PT84029B - Processo para a preparacao de n-acilaminoglicuronil-agliconas do antibiotico a 40926 e da aglicona do antibiotico a 40926 - Google Patents

Processo para a preparacao de n-acilaminoglicuronil-agliconas do antibiotico a 40926 e da aglicona do antibiotico a 40926

Info

Publication number: PT84029B
Authority: PT; Portugal
Prior art keywords: antibiotic; factor; aglycon; preparation; acylaminoglicuronyl
Prior art date: 1986-04-11

Application number

PT84029A

Other languages

English (en)

Other versions

PT84029A (en

Inventor

Enrico Selva

Giovanni Cassani

Ernest Riva

Francesco Parenti

Original Assignee

Lepetit Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-04-11

Filing date

1986-12-29

Publication date

1989-01-17

1986-12-29 Application filed by Lepetit Spa filed Critical Lepetit Spa

1987-01-01 Publication of PT84029A publication Critical patent/PT84029A/pt

1989-01-17 Publication of PT84029B publication Critical patent/PT84029B/pt

Links

230000003115 biocidal effect Effects 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
BEVDFPMXVNOQBI-AXNWEOKVSA-N (19R,22R,34S,37R,40R,52S)-64-[(2S,3R,4R,5S,6S)-3-amino-6-carboxy-4,5-dihydroxyoxan-2-yl]oxy-5,32-dichloro-2,26,31,49-tetrahydroxy-22-(methylamino)-21,35,38,54,56,59-hexaoxo-47-[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-7,13,28-trioxa-20,36,39,53,55,58-hexazaundecacyclo[38.14.2.23,6.214,17.219,34.18,12.123,27.129,33.141,45.010,37.046,51]hexahexaconta-3,5,8,10,12(64),14(63),15,17(62),23(61),24,26,29(60),30,32,41,43,45(57),46(51),47,49,65-henicosaene-52-carboxylic acid Chemical compound CN[C@@H]1c2ccc(O)c(Oc3cc(O)c(Cl)c(c3)[C@@H]3NC(=O)[C@@H](Cc4ccc(Oc5cc6cc(Oc7ccc(cc7Cl)C(O)C7NC(=O)[C@H](NC(=O)[C@@H]6NC3=O)c3cccc(c3)-c3c(O[C@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]6O)cc(O)cc3[C@H](NC7=O)C(O)=O)c5O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3N)C(O)=O)cc4)NC1=O)c2 BEVDFPMXVNOQBI-AXNWEOKVSA-N 0.000 abstract 7
DKVBOUDTNWVDEP-NJCHZNEYSA-N teicoplanin aglycone Chemical compound N([C@H](C(N[C@@H](C1=CC(O)=CC(O)=C1C=1C(O)=CC=C2C=1)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)OC=1C=C3C=C(C=1O)OC1=CC=C(C=C1Cl)C[C@H](C(=O)N1)NC([C@H](N)C=4C=C(O5)C(O)=CC=4)=O)C(=O)[C@@H]2NC(=O)[C@@H]3NC(=O)[C@@H]1C1=CC5=CC(O)=C1 DKVBOUDTNWVDEP-NJCHZNEYSA-N 0.000 abstract 6
208000035473 Communicable disease Diseases 0.000 abstract 1
102000003712 Complement factor B Human genes 0.000 abstract 1
108090000056 Complement factor B Proteins 0.000 abstract 1
244000005700 microbiome Species 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/19—Antibiotic
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Compounds Of Unknown Constitution (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicinal Preparation (AREA)

PT84029A 1986-04-11 1986-12-29 Processo para a preparacao de n-acilaminoglicuronil-agliconas do antibiotico a 40926 e da aglicona do antibiotico a 40926 PT84029B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB868608809A GB8608809D0 (en)	1986-04-11	1986-04-11	Antibiotic

Publications (2)

Publication Number	Publication Date
PT84029A PT84029A (en)	1987-01-01
PT84029B true PT84029B (pt)	1989-01-17

Family

ID=10596024

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT84029A PT84029B (pt)	1986-04-11	1986-12-29	Processo para a preparacao de n-acilaminoglicuronil-agliconas do antibiotico a 40926 e da aglicona do antibiotico a 40926

Country Status (22)

Country	Link
US (1)	US4868171A (pt)
EP (1)	EP0240609B1 (pt)
JP (1)	JPH0759593B2 (pt)
KR (2)	KR950010461B1 (pt)
CN (1)	CN1033043C (pt)
AT (1)	ATE70069T1 (pt)
AU (1)	AU601706B2 (pt)
DE (1)	DE3682767D1 (pt)
DK (1)	DK167770B1 (pt)
ES (1)	ES2040207T3 (pt)
FI (1)	FI86307C (pt)
GB (1)	GB8608809D0 (pt)
GR (1)	GR3003443T3 (pt)
HU (1)	HU196229B (pt)
IE (1)	IE59523B1 (pt)
IL (1)	IL81106A (pt)
MY (1)	MY101178A (pt)
NO (1)	NO172121C (pt)
NZ (1)	NZ218789A (pt)
PH (1)	PH23620A (pt)
PT (1)	PT84029B (pt)
ZA (1)	ZA869713B (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK363587A (da) *	1986-07-30	1988-01-31	Smithkline Beckman Corp	Antibiotika og fremstilling heraf under anvendelseaf actinomadura parvosata
GB8621912D0 (en) *	1986-09-11	1986-10-15	Lepetit Spa	Increasing ratio of components of anti-biotic complex
EP0376042B1 (en) *	1988-12-27	1996-03-13	GRUPPO LEPETIT S.p.A.	Improved chemical process for preparing antibiotic L 17392 (deglucoteicoplanin) and its salts
WO1992010516A1 (en) *	1990-12-05	1992-06-25	Gruppo Lepetit S.P.A.	38-decarboxy-38-hydroxymethyl derivatives of teicoplanin antibiotics, and a process for preparing them
EP0505735A1 (en)	1991-03-27	1992-09-30	GRUPPO LEPETIT S.p.A.	Antibiotic A 40926 ester derivatives
US5606036A (en) *	1991-03-27	1997-02-25	Gruppo Lepetit Spa	Antibiotic A 40926 ester derivatives
US5750509A (en) *	1991-07-29	1998-05-12	Gruppo Lepetit S.P.A.	Amide derivatives of antibiotic A 40926
CZ285703B6 (cs) *	1991-07-29	1999-10-13	Biosearch Italia S. P. A.	Amidové deriváty antibiotika A 40926
DE69633234T2 (de) *	1995-07-05	2005-09-15	Aventis Bulk S.P.A.	Reinigung von dalbeheptide-antibiotika mittels isoelektrofokussierung
KR20000010589A (ko)	1996-04-23	2000-02-15	클라우디오 쿼르타	항생제a40926의아미드유도체의개선된화학적제조방법
US7119061B2 (en) *	2002-11-18	2006-10-10	Vicuron Pharmaceuticals, Inc.	Dalbavancin compositions for treatment of bacterial infections
AU2003294262B2 (en) *	2002-11-18	2007-08-23	Vicuron Pharmaceuticals Inc.	Methods of administering dalbavancin for treatment of bacterial infections
US20060074014A1 (en)	2002-11-18	2006-04-06	Vicuron Pharmaceuticals Inc.	Dalbavancin compositions for treatment of bacterial infections
CN101851277B (zh) *	2009-03-12	2012-10-03	成都雅途生物技术有限公司	一种道古霉素关键中间体a40926 bo组分的纯化制备方法
CN102417919B (zh) *	2011-09-02	2017-05-24	山东鲁抗医药股份有限公司	一种发酵法生产高纯度替考拉宁的方法
CN110105435B (zh) *	2019-05-08	2023-12-08	宜昌东阳光生化制药有限公司	一种生产a40926的发酵培养基和发酵方法
CN112625925B (zh) *	2021-01-08	2022-04-19	浙江大学	一种达巴万星前体a40926b0高产菌株及应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RO86375B1 (ro) *	1982-03-24	1985-04-01	Eli Lilly And Company	Procedeu pentru prepararea antibioticului a 41030
GB8307847D0 (en) *	1983-03-22	1983-04-27	Lepetit Spa	Antibiotics l 17054 and l 17046
US4521335A (en) *	1983-07-13	1985-06-04	Smithkline Beckman Corporation	Aglycone and pseudo-aglycones of the AAD 216 antibiotics
AU579120B2 (en) *	1983-12-16	1988-11-17	Gruppo Lepetit S.P.A.	Chemical process for preparing antibiotic L 17392 (deglucoteicoplanin) and its salts
GB8425685D0 (en) *	1984-10-11	1984-11-14	Lepetit Spa	Antibiotic a 40926 complex

1986
- 1986-04-11 GB GB868608809A patent/GB8608809D0/en active Pending
- 1986-12-15 EP EP86117452A patent/EP0240609B1/en not_active Expired - Lifetime
- 1986-12-15 DE DE8686117452T patent/DE3682767D1/de not_active Expired - Lifetime
- 1986-12-15 ES ES198686117452T patent/ES2040207T3/es not_active Expired - Lifetime
- 1986-12-15 AT AT86117452T patent/ATE70069T1/de not_active IP Right Cessation
- 1986-12-19 DK DK617286A patent/DK167770B1/da not_active IP Right Cessation
- 1986-12-23 NZ NZ218789A patent/NZ218789A/xx unknown
- 1986-12-23 US US06/945,639 patent/US4868171A/en not_active Expired - Fee Related
- 1986-12-23 AU AU66883/86A patent/AU601706B2/en not_active Ceased
- 1986-12-23 IE IE338286A patent/IE59523B1/en not_active IP Right Cessation
- 1986-12-26 IL IL81106A patent/IL81106A/xx not_active IP Right Cessation
- 1986-12-29 KR KR1019860011488A patent/KR950010461B1/ko not_active Expired - Fee Related
- 1986-12-29 FI FI865320A patent/FI86307C/fi not_active IP Right Cessation
- 1986-12-29 PT PT84029A patent/PT84029B/pt not_active IP Right Cessation
- 1986-12-29 JP JP61315965A patent/JPH0759593B2/ja not_active Expired - Lifetime
- 1986-12-29 HU HU865504A patent/HU196229B/hu not_active IP Right Cessation
- 1986-12-29 ZA ZA869713A patent/ZA869713B/xx unknown
- 1986-12-29 NO NO865323A patent/NO172121C/no unknown
- 1986-12-30 CN CN86108977A patent/CN1033043C/zh not_active Expired - Fee Related
1987
- 1987-01-12 PH PH34710A patent/PH23620A/en unknown
- 1987-04-01 MY MYPI87000414A patent/MY101178A/en unknown
- 1987-07-01 KR KR1019870006804A patent/KR960010557B1/ko not_active Expired - Fee Related
1991
- 1991-12-27 GR GR91402185T patent/GR3003443T3/el unknown

Also Published As

Publication number	Publication date
KR870010194A (ko)	1987-11-30
DE3682767D1 (de)	1992-01-16
GB8608809D0 (en)	1986-05-14
EP0240609A3 (en)	1988-07-27
AU6688386A (en)	1987-10-15
FI865320A0 (fi)	1986-12-29
IL81106A (en)	1992-07-15
FI86307C (fi)	1992-08-10
GR3003443T3 (en)	1993-02-17
KR890002231A (ko)	1989-04-08
NO172121C (no)	1993-06-09
NZ218789A (en)	1990-09-26
NO172121B (no)	1993-03-01
PH23620A (en)	1989-09-11
MY101178A (en)	1991-07-31
NO865323L (no)	1987-10-12
PT84029A (en)	1987-01-01
IE863382L (en)	1987-10-11
ZA869713B (en)	1987-12-30
EP0240609B1 (en)	1991-12-04
ES2040207T3 (es)	1993-10-16
AU601706B2 (en)	1990-09-20
KR950010461B1 (ko)	1995-09-18
IL81106A0 (en)	1987-03-31
IE59523B1 (en)	1994-03-09
FI86307B (fi)	1992-04-30
FI865320L (fi)	1987-10-12
HU196229B (en)	1988-10-28
KR960010557B1 (ko)	1996-08-02
DK617286D0 (da)	1986-12-19
ATE70069T1 (de)	1991-12-15
EP0240609A2 (en)	1987-10-14
DK167770B1 (da)	1993-12-13
HUT43869A (en)	1987-12-28
JPS62242699A (ja)	1987-10-23
US4868171A (en)	1989-09-19
DK617286A (da)	1987-10-12
CN86108977A (zh)	1988-04-27
CN1033043C (zh)	1996-10-16
JPH0759593B2 (ja)	1995-06-28

Legal Events

Date

Code

Title

Description

1999-04-30

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19981231

Publication	Publication Date	Title
ATE70069T1 (de)	1991-12-15	Antibiotika-a40926-n-acylaminoglycuronyl-aglyko e und antibiotika-a40926-aglykone.
DE68917163D1 (de)	1994-09-08	Antibakterielle Mittel.
DE3683266D1 (de)	1992-02-13	Antibiotikum a 40926 mannosyl aglycon.
DE3782315D1 (de)	1992-11-26	Absorbierende produkte und deren herstellung.
DK312688A (da)	1988-06-09	Glykkopeptid-antibiotika
DK0406745T3 (da)	1995-02-27	Antibiotiske GE 2270 faktorer A1, A2, A3 og H
DK0451486T3 (da)	1995-05-08	Antibiotikum GE 2270 faktorer B1, B2, C1, C2, D1, D2, E og T
PT88254A (pt)	1989-06-30	Processo para a preparacao de derivados de eritromicina a modificada em c.12
DE3872916D1 (de)	1992-08-27	Herstellung und reinigung eines n,n-diethylaminophenols.
FI902851A7 (fi)	1990-12-10	4,5,5a,6-tetrahydro-3H-isoksatsolo/5,4,3-kl/akridiinijohdannaisia, menetelmä niiden valmistamiseksi ja niiden käyttö lääkkeinä
FI911397A7 (fi)	1991-03-22	2-Amino-7-karbamoyyli-1,2,3,4-tetrahydronaftaleenit, menetelmä niiden valmistamiseksi ja niiden käyttö lääkeaineina
AU6725387A (en)	1988-06-16	Drugs for the treatment and cure of all infectious diseases caused by pathogenic virulent micro-organisms