PT81793B - Processo para a preparacao de novos derivados peptidicos com estrutura policiclica azotada - Google Patents

Processo para a preparacao de novos derivados peptidicos com estrutura policiclica azotada

Info

Publication number: PT81793B
Authority: PT; Portugal
Prior art keywords: derivatives; peptidary; polycyclical; hazardous; preparing new
Prior art date: 1985-01-07

Application number

PT81793A

Other languages

English (en)

Other versions

PT81793A (fr

Inventor

Michel Vincent

Georges Remond

Claude Cudennec

Original Assignee

Adir

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-01-07

Filing date

1986-01-06

Publication date

1988-05-27

1986-01-06 Application filed by Adir filed Critical Adir

1986-02-01 Publication of PT81793A publication Critical patent/PT81793A/pt

1988-05-27 Publication of PT81793B publication Critical patent/PT81793B/pt

Links

231100001261 hazardous Toxicity 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
SLBZCKMOHSBDJK-UHFFFAOYSA-N [amino-[amino-(hydroxymethylsulfanyl)-sulfanylmethyl]sulfinyl-sulfanylmethyl]sulfanylmethanol Chemical compound OCSC(S)(N)S(=O)C(N)(S)SCO SLBZCKMOHSBDJK-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1019—Tetrapeptides with the first amino acid being basic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1021—Tetrapeptides with the first amino acid being acidic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Immunology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Indole Compounds (AREA)

PT81793A 1985-01-07 1986-01-06 Processo para a preparacao de novos derivados peptidicos com estrutura policiclica azotada PT81793B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8500140A FR2575753B1 (fr)	1985-01-07	1985-01-07	Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number	Publication Date
PT81793A PT81793A (fr)	1986-02-01
PT81793B true PT81793B (pt)	1988-05-27

Family

ID=9315046

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT81793A PT81793B (pt)	1985-01-07	1986-01-06	Processo para a preparacao de novos derivados peptidicos com estrutura policiclica azotada

Country Status (15)

Country	Link
US (1)	US4720484A (pt)
EP (1)	EP0190058B1 (pt)
JP (1)	JPS61161298A (pt)
AT (1)	ATE31537T1 (pt)
AU (1)	AU578781B2 (pt)
CA (1)	CA1270596A (pt)
DE (1)	DE3660010D1 (pt)
ES (1)	ES8707552A1 (pt)
FR (1)	FR2575753B1 (pt)
GR (1)	GR860023B (pt)
IE (1)	IE58273B1 (pt)
NZ (1)	NZ214722A (pt)
OA (1)	OA08182A (pt)
PT (1)	PT81793B (pt)
ZA (1)	ZA86105B (pt)

Families Citing this family (51)

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FR2610934B1 (fr) *	1987-02-13	1989-05-05	Adir	Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2616663B1 (fr) *	1987-06-16	1989-08-18	Adir	Nouveaux tripeptides a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CA1340588C (en) *	1988-06-13	1999-06-08	Balraj Krishan Handa	Amino acid derivatives
IE63490B1 (en) *	1988-11-24	1995-05-03	Hoechst Ag	Peptides having bradykinin antagonist action
US5648333A (en) *	1988-11-24	1997-07-15	Hoechst Aktiengesellschaft	Peptides having bradykinin antagonist action
FR2649110B1 (fr) *	1989-06-29	1994-10-21	Adir	Nouveaux derives peptidiques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5028593A (en) *	1989-08-15	1991-07-02	Board Of Regents, The University Of Texas System	Tuftsin analogs
GB8927913D0 (en) *	1989-12-11	1990-02-14	Hoffmann La Roche	Amino acid derivatives
EP0454302A3 (en) *	1990-03-30	1992-10-14	Banyu Pharmaceutical Co., Ltd.	Tuftsin derivatives
FR2663336B1 (fr) *	1990-06-18	1992-09-04	Adir	Nouveaux derives peptidiques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5391705A (en) *	1991-03-15	1995-02-21	Merrell Dow Pharmaceuticals Inc.	Polyfluorinated tripeptide thrombin inhibitors
US6177405B1 (en) *	1992-07-22	2001-01-23	Kenji Nishioka	Cyclic analogs of tuftsin
US5662885A (en) *	1994-07-22	1997-09-02	Resolution Pharmaceuticals Inc.	Peptide derived radionuclide chelators
EP0837875A4 (en) *	1995-03-29	1998-10-07	Merck & Co Inc	INHIBITORS OF FARNESYL PROTEIN TRANSFERASE
US6069232A (en) *	1995-10-02	2000-05-30	Hoechst Marion Roussel, Inc.	Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors
US5739354A (en) *	1996-03-26	1998-04-14	Hoechst Marion Roussel, Inc.	Process for the preparation of N-methyl-D-phenylalanyl-N- 1- 3- (aminoiminomethyl)amino!propyl!-3,3-difluoro-2-oxohexyl!-L-prolinamide
KR100509388B1 (ko)	1996-10-18	2005-08-23	버텍스 파마슈티칼스 인코포레이티드	세린 프로테아제, 특히 간염 ｃ 바이러스 ｎｓ３ 프로테아제의 저해제
SV2003000617A (es)	2000-08-31	2003-01-13	Lilly Co Eli	Inhibidores de la proteasa peptidomimetica ref. x-14912m
CA2449504A1 (en) *	2001-07-11	2003-01-23	Vertex Pharmaceuticals Incorporated	Bridged bicyclic serine protease inhibitors
BR0308118A (pt) *	2002-03-01	2005-01-11	Warner Lambert Co	Método para o tratamento de osteoartrite
TWI359147B (en)	2003-09-05	2012-03-01	Vertex Pharma	Inhibitors of serine proteases, particularly hcv n
US7767689B2 (en) *	2004-03-15	2010-08-03	Ptc Therapeutics, Inc.	Carboline derivatives useful in the treatment of cancer
US8076352B2 (en) *	2004-03-15	2011-12-13	Ptc Therapeutics, Inc.	Administration of carboline derivatives useful in the treatment of cancer and other diseases
UA92317C2 (ru) *	2004-03-15	2010-10-25	Пи-Ти-Си ТЕРАПЬЮТИКС, ИНК.	Производные карболина, пригодные для ингибирования развития кровеносных сосудов
US8076353B2 (en) *	2004-03-15	2011-12-13	Ptc Therapeutics, Inc.	Inhibition of VEGF translation
AU2005228950B2 (en)	2004-03-23	2012-02-02	Genentech, Inc.	Azabicyclo-octane inhibitors of IAP
DK2253614T3 (da)	2004-04-07	2013-01-07	Novartis Ag	IAP-inhibitorer
KR100984459B1 (ko) *	2004-07-02	2010-09-29	제넨테크, 인크.	Ｉａｐ의 억제제
DK1836201T4 (da) *	2004-12-20	2013-11-11	Genentech Inc	Pyrrolidininhibitorer af IAP.
KR20080033481A (ko) *	2005-08-02	2008-04-16	버텍스 파마슈티칼스 인코포레이티드	세린 프로테아제의 억제제
AR055395A1 (es)	2005-08-26	2007-08-22	Vertex Pharma	Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c
US7964624B1 (en)	2005-08-26	2011-06-21	Vertex Pharmaceuticals Incorporated	Inhibitors of serine proteases
CN101374829A (zh) *	2005-12-19	2009-02-25	健泰科生物技术公司	Iap的抑制剂
EP1991229A2 (en)	2006-02-27	2008-11-19	Vertex Pharmaceuticals Incorporated	Co-crystals and pharmaceutical compositions comprising the same
EP1993994A2 (en) *	2006-03-16	2008-11-26	Vertex Pharmceuticals Incorporated	Deuterated hepatitis c protease inhibitors
PE20110220A1 (es)	2006-08-02	2011-04-11	Novartis Ag	DERIVADOS DE 2-OXO-ETIL-AMINO-PROPIONAMIDA-PIRROLIDIN-2-IL-SUSTITUIDOS COMO INHIBIDORES DEL ENLACE DE LA PROTEINA Smac AL INHIBIDOR DE LA PROTEINA DE APOPTOSIS
EP2063905B1 (en)	2006-09-18	2014-07-30	Raptor Pharmaceutical Inc	Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
NZ577150A (en) *	2006-12-19	2012-04-27	Genentech Inc	Imidazopyridine inhibitors of iap
JP2010519329A (ja) *	2007-02-27	2010-06-03	バーテックスファーマシューティカルズインコーポレイテッド	セリンプロテアーゼ阻害剤
DK2114924T3 (da) *	2007-02-27	2012-04-10	Vertex Pharma	Co-krystaller og farmaceutiske sammensætninger omfattende disse
WO2008134679A1 (en) *	2007-04-30	2008-11-06	Genentech, Inc.	Inhibitors of iap
CN101835774B (zh) *	2007-08-30	2014-09-17	弗特克斯药品有限公司	共晶体和包含该共晶体的药物组合物
AU2009203971A1 (en) *	2008-01-11	2009-07-16	Genentech, Inc.	Inhibitors of IAP
JP2011529962A (ja)	2008-08-02	2011-12-15	ジェネンテック，インコーポレイテッド	Ｉａｐのインヒビター
US20110218211A1 (en) *	2008-08-16	2011-09-08	Genentech, Inc.	Azaindole inhibitors of iap
US20120077778A1 (en)	2010-09-29	2012-03-29	Andrea Bourdelais	Ladder-Frame Polyether Conjugates
MX346043B (es)	2012-01-06	2017-03-03	Novus Int Inc	Tensioactivos basados en sulfoxido.
US9284294B2 (en)	2012-02-09	2016-03-15	Novus International, Inc.	Functionalized polymer compositions
PL2871973T3 (pl)	2012-07-12	2019-02-28	Novus International Inc.	Kompozycje matrycy i warstwy do ochrony środków bioaktywnych
HK1255204A1 (zh)	2015-11-12	2019-08-09	Novus International Inc.	含硫化合物溶剂
US10584306B2 (en)	2017-08-11	2020-03-10	Board Of Regents Of The University Of Oklahoma	Surfactant microemulsions

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* Cited by examiner, † Cited by third party
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JPS5647895B2 (pt) *	1973-06-08	1981-11-12
US4353823A (en) *	1981-09-01	1982-10-12	Chipens Gunar I	Synthetic analog of tuftisin

1985
- 1985-01-07 FR FR8500140A patent/FR2575753B1/fr not_active Expired
1986
- 1986-01-06 JP JP61000483A patent/JPS61161298A/ja active Granted
- 1986-01-06 AU AU51854/86A patent/AU578781B2/en not_active Ceased
- 1986-01-06 NZ NZ214722A patent/NZ214722A/xx unknown
- 1986-01-06 EP EP86400010A patent/EP0190058B1/fr not_active Expired
- 1986-01-06 AT AT86400010T patent/ATE31537T1/de not_active IP Right Cessation
- 1986-01-06 IE IE2186A patent/IE58273B1/en not_active IP Right Cessation
- 1986-01-06 PT PT81793A patent/PT81793B/pt not_active IP Right Cessation
- 1986-01-06 CA CA000499067A patent/CA1270596A/fr not_active Expired - Lifetime
- 1986-01-06 DE DE8686400010T patent/DE3660010D1/de not_active Expired
- 1986-01-07 ES ES550716A patent/ES8707552A1/es not_active Expired
- 1986-01-07 GR GR860023A patent/GR860023B/el unknown
- 1986-01-07 OA OA58759A patent/OA08182A/xx unknown
- 1986-01-07 ZA ZA86105A patent/ZA86105B/xx unknown
- 1986-11-20 US US06/933,093 patent/US4720484A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JPS61161298A (ja)	1986-07-21
US4720484A (en)	1988-01-19
FR2575753B1 (fr)	1987-02-20
DE3660010D1 (en)	1988-02-04
CA1270596A (fr)	1990-06-19
IE58273B1 (en)	1993-08-25
AU578781B2 (en)	1988-11-03
IE860021L (en)	1986-07-07
FR2575753A1 (fr)	1986-07-11
GR860023B (en)	1986-05-06
EP0190058B1 (fr)	1987-12-23
ES550716A0 (es)	1987-08-01
JPH0229080B2 (pt)	1990-06-27
ATE31537T1 (de)	1988-01-15
EP0190058A1 (fr)	1986-08-06
ZA86105B (en)	1986-10-29
AU5185486A (en)	1986-07-10
NZ214722A (en)	1988-09-29
ES8707552A1 (es)	1987-08-01
PT81793A (fr)	1986-02-01
OA08182A (fr)	1987-10-30

Legal Events

Date

Code

Title

Description

1995-10-20

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19950531

Publication	Publication Date	Title
PT81793B (pt)	1988-05-27	Processo para a preparacao de novos derivados peptidicos com estrutura policiclica azotada
ES8604547A1 (es)	1986-02-01	Procedimiento para preparar nuevos derivados de acidos feni-laceticos
PT97710A (pt)	1992-02-28	Processo para a preparacao de novos derivados da amino-piperidina,da amino-pirrolidina e de amino-per-hidroazepina
AU5791190A (en)	1991-01-03	New peptide derivatives, process for preparing them and pharmaceutical compositions containing them
FI881892A0 (fi)	1988-04-22	Menetelmä uusien, terapeuttisesti käyttökelpoisten 1,2,5,6-tetrahydropyridiinijohdannaisten valmistamiseksi
ES548357A0 (es)	1987-01-16	Procedimiento para preparar derivados de n-(adamantil-1)-pirrolidon-5-carboxamida-2.
AU1166988A (en)	1988-08-18	New peptide derivatives having a polycyclic nitrogenous structure, process for the preparation thereof and pharmaceutical compositions containing them
NZ212515A (en)	1988-10-28	Piperazino-pyrimido(5,4-d pyrimidine derivatives and pharmaceutical compositions
AU1774188A (en)	1988-12-22	New tripeptide derivatives having a polycyclic nitrogenous structure, process of the preparation thereof and pharmaceutical compositions containing them
AU639154B2 (en)	1993-07-15	New imidazole compounds, a process for the preparation thereof, and pharmaceutical compositions containing them
TW333533B (en)	1998-06-11	Novel indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase
KR850007067A (ko)	1985-10-30	옥스아자포스포린 유도체의 염의 제조방법
AU651621B2 (en)	1994-07-28	New 17-beta-oestradiol derivatives, a method of preparing them, and drugs containing them
ES8504180A1 (es)	1985-04-01	Procedimiento para preparar nuevos derivados de piperidina