PT87033A - Process for preparing 13-spiro-2:-]tetrahydrofuran"-milbemycins - Google Patents

Process for preparing 13-spiro-2:-]tetrahydrofuran"-milbemycins

Info

Publication number: PT87033A
Authority: PT; Portugal
Prior art keywords: group; substituted; halogen; alkyl; alkoxy
Prior art date: 1987-03-24

Application number

PT87033A

Other languages

English (en)

Other versions

PT87033B (pt

Inventor

Peter Maienfisch

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-03-24

Filing date

1988-03-22

Publication date

1988-04-01

1988-03-22 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1988-04-01 Publication of PT87033A publication Critical patent/PT87033A/pt

1992-06-30 Publication of PT87033B publication Critical patent/PT87033B/pt

Links

WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 title abstract 5
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
229910052736 halogen Inorganic materials 0.000 abstract 6
125000005843 halogen group Chemical group 0.000 abstract 5
-1 hydroxy, benzyloxy Chemical group 0.000 abstract 4
125000001424 substituent group Chemical group 0.000 abstract 4
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 3
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 3
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
125000004455 (C1-C3) alkylthio group Chemical group 0.000 abstract 2
125000006677 (C1-C3) haloalkoxy group Chemical group 0.000 abstract 2
125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 2
125000006823 (C1-C6) acyl group Chemical group 0.000 abstract 2
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
125000006374 C2-C10 alkenyl group Chemical group 0.000 abstract 2
125000005865 C2-C10alkynyl group Chemical group 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000004093 cyano group Chemical group *C#N 0.000 abstract 2
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 2
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
241000238631 Hexapoda Species 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000005864 Sulphur Substances 0.000 abstract 1
241000607479 Yersinia pestis Species 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
244000144972 livestock Species 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
244000045947 parasite Species 0.000 abstract 1
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Environmental Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Dentistry (AREA)
Agronomy & Crop Science (AREA)
Pest Control & Pesticides (AREA)
Plant Pathology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Tropical Medicine & Parasitology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Fodder In General (AREA)

PT87033A 1987-03-24 1988-03-22 Processo para a preparacao de 13-espiro-2'-{tetra-hidrofurano}-milbemicinas PT87033B (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CH111787		1987-03-24
CH487887		1987-12-15

Publications (2)

Publication Number	Publication Date
PT87033A true PT87033A (pt)	1988-04-01
PT87033B PT87033B (pt)	1992-06-30

Family

ID=25686704

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT87033A PT87033B (pt)	1987-03-24	1988-03-22	Processo para a preparacao de 13-espiro-2'-{tetra-hidrofurano}-milbemicinas

Country Status (18)

Country	Link
US (2)	US4871719A (pt)
EP (1)	EP0284563B1 (pt)
JP (1)	JP2683583B2 (pt)
KR (1)	KR960004533B1 (pt)
AT (1)	ATE107307T1 (pt)
AU (1)	AU614509B2 (pt)
CA (1)	CA1300609C (pt)
DE (1)	DE3850160D1 (pt)
DK (1)	DK167682B1 (pt)
ES (1)	ES2054862T3 (pt)
FI (1)	FI92831C (pt)
HU (1)	HUT46322A (pt)
IE (1)	IE63143B1 (pt)
IL (1)	IL85810A (pt)
NZ (1)	NZ223970A (pt)
PH (1)	PH27027A (pt)
PT (1)	PT87033B (pt)
ZW (1)	ZW2788A1 (pt)

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CN102596968B (zh)	2009-07-30	2015-05-06	梅里亚有限公司	杀虫的4-氨基-噻吩并[2,3-d]-嘧啶化合物及其使用方法
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RS58417B1 (sr)	2011-09-12	2019-04-30	Merial Inc	Paraziticidne kompozicije koje sadrže izoksazolinsko aktivno sredstvo, postupci i upotrebe povezane sa njima
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BR122015032741B1 (pt)	2012-04-20	2019-11-26	Merial Ltd	composições parasiticídicas compreendendo derivados de benzimidazol, métodos e seus usos
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WO2015066277A1 (en)	2013-11-01	2015-05-07	Merial Limited	Antiparisitic and pesticidal isoxazoline compounds
EP3131398B1 (en)	2014-04-17	2019-10-23	Boehringer Ingelheim Animal Health USA Inc.	Use of malononitrile compounds for protecting animals from parasites
ES2842592T3 (es)	2014-05-19	2021-07-14	Boehringer Ingelheim Animal Health Usa Inc	Compuestos antihelmínticos
EP3157912B1 (en)	2014-06-19	2019-02-20	Merial, Inc.	Parasiticidal compositions comprising indole derivatives, methods and uses thereof
US10864193B2 (en)	2014-10-31	2020-12-15	Boehringer Ingelheim Animal Health USA Inc.	Parasiticidal compositions comprising fipronil at high concentrations
UY36570A (es)	2015-02-26	2016-10-31	Merial Inc	Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas
SG11201708068PA (en)	2015-04-08	2017-10-30	Merial Inc	Extended release injectable formulations comprising an isoxazoline active agent, methods and uses thereof
LT3298027T (lt)	2015-05-20	2021-08-10	Boehringer Ingelheim Animal Health USA Inc.	Antihelmintiniai depsipeptido junginiai
WO2016191389A2 (en)	2015-05-27	2016-12-01	Merial, Inc.	Compositions containing antimicrobial igy antibodies, for treatment and prevention of disorders and diseases caused by oral health compromising (ohc) microorganisms
UY37137A (es)	2016-02-24	2017-09-29	Merial Inc	Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos
WO2018039508A1 (en)	2016-08-25	2018-03-01	Merial, Inc.	Method for reducing unwanted effects in parasiticidal treatments
WO2018071535A1 (en)	2016-10-14	2018-04-19	Merial, Inc.	Pesticidal and parasiticidal vinyl isoxazoline compounds
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BR112020003217A2 (pt)	2017-08-14	2020-10-06	Boehringer Ingelheim Animal Health USA Inc.	compostos pesticidas e parasiticidas de pirazolisoxazolina
EP3749096A1 (en)	2018-02-08	2020-12-16	Boehringer Ingelheim Animal Health USA Inc.	Parasiticidal compositions comprising eprinomectin and praziquantel, methods and uses thereof
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1988
- 1988-03-16 US US07/168,766 patent/US4871719A/en not_active Expired - Fee Related
- 1988-03-18 DE DE3850160T patent/DE3850160D1/de not_active Expired - Fee Related
- 1988-03-18 ES ES88810175T patent/ES2054862T3/es not_active Expired - Lifetime
- 1988-03-18 AT AT88810175T patent/ATE107307T1/de not_active IP Right Cessation
- 1988-03-18 EP EP88810175A patent/EP0284563B1/de not_active Expired - Lifetime
- 1988-03-21 FI FI881328A patent/FI92831C/fi not_active IP Right Cessation
- 1988-03-21 PH PH36667A patent/PH27027A/en unknown
- 1988-03-22 CA CA000562065A patent/CA1300609C/en not_active Expired - Lifetime
- 1988-03-22 ZW ZW27/88A patent/ZW2788A1/xx unknown
- 1988-03-22 IL IL85810A patent/IL85810A/xx not_active IP Right Cessation
- 1988-03-22 NZ NZ223970A patent/NZ223970A/xx unknown
- 1988-03-22 PT PT87033A patent/PT87033B/pt active IP Right Grant
- 1988-03-23 JP JP63069204A patent/JP2683583B2/ja not_active Expired - Lifetime
- 1988-03-23 AU AU13502/88A patent/AU614509B2/en not_active Ceased
- 1988-03-23 IE IE87188A patent/IE63143B1/en not_active IP Right Cessation
- 1988-03-23 HU HU881498A patent/HUT46322A/hu unknown
- 1988-03-23 DK DK157188A patent/DK167682B1/da not_active IP Right Cessation
- 1988-03-24 KR KR88003168A patent/KR960004533B1/ko not_active Expired - Fee Related
1989
- 1989-07-13 US US07/380,844 patent/US4973711A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
IL85810A0 (en)	1988-09-30
AU1350288A (en)	1988-09-22
JP2683583B2 (ja)	1997-12-03
US4871719A (en)	1989-10-03
NZ223970A (en)	1990-05-28
IE63143B1 (en)	1995-03-22
DK167682B1 (da)	1993-12-06
HUT46322A (en)	1988-10-28
PT87033B (pt)	1992-06-30
ES2054862T3 (es)	1994-08-16
CA1300609C (en)	1992-05-12
ZW2788A1 (en)	1988-11-16
FI92831B (fi)	1994-09-30
EP0284563B1 (de)	1994-06-15
FI92831C (fi)	1995-01-10
DE3850160D1 (de)	1994-07-21
IL85810A (en)	1992-06-21
AU614509B2 (en)	1991-09-05
ATE107307T1 (de)	1994-07-15
JPS63255286A (ja)	1988-10-21
FI881328A0 (fi)	1988-03-21
EP0284563A2 (de)	1988-09-28
DK157188D0 (da)	1988-03-23
US4973711A (en)	1990-11-27
IE880871L (en)	1988-09-24
KR960004533B1 (en)	1996-04-06
FI881328A7 (fi)	1988-09-25
DK157188A (da)	1988-09-25
EP0284563A3 (en)	1989-10-25
PH27027A (en)	1993-02-01
KR880011169A (ko)	1988-10-27

Legal Events

Date	Code	Title	Description
1992-06-30	FG3A	Patent granted, date of granting	Effective date: 19911213
1997-09-30	PC3A	Transfer or assignment	Free format text: 970603 NOVARTIS AG CH

Publication	Publication Date	Title
PT87033A (pt)	1988-04-01	Process for preparing 13-spiro-2:-]tetrahydrofuran"-milbemycins
BE904086A (fr)	1986-07-22	Nouveau procede de fabrication d'un derive d'(aryl substitue)-1 dihydro-1,4 oxo-4 naphtyridine substances intermediaires utilisees pour cette fabrication et procedes de fabrication des substances intermediaires.
FR2449683A1 (fr)	1980-09-19	Nouveaux derives phenoxy d'acides gras du type ethers heterocycliques, leur procede de preparation et compositions herbicides les contenant
FR2364206A1 (fr)	1978-04-07	Nouveaux derives d'acides phenoxyvaleriques et compositions herbicides les contenant
BG48333A3 (en)	1991-01-15	Method for preparing of 2, 2- dimethyl cyclopropane carbonic acid derivatives
ATE90937T1 (de)	1993-07-15	Neue 3-methoximinopropionsaeureester und diese enthaltende fungizide.
SE8403268L (sv)	1984-12-22	1,4-dihydropyridinderivat, deras framstellning och farmaceutiska beredningar innehallande dessa
JPS5626853A (en)	1981-03-16	N-benzyl-haloacetamide derivative, its preparation, and herbicide comprising the same as active constituent
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GR910100202A (el)	1992-07-30	Μέθοδος δια την παρασκευή 2,2-διμεθυλ-5(2,5 διμεθυλοφαινοξυ)-πεντανοϊκού οξέος, ενδιάμεσων ουσιών και μέθοδος δια την παρασκευή των ενδιάμεσων ουσιών.
JPS5772928A (en)	1982-05-07	Novel 2-arylpropyl ether derivtive and thioether derviative, their preparations, insecticide, and acaricide
TNSN87067A1 (fr)	1990-01-01	Compositions fongicides a base de derives nicotiniques, nouveaux derives nicotiniques et leur preparation
PT67391B (fr)	1979-05-18	Methode de preparation d'une formulation insecticide et anti-parasitaire contenant du dimethylformamide comme synergisant et ameliorant des pyrethrines-pyrethrinoides et rotenones naturelles et de synthese
JPS5731643A (en)	1982-02-20	4-methyl-3-formylpentene-1-acid alkyl, manufacture, application thereof to 4-methyl-3-formyl-3-pentene-1-acid and novel intermediate product
JPS57139079A (en)	1982-08-27	8,9-epoxy derivative of antibiotic substance b-41 and its preparation
RO92308B (ro)	1987-12-01	Procedeu de preparare a unor silil-eteri cu actiune de atractanti sexuali pentru insecte
ES8503646A1 (es)	1985-03-16	Procedimiento para la obtencion de derivados de bencilurea.
FR2409977A1 (fr)	1979-06-22	Procede de production d'esters m-phenoxybenzyliques
JPS54132597A (en)	1979-10-15	1,4-benzazine derivative, and agricultural and horticultural fungicide containing thereof as effective component
JPS5639049A (en)	1981-04-14	Phenyl acetate, its preparation, insecticide, and acaricide
JPS6452771A (en)	1989-02-28	Amino-containing 1,3-dithian compound and insecticidal and acaricidal composition containing said compound
JPS5490111A (en)	1979-07-17	4-methyl-3-sulfenyl-3-allyl-4-penten-2-one and preparation thereof
JPS5490183A (en)	1979-07-17	3,4-dihydrocarbostyryl derivative, and agricultural and horticultural fungicides containing it as active constituent
KR790000395B1 (en)	1979-05-11	Process for preparation of benzimidazole-1-carboximid acid esters
ES8400443A1 (es)	1983-10-16	Mejoras introducidas en un procedimiento para la preparacion de hidroximidatos y tiolhidroximidatos heterobiciclicos y derivados ester carbamato de lso mismos.