ES2032051T3 - Procedimiento para la preparacion de 17alfa-etinil-17beta-hidroxi-18-metil-4,15-estradien-3-ona y los nuevos productos intermedios para este procedimiento. - Google Patents

Procedimiento para la preparacion de 17alfa-etinil-17beta-hidroxi-18-metil-4,15-estradien-3-ona y los nuevos productos intermedios para este procedimiento.

Info

Publication number
ES2032051T3
ES2032051T3 ES198888730075T ES88730075T ES2032051T3 ES 2032051 T3 ES2032051 T3 ES 2032051T3 ES 198888730075 T ES198888730075 T ES 198888730075T ES 88730075 T ES88730075 T ES 88730075T ES 2032051 T3 ES2032051 T3 ES 2032051T3
Authority
ES
Spain
Prior art keywords
procedure
estradien
methyl
carbon atoms
etinil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198888730075T
Other languages
English (en)
Inventor
Rolf Dr. Bohlmann
Henry Dr. Laurent
Helmut Dr. Hofmeister
Rudolf Prof. Dr. Wiechert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of ES2032051T3 publication Critical patent/ES2032051T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0096—Alkynyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE DESCRIBE UN PROCEDIMIENTO PARA OBTENCION DE 17-ALFA-ETINIL17BETA-HIDROXI-18-METIL-4,15-ESTRADIEN-3-ONA , CARACTERIZADO PORQUE UN 17-ENOLESTER DE LA FORMULA GENERAL (II) DONDE R1 ES UN RESTO ALQUILO CON 1-3 ATOMOS DE CARBON Y R2 ES UN GRUPO ACILO O UN GRUPO TRIALQUILSILILO CON HASTA 10 ATOMOS DE C, BAJO CATALISIS CON PALADIO SE TRANSFORMA EN COMPUESTOS DE FORMULA GERAL (III) DONDE R1 ES UN RESTO ALQUILO CON 1-3 ATOMOS DE C, DEL MODO CONOCIDO SE RDUCEN LOS GRUPOS 17-CETO, EL ANILLO AROMATICO A DESPUES DE AMONIACO LIQUIDO SE CONVIERTEN EN 3-METOXI-2,5(10) CON 15 ESTRATRIEN-17-BETA-OL, LOS GRUPOS 17-HIDROXI PASAN OTRA VEZ A GRUPOS 17-CETO, LOS GRUPO 17 CETO SE ETINILIZAN Y SE ESCINDEN EN 3-ENOLETER
ES198888730075T 1987-03-31 1988-03-25 Procedimiento para la preparacion de 17alfa-etinil-17beta-hidroxi-18-metil-4,15-estradien-3-ona y los nuevos productos intermedios para este procedimiento. Expired - Lifetime ES2032051T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873710728 DE3710728A1 (de) 1987-03-31 1987-03-31 Verfahren zur herstellung von 17(alpha)-ethinyl-17ss-hydroxy-18-methyl-4,15-estradien-3-on und die neuen zwischenprodukte fuer dieses verfahren

Publications (1)

Publication Number Publication Date
ES2032051T3 true ES2032051T3 (es) 1993-01-01

Family

ID=6324491

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198888730075T Expired - Lifetime ES2032051T3 (es) 1987-03-31 1988-03-25 Procedimiento para la preparacion de 17alfa-etinil-17beta-hidroxi-18-metil-4,15-estradien-3-ona y los nuevos productos intermedios para este procedimiento.

Country Status (14)

Country Link
US (1) US4923640A (es)
EP (1) EP0285548B1 (es)
JP (1) JP2752366B2 (es)
AT (1) ATE56214T1 (es)
AU (1) AU611426B2 (es)
CA (1) CA1306993C (es)
DD (1) DD281191A5 (es)
DE (2) DE3710728A1 (es)
DK (1) DK171850B1 (es)
ES (1) ES2032051T3 (es)
GR (1) GR3000953T3 (es)
HU (2) HU200472B (es)
IE (1) IE62481B1 (es)
PT (1) PT87117B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4232521A1 (de) * 1992-09-22 1994-03-24 Schering Ag Gestagen wirksame 4,5;11,12-Estradiene, Verfahren zu ihrer Herstellung, diese Estradiene enthaltende Arzneimittel sowie deren Verwendung zur Herstellung von Arzneimitteln
IT1271004B (it) * 1994-09-09 1997-05-26 Ind Chimica Srl Processo per la preparazione del gestodene
JPH099304A (ja) * 1995-06-24 1997-01-10 Matsushita Electric Ind Co Ltd ビーム位置シミュレーション調整装置
JP2014505721A (ja) * 2011-02-17 2014-03-06 ルピン・リミテッド レボノルゲストレルを調製するための改良された方法
HUE029252T2 (en) * 2011-06-01 2017-02-28 Estetra Sprl Process for the preparation of intermediates of estetrol
SG195121A1 (en) 2011-06-01 2013-12-30 Estetra S A Process for the production of estetrol intermediates
EP2383279A1 (en) 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Process for the preparation of estetrol

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1476573A (fr) * 1965-09-13 1967-04-14 Dérivés du gonatriène et leur procédé de préparation
DK133051C (da) * 1973-07-13 1976-08-16 Schering Ag Analogifremgangsmade til fremstilling af 1,3-oxygenerede 8alfa-ostratriener
DE2439082A1 (de) * 1974-08-12 1976-02-26 Schering Ag 17 alpha-hydroxy-1,3,5(10),15-oestratetraene und verfahren zu ihrer herstellung
DE2456068A1 (de) * 1974-11-23 1976-08-12 Schering Ag Verfahren zur herstellung von oestren3,17-dion-derivaten
US4081537A (en) * 1975-10-10 1978-03-28 Schering Aktiengesellschaft Δ15 -Steroids and pharmaceutical compositions thereof
DE2546062A1 (de) * 1975-10-10 1977-04-21 Schering Ag Delta hoch 15 -steroide
CN1008820B (zh) * 1985-05-10 1990-07-18 施林工业产权保护股份公司 17α-乙炔基-17β-羟基-18-甲基-4，15-雌甾二烯-3-酮的制备方法

Also Published As

Publication number Publication date
DD281191A5 (de) 1990-08-01
EP0285548B1 (de) 1990-09-05
GR3000953T3 (en) 1991-12-10
DK168288A (da) 1988-10-01
IE880955L (en) 1988-09-30
JP2752366B2 (ja) 1998-05-18
HUT46925A (en) 1988-12-28
DE3860541D1 (de) 1990-10-11
EP0285548A1 (de) 1988-10-05
IE62481B1 (en) 1995-02-08
AU1403088A (en) 1988-09-29
DK168288D0 (da) 1988-03-25
PT87117B (pt) 1992-07-31
DK171850B1 (da) 1997-07-07
CA1306993C (en) 1992-09-01
PT87117A (pt) 1988-04-01
HU200472B (en) 1990-06-28
DE3710728A1 (de) 1988-10-13
JPS63258487A (ja) 1988-10-25
AU611426B2 (en) 1991-06-13
US4923640A (en) 1990-05-08
ATE56214T1 (de) 1990-09-15
HU200471B (en) 1990-06-28

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