PT90219A - Processo para a preparacao de 4-desmetoxidaunomicinona - Google Patents

Processo para a preparacao de 4-desmetoxidaunomicinona

Info

Publication number: PT90219A
Authority: PT; Portugal
Prior art keywords: demethoxy; group; methoxideunomicinone; preparation; demethyldaunomycinone
Prior art date: 1988-04-11

Application number

PT90219A

Other languages

English (en)

Other versions

PT90219B (pt

Inventor

Walter Cabri

Silvia De Bernardinis

Franco Francalanci

Sergio Penco

Original Assignee

Erba Farmitalia

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-04-11

Filing date

1989-04-07

Publication date

1989-11-10

1989-04-07 Application filed by Erba Farmitalia filed Critical Erba Farmitalia

1989-11-10 Publication of PT90219A publication Critical patent/PT90219A/pt

1994-07-29 Publication of PT90219B publication Critical patent/PT90219B/pt

Links

PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 abstract 2
KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 2
DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 abstract 2
XYDJGVROLWFENK-YBTHPKLGSA-N (7s,9s)-9-acetyl-4,6,7,9,11-pentahydroxy-8,10-dihydro-7h-tetracene-5,12-dione Chemical compound O=C1C2=C(O)C=CC=C2C(=O)C2=C1C(O)=C1[C@@H](O)C[C@@](C(=O)C)(O)CC1=C2O XYDJGVROLWFENK-YBTHPKLGSA-N 0.000 abstract 1
ZUFQFGSMHXKORU-UHFFFAOYSA-N 9-acetyl-6,7,9,11-tetrahydroxy-8,10-dihydro-7h-tetracene-5,12-dione Chemical compound O=C1C2=CC=CC=C2C(=O)C2=C1C(O)=C1C(O)CC(C(=O)C)(O)CC1=C2O ZUFQFGSMHXKORU-UHFFFAOYSA-N 0.000 abstract 1
TWCMVXMQHSVIOJ-UHFFFAOYSA-N Aglycone of yadanzioside D Natural products COC(=O)C12OCC34C(CC5C(=CC(O)C(O)C5(C)C3C(O)C1O)C)OC(=O)C(OC(=O)C)C24 TWCMVXMQHSVIOJ-UHFFFAOYSA-N 0.000 abstract 1
PLMKQQMDOMTZGG-UHFFFAOYSA-N Astrantiagenin E-methylester Natural products CC12CCC(O)C(C)(CO)C1CCC1(C)C2CC=C2C3CC(C)(C)CCC3(C(=O)OC)CCC21C PLMKQQMDOMTZGG-UHFFFAOYSA-N 0.000 abstract 1
XDXDZDZNSLXDNA-TZNDIEGXSA-N Idarubicin Chemical compound C1[C@H](N)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2C[C@@](O)(C(C)=O)C1 XDXDZDZNSLXDNA-TZNDIEGXSA-N 0.000 abstract 1
XDXDZDZNSLXDNA-UHFFFAOYSA-N Idarubicin Natural products C1C(N)C(O)C(C)OC1OC1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2CC(O)(C(C)=O)C1 XDXDZDZNSLXDNA-UHFFFAOYSA-N 0.000 abstract 1
230000003197 catalytic effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
PFOARMALXZGCHY-UHFFFAOYSA-N homoegonol Natural products C1=C(OC)C(OC)=CC=C1C1=CC2=CC(CCCO)=CC(OC)=C2O1 PFOARMALXZGCHY-UHFFFAOYSA-N 0.000 abstract 1
229960000908 idarubicin Drugs 0.000 abstract 1
229910052759 nickel Inorganic materials 0.000 abstract 1
229910052763 palladium Inorganic materials 0.000 abstract 1
AVNRJUHUOZDFKS-UHFFFAOYSA-N phenyl(3-phenylphosphanylpropyl)phosphane Chemical compound C=1C=CC=CC=1PCCCPC1=CC=CC=C1 AVNRJUHUOZDFKS-UHFFFAOYSA-N 0.000 abstract 1
229910052723 transition metal Inorganic materials 0.000 abstract 1
150000003624 transition metals Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Catalysts (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

PT90219A 1988-04-11 1989-04-07 Processo para a preparacao de 4-desmetoxidaunomicinona PT90219B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB888808475A GB8808475D0 (en)	1988-04-11	1988-04-11	Process for preparing 4-demethoxydauno-mycinone

Publications (2)

Publication Number	Publication Date
PT90219A true PT90219A (pt)	1989-11-10
PT90219B PT90219B (pt)	1994-07-29

Family

ID=10634959

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT90219A PT90219B (pt)	1988-04-11	1989-04-07	Processo para a preparacao de 4-desmetoxidaunomicinona

Country Status (27)

Country	Link
US (1)	US5103029A (pt)
EP (1)	EP0337665B1 (pt)
JP (1)	JP2746997B2 (pt)
KR (1)	KR0136907B1 (pt)
CN (1)	CN1024000C (pt)
AT (1)	ATE85601T1 (pt)
AU (1)	AU604405B2 (pt)
CA (1)	CA1337762C (pt)
CZ (1)	CZ278973B6 (pt)
DE (1)	DE68904797T2 (pt)
DK (1)	DK170157B1 (pt)
ES (1)	ES2045417T3 (pt)
FI (1)	FI90411C (pt)
GB (1)	GB8808475D0 (pt)
HU (1)	HU201772B (pt)
IE (1)	IE63713B1 (pt)
IL (1)	IL89879A (pt)
MY (2)	MY104427A (pt)
NO (1)	NO170213C (pt)
NZ (1)	NZ228635A (pt)
PH (1)	PH25499A (pt)
PT (1)	PT90219B (pt)
RU (1)	RU1833361C (pt)
SK (1)	SK215289A3 (pt)
UA (1)	UA19150A (pt)
YU (1)	YU47310B (pt)
ZA (1)	ZA892560B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8803301D0 (en) *	1988-02-12	1988-03-09	Erba Carlo Spa	Process for preparation of 4-demethoxy-daunomycinone aglycone of 4-demethoxy-daunorubicin
GB8808475D0 (en) *	1988-04-11	1988-05-11	Erba Carlo Spa	Process for preparing 4-demethoxydauno-mycinone
GB8904794D0 (en) *	1989-03-02	1989-04-12	Erba Carlo Spa	Process for preparing anthracyclinones
AUPQ319799A0 (en) *	1999-10-01	1999-10-28	Institute Of Drug Technology Australia Limited	Chemical methods
IT1318532B1 (it)	2000-05-19	2003-08-27	Antibioticos Spa	Procedimento di sintesi di derivati antraciclinici.
JP4688315B2 (ja) *	2001-02-28	2011-05-25	メルシャン株式会社	４−デメトキシダウノマイシノンの製造
US7053191B2 (en) *	2003-05-21	2006-05-30	Solux Corporation	Method of preparing 4-R-substituted 4-demethoxydaunorubicin
EP1781589B1 (en) *	2004-08-23	2010-04-14	Sicor Inc.	Synthesis of idarubin aglycone
US8802830B2 (en) *	2005-12-20	2014-08-12	Solux Corporation	Synthesis of epirubicin from 13-dihydrodaunorubicine
US8357785B2 (en) *	2008-01-08	2013-01-22	Solux Corporation	Method of aralkylation of 4′-hydroxyl group of anthracylins
US8846882B2 (en)	2011-04-29	2014-09-30	Synbias Pharma Ag	Method of producing 4-demethoxydaunorubicin
CN107698634B (zh) *	2017-09-22	2020-03-10	南京正大天晴制药有限公司	一种盐酸伊达比星的制备方法
CN115616907B (zh) *	2022-09-22	2023-08-04	上海海事大学	一种无人艇航向智能规划方法及控制器

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4020270A (en) *	1974-05-02	1977-04-26	Societa' Farmaceutici Italia S.P.A.	L-lyxohex-1-enopyranose derivative
GB1467383A (en) *	1974-06-12	1977-03-16	Farmaceutici Italia	Daunomycin analogues
US4012784A (en) *	1975-11-28	1977-03-15	Minnesota Mining & Manufacturing Company	Voice logging recorder including decks dedicated for both logging and recall operations
GB1527050A (en) *	1976-06-19	1978-10-04	Farmaceutici Italia	Optically active anthracyclinones
DE2630237A1 (de) *	1976-07-06	1978-01-19	Blaupunkt Werke Gmbh	Verfahren zur herstellung von besser abstimmbaren dickschichtwiderstaenden
US4348388A (en) *	1980-04-02	1982-09-07	G.D. Searle & Co.	11-Amino-11-deoxydaunorubicin and analogs
US4495103A (en) *	1982-07-30	1985-01-22	Sumitomo Chemical Company, Ltd.	Preparation of optically active 4-demethoxydaunomycinone
GB8803301D0 (en) *	1988-02-12	1988-03-09	Erba Carlo Spa	Process for preparation of 4-demethoxy-daunomycinone aglycone of 4-demethoxy-daunorubicin
GB8808475D0 (en) *	1988-04-11	1988-05-11	Erba Carlo Spa	Process for preparing 4-demethoxydauno-mycinone
GB8824947D0 (en) *	1988-10-25	1988-11-30	Erba Carlo Spa	New 4-substituted anthracyclinones & process for preparing them

1988
- 1988-04-11 GB GB888808475A patent/GB8808475D0/en active Pending
1989
- 1989-04-06 NZ NZ228635A patent/NZ228635A/en unknown
- 1989-04-06 DE DE8989303418T patent/DE68904797T2/de not_active Expired - Lifetime
- 1989-04-06 AT AT89303418T patent/ATE85601T1/de not_active IP Right Cessation
- 1989-04-06 EP EP89303418A patent/EP0337665B1/en not_active Expired - Lifetime
- 1989-04-06 US US07/333,951 patent/US5103029A/en not_active Expired - Lifetime
- 1989-04-06 ES ES89303418T patent/ES2045417T3/es not_active Expired - Lifetime
- 1989-04-06 PH PH38455A patent/PH25499A/en unknown
- 1989-04-06 IE IE109489A patent/IE63713B1/en not_active IP Right Cessation
- 1989-04-07 RU SU894613820A patent/RU1833361C/ru active
- 1989-04-07 UA UA4613820A patent/UA19150A/uk unknown
- 1989-04-07 NO NO891457A patent/NO170213C/no not_active IP Right Cessation
- 1989-04-07 IL IL89879A patent/IL89879A/xx unknown
- 1989-04-07 SK SK2152-89A patent/SK215289A3/sk unknown
- 1989-04-07 CZ CS892152A patent/CZ278973B6/cs not_active IP Right Cessation
- 1989-04-07 PT PT90219A patent/PT90219B/pt not_active IP Right Cessation
- 1989-04-07 AU AU32572/89A patent/AU604405B2/en not_active Expired
- 1989-04-07 ZA ZA892560A patent/ZA892560B/xx unknown
- 1989-04-07 DK DK169289A patent/DK170157B1/da not_active IP Right Cessation
- 1989-04-08 KR KR1019890004646A patent/KR0136907B1/ko not_active Expired - Lifetime
- 1989-04-08 CN CN89102090A patent/CN1024000C/zh not_active Expired - Lifetime
- 1989-04-10 HU HU891714A patent/HU201772B/hu unknown
- 1989-04-10 JP JP1090494A patent/JP2746997B2/ja not_active Expired - Lifetime
- 1989-04-10 FI FI891677A patent/FI90411C/fi not_active IP Right Cessation
- 1989-04-10 YU YU71889A patent/YU47310B/sh unknown
- 1989-04-10 MY MYPI89000454A patent/MY104427A/en unknown
- 1989-04-10 CA CA000596190A patent/CA1337762C/en not_active Expired - Lifetime
1993
- 1993-06-09 MY MYPI93001126A patent/MY110352A/en unknown

Also Published As

Publication number	Publication date
EP0337665A3 (en)	1990-04-11
JP2746997B2 (ja)	1998-05-06
NO170213B (no)	1992-06-15
DK170157B1 (da)	1995-06-06
MY110352A (en)	1998-04-30
NO891457L (no)	1989-10-12
FI90411B (fi)	1993-10-29
ZA892560B (en)	1990-12-28
SK278267B6 (en)	1996-06-05
RU1833361C (ru)	1993-08-07
DK169289D0 (da)	1989-04-07
HU201772B (en)	1990-12-28
CZ278973B6 (en)	1994-11-16
CN1038089A (zh)	1989-12-20
HUT49624A (en)	1989-10-30
YU71889A (en)	1991-02-28
NZ228635A (en)	1991-03-26
PT90219B (pt)	1994-07-29
US5103029A (en)	1992-04-07
ATE85601T1 (de)	1993-02-15
ES2045417T3 (es)	1994-01-16
CN1024000C (zh)	1994-03-16
CZ215289A3 (en)	1994-04-13
JPH01308243A (ja)	1989-12-12
SK215289A3 (en)	1996-06-05
DK169289A (da)	1989-10-12
IE63713B1 (en)	1995-05-31
AU604405B2 (en)	1990-12-13
KR890016058A (ko)	1989-11-28
NO170213C (no)	1992-09-23
FI90411C (fi)	1994-02-10
FI891677L (fi)	1989-10-12
UA19150A (uk)	1997-12-25
FI891677A0 (fi)	1989-04-10
EP0337665B1 (en)	1993-02-10
PH25499A (en)	1991-07-24
IE891094L (en)	1989-10-11
DE68904797T2 (de)	1993-05-27
CA1337762C (en)	1995-12-19
MY104427A (en)	1994-03-31
IL89879A0 (en)	1989-12-15
EP0337665A2 (en)	1989-10-18
YU47310B (sh)	1995-01-31
DE68904797D1 (de)	1993-03-25
NO891457D0 (no)	1989-04-07
AU3257289A (en)	1989-10-12
IL89879A (en)	1993-07-08
GB8808475D0 (en)	1988-05-11
KR0136907B1 (ko)	1998-04-25

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Legal Events

Date	Code	Title	Description
1994-07-29	FG3A	Patent granted, date of granting	Effective date: 19940110
1997-03-31	PC3A	Transfer or assignment	Free format text: 961212 PHARMACIA & UPJOHN S.P.A. IT
1997-03-31	TE3A	Change of address (patent)
2009-04-16	MM4A	Annulment/lapse due to non-payment of fees, searched and examined patent	Free format text: MAXIMUM VALIDITY LIMIT REACHED Effective date: 20090407