PT87117A - Verfahren zur herstellung von 17alpha-ethinyl-17beta-hydroxy-18-methyl-4,15-estradien-3-on und die neuen zwischenprodukte fuer dieses verfahren - Google Patents

Verfahren zur herstellung von 17alpha-ethinyl-17beta-hydroxy-18-methyl-4,15-estradien-3-on und die neuen zwischenprodukte fuer dieses verfahren

Info

Publication number: PT87117A
Authority: PT; Portugal
Prior art keywords: hydroxy; verfahren; estradien; methyl; zwischenprodukte
Prior art date: 1987-03-31

Application number

PT87117A

Other languages

English (en)

Other versions

PT87117B (pt

Inventor

Rudolf Wiechert

Rolf Bohlmann

Henry Laurent

Hlmut Hoemeister

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-03-31

Filing date

1988-03-30

Publication date

1988-04-01

1988-03-30 Application filed by Schering Ag filed Critical Schering Ag

1988-04-01 Publication of PT87117A publication Critical patent/PT87117A/pt

1992-07-31 Publication of PT87117B publication Critical patent/PT87117B/pt

Links

125000004432 carbon atom Chemical group C* 0.000 abstract 3
KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 2
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 1
238000006027 Birch reduction reaction Methods 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
238000006555 catalytic reaction Methods 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
SIGSPDASOTUPFS-XUDSTZEESA-N gestodene Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](C=C4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 SIGSPDASOTUPFS-XUDSTZEESA-N 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
229910052763 palladium Inorganic materials 0.000 abstract 1
125000004665 trialkylsilyl group Chemical group 0.000 abstract 1
MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
- C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
- C07J1/0096—Alkynyl derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PT87117A 1987-03-31 1988-03-30 Processo para a preparacao de 17 a-etinil-17 b-hidroxi-18-metil-4,15-estradieno-3-ona e novos produtos intermediarios para este processo PT87117B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19873710728 DE3710728A1 (de)	1987-03-31	1987-03-31	Verfahren zur herstellung von 17(alpha)-ethinyl-17ss-hydroxy-18-methyl-4,15-estradien-3-on und die neuen zwischenprodukte fuer dieses verfahren

Publications (2)

Publication Number	Publication Date
PT87117A true PT87117A (pt)	1988-04-01
PT87117B PT87117B (pt)	1992-07-31

Family

ID=6324491

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT87117A PT87117B (pt)	1987-03-31	1988-03-30	Processo para a preparacao de 17 a-etinil-17 b-hidroxi-18-metil-4,15-estradieno-3-ona e novos produtos intermediarios para este processo

Country Status (14)

Country	Link
US (1)	US4923640A (pt)
EP (1)	EP0285548B1 (pt)
JP (1)	JP2752366B2 (pt)
AT (1)	ATE56214T1 (pt)
AU (1)	AU611426B2 (pt)
CA (1)	CA1306993C (pt)
DD (1)	DD281191A5 (pt)
DE (2)	DE3710728A1 (pt)
DK (1)	DK171850B1 (pt)
ES (1)	ES2032051T3 (pt)
GR (1)	GR3000953T3 (pt)
HU (2)	HU200472B (pt)
IE (1)	IE62481B1 (pt)
PT (1)	PT87117B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4232521A1 (de) *	1992-09-22	1994-03-24	Schering Ag	Gestagen wirksame 4,5;11,12-Estradiene, Verfahren zu ihrer Herstellung, diese Estradiene enthaltende Arzneimittel sowie deren Verwendung zur Herstellung von Arzneimitteln
IT1271004B (it) *	1994-09-09	1997-05-26	Ind Chimica Srl	Processo per la preparazione del gestodene
JPH099304A (ja) *	1995-06-24	1997-01-10	Matsushita Electric Ind Co Ltd	ビーム位置シミュレーション調整装置
WO2012110947A1 (en) *	2011-02-17	2012-08-23	Lupin Limited	An improved process for preparation of levonorgestrel
WO2012164096A1 (en) *	2011-06-01	2012-12-06	Estetra S.A.	Process for the production of estetrol intermediates
BR112013030833B1 (pt)	2011-06-01	2019-09-03	Estetra S A	processo para a preparação de um composto de fórmula (i) e processo para a preparação de estetrol
EP2383279A1 (en)	2011-07-19	2011-11-02	Pantarhei Bioscience B.V.	Process for the preparation of estetrol

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1476573A (fr) *	1965-09-13	1967-04-14		Dérivés du gonatriène et leur procédé de préparation
DK133051C (da) *	1973-07-13	1976-08-16	Schering Ag	Analogifremgangsmade til fremstilling af 1,3-oxygenerede 8alfa-ostratriener
DE2439082A1 (de) *	1974-08-12	1976-02-26	Schering Ag	17 alpha-hydroxy-1,3,5(10),15-oestratetraene und verfahren zu ihrer herstellung
DE2456068A1 (de) *	1974-11-23	1976-08-12	Schering Ag	Verfahren zur herstellung von oestren3,17-dion-derivaten
DE2546062A1 (de) *	1975-10-10	1977-04-21	Schering Ag	Delta hoch 15 -steroide
US4081537A (en) *	1975-10-10	1978-03-28	Schering Aktiengesellschaft	Δ15 -Steroids and pharmaceutical compositions thereof
CN1008820B (zh) *	1985-05-10	1990-07-18	施林工业产权保护股份公司	17α-乙炔基-17β-羟基-18-甲基-4，15-雌甾二烯-3-酮的制备方法

1987
- 1987-03-31 DE DE19873710728 patent/DE3710728A1/de not_active Withdrawn
1988
- 1988-03-25 DE DE8888730075T patent/DE3860541D1/de not_active Expired - Lifetime
- 1988-03-25 ES ES198888730075T patent/ES2032051T3/es not_active Expired - Lifetime
- 1988-03-25 DK DK168288A patent/DK171850B1/da not_active IP Right Cessation
- 1988-03-25 EP EP88730075A patent/EP0285548B1/de not_active Expired - Lifetime
- 1988-03-25 AT AT88730075T patent/ATE56214T1/de not_active IP Right Cessation
- 1988-03-29 JP JP63073503A patent/JP2752366B2/ja not_active Expired - Lifetime
- 1988-03-29 DD DD88314162A patent/DD281191A5/de not_active IP Right Cessation
- 1988-03-29 AU AU14030/88A patent/AU611426B2/en not_active Expired
- 1988-03-30 PT PT87117A patent/PT87117B/pt not_active IP Right Cessation
- 1988-03-30 HU HU881582A patent/HU200472B/hu unknown
- 1988-03-30 CA CA000562962A patent/CA1306993C/en not_active Expired - Lifetime
- 1988-03-30 IE IE95588A patent/IE62481B1/en not_active IP Right Cessation
- 1988-03-31 US US07/176,111 patent/US4923640A/en not_active Expired - Lifetime
- 1988-10-04 HU HU895125A patent/HU200471B/hu unknown
1990
- 1990-10-19 GR GR90400304T patent/GR3000953T3/el unknown

Also Published As

Publication number	Publication date
DK168288D0 (da)	1988-03-25
AU1403088A (en)	1988-09-29
JP2752366B2 (ja)	1998-05-18
HUT46925A (en)	1988-12-28
ATE56214T1 (de)	1990-09-15
HU200471B (en)	1990-06-28
IE880955L (en)	1988-09-30
GR3000953T3 (en)	1991-12-10
DK171850B1 (da)	1997-07-07
CA1306993C (en)	1992-09-01
AU611426B2 (en)	1991-06-13
DE3710728A1 (de)	1988-10-13
EP0285548A1 (de)	1988-10-05
ES2032051T3 (es)	1993-01-01
JPS63258487A (ja)	1988-10-25
IE62481B1 (en)	1995-02-08
HU200472B (en)	1990-06-28
DK168288A (da)	1988-10-01
DD281191A5 (de)	1990-08-01
EP0285548B1 (de)	1990-09-05
PT87117B (pt)	1992-07-31
US4923640A (en)	1990-05-08
DE3860541D1 (de)	1990-10-11

Similar Documents

Publication	Publication Date	Title
ATE8274T1 (de)	1984-07-15	Verfahren zur herstellung von 3-beta,7-betadihydroxy-delta-5-steroiden.
ATE56214T1 (de)	1990-09-15	Verfahren zur herstellung von 17alpha-ethinyl17beta-hydroxy-18-methyl-4,15-estradien-3-on und die neuen zwischenprodukte fuer dieses verfahren.
ES477364A1 (es)	1980-10-01	Un proceso para producir un ester glicolipido hidroxialqui- loeterificado.
KR830005092A (ko)	1983-07-23	시클로프로판 카르복실산의 새로운 유도체
IL77010A0 (en)	1986-04-29	Fatty acid esters,process for the preparation thereof and cosmetic preparations containing the same
KR840005465A (ko)	1984-11-12	19-티오-안드로스탄 유도체의 제조 방법
PL244685A1 (en)	1985-04-24	Process for preparing novel 6 -methylcorticoids
CH614217A5 (en)	1979-11-15	Process for the preparation of 1,3,5(10)-8alpha-oestratrienes
KR870000355A (ko)	1987-02-18	글루타치온 모노알킬 에스테르 황산염의 제조방법
ATE44532T1 (de)	1989-07-15	Verfahren zur herstellung von pregnan-derivaten.
ES417737A1 (es)	1976-02-16	Procedimiento para la preparacion de esteroides de la seriedel pregnano.
KR920009842A (ko)	1992-06-25	아로마타제 억제제로서의 2β,19-에틸렌 브릿지된 스테로이드
ATE60785T1 (de)	1991-02-15	Verfahren zur herstellung von estran-derivaten.
ATE71106T1 (de)	1992-01-15	Verfahren zur herstellung von 1-methyl-androsta- 1,4-dien-3,17-dion und die neuen zwischenprodukte fuer dieses verfahren.
SE8205170D0 (sv)	1982-09-10	Sett att framstella 3-oxo-6-halo- ?724-11-hydroxisteroidforeningar
JPS5788200A (en)	1982-06-01	Synthetic intermediate of corticoids
NL930069I1 (nl)	1993-09-01	Werkwijze voor de bereiding van 17-alfa-acyloxy-6-chloor-1-alfa,2-alfa-methyleen-4,6-pregnadieen-3,20-dionen
ES393891A1 (es)	1974-07-01	Procedimiento para la obtencion de derivados de la dibenzo (b,f) (1,4) oxacepina.
JPS56147799A (en)	1981-11-16	Transition of vinylsteroid
GB1320362A (en)	1973-06-13	21-phosphonoalkanoyloxy-pregnanes
GB1024813A (en)	1966-04-06	Improvements in or relating to steroids and the manufacture thereof
FR2438055A1 (fr)	1980-04-30	Nouveaux homo-nor-steroides et leurs methodes de preparation
GB1045035A (en)	1966-10-05	1ª-methyl-í¸-5ª-androsten-17ª-ols and a process for their manufacture
GB1097030A (en)	1967-12-29	Improvements in or relating to the synthesis of biochemical aldosterones
KR830005262A (ko)	1983-08-03	안드로스탄 카보리오에이트의 제조방법

Legal Events

Date

Code

Title

Description

1992-07-31

FG3A

Patent granted, date of granting

Effective date: 19920110

2008-04-11

MM4A

Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: MAXIMUM VALIDITY LIMIT REACHED

Effective date: 20080330