PT87013A - Processo de preparacao de compostos heterociclicos derivados da quinazolina e da pirazina e de composicoes farmaceuticas que os contem - Google Patents

Processo de preparacao de compostos heterociclicos derivados da quinazolina e da pirazina e de composicoes farmaceuticas que os contem

Info

Publication number: PT87013A
Authority: PT; Portugal
Prior art keywords: alkyl; heterocyclic compounds; quinazoline; pyrazine; preparation
Prior art date: 1987-03-18

Application number

PT87013A

Other languages

English (en)

Other versions

PT87013B (pt

Inventor

Holger Claus Hansen

Frank Watjen

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-03-18

Filing date

1988-03-18

Publication date

1989-03-30

1988-03-18 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1989-03-30 Publication of PT87013A publication Critical patent/PT87013A/pt

1995-03-01 Publication of PT87013B publication Critical patent/PT87013B/pt

Links

150000002391 heterocyclic compounds Chemical class 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 title 2
PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
229910052736 halogen Inorganic materials 0.000 abstract 2
125000006728 (C1-C6) alkynyl group Chemical group 0.000 abstract 1
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
229940125681 anticonvulsant agent Drugs 0.000 abstract 1
239000001961 anticonvulsive agent Substances 0.000 abstract 1
239000002249 anxiolytic agent Substances 0.000 abstract 1
230000000949 anxiolytic effect Effects 0.000 abstract 1
229940005530 anxiolytics Drugs 0.000 abstract 1
125000004104 aryloxy group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
239000003326 hypnotic agent Substances 0.000 abstract 1
230000000147 hypnotic effect Effects 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
239000002664 nootropic agent Substances 0.000 abstract 1
230000001777 nootropic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Anesthesiology (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Plural Heterocyclic Compounds (AREA)
Luminescent Compositions (AREA)

PT87013A 1987-03-18 1988-03-18 Processo de preparacao de compostos heterociclicos derivados da quinazolina e da pirazina e de composicoes farmaceuticas que os contem PT87013B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK137487A DK155524C (da)	1987-03-18	1987-03-18	Kondenserede imidazolderivater og farmaceutiske praeparater indeholdende disse

Publications (2)

Publication Number	Publication Date
PT87013A true PT87013A (pt)	1989-03-30
PT87013B PT87013B (pt)	1995-03-01

Family

ID=8104158

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT87013A PT87013B (pt)	1987-03-18	1988-03-18	Processo de preparacao de compostos heterociclicos derivados da quinazolina e da pirazina e de composicoes farmaceuticas que os contem

Country Status (18)

Country	Link
US (2)	US4873244A (pt)
EP (1)	EP0283162B1 (pt)
JP (1)	JPS6463581A (pt)
KR (1)	KR960010455B1 (pt)
AT (1)	ATE92926T1 (pt)
AU (1)	AU607469B2 (pt)
CA (1)	CA1308712C (pt)
DE (1)	DE3883033T2 (pt)
DK (1)	DK155524C (pt)
ES (1)	ES2058251T3 (pt)
FI (1)	FI92700C (pt)
IE (1)	IE62320B1 (pt)
IL (1)	IL85295A (pt)
NO (1)	NO169340C (pt)
NZ (1)	NZ223777A (pt)
PH (2)	PH24076A (pt)
PT (1)	PT87013B (pt)
ZA (1)	ZA881140B (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK160876C (da) *	1987-12-08	1991-10-14	Novo Nordisk As	Imidazoquinoxalinforbindelser, fremgangsmaade til deres fremstilling, anvendelse af forbindelserne og farmaceutiske praeparater, hvori forbindelserne indgaar
IL90315A0 (en) *	1988-06-01	1989-12-15	Ferrosan As	Imidazoquinoxaline compounds,their preparation and pharmaceutical compositions containing them
DK161148C (da) *	1988-06-14	1991-11-18	Novo Nordisk As	Imidazoquinoxalinforbindelser, fremgangsmaade til fremstilling deraf samt farmaceutiske praeprater indeholdende forbindelserne
DK626288D0 (da) *	1988-11-10	1988-11-10	Ferrosan As	Kemisk proces til fremstilling af imidazoquinoxaliner og mellemprodukter til brug i processen
DK588489D0 (da) *	1989-11-22	1989-11-22	Ferrosan As	Heterocykliske forbindelser, deres fremstilling og anvendelse
DK588389D0 (da) *	1989-11-22	1989-11-22	Ferrosan As	Heterocykliske forbindelser, deres fremstilling og anvendelse
FR2659329B1 (fr) *	1990-03-09	1994-06-03	Adir	Nouveaux derives d'imidazo [1,2-c] quinazoline, leur procede de preparation et les compositions pharmaceutiques les renfermant.
DK151890D0 (da) *	1990-06-22	1990-06-22	Ferrosan As	Heterocykliske forbindelser deres fremstilling og brug
US5276028A (en) *	1990-06-22	1994-01-04	Nordisk A/S	Imidazoquinoxaline compounds
DK204291D0 (da) *	1991-12-20	1991-12-20	Novo Nordisk As	Heterocykliske forbindelser deres fremstilling og anvendelse
US5371080A (en) *	1990-06-22	1994-12-06	Novo Nordisk A/S	Imidazoquinazoline compounds and their use
WO1992004350A1 (en) *	1990-09-04	1992-03-19	The Upjohn Company	Oxygenated quinoxalines
EP0590022A1 (en) *	1991-06-14	1994-04-06	PHARMACIA & UPJOHN COMPANY	IMIDAZO 1,5-a]QUINOXALINES
WO1993012113A1 (en) *	1991-12-17	1993-06-24	The Upjohn Company	3-SUBSTITUTED IMIDAZO (1,5-a) AND IMIDAZO (1,5-a)-TRIAZOLO (1,5-c) QUINOXALINES AND QUINAZOLINES WITH CNS ACTIVITY
EP0625982B1 (en) *	1992-02-13	2002-06-12	PHARMACIA & UPJOHN COMPANY	4-oxo- and 4h-imidazo(5,1-c)(1,4)benzoxazines useful as benzodiazepine receptor-binding agents
JPH07503970A (ja) *	1992-02-19	1995-04-27	ジ・アップジョン・カンパニー	ＣＮＳ活性を有する３−置換イミダゾ（１，５−ａ）−キノキサリン類およびキナゾリン類
US5367077A (en) *	1992-04-08	1994-11-22	Neurogen Corporation	Certain cycloalkyl and azacycloalkyl pyrrolopyridines; a new class of gaba rain receptor ligands
USRE35840E (en) *	1993-11-19	1998-07-07	Pharmacia & Upjohn Company	Imidazo 1,5-a!quinolines for treatment of anxiety and sleep disorders
IL112235A (en) *	1994-01-03	2000-06-29	Acea Pharm Inc	1,4-dihydro-pyrido¬2,3-b¾pyrazine-2,3-dione (5 or 8) oxide derivatives and pharmaceutical compositions containing them
FR2799757B1 (fr) *	1999-10-15	2001-12-14	Adir	Nouveaux derives polycycliques azaindoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6888004B2 (en) *	2001-01-26	2005-05-03	Bristol-Myers Squibb Company	Imidazolyl derivatives as corticotropin releasing factor inhibitors
WO2017149469A1 (en)	2016-03-03	2017-09-08	Emcure Pharmaceuticals Limited	Heterocyclic compounds useful as ido and/or tdo modulators

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4440929A (en) *	1981-07-16	1984-04-03	Usv Pharmaceutical Corporation	Imidazoquinoxaline compounds
DK476885D0 (da) *	1985-10-17	1985-10-17	Ferrosan As	Heterocycliske forbindelser og fremgangsmaader til fremstilling heraf
DE202441T1 (de) *	1985-05-17	1987-03-19	Aktieselskabet Ferrosan, Soeborg	Oxadiazolylimidazobenzodiazepine, verfahren zu ihrer herstellung und pharmazeutische zubereitungen.
US4771051A (en) *	1985-05-17	1988-09-13	A/S Ferrosan	3-substituted-4,5-dihydro-5-oxo imidazoquinazolines, their preparation, and their use in treating benzodiazepin receptor-related ailments
EP0226282B1 (en) *	1985-10-17	1989-07-05	A/S Ferrosan	Heterocyclic compounds and their preparation and use
DK160876C (da) *	1987-12-08	1991-10-14	Novo Nordisk As	Imidazoquinoxalinforbindelser, fremgangsmaade til deres fremstilling, anvendelse af forbindelserne og farmaceutiske praeparater, hvori forbindelserne indgaar
IL90315A0 (en) *	1988-06-01	1989-12-15	Ferrosan As	Imidazoquinoxaline compounds,their preparation and pharmaceutical compositions containing them

1987
- 1987-03-18 DK DK137487A patent/DK155524C/da not_active IP Right Cessation
1988
- 1988-02-02 IL IL85295A patent/IL85295A/xx not_active IP Right Cessation
- 1988-02-10 PH PH36480A patent/PH24076A/en unknown
- 1988-02-16 US US07/156,363 patent/US4873244A/en not_active Expired - Fee Related
- 1988-02-18 IE IE43888A patent/IE62320B1/en not_active IP Right Cessation
- 1988-02-18 ZA ZA881140A patent/ZA881140B/xx unknown
- 1988-02-22 FI FI880815A patent/FI92700C/fi not_active IP Right Cessation
- 1988-03-01 DE DE88301783T patent/DE3883033T2/de not_active Expired - Fee Related
- 1988-03-01 EP EP88301783A patent/EP0283162B1/en not_active Expired - Lifetime
- 1988-03-01 ES ES88301783T patent/ES2058251T3/es not_active Expired - Lifetime
- 1988-03-01 AT AT88301783T patent/ATE92926T1/de not_active IP Right Cessation
- 1988-03-07 NZ NZ223777A patent/NZ223777A/xx unknown
- 1988-03-16 KR KR1019880002727A patent/KR960010455B1/ko not_active Expired - Fee Related
- 1988-03-17 JP JP63062068A patent/JPS6463581A/ja active Pending
- 1988-03-17 CA CA000561758A patent/CA1308712C/en not_active Expired - Lifetime
- 1988-03-17 NO NO881191A patent/NO169340C/no unknown
- 1988-03-18 PT PT87013A patent/PT87013B/pt not_active IP Right Cessation
- 1988-03-18 AU AU13259/88A patent/AU607469B2/en not_active Ceased
- 1988-07-18 PH PH37235A patent/PH24165A/en unknown
1989
- 1989-04-20 US US07/340,901 patent/US4902686A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
KR880011157A (ko)	1988-10-26
NO169340C (no)	1992-06-10
IL85295A (en)	1991-12-12
DE3883033T2 (de)	1993-12-16
IE62320B1 (en)	1995-01-25
KR960010455B1 (ko)	1996-08-01
DK155524C (da)	1989-09-11
EP0283162B1 (en)	1993-08-11
ES2058251T3 (es)	1994-11-01
JPS6463581A (en)	1989-03-09
DK137487D0 (da)	1987-03-18
NO881191D0 (no)	1988-03-17
AU1325988A (en)	1988-09-22
US4902686A (en)	1990-02-20
ATE92926T1 (de)	1993-08-15
NZ223777A (en)	1989-09-27
PT87013B (pt)	1995-03-01
FI92700C (fi)	1994-12-27
DK137487A (da)	1988-09-19
PH24076A (en)	1990-03-05
NO881191L (no)	1988-09-19
ZA881140B (en)	1988-08-15
EP0283162A3 (en)	1990-05-30
US4873244A (en)	1989-10-10
PH24165A (en)	1990-03-22
DK155524B (da)	1989-04-17
AU607469B2 (en)	1991-03-07
EP0283162A2 (en)	1988-09-21
DE3883033D1 (de)	1993-09-16
FI92700B (fi)	1994-09-15
FI880815A7 (fi)	1988-09-19
FI880815A0 (fi)	1988-02-22
IE880438L (en)	1988-09-18
CA1308712C (en)	1992-10-13
NO169340B (no)	1992-03-02

Legal Events

Date

Code

Title

Description

1995-03-01

FG3A

Patent granted, date of granting

Effective date: 19940817

1999-06-30

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19990228

Publication	Publication Date	Title
NO881191D0 (no)	1988-03-17	Fremgangsmaate for fremstilling av heterocykliske forbindelser.
MX9102582A (es)	1993-01-01	Derivados de indol 3,7-disubstituidos, procedimiento para su preparacion y composicion farmaceutica que los contiene.
NO905608D0 (no)	1990-12-27	Fremgangsmaate for fremstilling av a-nor-steroid-3-karboksylsyrederivater.
ATE145643T1 (de)	1996-12-15	1,3,5-triazinderivate, ihre herstellung und ihre verwendung als lichtschutzmittel
PT84690B (pt)	1989-11-30	Processo de preparacao de novos derivados da benzodiazepina e de composicoes farmaceuticas que os contem
IL80320A (en)	1990-02-09	3-substituted-4,5-dihydro-5-oxo-imidazo(1,5-a)quinazoline derivatives,their preparation and pharmaceutical compositions containing them
FI842112A0 (fi)	1984-05-25	Foerfarande foer framstaellning av- karbolin-3-karboxylsyraderivat.
ATE131168T1 (de)	1995-12-15	Tetrazyklische imidazochinazolinderivate, deren herstellung und pharmazeutische zusammensetzungen.
DK0457215T3 (da)	1996-06-10	3-deamino-4-desoxy-4-amino-8-fluoranthracycliner samt fremgangsmåder til fremstilling deraf
FI870994A0 (fi)	1987-03-06	Foerfarande foer framstaellning av stabila, injekterbara farmaceutiska kompositioner, vilka innehaoller 1,4-dihydroxi-5,8-bis/2-(2-hydroxietylamino)etylamino/ antrakinondihydroklorid.
IT1199339B (it)	1988-12-30	N-alchil derivati della 2-ammino-6,7-dimetossi tetralina,procedimenti per la loro preparazione e composizioni farmaceutiche ad attivita'an tiipertensiva che li contengono
ATE85056T1 (de)	1993-02-15	Tetracyclische indolderivate.
ES2101531T3 (es)	1997-07-01	Derivados de benzo(f)quinoxalinadiona, su preparacion y su utilizacion en medicamentos.
NO884431L (no)	1989-04-07	Fremgangsmaate for fremstilling av heterocykliske forbindelser.
FR2645538B1 (fr)	1991-07-19	Trichlorhydrate de (diethylamino-3 propyl)-amino-1 methyl-5 dipyrido (4,3-b) (3,4-f) indole