PT91364A - Processo para a preparacao de derivados de 3-piperazinil-benzazol e de composicoes farmaceuticas que os contem - Google Patents
Processo para a preparacao de derivados de 3-piperazinil-benzazol e de composicoes farmaceuticas que os contemInfo
- Publication number
- PT91364A PT91364A PT91364A PT9136489A PT91364A PT 91364 A PT91364 A PT 91364A PT 91364 A PT91364 A PT 91364A PT 9136489 A PT9136489 A PT 9136489A PT 91364 A PT91364 A PT 91364A
- Authority
- PT
- Portugal
- Prior art keywords
- pharmaceutical compositions
- piperazinyl
- compositions containing
- preparation
- compounds
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- VASVHOLFOSSBKT-UHFFFAOYSA-N 3-piperazin-1-yl-1h-indole Chemical class C1CNCCN1C1=CNC2=CC=CC=C12 VASVHOLFOSSBKT-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000000164 antipsychotic agent Substances 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22841788A | 1988-08-05 | 1988-08-05 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT91364A true PT91364A (pt) | 1990-03-08 |
| PT91364B PT91364B (pt) | 1995-03-31 |
Family
ID=22857091
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT91364A PT91364B (pt) | 1988-08-05 | 1989-08-03 | Processo para a preparacao de derivados de 3-piperazinil-benzazol e de composicoes farmaceuticas que os contem |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0353821B1 (pt) |
| JP (1) | JP2779216B2 (pt) |
| KR (1) | KR0145706B1 (pt) |
| CN (1) | CN1023602C (pt) |
| AT (1) | ATE122348T1 (pt) |
| AU (1) | AU619877B2 (pt) |
| CA (1) | CA1331609C (pt) |
| DE (1) | DE68922537T2 (pt) |
| DK (1) | DK175124B1 (pt) |
| ES (1) | ES2074462T3 (pt) |
| FI (1) | FI90238C (pt) |
| HU (1) | HU206341B (pt) |
| IE (1) | IE66198B1 (pt) |
| IL (1) | IL91194A (pt) |
| NO (1) | NO176051C (pt) |
| NZ (1) | NZ230045A (pt) |
| PH (1) | PH26550A (pt) |
| PT (1) | PT91364B (pt) |
| SU (1) | SU1687030A3 (pt) |
| ZA (1) | ZA895978B (pt) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5364866A (en) | 1989-05-19 | 1994-11-15 | Hoechst-Roussel Pharmaceuticals, Inc. | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics |
| US5561128A (en) * | 1989-05-19 | 1996-10-01 | Hoechst-Roussel Pharmaceuticals, Inc. | N-[(4-(heteroaryl)-1-piperidinyl)alkyl]-10,11-dihydro-5H-dibenz[B,F]azepines and related compounds and their therapeutic utility |
| US5776963A (en) * | 1989-05-19 | 1998-07-07 | Hoechst Marion Roussel, Inc. | 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility |
| US4954503A (en) * | 1989-09-11 | 1990-09-04 | Hoechst-Roussel Pharmaceuticals, Inc. | 3-(1-substituted-4-piperazinyl)-1H-indazoles |
| FR2671350A1 (fr) * | 1991-01-08 | 1992-07-10 | Adir | Nouveaux derives de benzisoxazole et de benzisothiazole, leur procede de preparation, et les compositions pharmaceutiques les renfermant. |
| US5041445A (en) * | 1990-05-21 | 1991-08-20 | Hoechst-Roussel Pharmaceuticals Incorporated | 3-[1-thiazolidinylbutyl-4-piperazinyl]-1H-indazoles |
| CA2118936A1 (en) * | 1991-09-25 | 1993-04-01 | Gene M. Bright | Neuroleptic 2-substituted perhydro-1-h-pyrido[1,2-a]pyrazines |
| GB9202915D0 (en) * | 1992-02-12 | 1992-03-25 | Wellcome Found | Chemical compounds |
| EP0635506A4 (en) * | 1993-02-04 | 1995-04-12 | Meiji Seika Co | CONNECTION WITH ANTIPSYCHOTIC EFFECT. |
| EP0794185A4 (en) * | 1994-11-25 | 1998-03-25 | Meiji Seika Co | BICYCLIC THIAZOLE COMPOUND |
| KR100315939B1 (ko) * | 1995-11-07 | 2002-01-16 | 디. 제이. 우드, 스피겔 알렌 제이 | 3-(1-피페라지닐)-1,2-벤즈이소티아졸의제조방법및중간체 |
| US6187774B1 (en) * | 1996-03-04 | 2001-02-13 | Yoshitomi Pharmaceutical Industries, Ltd. | Fused heterocyclic compounds and pharmaceutical applications thereof |
| HUP0400389A3 (en) | 2001-03-29 | 2008-03-28 | Schering Corp | Aryl oxime-piperazines useful as ccr5 antagonists and pharmaceutical compositions containing them |
| PL378120A1 (pl) * | 2003-02-14 | 2006-03-06 | Wyeth | Heterocyklilo-3-sulfonyloindazole jako ligandy 5-hydroksytryptaminy |
| EP2337783A1 (en) * | 2008-09-23 | 2011-06-29 | F. Hoffmann-La Roche AG | Isoxazolo[4,5]pyridin-3-yl-piperazin derivatives useful as modulatorsof dopamine d3 receptors |
| US11676855B2 (en) * | 2020-02-26 | 2023-06-13 | Taiwan Semiconductor Manufacturing Co., Ltd. | Patterning interconnects and other structures by photo-sensitizing method |
| CN114634479B (zh) * | 2020-12-16 | 2025-02-07 | 北京盈科瑞创新药物研究有限公司 | 一种派嗪衍生物、其制备方法及应用 |
| CA3245085A1 (en) * | 2022-01-11 | 2023-07-20 | Suven Life Sciences Limited | HETEROCYCLIC DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4411901A (en) * | 1981-12-23 | 1983-10-25 | Mead Johnson & Company | Benzisothiazole and benzisoxazole piperazine derivatives |
| US4452799A (en) | 1981-12-23 | 1984-06-05 | Mead Johnson & Company | Benzisothiazole and benzisoxazole piperazine derivatives |
| HU198036B (en) * | 1983-08-22 | 1989-07-28 | Hoechst Roussel Pharma | Process for production of derivatives of 3-piperidil-/1h/-indasole and medical preparatives containing them |
| US4524206A (en) | 1983-09-12 | 1985-06-18 | Mead Johnson & Company | 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives |
| US4590196A (en) | 1984-08-23 | 1986-05-20 | Bristol-Myers Company | Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives |
| US4804663A (en) * | 1985-03-27 | 1989-02-14 | Janssen Pharmaceutica N.V. | 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles |
| EP0302423A3 (en) | 1987-08-07 | 1991-01-09 | Hoechst-Roussel Pharmaceuticals Incorporated | 1-phenyl-3-(1-piperazinyl)-1h-indazoles, a process and intermediates for their preparation, and the use thereof as medicaments |
-
1989
- 1989-07-21 NZ NZ230045A patent/NZ230045A/en unknown
- 1989-07-26 SU SU894614564A patent/SU1687030A3/ru active
- 1989-07-28 AT AT89201981T patent/ATE122348T1/de not_active IP Right Cessation
- 1989-07-28 ES ES89201981T patent/ES2074462T3/es not_active Expired - Lifetime
- 1989-07-28 EP EP89201981A patent/EP0353821B1/en not_active Expired - Lifetime
- 1989-07-28 DE DE68922537T patent/DE68922537T2/de not_active Expired - Fee Related
- 1989-07-28 CA CA000606919A patent/CA1331609C/en not_active Expired - Fee Related
- 1989-08-01 AU AU39171/89A patent/AU619877B2/en not_active Ceased
- 1989-08-02 JP JP1199515A patent/JP2779216B2/ja not_active Expired - Fee Related
- 1989-08-03 IL IL9119489A patent/IL91194A/en not_active IP Right Cessation
- 1989-08-03 PT PT91364A patent/PT91364B/pt not_active IP Right Cessation
- 1989-08-04 ZA ZA895978A patent/ZA895978B/xx unknown
- 1989-08-04 FI FI893701A patent/FI90238C/fi not_active IP Right Cessation
- 1989-08-04 DK DK198903836A patent/DK175124B1/da not_active IP Right Cessation
- 1989-08-04 NO NO893168A patent/NO176051C/no unknown
- 1989-08-04 IE IE253589A patent/IE66198B1/en not_active IP Right Cessation
- 1989-08-04 HU HU893967A patent/HU206341B/hu not_active IP Right Cessation
- 1989-08-04 PH PH39057A patent/PH26550A/en unknown
- 1989-08-04 KR KR1019890011154A patent/KR0145706B1/ko not_active Expired - Fee Related
- 1989-08-05 CN CN89106438A patent/CN1023602C/zh not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT92806A (pt) | Processo para a preparacao de derivados de 2-amino-pirimidinona e de composicoes farmaceuticas que os contem | |
| PT92206A (pt) | Processo para a preparacao de derivados de 3-piperidinil-1,2-benzizoxazois e de composicoes farmaceuticas que os contem | |
| PT89047A (pt) | Processo para a preparacao de derivados de piridazinamina | |
| PT93531A (pt) | Processo para a preparacao de derivados de n-(3-hidroxi-4-piperidinil)(dihidrobenzofurano,dihidro-2h-benzopirano ou dihidrobenzodioxin)carboxamidas e de composicoes farmaceuticas que os contem | |
| DK8885D0 (da) | N-heterocyclyl-4-piperidinaminderivater og fremgangsmaade til fremstilling deraf | |
| FI893701A0 (fi) | Menetelmä antipsykoottisten 3-piperatsinyylibentsatsolijohdannaisten valmistamiseksi | |
| PT91613A (pt) | Process for the preparation of antihypertensive 3-piperidinyl-indazole derivatives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG3A | Patent granted, date of granting |
Effective date: 19940922 |
|
| MM4A | Annulment/lapse due to non-payment of fees, searched and examined patent |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20070322 |