PT87538A - Process for the preparation of beta-(fluoromethylene)-5-hydroxytryptophan and derivatives as prodrugs for mao inhibition and of pharmaceutical compositions containing the same - Google Patents
Process for the preparation of beta-(fluoromethylene)-5-hydroxytryptophan and derivatives as prodrugs for mao inhibition and of pharmaceutical compositions containing the sameInfo
- Publication number
- PT87538A PT87538A PT87538A PT8753888A PT87538A PT 87538 A PT87538 A PT 87538A PT 87538 A PT87538 A PT 87538A PT 8753888 A PT8753888 A PT 8753888A PT 87538 A PT87538 A PT 87538A
- Authority
- PT
- Portugal
- Prior art keywords
- fluoromethylene
- hydroxytryptophan
- prodrugs
- beta
- derivatives
- Prior art date
Links
- IWARRHXTRWGFED-NSHDSACASA-N (2s)-2-amino-4-fluoro-3-(5-hydroxy-1h-indol-3-yl)but-3-enoic acid Chemical compound C1=C(O)C=C2C(C(=CF)[C@@H](C(O)=O)N)=CNC2=C1 IWARRHXTRWGFED-NSHDSACASA-N 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/053,212 US4822812A (en) | 1987-05-21 | 1987-05-21 | β-(Fluoromethylene)-5-hydroxytryptophan and derivatives and their use as prodrugs for MAO inhibition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT87538A true PT87538A (pt) | 1989-05-31 |
| PT87538B PT87538B (pt) | 1992-09-30 |
Family
ID=21982670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT87538A PT87538B (pt) | 1987-05-21 | 1988-05-19 | Processo para a preparacao de novos pro-farmacos derivados de beta-(fluorometileno)-5-hidroxitriptofano utilizados como inibidores da mao e de composicoes farmaceuticas que os contem |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4822812A (pt) |
| EP (1) | EP0291998A3 (pt) |
| JP (1) | JP2520285B2 (pt) |
| KR (1) | KR960016521B1 (pt) |
| CN (1) | CN1031222A (pt) |
| AR (1) | AR246952A1 (pt) |
| AU (1) | AU605865B2 (pt) |
| CA (1) | CA1310973C (pt) |
| DK (1) | DK169330B1 (pt) |
| FI (1) | FI90531C (pt) |
| HU (2) | HU199790B (pt) |
| IL (1) | IL86387A0 (pt) |
| NO (1) | NO172576C (pt) |
| NZ (1) | NZ224661A (pt) |
| PH (1) | PH25384A (pt) |
| PT (1) | PT87538B (pt) |
| ZA (1) | ZA883442B (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5488188A (en) * | 1994-09-29 | 1996-01-30 | Merrell Dow Pharmaceuticals Inc. | Process for the preparation of (E)-1-amino-2-(fluoromethylene)-4-(p-fluorophenyl)butane, novel processes for preparing an intermediate thereof, and novel intermediates thereof |
| ITRM20020255A1 (it) * | 2002-05-09 | 2003-11-10 | Polifarma Spa | Tautomero enolico dell'acido 3-indolilpiruvico, suoi sali e usi terapeutici. |
| US6972014B2 (en) * | 2003-01-04 | 2005-12-06 | Endocare, Inc. | Open system heat exchange catheters and methods of use |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2513597B2 (de) * | 1975-03-27 | 1977-06-02 | L-5-hydroxytryptophan-l-glutamatmonohydrat, verfahren zu seiner herstellung und arzneimittel | |
| US4183858A (en) * | 1977-07-01 | 1980-01-15 | Merrell Toraude Et Compagnie | α-Vinyl tryptophanes |
| FR2499076A1 (fr) * | 1981-02-02 | 1982-08-06 | Panmedica Laboratoires | Nouveaux derives de l'acide ((indol-3 yl)-3 amino-2 propionyloxy)-2 acetique, procedes pour leur preparation et medicaments les contenant |
| US4421767A (en) * | 1981-06-01 | 1983-12-20 | Merrell Toraude Et Compagnie | Compounds and methods for treating depression |
| US4454158A (en) * | 1981-06-01 | 1984-06-12 | Merrell Toraude Et Compagnie | Allyl amine MAO inhibitors |
| ZA855101B (en) * | 1984-07-13 | 1986-05-28 | Merrell Dow Pharma | Fluoroallylaine derivatives |
-
1987
- 1987-05-21 US US07/053,212 patent/US4822812A/en not_active Expired - Lifetime
-
1988
- 1988-05-15 IL IL86387A patent/IL86387A0/xx not_active IP Right Cessation
- 1988-05-16 AR AR88310862A patent/AR246952A1/es active
- 1988-05-16 ZA ZA883442A patent/ZA883442B/xx unknown
- 1988-05-16 CA CA000566913A patent/CA1310973C/en not_active Expired - Lifetime
- 1988-05-17 NZ NZ224661A patent/NZ224661A/xx unknown
- 1988-05-17 AU AU16347/88A patent/AU605865B2/en not_active Ceased
- 1988-05-18 PH PH36944A patent/PH25384A/en unknown
- 1988-05-19 KR KR1019880005872A patent/KR960016521B1/ko not_active Expired - Fee Related
- 1988-05-19 FI FI882360A patent/FI90531C/fi not_active IP Right Cessation
- 1988-05-19 PT PT87538A patent/PT87538B/pt not_active IP Right Cessation
- 1988-05-20 HU HU882617A patent/HU199790B/hu not_active IP Right Cessation
- 1988-05-20 DK DK278388A patent/DK169330B1/da not_active IP Right Cessation
- 1988-05-20 NO NO882240A patent/NO172576C/no not_active IP Right Cessation
- 1988-05-20 HU HU89172A patent/HUT50117A/hu unknown
- 1988-05-20 CN CN88103199A patent/CN1031222A/zh active Pending
- 1988-05-20 JP JP63122187A patent/JP2520285B2/ja not_active Expired - Lifetime
- 1988-05-20 EP EP88108125A patent/EP0291998A3/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| HUT50117A (en) | 1989-12-28 |
| HU199790B (en) | 1990-03-28 |
| US4822812A (en) | 1989-04-18 |
| NO882240L (no) | 1988-11-22 |
| PH25384A (en) | 1991-06-03 |
| KR880013891A (ko) | 1988-12-22 |
| FI882360A0 (fi) | 1988-05-19 |
| HUT47905A (en) | 1989-04-28 |
| JP2520285B2 (ja) | 1996-07-31 |
| JPS63303965A (ja) | 1988-12-12 |
| EP0291998A2 (en) | 1988-11-23 |
| IL86387A0 (en) | 1988-11-15 |
| FI882360L (fi) | 1988-11-22 |
| NZ224661A (en) | 1990-08-28 |
| IL86387A (pt) | 1992-12-01 |
| AR246952A1 (es) | 1994-10-31 |
| AU605865B2 (en) | 1991-01-24 |
| NO172576B (no) | 1993-05-03 |
| CA1310973C (en) | 1992-12-01 |
| DK278388A (da) | 1988-11-22 |
| ZA883442B (en) | 1988-11-16 |
| CN1031222A (zh) | 1989-02-22 |
| PT87538B (pt) | 1992-09-30 |
| DK169330B1 (da) | 1994-10-10 |
| NO882240D0 (no) | 1988-05-20 |
| KR960016521B1 (ko) | 1996-12-14 |
| EP0291998A3 (en) | 1989-01-25 |
| FI90531B (fi) | 1993-11-15 |
| AU1634788A (en) | 1988-11-24 |
| NO172576C (no) | 1993-08-11 |
| FI90531C (fi) | 1994-02-25 |
| DK278388D0 (da) | 1988-05-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG3A | Patent granted, date of granting |
Effective date: 19920305 |
|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20040906 |