PT88883A - Processo para a preparacao de derivados n-manonojirimicina uteis como medicamentos - Google Patents
Processo para a preparacao de derivados n-manonojirimicina uteis como medicamentosInfo
- Publication number
- PT88883A PT88883A PT88883A PT8888388A PT88883A PT 88883 A PT88883 A PT 88883A PT 88883 A PT88883 A PT 88883A PT 8888388 A PT8888388 A PT 8888388A PT 88883 A PT88883 A PT 88883A
- Authority
- PT
- Portugal
- Prior art keywords
- manonojyrimycin
- uterine
- medicines
- derivatives
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3736771 | 1987-10-30 | ||
| DE3814549A DE3814549A1 (de) | 1987-10-30 | 1988-04-29 | N-substituierte derivate von 1-desoxynojirimycin und 1-desoxymannonojirimycin, verfahren zu deren herstellung und deren verwendung in arzneimitteln |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT88883A true PT88883A (pt) | 1989-07-31 |
Family
ID=25861279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT88883A PT88883A (pt) | 1987-10-30 | 1988-10-28 | Processo para a preparacao de derivados n-manonojirimicina uteis como medicamentos |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4940705A (pt) |
| EP (1) | EP0313974A1 (pt) |
| JP (1) | JPH01151553A (pt) |
| KR (1) | KR890006540A (pt) |
| AU (1) | AU603012B2 (pt) |
| DE (1) | DE3814549A1 (pt) |
| DK (1) | DK601988A (pt) |
| FI (1) | FI884966A7 (pt) |
| HU (1) | HU201560B (pt) |
| IL (1) | IL88182A0 (pt) |
| NO (1) | NO884625L (pt) |
| NZ (1) | NZ226741A (pt) |
| PT (1) | PT88883A (pt) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0350012A3 (en) * | 1988-07-08 | 1990-09-05 | Meiji Seika Kaisha Ltd. | Antiviral composition |
| US5100797A (en) * | 1989-06-27 | 1992-03-31 | Monsanto Company | Fucosidase inhibitors |
| US5217979A (en) * | 1989-09-22 | 1993-06-08 | Merrell Dow Pharmaceuticals Inc. | Substituted alkyl piperidines |
| DE3936295A1 (de) * | 1989-11-01 | 1991-05-02 | Bayer Ag | Verfahren zur herstellung von zwischenprodukten und zur synthese von n-(2-hydroxyethyl)-2-hydroxymethyl-3,4,5-trihydroxypiperidine |
| US5536732A (en) * | 1990-04-27 | 1996-07-16 | Merrell Pharmaceuticals Inc. | N-derivatives of 1-deoxy nojirimycin |
| US5252587A (en) * | 1990-04-27 | 1993-10-12 | Merrell Dow Pharmaceuticals, Inc. | N-derivatives of 1-deoxy nojirimycin |
| US5244922A (en) * | 1990-09-04 | 1993-09-14 | Burzynski Stanislaw R | Methods for treating viral infections |
| US5254587A (en) * | 1990-09-04 | 1993-10-19 | Burzynski Stanislaw R | Methods for treating AIDS |
| US5089508A (en) * | 1990-09-04 | 1992-02-18 | Burzynski Stanislaw R | Methods for treating aids |
| ES2087277T3 (es) * | 1990-09-20 | 1996-07-16 | Monsanto Co | Procedimiento para producir 1-desoxinojirimicina n-sustituida. |
| US5401645A (en) * | 1992-03-16 | 1995-03-28 | Monsanto Company | Process for producing n-substituted polyhydroxy nitrogen-containing heterocycles utilizing acetobacteraceae and corynebacterium |
| US5350758A (en) * | 1992-07-08 | 1994-09-27 | Merrell Dow Pharmaceuticals Inc. | Piperidyl sulfonamides and sulfoxamides as inhibitors of cholesterol biosynthesis |
| US20030100532A1 (en) * | 1997-02-14 | 2003-05-29 | Gary S. Jacob | Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections |
| US6689759B1 (en) | 1998-02-12 | 2004-02-10 | G. D. Searle & Co. | Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy |
| ATE402701T1 (de) * | 1999-02-12 | 2008-08-15 | United Therapeutics Corp | N-(8,8,8-trifluorooctyl)-1,5-dideoxy-1,5-imino- - glucitol zur behandlung von hepatitis-virus- infektionen |
| JP2003505501A (ja) | 1999-02-12 | 2003-02-12 | ジー・ディー・サール・アンド・カンパニー | 肝炎ウィルス感染の処置のためのグルカミン化合物 |
| US8716558B2 (en) * | 1999-06-30 | 2014-05-06 | Marker Gene Technologies, Inc. | Method of altering glycosylation of proteins in response to nojirimycin glucuronide in a plant cell expressing glucuronidase |
| EP1261339A1 (en) * | 2000-02-14 | 2002-12-04 | Pharmacia Corporation | Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds for treating hepatitis virus infections |
| EP1181277A4 (en) | 2000-03-31 | 2005-08-10 | Univ Michigan State | PROCESS FOR THE PREPARATION OF 1,5-DIDESOXY-1,5-IMINO HEXITOLS FROM OXIMES OR IMINES |
| AT502145B1 (de) * | 2005-03-24 | 2012-01-15 | Univ Graz Tech | Glycosidase-hemmendes iminoalditol |
| EP1903034A1 (en) * | 2006-09-19 | 2008-03-26 | Technische Universität Graz | Iminosugar glycoconjugates |
| KR101459530B1 (ko) * | 2009-09-04 | 2014-11-07 | 유나이티드 세러퓨틱스 코오포레이션 | 폭스바이러스 감염의 치료 방법 |
| WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
| LT3495367T (lt) | 2012-06-13 | 2021-02-25 | Incyte Holdings Corporation | Pakeistieji tricikliniai junginiai, kaip fgfr inhibitoriai |
| WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| LT2986610T (lt) | 2013-04-19 | 2018-04-10 | Incyte Holdings Corporation | Bicikliniai heterociklai, kaip fgfr inhibitoriai |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| WO2016134294A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
| SG11201706287PA (en) | 2015-02-20 | 2017-09-28 | Incyte Corp | Bicyclic heterocycles as fgfr inhibitors |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| ES3061844T3 (en) | 2018-05-04 | 2026-04-07 | Incyte Corp | Salts of an fgfr inhibitor |
| MX2020011718A (es) | 2018-05-04 | 2021-02-15 | Incyte Corp | Formas solidas de un inhibidor de receptores del factor de crecimiento de fibroblastos (fgfr) y procesos para prepararlas. |
| US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
| US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| US12122767B2 (en) | 2019-10-01 | 2024-10-22 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| TWI891666B (zh) | 2019-10-14 | 2025-08-01 | 美商英塞特公司 | 作為ｆｇｆｒ抑制劑之雙環雜環 |
| US11566028B2 (en) | 2019-10-16 | 2023-01-31 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| CA3163875A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| WO2021113462A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Derivatives of an fgfr inhibitor |
| US12012409B2 (en) | 2020-01-15 | 2024-06-18 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| TW202304459A (zh) | 2021-04-12 | 2023-02-01 | 美商英塞特公司 | 包含ｆｇｆｒ抑制劑及ｎｅｃｔｉｎ－４靶向劑之組合療法 |
| JP2024522189A (ja) | 2021-06-09 | 2024-06-11 | インサイト・コーポレイション | Ｆｇｆｒ阻害剤としての三環式ヘテロ環 |
| EP4352060A1 (en) | 2021-06-09 | 2024-04-17 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3507019A1 (de) * | 1985-02-28 | 1986-08-28 | Bayer Ag, 5090 Leverkusen | Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung |
-
1988
- 1988-04-29 DE DE3814549A patent/DE3814549A1/de not_active Withdrawn
- 1988-10-18 NO NO88884625A patent/NO884625L/no unknown
- 1988-10-19 EP EP88117369A patent/EP0313974A1/de not_active Withdrawn
- 1988-10-26 US US07/262,902 patent/US4940705A/en not_active Expired - Fee Related
- 1988-10-26 JP JP63268345A patent/JPH01151553A/ja active Pending
- 1988-10-27 NZ NZ226741A patent/NZ226741A/en unknown
- 1988-10-27 FI FI884966A patent/FI884966A7/fi not_active IP Right Cessation
- 1988-10-27 IL IL88182A patent/IL88182A0/xx unknown
- 1988-10-28 KR KR1019880014114A patent/KR890006540A/ko not_active Withdrawn
- 1988-10-28 DK DK601988A patent/DK601988A/da not_active Application Discontinuation
- 1988-10-28 PT PT88883A patent/PT88883A/pt not_active Application Discontinuation
- 1988-10-28 HU HU885629A patent/HU201560B/hu not_active IP Right Cessation
- 1988-10-31 AU AU24547/88A patent/AU603012B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| FI884966L (fi) | 1989-05-01 |
| FI884966A7 (fi) | 1989-05-01 |
| HU201560B (en) | 1990-11-28 |
| EP0313974A1 (de) | 1989-05-03 |
| IL88182A0 (en) | 1989-06-30 |
| NO884625L (no) | 1989-05-02 |
| JPH01151553A (ja) | 1989-06-14 |
| DK601988D0 (da) | 1988-10-28 |
| FI884966A0 (fi) | 1988-10-27 |
| NZ226741A (en) | 1991-07-26 |
| AU603012B2 (en) | 1990-11-01 |
| AU2454788A (en) | 1989-05-04 |
| HUT50190A (en) | 1989-12-28 |
| NO884625D0 (no) | 1988-10-18 |
| KR890006540A (ko) | 1989-06-14 |
| DE3814549A1 (de) | 1989-05-18 |
| DK601988A (da) | 1989-05-01 |
| US4940705A (en) | 1990-07-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT82794B (pt) | Processo para a preparacao de derivados de 3-fenil-4-cianopirrole uteis como microbicidas | |
| PT88261A (pt) | Processo para a preparacao de nucleosidos com efeito terapeutico | |
| BR8802484A (pt) | Processo para a preparacao de isocianatos | |
| PT81859B (pt) | Processo para a preparacao de derivados de tiazolidinodionas | |
| PT83389B (pt) | Processo para a preparacao de derivados de sulfonilureia uteis como agentes anti-tumurais | |
| PT87707A (pt) | Processo para a preparacao de derivados de 2-anilino-pirimidina | |
| PT89264A (pt) | Processo para a preparacao de compostos azabiciclicos | |
| PT84561B (pt) | Processo aperfeicoado para a preparacao de derivados macrolidos | |
| PT89205A (pt) | Processo para a preparacao de derivados de indano | |
| PT88225A (pt) | Processo para a preparacao de formulacoes farmaceuticas contendo di-hidropiridinas | |
| PT94045A (pt) | Processo para a preparacao de derivados de 2-piperidino-1-alcanol uteis como agentes anti-isquemicos | |
| BR8801238A (pt) | Processo para preparacao de ibuprofeno | |
| PT88181A (pt) | Processo para a preparacao de derivados aralquilaminoalcoxifenilo | |
| BR8702112A (pt) | Processo para a preparacao de um derivado de pirazol pirimidina | |
| PT89039A (pt) | Processo para a preparacao de l-ramnose | |
| PT89195A (pt) | Processo para a preparacao de derivados de triazole uteis como agentes anti-fungicos | |
| PT91027A (pt) | Processo para a preparacao de derivados peptidicos | |
| PT89775A (pt) | Processo para a preparacao de derivados de isoquinolina | |
| BR8803678A (pt) | Processo para a preparacao de polieteramidas | |
| PT89056A (pt) | Processo para a preparacao de hidroxilaminas substituidas | |
| PT92539A (pt) | Processo para a preparacao de derivados de anfotericina b | |
| PT83462B (pt) | Processo para a preparacao de derivados piridinilo uteis como microbicidas | |
| PT88924A (pt) | Processo para a preparacao de derivados de ginkgolidos | |
| PT88920A (pt) | Processo para a preparacao de novas fluorometoxifenil-di-hidropiridinas uteis como medicamentos | |
| PT90868A (pt) | Processo para a preparacao de novas dibenzo-ciclo-heptenil, ciclo-heptil- e oxapinilaminas utilizaveis como anti-histaminicos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC3A | Refusal |
Effective date: 19921105 |