PT87465A - Process for the preparation of (z)-6-(substituted methylene)-penems - Google Patents

Process for the preparation of (z)-6-(substituted methylene)-penems

Info

Publication number: PT87465A
Authority: PT; Portugal
Prior art keywords: isomer; preparation; substituted methylene; penems; antibacterial
Prior art date: 1987-05-14

Application number

PT87465A

Other languages

English (en)

Other versions

PT87465B (pt

Inventor

Nigel John Perryman Broom

Original Assignee

Beecham Group Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-05-14

Filing date

1988-05-12

Publication date

1989-05-31

1988-05-12 Application filed by Beecham Group Plc filed Critical Beecham Group Plc

1989-05-31 Publication of PT87465A publication Critical patent/PT87465A/pt

1992-09-30 Publication of PT87465B publication Critical patent/PT87465B/pt

Links

238000000034 method Methods 0.000 title abstract 2
125000001570 methylene group Chemical class [H]C([H])([*:1])[*:2] 0.000 title 1
-1 6-(substituted methylene)-2-penem compounds Chemical class 0.000 abstract 2
108090000204 Dipeptidase 1 Proteins 0.000 abstract 1
230000000844 anti-bacterial effect Effects 0.000 abstract 1
102000006635 beta-lactamase Human genes 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Saccharide Compounds (AREA)
Cephalosporin Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Reverberation, Karaoke And Other Acoustics (AREA)
Mechanical Coupling Of Light Guides (AREA)
Glass Compositions (AREA)
Iron Core Of Rotating Electric Machines (AREA)
Pyridine Compounds (AREA)

PT87465A 1987-05-14 1988-05-12 Processo para a preparacao de (z)-6-(metileno substituido)-penems PT87465B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB878711391A GB8711391D0 (en)	1987-05-14	1987-05-14	Process

Publications (2)

Publication Number	Publication Date
PT87465A true PT87465A (pt)	1989-05-31
PT87465B PT87465B (pt)	1992-09-30

Family

ID=10617325

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT87465A PT87465B (pt)	1987-05-14	1988-05-12	Processo para a preparacao de (z)-6-(metileno substituido)-penems

Country Status (15)

Country	Link
US (1)	US4897476A (pt)
EP (1)	EP0291304B1 (pt)
JP (1)	JPH0816112B2 (pt)
KR (1)	KR880013944A (pt)
AT (1)	ATE72815T1 (pt)
AU (1)	AU614517B2 (pt)
CA (1)	CA1300603C (pt)
DE (1)	DE3868534D1 (pt)
DK (1)	DK260288A (pt)
ES (1)	ES2030167T3 (pt)
GB (1)	GB8711391D0 (pt)
GR (1)	GR3003907T3 (pt)
NZ (1)	NZ224592A (pt)
PT (1)	PT87465B (pt)
ZA (1)	ZA883346B (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8729613D0 (en) *	1987-12-18	1988-02-03	Beecham Group Plc	Novel compounds
US5693515A (en) *	1995-04-28	1997-12-02	Arris Pharmaceutical Corporation	Metal complexed serine protease inhibitors
US6255091B1 (en) *	1995-04-28	2001-07-03	Axys Pharmaceuticals, Inc.	Potentiating metal mediated serine protease inhibitors with cobalt or zinc ions
CN114681435A (zh)	2020-12-31	2022-07-01	上海汇伦生物科技有限公司	吸入用药物组合物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0050927B1 (en) *	1980-10-25	1985-03-27	Beecham Group Plc	The preparation of beta-lactam antibiotics
EP0120613A1 (en) *	1983-03-02	1984-10-03	Beecham Group Plc	Penem derivatives and precursors
FI82471C (fi) *	1984-01-26	1991-03-11	Beecham Group Plc	Foerfarande foer framstaellning av farmakologiskt aktiva 6-metylenpenemderivater.
GB8402086D0 (en) *	1984-01-26	1984-02-29	Beecham Group Plc	Compounds
GB8518422D0 (en) *	1985-07-22	1985-08-29	Beecham Group Plc	Compounds
ATE159021T1 (de) *	1986-01-17	1997-10-15	Beecham Group Plc	Verfahren zur herstellung von penem derivaten und zwischenprodukte zu dieser herstellung
AT396788B (de) *	1990-02-07	1993-11-25	Hofer Kerzen Gmbh	Kerzenleuchte

1987
- 1987-05-14 GB GB878711391A patent/GB8711391D0/en active Pending
1988
- 1988-05-11 DK DK260288A patent/DK260288A/da not_active Application Discontinuation
- 1988-05-11 ZA ZA883346A patent/ZA883346B/xx unknown
- 1988-05-12 AT AT88304295T patent/ATE72815T1/de not_active IP Right Cessation
- 1988-05-12 PT PT87465A patent/PT87465B/pt not_active IP Right Cessation
- 1988-05-12 EP EP88304295A patent/EP0291304B1/en not_active Expired - Lifetime
- 1988-05-12 CA CA000566571A patent/CA1300603C/en not_active Expired - Fee Related
- 1988-05-12 JP JP63115927A patent/JPH0816112B2/ja not_active Expired - Lifetime
- 1988-05-12 DE DE8888304295T patent/DE3868534D1/de not_active Expired - Lifetime
- 1988-05-12 AU AU16092/88A patent/AU614517B2/en not_active Ceased
- 1988-05-12 US US07/193,746 patent/US4897476A/en not_active Expired - Lifetime
- 1988-05-12 ES ES198888304295T patent/ES2030167T3/es not_active Expired - Lifetime
- 1988-05-12 NZ NZ224592A patent/NZ224592A/xx unknown
- 1988-05-13 KR KR1019880005594A patent/KR880013944A/ko not_active Withdrawn
1992
- 1992-02-27 GR GR920400320T patent/GR3003907T3/el unknown

Also Published As

Publication number	Publication date
US4897476A (en)	1990-01-30
DE3868534D1 (de)	1992-04-02
EP0291304A1 (en)	1988-11-17
GR3003907T3 (pt)	1993-03-16
DK260288D0 (da)	1988-05-11
NZ224592A (en)	1990-07-26
JPH0816112B2 (ja)	1996-02-21
PT87465B (pt)	1992-09-30
EP0291304B1 (en)	1992-02-26
AU1609288A (en)	1988-11-17
ZA883346B (en)	1989-11-29
JPS63303985A (ja)	1988-12-12
KR880013944A (ko)	1988-12-22
DK260288A (da)	1988-11-15
ATE72815T1 (de)	1992-03-15
AU614517B2 (en)	1991-09-05
CA1300603C (en)	1992-05-12
ES2030167T3 (es)	1992-10-16
GB8711391D0 (en)	1987-06-17

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Legal Events

Date

Code

Title

Description

1992-09-30

FG3A

Patent granted, date of granting

Effective date: 19920310

1994-02-28

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19930930