PT87033A - Process for preparing 13-spiro-2:-]tetrahydrofuran"-milbemycins - Google Patents
Process for preparing 13-spiro-2:-]tetrahydrofuran"-milbemycinsInfo
- Publication number
- PT87033A PT87033A PT87033A PT8703388A PT87033A PT 87033 A PT87033 A PT 87033A PT 87033 A PT87033 A PT 87033A PT 8703388 A PT8703388 A PT 8703388A PT 87033 A PT87033 A PT 87033A
- Authority
- PT
- Portugal
- Prior art keywords
- group
- substituted
- halogen
- alkyl
- alkoxy
- Prior art date
Links
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 title abstract 5
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 229910052736 halogen Inorganic materials 0.000 abstract 6
- 125000005843 halogen group Chemical group 0.000 abstract 5
- -1 hydroxy, benzyloxy Chemical group 0.000 abstract 4
- 125000001424 substituent group Chemical group 0.000 abstract 4
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
- 125000004455 (C1-C3) alkylthio group Chemical group 0.000 abstract 2
- 125000006677 (C1-C3) haloalkoxy group Chemical group 0.000 abstract 2
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 2
- 125000006823 (C1-C6) acyl group Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 abstract 2
- 125000005865 C2-C10alkynyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
- 241000238631 Hexapoda Species 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 241000607479 Yersinia pestis Species 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 244000144972 livestock Species 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 244000045947 parasite Species 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Fodder In General (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH111787 | 1987-03-24 | ||
| CH487887 | 1987-12-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT87033A true PT87033A (pt) | 1988-04-01 |
| PT87033B PT87033B (pt) | 1992-06-30 |
Family
ID=25686704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT87033A PT87033B (pt) | 1987-03-24 | 1988-03-22 | Processo para a preparacao de 13-espiro-2'-{tetra-hidrofurano}-milbemicinas |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US4871719A (pt) |
| EP (1) | EP0284563B1 (pt) |
| JP (1) | JP2683583B2 (pt) |
| KR (1) | KR960004533B1 (pt) |
| AT (1) | ATE107307T1 (pt) |
| AU (1) | AU614509B2 (pt) |
| CA (1) | CA1300609C (pt) |
| DE (1) | DE3850160D1 (pt) |
| DK (1) | DK167682B1 (pt) |
| ES (1) | ES2054862T3 (pt) |
| FI (1) | FI92831C (pt) |
| HU (1) | HUT46322A (pt) |
| IE (1) | IE63143B1 (pt) |
| IL (1) | IL85810A (pt) |
| NZ (1) | NZ223970A (pt) |
| PH (1) | PH27027A (pt) |
| PT (1) | PT87033B (pt) |
| ZW (1) | ZW2788A1 (pt) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4906619A (en) * | 1988-07-22 | 1990-03-06 | Merck & Co., Inc. | Alkyl avermectin derivatives |
| NZ232422A (en) * | 1989-02-16 | 1992-11-25 | Merck & Co Inc | 13-ketal milbemycin derivatives and parasiticides |
| US6001822A (en) * | 1989-04-11 | 1999-12-14 | Pfizer Inc. | Antiparasitic formulations |
| US6514951B1 (en) | 1989-12-15 | 2003-02-04 | American Cyanamid Company | Pour-on formulations effective for the control of internal and external parasites of homothermic animals |
| JP3804072B2 (ja) * | 1991-08-07 | 2006-08-02 | 日産化学工業株式会社 | 水性懸濁状農薬製剤 |
| CN100339352C (zh) * | 1996-08-05 | 2007-09-26 | 拜尔公司 | 2－和2,5－取代的苯基酮烯醇 |
| KR970014851A (ko) * | 1997-01-03 | 1997-04-28 | 김동규 | 음식물 쓰레기의 건조발효방법 및 그 건조발효장치 |
| KR100499438B1 (ko) * | 1997-12-03 | 2005-07-07 | 머크 앤드 캄파니 인코포레이티드 | 수소화 피마자유를 함유하는 지속성 주사제 |
| ES2359973T3 (es) * | 1998-03-19 | 2011-05-30 | MERCK SHARP & DOHME CORP. | Composiciones poliméricas líquidas para la liberación controlada de sustancias bioactivas. |
| US7229447B1 (en) | 1998-08-25 | 2007-06-12 | Advanced Photodynamics Technologies, Inc. | Photodynamic therapy utilizing a solution of photosensitizing compound and surfactant |
| US6787342B2 (en) | 2000-02-16 | 2004-09-07 | Merial Limited | Paste formulations |
| JP2003531828A (ja) | 2000-02-26 | 2003-10-28 | アドバンスト フォトダイナミック テクノロジーズ， インコーポレイテッド | 光感光性物質および界面活性剤を使用する、光力学的な細胞および無細胞生物の根絶 |
| US7001889B2 (en) * | 2002-06-21 | 2006-02-21 | Merial Limited | Anthelmintic oral homogeneous veterinary pastes |
| US20060205681A1 (en) * | 2002-06-21 | 2006-09-14 | Maryam Moaddeb | Homogenous paste formulations |
| US20040077703A1 (en) * | 2002-10-02 | 2004-04-22 | Soll Mark D. | Nodulisporic acid derivative spot-on formulations for combating parasites |
| US7531186B2 (en) * | 2003-12-17 | 2009-05-12 | Merial Limited | Topical formulations comprising 1-N-arylpyrazole derivatives and amitraz |
| US8362086B2 (en) | 2005-08-19 | 2013-01-29 | Merial Limited | Long acting injectable formulations |
| US20080027011A1 (en) * | 2005-12-20 | 2008-01-31 | Hassan Nached | Homogeneous paste and gel formulations |
| MX2008016411A (es) | 2006-07-05 | 2009-04-28 | Aventis Agriculture | Compuestos derivados de 1-aril-5-alquil pirazol, procesos para hacerlos y metodos para usarlos. |
| PL3088384T3 (pl) | 2007-05-15 | 2019-06-28 | Merial, Inc. | Związki aryloazol-2-ilo-cyjanoetyloaminowe, sposób ich wytwarzania oraz sposób ich stosowania |
| WO2009070687A1 (en) | 2007-11-26 | 2009-06-04 | Merial Limited | Solvent systems for pour-on formulations for combating parasites |
| NZ590141A (en) * | 2008-06-24 | 2012-05-25 | Merial Ltd | Anthelminthic formulations including castor oil and another vegetable oil |
| PL3050874T3 (pl) | 2008-11-14 | 2019-07-31 | Merial Inc. | Wzbogacone enancjomerycznie aryloazol-2-ilocyjanoetyloaminowe związki pasożytobójcze |
| SG171751A1 (en) * | 2008-11-19 | 2011-07-28 | Merial Ltd | Compositions comprising an aryl pyrazole and/ or a formamidine methods and uses thereof |
| US9173728B2 (en) | 2008-11-19 | 2015-11-03 | Merial Inc. | Multi-cavity container having offset indentures for dispensing fluids |
| AR074482A1 (es) | 2008-12-04 | 2011-01-19 | Merial Ltd | Derivados dimericos de avermectina y milbemicina |
| ES2545738T3 (es) | 2009-07-30 | 2015-09-15 | Merial, Inc. | Compuestos insecticidas a base de 4-amino-tieno[2,3-d]-pirimidina y procedimientos para su uso |
| WO2011069143A1 (en) | 2009-12-04 | 2011-06-09 | Merial Limited | Pesticidal bis-organosulfur compounds |
| EP2512467A1 (en) | 2009-12-17 | 2012-10-24 | Merial Limited | Compositions comprising macrocyclic lactone compounds and spirodioxepinoindoles |
| ME02432B (me) | 2009-12-17 | 2016-09-20 | Merial Inc | Antiparazitska jedinjenja dihidroazola i kompozicije koje ih sadrže |
| UA108641C2 (uk) | 2010-04-02 | 2015-05-25 | Паразитицидна композиція, яка містить чотири активних агенти, та спосіб її застосування | |
| SI2568980T1 (sl) | 2010-05-12 | 2016-02-29 | Merial, Inc. | Injekcijske paraziticidne formulacije levamizola in makrocikličnih laktonov |
| DK2640728T3 (en) | 2010-11-16 | 2016-11-28 | Merial Inc | NEW MONENSINDERIVATER FOR TREATMENT AND PREVENTION OF protozoal INFECTIONS |
| WO2012078605A1 (en) | 2010-12-07 | 2012-06-14 | Merial Limited | Topical combination formulations of macrocyclic lactones with synthetic pyrethroids |
| WO2013003168A1 (en) | 2011-06-27 | 2013-01-03 | Merial Limited | Novel insect-repellent coumarin derivatives, syntheses, and methods of use |
| US8946270B2 (en) | 2011-06-27 | 2015-02-03 | Merial Limited | Amido-pyridyl ether compounds and compositions and their use against parasites |
| PT3172964T (pt) | 2011-09-12 | 2020-11-30 | Boehringer Ingelheim Animal Health Usa Inc | Composições parasiticidas compreendendo um agente ativo de isoxazolina, método e utilizações das mesmas |
| WO2013044118A2 (en) | 2011-09-23 | 2013-03-28 | Merial Limited | Indirect modeling of new repellent molecules active against insects, acarids, and other arthropods |
| JP6249568B2 (ja) | 2011-11-17 | 2017-12-20 | メリアル インコーポレイテッド | アリールピラゾールと置換イミダゾールを含む組成物、その使用方法 |
| BR122020002199B1 (pt) | 2011-12-02 | 2021-01-19 | Merial, Inc. | formulações de moxidectina injetável de ação prolongada e novas formas de cristal de moxidectina |
| CN104168900A (zh) | 2012-02-06 | 2014-11-26 | 梅里亚有限公司 | 包含全身性地起作用的活性剂的杀寄生虫口服兽用组合物、方法及其用途 |
| JO3626B1 (ar) | 2012-02-23 | 2020-08-27 | Merial Inc | تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها |
| NZ711847A (en) | 2012-04-20 | 2015-11-27 | Merial Inc | Parasiticidal compositions comprising benzimidazole derivatives, methods and uses thereof |
| CA2891926A1 (en) | 2012-11-20 | 2014-05-30 | Merial, Inc. | Anthelmintic compounds and compositions and method of using thereof |
| LT2950795T (lt) | 2013-01-31 | 2018-06-25 | Merial, Inc. | Leišmaniozės gydymo ir naikinimo būdas naudojant feksinidazolą |
| CN105873925B (zh) | 2013-11-01 | 2019-09-10 | 勃林格殷格翰动物保健美国公司 | 抗寄生物的和杀虫的异噁唑啉化合物 |
| ES2765405T3 (es) | 2014-04-17 | 2020-06-09 | Boehringer Ingelheim Animal Health Usa Inc | Utilización de compuestos de malononitrilo para proteger animales de parásitos |
| MX375153B (es) | 2014-05-19 | 2025-03-06 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos antihelminticos. |
| BR122020023385B1 (pt) | 2014-06-19 | 2021-05-25 | Merial, Inc | composições parasiticidas compreendendo derivados de indol, métodos e usos dos mesmos |
| US10864193B2 (en) | 2014-10-31 | 2020-12-15 | Boehringer Ingelheim Animal Health USA Inc. | Parasiticidal compositions comprising fipronil at high concentrations |
| PY1609250A (es) | 2015-02-26 | 2018-03-01 | Merial Inc | Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas |
| EP3280413A1 (en) | 2015-04-08 | 2018-02-14 | Merial, Inc. | Extended release injectable formulations comprising an isoxazoline active agent, methods and uses thereof |
| CN107835818B (zh) | 2015-05-20 | 2022-04-29 | 勃林格殷格翰动物保健美国公司 | 驱虫缩酚酸肽化合物 |
| US20160347829A1 (en) | 2015-05-27 | 2016-12-01 | Merial Inc. | Compositions containing antimicrobial IgY antibodies, for treatment and prevention of disorders and diseases caused by oral health compromising (OHC) microorganisms |
| UY37137A (es) | 2016-02-24 | 2017-09-29 | Merial Inc | Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos |
| WO2018039508A1 (en) | 2016-08-25 | 2018-03-01 | Merial, Inc. | Method for reducing unwanted effects in parasiticidal treatments |
| CN110381738B (zh) | 2016-10-14 | 2021-07-16 | 勃林格殷格翰动物保健美国公司 | 农药的和杀寄生物的乙烯基异噁唑啉化合物 |
| EP3541789A1 (en) | 2016-11-16 | 2019-09-25 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic depsipeptide compounds |
| EP3644741B1 (en) | 2017-06-26 | 2023-06-07 | Boehringer Ingelheim Animal Health USA Inc. | Dual active parasiticidal granule compositions, methods and uses thereof |
| ES2944616T3 (es) | 2017-08-14 | 2023-06-22 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos de pirazol-isoxazolina plaguicidas y parasiticidas |
| EP3749096A1 (en) | 2018-02-08 | 2020-12-16 | Boehringer Ingelheim Animal Health USA Inc. | Parasiticidal compositions comprising eprinomectin and praziquantel, methods and uses thereof |
| MX2021000293A (es) | 2018-07-09 | 2021-07-15 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos heterociclicos antihelminticos. |
| EP3883648A1 (en) | 2018-11-20 | 2021-09-29 | Boehringer Ingelheim Animal Health USA Inc. | Indazolylcyanoethylamino compound, compositions of same, method of making, and methods of using thereof |
| AU2020208145B2 (en) | 2019-01-16 | 2023-02-02 | Boehringer Ingelheim Vetmedica Gmbh | Topical compositions comprising a neonicotinoid and a macrocyclic lactone, methods and uses thereof |
| PY2013845A (es) | 2019-03-01 | 2021-02-09 | Boehringer Ingelheim Animal Health Usa Inc | Composiciones inyectables de clorsulón, sus métodos y usos |
| JP7637630B2 (ja) | 2019-03-19 | 2025-02-28 | ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー | 駆虫性アザベンゾチオフェンおよびアザベンゾフラン化合物 |
| CA3146043A1 (en) | 2019-07-22 | 2021-01-28 | Intervet International B.V. | Soft chewable veterinary dosage form |
| PH12022553222A1 (en) | 2020-05-29 | 2024-02-12 | Boehringer Ingelheim Animal Health Usa Inc | Anthelmintic heterocyclic compounds |
| JP2024504208A (ja) | 2020-12-21 | 2024-01-30 | ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー | イソオキサゾリン化合物を含む殺寄生虫首輪 |
| WO2025257633A1 (en) | 2024-06-12 | 2025-12-18 | Boehringer Ingelheim Vetmedica Gmbh | Long-acting castor oil-containing injectable formulations and methods of use thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3950360A (en) * | 1972-06-08 | 1976-04-13 | Sankyo Company Limited | Antibiotic substances |
| US4173571A (en) * | 1977-12-19 | 1979-11-06 | Merck & Co., Inc. | 13-Halo and 13-deoxy derivatives of C-076 compounds |
| US4328335A (en) * | 1979-08-13 | 1982-05-04 | Merck & Co., Inc. | Process for the interconversion of C-076 compounds |
| JPS5632481A (en) * | 1979-08-23 | 1981-04-01 | Sankyo Co Ltd | Antibiotic b-41d, its preparation, and acaricide and anthelminthic agent and repellent containing the same as active constituent |
| US4457920A (en) * | 1981-09-03 | 1984-07-03 | Merck & Co., Inc. | 4a-Substituted avermectin compounds |
| EP0165900A3 (de) * | 1984-06-08 | 1986-05-28 | Ciba-Geigy Ag | Neue Lactone, Verfahren zu ihrer Herstellung und ihre Verwendung in der Schädlingsbekämpfung |
| DE3532794A1 (de) * | 1984-09-14 | 1986-04-17 | Glaxo Group Ltd., London | Antibiotika, verfahren zu deren herstellung und diese verbindungen enthaltende mittel |
| HUT39739A (en) * | 1984-12-04 | 1986-10-29 | Ciba Geigy Ag | Process for production of derivatives of 13,3-milbemycin and medical preparatives containing thereof |
| ES8802229A1 (es) * | 1985-04-30 | 1988-04-16 | Glaxo Group Ltd | Un procedimiento para preparar nuevos derivados lactonicos macrociclicos. |
| US4778809A (en) * | 1985-08-23 | 1988-10-18 | Ciba-Geigy Corporation | 5-esters of milbemycins for controlling parasitic pests |
| US4833168A (en) * | 1986-10-03 | 1989-05-23 | Merck & Co., Inc. | Avermectin reformatsky adducts |
-
1988
- 1988-03-16 US US07/168,766 patent/US4871719A/en not_active Expired - Fee Related
- 1988-03-18 EP EP88810175A patent/EP0284563B1/de not_active Expired - Lifetime
- 1988-03-18 DE DE3850160T patent/DE3850160D1/de not_active Expired - Fee Related
- 1988-03-18 ES ES88810175T patent/ES2054862T3/es not_active Expired - Lifetime
- 1988-03-18 AT AT88810175T patent/ATE107307T1/de not_active IP Right Cessation
- 1988-03-21 PH PH36667A patent/PH27027A/en unknown
- 1988-03-21 FI FI881328A patent/FI92831C/fi not_active IP Right Cessation
- 1988-03-22 NZ NZ223970A patent/NZ223970A/xx unknown
- 1988-03-22 PT PT87033A patent/PT87033B/pt active IP Right Grant
- 1988-03-22 IL IL85810A patent/IL85810A/xx not_active IP Right Cessation
- 1988-03-22 ZW ZW27/88A patent/ZW2788A1/xx unknown
- 1988-03-22 CA CA000562065A patent/CA1300609C/en not_active Expired - Lifetime
- 1988-03-23 HU HU881498A patent/HUT46322A/hu unknown
- 1988-03-23 IE IE87188A patent/IE63143B1/en not_active IP Right Cessation
- 1988-03-23 AU AU13502/88A patent/AU614509B2/en not_active Ceased
- 1988-03-23 JP JP63069204A patent/JP2683583B2/ja not_active Expired - Lifetime
- 1988-03-23 DK DK157188A patent/DK167682B1/da not_active IP Right Cessation
- 1988-03-24 KR KR88003168A patent/KR960004533B1/ko not_active Expired - Fee Related
-
1989
- 1989-07-13 US US07/380,844 patent/US4973711A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| FI92831C (fi) | 1995-01-10 |
| IE63143B1 (en) | 1995-03-22 |
| AU614509B2 (en) | 1991-09-05 |
| FI881328A0 (fi) | 1988-03-21 |
| EP0284563A2 (de) | 1988-09-28 |
| IE880871L (en) | 1988-09-24 |
| KR880011169A (ko) | 1988-10-27 |
| ES2054862T3 (es) | 1994-08-16 |
| DK167682B1 (da) | 1993-12-06 |
| JP2683583B2 (ja) | 1997-12-03 |
| ATE107307T1 (de) | 1994-07-15 |
| FI92831B (fi) | 1994-09-30 |
| US4973711A (en) | 1990-11-27 |
| IL85810A (en) | 1992-06-21 |
| AU1350288A (en) | 1988-09-22 |
| JPS63255286A (ja) | 1988-10-21 |
| DK157188A (da) | 1988-09-25 |
| DK157188D0 (da) | 1988-03-23 |
| PH27027A (en) | 1993-02-01 |
| KR960004533B1 (en) | 1996-04-06 |
| EP0284563B1 (de) | 1994-06-15 |
| EP0284563A3 (en) | 1989-10-25 |
| IL85810A0 (en) | 1988-09-30 |
| PT87033B (pt) | 1992-06-30 |
| DE3850160D1 (de) | 1994-07-21 |
| FI881328A7 (fi) | 1988-09-25 |
| CA1300609C (en) | 1992-05-12 |
| ZW2788A1 (en) | 1988-11-16 |
| HUT46322A (en) | 1988-10-28 |
| US4871719A (en) | 1989-10-03 |
| NZ223970A (en) | 1990-05-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG3A | Patent granted, date of granting |
Effective date: 19911213 |
|
| PC3A | Transfer or assignment |
Free format text: 970603 NOVARTIS AG CH |