DK617286A - Antibiotikum a 40926 n-acylaminoglucuronyl-aglyconer og antibiotikuma 40926 aglycon og additionssalte deraf, fremgangsmaade til fremstilling af saadanne forbindelser og laegemiddelpraeparat indeholdende dem - Google Patents

Antibiotikum a 40926 n-acylaminoglucuronyl-aglyconer og antibiotikuma 40926 aglycon og additionssalte deraf, fremgangsmaade til fremstilling af saadanne forbindelser og laegemiddelpraeparat indeholdende dem

Info

Publication number: DK617286A
Authority: DK; Denmark
Prior art keywords: antibiotic; aglycon; acylaminoglucuronyl; preparation; antibioticum
Prior art date: 1986-04-11

Application number

DK617286A

Other languages

English (en)

Other versions

DK617286D0 (da

DK167770B1 (da

Inventor

Enrico Selva

Ernesto Riva

Giovanni Cassani

Francesco Parenti

Original Assignee

Lepetit Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-04-11

Filing date

1986-12-19

Publication date

1987-10-12

1986-12-19 Application filed by Lepetit Spa filed Critical Lepetit Spa

1986-12-19 Publication of DK617286D0 publication Critical patent/DK617286D0/da

1987-10-12 Publication of DK617286A publication Critical patent/DK617286A/da

1993-12-13 Application granted granted Critical

1993-12-13 Publication of DK167770B1 publication Critical patent/DK167770B1/da

Links

BEVDFPMXVNOQBI-AXNWEOKVSA-N (19R,22R,34S,37R,40R,52S)-64-[(2S,3R,4R,5S,6S)-3-amino-6-carboxy-4,5-dihydroxyoxan-2-yl]oxy-5,32-dichloro-2,26,31,49-tetrahydroxy-22-(methylamino)-21,35,38,54,56,59-hexaoxo-47-[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-7,13,28-trioxa-20,36,39,53,55,58-hexazaundecacyclo[38.14.2.23,6.214,17.219,34.18,12.123,27.129,33.141,45.010,37.046,51]hexahexaconta-3,5,8,10,12(64),14(63),15,17(62),23(61),24,26,29(60),30,32,41,43,45(57),46(51),47,49,65-henicosaene-52-carboxylic acid Chemical compound CN[C@@H]1c2ccc(O)c(Oc3cc(O)c(Cl)c(c3)[C@@H]3NC(=O)[C@@H](Cc4ccc(Oc5cc6cc(Oc7ccc(cc7Cl)C(O)C7NC(=O)[C@H](NC(=O)[C@@H]6NC3=O)c3cccc(c3)-c3c(O[C@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]6O)cc(O)cc3[C@H](NC7=O)C(O)=O)c5O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3N)C(O)=O)cc4)NC1=O)c2 BEVDFPMXVNOQBI-AXNWEOKVSA-N 0.000 title abstract 8
DKVBOUDTNWVDEP-NJCHZNEYSA-N teicoplanin aglycone Chemical compound N([C@H](C(N[C@@H](C1=CC(O)=CC(O)=C1C=1C(O)=CC=C2C=1)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)OC=1C=C3C=C(C=1O)OC1=CC=C(C=C1Cl)C[C@H](C(=O)N1)NC([C@H](N)C=4C=C(O5)C(O)=CC=4)=O)C(=O)[C@@H]2NC(=O)[C@@H]3NC(=O)[C@@H]1C1=CC5=CC(O)=C1 DKVBOUDTNWVDEP-NJCHZNEYSA-N 0.000 title abstract 7
238000000034 method Methods 0.000 title abstract 2
150000003839 salts Chemical class 0.000 title abstract 2
229940126601 medicinal product Drugs 0.000 title 1
239000000203 mixture Substances 0.000 title 1
208000035473 Communicable disease Diseases 0.000 abstract 1
102000003712 Complement factor B Human genes 0.000 abstract 1
108090000056 Complement factor B Proteins 0.000 abstract 1
230000003115 biocidal effect Effects 0.000 abstract 1
244000005700 microbiome Species 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/19—Antibiotic
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Compounds Of Unknown Constitution (AREA)
Medicinal Preparation (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK617286A 1986-04-11 1986-12-19 Antibiotikum a 40926 n-acylaminoglucuronyl-aglyconer og antibiotikum a 40926 aglycon og farmaceutisk acceptable additionssalte deraf, fremgangsmaade til fremstilling af saadanne forbindelser, farmaceutisk praeparat indeholdende forbindelserne samt anvendelse af saadanne forbindelser til fremstilling af et medikament DK167770B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB868608809A GB8608809D0 (en)	1986-04-11	1986-04-11	Antibiotic
GB8608809		1986-04-11

Publications (3)

Publication Number	Publication Date
DK617286D0 DK617286D0 (da)	1986-12-19
DK617286A true DK617286A (da)	1987-10-12
DK167770B1 DK167770B1 (da)	1993-12-13

Family

ID=10596024

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK617286A DK167770B1 (da)	1986-04-11	1986-12-19	Antibiotikum a 40926 n-acylaminoglucuronyl-aglyconer og antibiotikum a 40926 aglycon og farmaceutisk acceptable additionssalte deraf, fremgangsmaade til fremstilling af saadanne forbindelser, farmaceutisk praeparat indeholdende forbindelserne samt anvendelse af saadanne forbindelser til fremstilling af et medikament

Country Status (22)

Country	Link
US (1)	US4868171A (da)
EP (1)	EP0240609B1 (da)
JP (1)	JPH0759593B2 (da)
KR (2)	KR950010461B1 (da)
CN (1)	CN1033043C (da)
AT (1)	ATE70069T1 (da)
AU (1)	AU601706B2 (da)
DE (1)	DE3682767D1 (da)
DK (1)	DK167770B1 (da)
ES (1)	ES2040207T3 (da)
FI (1)	FI86307C (da)
GB (1)	GB8608809D0 (da)
GR (1)	GR3003443T3 (da)
HU (1)	HU196229B (da)
IE (1)	IE59523B1 (da)
IL (1)	IL81106A (da)
MY (1)	MY101178A (da)
NO (1)	NO172121C (da)
NZ (1)	NZ218789A (da)
PH (1)	PH23620A (da)
PT (1)	PT84029B (da)
ZA (1)	ZA869713B (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK363587A (da) *	1986-07-30	1988-01-31	Smithkline Beckman Corp	Antibiotika og fremstilling heraf under anvendelseaf actinomadura parvosata
GB8621912D0 (en) *	1986-09-11	1986-10-15	Lepetit Spa	Increasing ratio of components of anti-biotic complex
ES2084595T3 (es) *	1988-12-27	1996-05-16	Lepetit Spa	Procedimiento quimico mejorado para preparar el antibiotico l/17392 (desglucoteicoplanina) y sus sales.
ATE134379T1 (de) *	1990-12-05	1996-03-15	Lepetit Spa	38-decarboxy-38-hydroxymethylderivate von teicoplaninantibiotika, und verfahren zu deren herstellung
US5606036A (en) *	1991-03-27	1997-02-25	Gruppo Lepetit Spa	Antibiotic A 40926 ester derivatives
JP3314930B2 (ja)	1991-03-27	2002-08-19	バイオサーチ・イタリア・ソチエタ・ペル・アチオニ	抗生物質ａ４０９２６エステル誘導体
US5750509A (en) *	1991-07-29	1998-05-12	Gruppo Lepetit S.P.A.	Amide derivatives of antibiotic A 40926
DK0596929T3 (da) *	1991-07-29	1995-09-11	Lepetit Spa	Amidderivater af antibiotikum A 40926
AU701463B2 (en) *	1995-07-05	1999-01-28	Sanofi Aventis S.P.A.	Purification of dalbaheptide antibiotics by isoelectric focusing
DK0912604T3 (da)	1996-04-23	2002-03-25	Biosearch Italia Spa	Forbedret kemisk fremgangsmåde til fremstilling af amidderivater af A 40926 antibiotikum
US7119061B2 (en)	2002-11-18	2006-10-10	Vicuron Pharmaceuticals, Inc.	Dalbavancin compositions for treatment of bacterial infections
EP1565201B1 (en) *	2002-11-18	2018-10-31	Vicuron Pharmaceuticals, Inc.	Methods of administering dalbavancin for treatment of bacterial infections
US20060074014A1 (en) *	2002-11-18	2006-04-06	Vicuron Pharmaceuticals Inc.	Dalbavancin compositions for treatment of bacterial infections
CN101851277B (zh) *	2009-03-12	2012-10-03	成都雅途生物技术有限公司	一种道古霉素关键中间体a40926 bo组分的纯化制备方法
CN102417919B (zh) *	2011-09-02	2017-05-24	山东鲁抗医药股份有限公司	一种发酵法生产高纯度替考拉宁的方法
CN110105435B (zh) *	2019-05-08	2023-12-08	宜昌东阳光生化制药有限公司	一种生产a40926的发酵培养基和发酵方法
CN112625925B (zh) *	2021-01-08	2022-04-19	浙江大学	一种达巴万星前体a40926b0高产菌株及应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI75190C (fi) *	1982-03-24	1988-05-09	Lilly Co Eli	Foerfarande foer framstaellning av ett antibiotikum a41030-komplex eller dess faktorer a, b, c, d, e, f och g.
GB8307847D0 (en) *	1983-03-22	1983-04-27	Lepetit Spa	Antibiotics l 17054 and l 17046
US4521335A (en) *	1983-07-13	1985-06-04	Smithkline Beckman Corporation	Aglycone and pseudo-aglycones of the AAD 216 antibiotics
AU579120B2 (en) *	1983-12-16	1988-11-17	Gruppo Lepetit S.P.A.	Chemical process for preparing antibiotic L 17392 (deglucoteicoplanin) and its salts
GB8425685D0 (en) *	1984-10-11	1984-11-14	Lepetit Spa	Antibiotic a 40926 complex

1986
- 1986-04-11 GB GB868608809A patent/GB8608809D0/en active Pending
- 1986-12-15 EP EP86117452A patent/EP0240609B1/en not_active Expired - Lifetime
- 1986-12-15 AT AT86117452T patent/ATE70069T1/de not_active IP Right Cessation
- 1986-12-15 ES ES198686117452T patent/ES2040207T3/es not_active Expired - Lifetime
- 1986-12-15 DE DE8686117452T patent/DE3682767D1/de not_active Expired - Lifetime
- 1986-12-19 DK DK617286A patent/DK167770B1/da not_active IP Right Cessation
- 1986-12-23 NZ NZ218789A patent/NZ218789A/xx unknown
- 1986-12-23 US US06/945,639 patent/US4868171A/en not_active Expired - Fee Related
- 1986-12-23 AU AU66883/86A patent/AU601706B2/en not_active Ceased
- 1986-12-23 IE IE338286A patent/IE59523B1/en not_active IP Right Cessation
- 1986-12-26 IL IL81106A patent/IL81106A/xx not_active IP Right Cessation
- 1986-12-29 JP JP61315965A patent/JPH0759593B2/ja not_active Expired - Lifetime
- 1986-12-29 ZA ZA869713A patent/ZA869713B/xx unknown
- 1986-12-29 PT PT84029A patent/PT84029B/pt not_active IP Right Cessation
- 1986-12-29 KR KR1019860011488A patent/KR950010461B1/ko not_active Expired - Fee Related
- 1986-12-29 FI FI865320A patent/FI86307C/fi not_active IP Right Cessation
- 1986-12-29 NO NO865323A patent/NO172121C/no unknown
- 1986-12-29 HU HU865504A patent/HU196229B/hu not_active IP Right Cessation
- 1986-12-30 CN CN86108977A patent/CN1033043C/zh not_active Expired - Fee Related
1987
- 1987-01-12 PH PH34710A patent/PH23620A/en unknown
- 1987-04-01 MY MYPI87000414A patent/MY101178A/en unknown
- 1987-07-01 KR KR1019870006804A patent/KR960010557B1/ko not_active Expired - Fee Related
1991
- 1991-12-27 GR GR91402185T patent/GR3003443T3/el unknown

Also Published As

Publication number	Publication date
GR3003443T3 (en)	1993-02-17
AU6688386A (en)	1987-10-15
FI86307B (fi)	1992-04-30
IL81106A (en)	1992-07-15
NO172121B (no)	1993-03-01
IE863382L (en)	1987-10-11
JPS62242699A (ja)	1987-10-23
KR950010461B1 (ko)	1995-09-18
NO172121C (no)	1993-06-09
JPH0759593B2 (ja)	1995-06-28
HUT43869A (en)	1987-12-28
HU196229B (en)	1988-10-28
DK617286D0 (da)	1986-12-19
FI86307C (fi)	1992-08-10
PT84029B (pt)	1989-01-17
EP0240609B1 (en)	1991-12-04
NO865323L (no)	1987-10-12
AU601706B2 (en)	1990-09-20
KR890002231A (ko)	1989-04-08
PT84029A (en)	1987-01-01
FI865320L (fi)	1987-10-12
MY101178A (en)	1991-07-31
ZA869713B (en)	1987-12-30
FI865320A0 (fi)	1986-12-29
CN86108977A (zh)	1988-04-27
IL81106A0 (en)	1987-03-31
DK167770B1 (da)	1993-12-13
US4868171A (en)	1989-09-19
EP0240609A2 (en)	1987-10-14
DE3682767D1 (de)	1992-01-16
ATE70069T1 (de)	1991-12-15
KR960010557B1 (ko)	1996-08-02
ES2040207T3 (es)	1993-10-16
CN1033043C (zh)	1996-10-16
GB8608809D0 (en)	1986-05-14
EP0240609A3 (en)	1988-07-27
KR870010194A (ko)	1987-11-30
IE59523B1 (en)	1994-03-09
NZ218789A (en)	1990-09-26
PH23620A (en)	1989-09-11

Legal Events

Date	Code	Title	Description
1993-12-13	B1	Patent granted (law 1993)
1999-08-23	PBP	Patent lapsed

Publication	Publication Date	Title
DK617286D0 (da)	1986-12-19	Antibiotikum a 40926 n-acylaminoglucuronyl-aglyconer og antibiotikuma 40926 aglycon og additionssalte deraf, fremgangsmaade til fremstilling af saadanne forbindelser og laegemiddelpraeparat indeholdende dem
ATE71113T1 (de)	1992-01-15	Antibiotikum a 40926 mannosyl aglycon.
DE69019533D1 (de)	1995-06-22	Behandlung von hiv-infizierungen und nützliche verbindungen dafür.
ATE45153T1 (de)	1989-08-15	Benzisoselenazolthione, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische produkte.
NO902800D0 (no)	1990-06-22	Fremgangsmaate for fremstilling av 11beta-aryl-4-oestrener.
UA48958C2 (uk)	2002-09-16	9-o-оксимові похідні еритроміцину а та фармацевтична композиція на їх основі
DK0406745T3 (da)	1995-02-27	Antibiotiske GE 2270 faktorer A1, A2, A3 og H
DE3887068D1 (de)	1994-02-24	2,2-Dimethylchromenderivate, Verfahren zur Herstellung und diese enthaltende pharmazeutische Zusammenstellungen.
DK0451486T3 (da)	1995-05-08	Antibiotikum GE 2270 faktorer B1, B2, C1, C2, D1, D2, E og T
FI951561A7 (fi)	1995-03-31	Uudet 17 -substituoidut 4-androstaanijohdannaiset, niitä sisältävät farmaseuttiset koostumukset ja menetelmä niiden valmistamiseksi
ATE215941T1 (de)	2002-04-15	Isoflavonderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
DE69016592D1 (de)	1995-03-16	4-Amidino-Chroman und 4-Amidino-Pyrano(3,2-c)pyridinderivate, Verfahren zur Herstellung und diese enthaltende pharmazeutische Zusammenstellungen.
DK0916663T3 (da)	2003-07-28	18beta, 19beta-diacetyloxy-18alpha, 19alpha-epoxy-3,13(16), 14-clerodatrien-2-on (Esculentin A) og 18beta, 19beta-diacetyloxy-18alpha, 19alpha-epoxy-3, 12, 14-clerodatrien-2beta-isovaleryloxy-6beta, 7alpha-diol (Esculentin B), fremgangsmåde........
IT8919543A0 (it)	1989-02-23	Derivati del 1 arilsolfonil pirrolidin 2 tione oppure del 1 arilsolfonil piperidin 2 tione, loro procedimento di preparazione e loro impiego come medicinali.
AU6725387A (en)	1988-06-16	Drugs for the treatment and cure of all infectious diseases caused by pathogenic virulent micro-organisms