GR3000953T3 - Process for the preparation of 17-alpha-ethynyl-17-beta-hydroxy-18-methyl-4,15-estradien-3-one, and intermediates for this process - Google Patents

Process for the preparation of 17-alpha-ethynyl-17-beta-hydroxy-18-methyl-4,15-estradien-3-one, and intermediates for this process

Info

Publication number: GR3000953T3
Authority: GR; Greece
Prior art keywords: beta; hydroxy; estradien; ethynyl; carbon atoms
Prior art date: 1987-03-31

Application number

GR90400304T

Other languages

English (en)

Inventor

Rolf Dr Bohlmann

Henry Dr Laurent

Helmut Dr Hofmeister

Rudolf Prof Dr Wiechert

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-03-31

Filing date

1990-10-19

Publication date

1991-12-10

1990-10-19 Application filed by Schering Ag filed Critical Schering Ag

1991-12-10 Publication of GR3000953T3 publication Critical patent/GR3000953T3/el

Links

238000000034 method Methods 0.000 title abstract 3
SIGSPDASOTUPFS-XUDSTZEESA-N gestodene Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](C=C4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 SIGSPDASOTUPFS-XUDSTZEESA-N 0.000 title abstract 2
239000000543 intermediate Substances 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 3
KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 2
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 1
238000006027 Birch reduction reaction Methods 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
238000006555 catalytic reaction Methods 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
229910052763 palladium Inorganic materials 0.000 abstract 1
125000004665 trialkylsilyl group Chemical group 0.000 abstract 1
MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
- C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
- C07J1/0096—Alkynyl derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

GR90400304T 1987-03-31 1990-10-19 Process for the preparation of 17-alpha-ethynyl-17-beta-hydroxy-18-methyl-4,15-estradien-3-one, and intermediates for this process GR3000953T3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19873710728 DE3710728A1 (de)	1987-03-31	1987-03-31	Verfahren zur herstellung von 17(alpha)-ethinyl-17ss-hydroxy-18-methyl-4,15-estradien-3-on und die neuen zwischenprodukte fuer dieses verfahren

Publications (1)

Publication Number	Publication Date
GR3000953T3 true GR3000953T3 (en)	1991-12-10

Family

ID=6324491

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR90400304T GR3000953T3 (en)	1987-03-31	1990-10-19	Process for the preparation of 17-alpha-ethynyl-17-beta-hydroxy-18-methyl-4,15-estradien-3-one, and intermediates for this process

Country Status (14)

Country	Link
US (1)	US4923640A (el)
EP (1)	EP0285548B1 (el)
JP (1)	JP2752366B2 (el)
AT (1)	ATE56214T1 (el)
AU (1)	AU611426B2 (el)
CA (1)	CA1306993C (el)
DD (1)	DD281191A5 (el)
DE (2)	DE3710728A1 (el)
DK (1)	DK171850B1 (el)
ES (1)	ES2032051T3 (el)
GR (1)	GR3000953T3 (el)
HU (2)	HU200472B (el)
IE (1)	IE62481B1 (el)
PT (1)	PT87117B (el)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4232521A1 (de) *	1992-09-22	1994-03-24	Schering Ag	Gestagen wirksame 4,5;11,12-Estradiene, Verfahren zu ihrer Herstellung, diese Estradiene enthaltende Arzneimittel sowie deren Verwendung zur Herstellung von Arzneimitteln
IT1271004B (it) *	1994-09-09	1997-05-26	Ind Chimica Srl	Processo per la preparazione del gestodene
JPH099304A (ja) *	1995-06-24	1997-01-10	Matsushita Electric Ind Co Ltd	ビーム位置シミュレーション調整装置
JP2014505721A (ja) *	2011-02-17	2014-03-06	ルピン・リミテッド	レボノルゲストレルを調製するための改良された方法
HUE029252T2 (en) *	2011-06-01	2017-02-28	Estetra Sprl	Process for the preparation of intermediates of estetrol
SG195121A1 (en)	2011-06-01	2013-12-30	Estetra S A	Process for the production of estetrol intermediates
EP2383279A1 (en)	2011-07-19	2011-11-02	Pantarhei Bioscience B.V.	Process for the preparation of estetrol

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1476573A (fr) *	1965-09-13	1967-04-14		Dérivés du gonatriène et leur procédé de préparation
DK133051C (da) *	1973-07-13	1976-08-16	Schering Ag	Analogifremgangsmade til fremstilling af 1,3-oxygenerede 8alfa-ostratriener
DE2439082A1 (de) *	1974-08-12	1976-02-26	Schering Ag	17 alpha-hydroxy-1,3,5(10),15-oestratetraene und verfahren zu ihrer herstellung
DE2456068A1 (de) *	1974-11-23	1976-08-12	Schering Ag	Verfahren zur herstellung von oestren3,17-dion-derivaten
US4081537A (en) *	1975-10-10	1978-03-28	Schering Aktiengesellschaft	Δ15 -Steroids and pharmaceutical compositions thereof
DE2546062A1 (de) *	1975-10-10	1977-04-21	Schering Ag	Delta hoch 15 -steroide
CN1008820B (zh) *	1985-05-10	1990-07-18	施林工业产权保护股份公司	17α-乙炔基-17β-羟基-18-甲基-4，15-雌甾二烯-3-酮的制备方法

1987
- 1987-03-31 DE DE19873710728 patent/DE3710728A1/de not_active Withdrawn
1988
- 1988-03-25 DE DE8888730075T patent/DE3860541D1/de not_active Expired - Lifetime
- 1988-03-25 AT AT88730075T patent/ATE56214T1/de not_active IP Right Cessation
- 1988-03-25 EP EP88730075A patent/EP0285548B1/de not_active Expired - Lifetime
- 1988-03-25 ES ES198888730075T patent/ES2032051T3/es not_active Expired - Lifetime
- 1988-03-25 DK DK168288A patent/DK171850B1/da not_active IP Right Cessation
- 1988-03-29 AU AU14030/88A patent/AU611426B2/en not_active Expired
- 1988-03-29 DD DD88314162A patent/DD281191A5/de not_active IP Right Cessation
- 1988-03-29 JP JP63073503A patent/JP2752366B2/ja not_active Expired - Lifetime
- 1988-03-30 CA CA000562962A patent/CA1306993C/en not_active Expired - Lifetime
- 1988-03-30 IE IE95588A patent/IE62481B1/en not_active IP Right Cessation
- 1988-03-30 PT PT87117A patent/PT87117B/pt not_active IP Right Cessation
- 1988-03-30 HU HU881582A patent/HU200472B/hu unknown
- 1988-03-31 US US07/176,111 patent/US4923640A/en not_active Expired - Lifetime
- 1988-10-04 HU HU895125A patent/HU200471B/hu unknown
1990
- 1990-10-19 GR GR90400304T patent/GR3000953T3/el unknown

Also Published As

Publication number	Publication date
DD281191A5 (de)	1990-08-01
ES2032051T3 (es)	1993-01-01
EP0285548B1 (de)	1990-09-05
DK168288A (da)	1988-10-01
IE880955L (en)	1988-09-30
JP2752366B2 (ja)	1998-05-18
HUT46925A (en)	1988-12-28
DE3860541D1 (de)	1990-10-11
EP0285548A1 (de)	1988-10-05
IE62481B1 (en)	1995-02-08
AU1403088A (en)	1988-09-29
DK168288D0 (da)	1988-03-25
PT87117B (pt)	1992-07-31
DK171850B1 (da)	1997-07-07
CA1306993C (en)	1992-09-01
PT87117A (pt)	1988-04-01
HU200472B (en)	1990-06-28
DE3710728A1 (de)	1988-10-13
JPS63258487A (ja)	1988-10-25
AU611426B2 (en)	1991-06-13
US4923640A (en)	1990-05-08
ATE56214T1 (de)	1990-09-15
HU200471B (en)	1990-06-28

Publication	Publication Date	Title
GR3000953T3 (en)	1991-12-10	Process for the preparation of 17-alpha-ethynyl-17-beta-hydroxy-18-methyl-4,15-estradien-3-one, and intermediates for this process
EP0050325A3 (en)	1982-08-18	Process for the preparation of intermediates in the synthesis of vitamin-d3 metabolites, and intermediates
RO93593B (ro)	1988-01-01	Procedeu de preparare a unor 6-alfa-metilcorticoizi
CH614217A5 (en)	1979-11-15	Process for the preparation of 1,3,5(10)-8alpha-oestratrienes
GR80583B (en)	1985-02-04	Estran and androstan derivatives, method for the preparation thereof and preparations containing said compounds
GB1147803A (en)	1969-04-10	Improvements in or relating to novel steroids and the manufacture thereof
HUT38951A (en)	1986-07-28	Process for preparing pregnane derivatives
KR920009842A (ko)	1992-06-25	아로마타제 억제제로서의 2β,19-에틸렌 브릿지된 스테로이드
AU567934B2 (en)	1987-12-10	Preparation 21-hydroxy-20-keto-delta 16 steroids and intermediates
AU539401B2 (en)	1984-09-27	Cardenolide bis-digitoxosides
EP0139907A3 (en)	1985-06-05	Estrane derivatives
GB1073988A (en)	1967-06-28	Process for preparing steroid compounds, and the compounds thus prepared
ATE40347T1 (de)	1989-02-15	Verfahren zur herstellung von chlorierten ethylenisch ungesaettigten verbidungen.
GB1055353A (en)	1967-01-18	Process for the preparation of 3-hydroxy-and 3-alkoxy-estratrienes and intermediates therefor
ES393891A1 (es)	1974-07-01	Procedimiento para la obtencion de derivados de la dibenzo (b,f) (1,4) oxacepina.
GR3003700T3 (el)	1993-03-16
GB1130052A (en)	1968-10-09	Improvements in or relating to steroids and intermediates for the production thereof
GB1528212A (en)	1978-10-11	Estrogen derivatives
JPS56147799A (en)	1981-11-16	Transition of vinylsteroid
FR2438055A1 (fr)	1980-04-30	Nouveaux homo-nor-steroides et leurs methodes de preparation
GB1151209A (en)	1969-05-07	Pentacyclic Steroid Intermediates and Method of Preparing the same
GB1024813A (en)	1966-04-06	Improvements in or relating to steroids and the manufacture thereof
KR790000747B1 (en)	1979-06-29	Process for separation of 19-nor-4-androstene-3,17-dion
GB1251922A (el)	1971-11-03
GB979891A (en)	1965-01-06	Process for the production of new steroid compounds