためのｃｅｔｐ阻害剤としてのｎ−（（３−ベンジル）−２，２−（ビス−フェニル）−プロパン−１−アミン誘導体
ATE518544T1 (de)	2007-03-12	2011-08-15	Zadec Aps	Rotbusch-extrakt gegen diabetes
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX2009013293A (es)	2007-06-04	2010-02-15	Synergy Pharmaceuticals Inc	Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos.
EP2810951B1 (fr)	2008-06-04	2017-03-15	Synergy Pharmaceuticals Inc.	Agonistes de guanylate cyclase utile dans le traitement de troubles gastro-intestinaux, d'une inflammation, d'un cancer et d'autres troubles
CA2730603C (fr)	2008-07-16	2019-09-24	Synergy Pharmaceuticals Inc.	Agonistes de la guanylate cyclase utiles dans le traitement des affections gastro-intestinales, de l'inflammation gastro-intestinale, du cancer gastro-intestinal et d'autres affections
CA2799708A1 (fr)	2010-05-21	2011-11-24	Pfizer Inc.	2-phenylbenzoylamides
US20130156720A1 (en)	2010-08-27	2013-06-20	Ironwood Pharmaceuticals, Inc.	Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
CN102462726B (zh) *	2010-11-04	2016-03-09	中国医学科学院药物研究所	白树总生物碱及多羟基生物碱化合物的提取、分离及用途
CA2828343A1 (fr)	2011-03-04	2012-09-13	The Scripps Research Institute	Peptides de type edn3 et utilisations associees
US20140323705A1 (en) *	2011-05-13	2014-10-30	Markus Hederos	Manufacture of lacto-n-tetraose
MY188344A (en)	2012-03-09	2021-12-01	Biotropics Malaysia Berhad	Extract formulations of rhodamnia cinerea and uses thereof
JP2016514671A (ja)	2013-03-15	2016-05-23	シナジーファーマシューティカルズインコーポレイテッド	グアニル酸シクラーゼのアゴニストおよびその使用
JP2016514670A (ja)	2013-03-15	2016-05-23	シナジーファーマシューティカルズインコーポレイテッド	他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト
SG11201507496UA (en)	2013-04-17	2015-11-27	Pfizer	N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
EA201592263A1 (ru)	2013-06-05	2016-05-31	Синерджи Фармасьютикалз, Инк.	Ультрачистые агонисты гуанилатциклазы c, способ их получения и использования
EP3186242B1 (fr)	2014-08-29	2021-10-06	Tes Pharma S.r.l.	Inhibiteurs de la semialdéhyde décarboxylase de l'acide alpha-amino-bêta-carboxymuconique
WO2016055901A1 (fr)	2014-10-08	2016-04-14	Pfizer Inc.	Composés d'amide substitué
CN104530150A (zh) *	2015-01-14	2015-04-22	佛山市赛维斯医药科技有限公司	含胺基苯和双葡萄糖苷结构化合物、其制备方法和用途
AU2017342083A1 (en)	2016-10-14	2019-04-11	Tes Pharma S.R.L.	Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
IT201700078102A1 (it)	2017-07-11	2019-01-11	Dipharma Francis Srl	Sintesi di un azazucchero e suoi intermedi
CN108828121B (zh) *	2018-06-14	2020-06-05	华润三九医药股份有限公司	一种白树药材中α-高野尻霉素的含量检测方法
AR117122A1 (es)	2018-11-20	2021-07-14	Tes Pharma S R L	INHIBIDORES DE LA ÁCIDO a-AMINO-b-CARBOXIMUCÓNICO SEMIALDEHÍDO DESCARBOXILASA
US11248001B2 (en)	2019-01-18	2022-02-15	Astrazeneca Ab	PCSK9 inhibitors and methods of use thereof

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US4065562A (en) *	1975-12-29	1977-12-27	Nippon Shinyaku Co., Ltd.	Method and composition for reducing blood glucose levels
NO154918C (no) *	1977-08-27	1987-01-14	Bayer Ag	Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin.
DE2848117A1 (de) *	1978-11-06	1980-05-14	Bayer Ag	Derivate des 2-hydroxymethyl-3,4,5- trihydroxy-piperidins, ihre herstellung und verwendung zur beeinflussung des kohlenhydrat- und fettstoffwechsels
DE2942365A1 (de) *	1979-10-19	1981-05-14	Bayer Ag, 5090 Leverkusen	2-hydroxyalkyl-3,4,5-trihydroxy-(pi)-peridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
GB2064527B (en) *	1979-12-08	1984-05-02	Nippon Shinyaku Co Ltd	Moranoline derivatives and process for preparation thereof
IT1210476B (it) *	1981-05-28	1989-09-14	Erba Farmitalia	Antracicline.

1984
- 1984-12-18 US US06/683,127 patent/US4634765A/en not_active Expired - Lifetime
1985
- 1985-12-05 AU AU50810/85A patent/AU574246B2/en not_active Ceased
- 1985-12-13 CA CA000497607A patent/CA1240989A/fr not_active Expired
- 1985-12-13 ZA ZA859573A patent/ZA859573B/xx unknown
- 1985-12-13 FI FI854944A patent/FI80707C/fi not_active IP Right Cessation
- 1985-12-16 PT PT81689A patent/PT81689B/pt not_active IP Right Cessation
- 1985-12-16 NZ NZ214570A patent/NZ214570A/en unknown
- 1985-12-16 IE IE317985A patent/IE58186B1/en not_active IP Right Cessation
- 1985-12-16 HU HU854804A patent/HU194263B/hu not_active IP Right Cessation
- 1985-12-17 ES ES550060A patent/ES8706164A1/es not_active Expired
- 1985-12-17 CN CN85109548A patent/CN1016784B/zh not_active Expired
- 1985-12-17 AT AT85116117T patent/ATE62249T1/de not_active IP Right Cessation
- 1985-12-17 EP EP85116117A patent/EP0186103B1/fr not_active Expired - Lifetime
- 1985-12-17 JP JP60282167A patent/JPS61158994A/ja active Granted
- 1985-12-17 DK DK587085A patent/DK587085A/da not_active Application Discontinuation
- 1985-12-17 NO NO855087A patent/NO162387B/no unknown
- 1985-12-17 DE DE8585116117T patent/DE3582420D1/de not_active Expired - Fee Related
- 1985-12-17 GR GR853032A patent/GR853032B/el unknown
- 1985-12-18 PH PH33204A patent/PH23660A/en unknown
- 1985-12-18 KR KR1019850009529A patent/KR900005607B1/ko not_active Expired

Also Published As

Publication number	Publication date
CA1240989A (fr)	1988-08-23
PT81689A (en)	1986-01-01
FI854944A0 (fi)	1985-12-13
DK587085A (da)	1986-06-19
KR860004921A (ko)	1986-07-16
FI854944L (fi)	1986-06-19
FI80707B (fi)	1990-03-30
CN85109548A (zh)	1986-07-09
EP0186103A2 (fr)	1986-07-02
NZ214570A (en)	1988-03-30
NO162387B (no)	1989-09-11
FI80707C (fi)	1990-07-10
JPH0565519B2 (fr)	1993-09-17
ES8706164A1 (es)	1987-06-01
DE3582420D1 (de)	1991-05-08
US4634765A (en)	1987-01-06
PH23660A (en)	1989-09-27
JPS61158994A (ja)	1986-07-18
EP0186103A3 (en)	1988-02-03
CN1016784B (zh)	1992-05-27
AU5081085A (en)	1986-06-26
IE853179L (en)	1986-06-18
NO855087L (no)	1986-06-19
HU194263B (en)	1988-01-28
DK587085D0 (da)	1985-12-17
GR853032B (fr)	1986-04-18
ZA859573B (en)	1986-08-27
ES550060A0 (es)	1987-06-01
KR900005607B1 (ko)	1990-07-31
AU574246B2 (en)	1988-06-30
IE58186B1 (en)	1993-07-28
EP0186103B1 (fr)	1991-04-03
ATE62249T1 (de)	1991-04-15
HUT40137A (en)	1986-11-28

Legal Events

Date

Code

Title

Description

1995-05-04

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19941130

Publication	Publication Date	Title
ATE62249T1 (de)	1991-04-15	Homodisaccharide hypoglycemische mittel.
DE3587943D1 (de)	1994-12-15	Verbinder für Hochleistungsstrahl.
FI870726A7 (fi)	1987-08-21	Suojattuja entsyymijärjestelmiä.
FI854363L (fi)	1986-05-09	Prefabricerade moduler och anvaendning av dem i byggnadsindustrin.
DE3575457D1 (de)	1990-02-22	Elastisches motorlager.
FI852822A7 (fi)	1986-01-21	Kuteeton, joustava nauha.
DE3583852D1 (de)	1991-09-26	Naehrstoffzusammensetzungen.
FI863724A7 (fi)	1987-03-17	Uusia dispergoituvia, aktiivisia liimakoostumuksia.
IT8520586A0 (it)	1985-05-06	Cavi stabili ad alta temperatura e dispositivi da essi ottenuti.
IT1215310B (it)	1990-01-31	Carbammato di cellulosa. procedimento per precipitare
DE3485210D1 (de)	1991-11-28	Immobilisierte enzymzusammensetzungen.
IT8419926A0 (it)	1984-03-07	Composizioni polimeriche dotate di autoestinguenza contenenti bromidrato di melammina.
DE3761404D1 (de)	1990-02-15	Blitzableiter-isolator.
AU4386485A (en)	1986-01-02	Cyclic prodrugs of anti-inflammatory oxicams which are 1,3-oxazino(5,6-c)1,2-benzothiazines
ES1009564Y (es)	1990-02-16	Modulo multiple de proteccion integral.
FI853777L (fi)	1985-09-30	Fina partiklar med en ytbelaeggning av metall eller metallfoerening, saerskilt ett katalytiskt aktivt aemne och saett att framstaella dem.
DE3674377D1 (de)	1990-10-25	Pflanzenschutzzusammensetzung.
IT1206131B (it)	1989-04-14	Composizione di policarbonato autoestinguente.
IT8320903A0 (it)	1983-05-03	Composizione di policarbonato autoestinguente.
IT8320426A0 (it)	1983-04-01	Composizione di policarbonato autoestinguente.
IT8222968A0 (it)	1982-08-25	Composizione di policarbonato autoestinguente.
IT8222965A0 (it)	1982-08-25	Composizione di policarbonato autoestinguente.
IT8222987A0 (it)	1982-08-26	Composizione di policarbonato autoestinguente.
IT8221699A0 (it)	1982-06-04	Composizione di policarbonato autoestinguente.
IT8222964A0 (it)	1982-08-25	Composizione di policarbonato autoestinguente.