PT92488A - Processo para a preparacao de novas piperazinilalquil-3(2h)-piridazinonas - Google Patents

Processo para a preparacao de novas piperazinilalquil-3(2h)-piridazinonas

Info

Publication number
PT92488A
PT92488A PT92488A PT9248889A PT92488A PT 92488 A PT92488 A PT 92488A PT 92488 A PT92488 A PT 92488A PT 9248889 A PT9248889 A PT 9248889A PT 92488 A PT92488 A PT 92488A
Authority
PT
Portugal
Prior art keywords
alkyl
unsubstituted
substituted
hydrogen
phenyl
Prior art date
Application number
PT92488A
Other languages
English (en)
Other versions
PT92488B (pt
Inventor
Heinz Blaschke
Heimo Stroissnig
Harald Fellier
Rita Enzenhofer
Original Assignee
Hafslund Nycomed Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hafslund Nycomed Pharma filed Critical Hafslund Nycomed Pharma
Publication of PT92488A publication Critical patent/PT92488A/pt
Publication of PT92488B publication Critical patent/PT92488B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/22—Nitrogen and oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
PT92488A 1988-12-06 1989-12-04 Processo para a preparacao de novas piperazinilalquil-3(2h)-piridazinonas PT92488B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT299188 1988-12-06

Publications (2)

Publication Number Publication Date
PT92488A true PT92488A (pt) 1990-06-29
PT92488B PT92488B (pt) 1995-08-09

Family

ID=3543605

Family Applications (1)

Application Number Title Priority Date Filing Date
PT92488A PT92488B (pt) 1988-12-06 1989-12-04 Processo para a preparacao de novas piperazinilalquil-3(2h)-piridazinonas

Country Status (28)

Country Link
US (1) US5034391A (pt)
EP (1) EP0372305B1 (pt)
JP (1) JPH02200676A (pt)
KR (1) KR900009626A (pt)
CN (1) CN1022565C (pt)
AT (1) ATE92487T1 (pt)
AU (1) AU622501B2 (pt)
CA (1) CA2004298A1 (pt)
DD (1) DD290885A5 (pt)
DE (1) DE58905151D1 (pt)
DK (1) DK169102B1 (pt)
ES (1) ES2058449T3 (pt)
FI (1) FI93956C (pt)
GR (1) GR3008659T3 (pt)
HU (1) HU203748B (pt)
IE (1) IE62890B1 (pt)
IL (1) IL92442A0 (pt)
LT (2) LTIP1615A (pt)
LV (1) LV10273B (pt)
MD (2) MD382C2 (pt)
MY (1) MY106282A (pt)
NO (1) NO173441C (pt)
NZ (1) NZ231625A (pt)
PT (1) PT92488B (pt)
RU (2) RU1823874C (pt)
UA (1) UA19756A1 (pt)
YU (1) YU229289A (pt)
ZA (1) ZA899320B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5162321A (en) * 1989-12-20 1992-11-10 Adir Et Compagnie 1-naphthyl piperazines useful as 5-HT1A receptor ligands
ES2149761T3 (es) * 1990-04-25 2000-11-16 Nissan Chemical Ind Ltd Derivado de piridazinona.
HU214320B (hu) * 1991-12-20 1998-03-02 EGIS Gyógyszergyár Rt. Eljárás új 3(2H)-piridazinon-származékok és ezeket tartalmazó gyógyszerkészítmények előállítására
IT1254469B (it) * 1992-02-25 1995-09-25 Recordati Chem Pharm Derivati benzopiranici e benzotiopiranici
US5474994A (en) * 1992-05-26 1995-12-12 Recordati S.A., Chemical And Pharmaceutical Company Bicyclic heterocyclic derivatives having α1 -adrenergic and 5HT1A
US5605896A (en) * 1992-02-25 1997-02-25 Recordati S.A., Chemical And Pharmaceutical Company Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities
IT1258315B (it) * 1992-04-10 1996-02-22 Recordati Chem Pharm Derivati del flavone
US6960597B2 (en) * 2000-06-30 2005-11-01 Orth-Mcneil Pharmaceutical, Inc. Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists
HU225955B1 (en) * 2001-07-26 2008-01-28 Egis Gyogyszergyar Nyilvanosan Novel 2h-pyridazin-3-one derivatives, process for their preparation, their use and pharmaceutical compositions containing them
HU227237B1 (en) * 2001-09-27 2010-12-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Substituted alkylpyridazinone derivatives, process for their preparation, pharmaceutical compositions containing them
JP2005519895A (ja) * 2002-01-18 2005-07-07 ファルマシア・コーポレーション Ｐ３８阻害剤としての置換ピリダジノン
HU227592B1 (en) * 2002-11-13 2011-09-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Use of substituted alkyl-piridazinone derivatives for the treatment of memory decline and learning malfunctions
US20050176755A1 (en) * 2003-10-31 2005-08-11 Dyatkin Alexey B. Aza-bridged-bicyclic amino acid derivatives as alpha4 integrin antagonists
CA2555227A1 (en) * 2004-02-10 2005-08-25 Janssen Pharmaceutica, N.V. Pyridazinone ureas as antagonists of .alpha.4 integrins
KR20070004676A (ko) * 2004-02-10 2007-01-09 얀센 파마슈티카 엔.브이. 알파４ 인테그린의 길항제로서의 피리다지논
CA2789151A1 (en) * 2010-02-08 2011-08-11 Allergan, Inc. Pyridazine derivatives useful as cannabinoid-2 agonists

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1086238B (de) * 1959-02-03 1960-08-04 Basf Ag Verfahren zur Herstellung von (4, 5)-Dihalogenpyridazonen-(6)
US3398151A (en) * 1966-02-01 1968-08-20 Mead Johnson & Co Azaspirodecanediones and azaspiroundecanediones
BE755015A (fr) * 1969-08-20 1971-02-01 Byk Gulden Lomberg Chem Fab Piperazinyl-alcoylamino-uraciles substitues par un groupe aryle, leurs ethers et thioethers, ainsi que leur procede de preparation
FR2124164A1 (en) * 1971-02-10 1972-09-22 Ferlux Phenyl pyridazonyl piperazines - analgesics hypotensives sedatives and antibacterials
DE2334009A1 (de) * 1973-07-04 1975-01-23 Boehringer Mannheim Gmbh Purin-derivate sowie verfahren zu ihrer herstellung
FR2261756A1 (en) * 1974-02-27 1975-09-19 Roussel Uclaf 2-Thiazole-N-(Piperazino or piperidino) alkyl carboxamides - as hypotensive and anti-hypertensive agents of low toxicity
LU74319A1 (pt) * 1976-02-09 1977-08-19
JPS5742679A (en) * 1980-08-29 1982-03-10 Otsuka Pharmaceut Co Ltd Preparation of phenylpiperazine derivative
JPH0641454B2 (ja) * 1985-02-27 1994-06-01 日産化学工業株式会社 ピリダジノン誘導体
US4892947A (en) * 1985-04-27 1990-01-09 Nissan Chemical Industries Ltd. 3(2H)Pyridazinone, process for its preparation and anti-allergic agent containing it
YU134686A (en) * 1985-07-30 1988-02-29 Nissan Chemical Ind Ltd Process for preparing new derivatives 3-(2h)-pyridazinone
HU195645B (en) * 1985-10-30 1988-06-28 Gyogyszerkutato Intezet Process for preparing novel 3(2h)-pyridazinone derivatives and pharmaceutical compositions comprising the same
US4859672A (en) * 1986-10-29 1989-08-22 Rorer Pharmaceutical Corporation Pyrido[2,3-d]pyrimidinone and imidazo[4,5-b]pyrimidinone
HU198696B (en) * 1987-01-20 1989-11-28 Nissan Chemical Ind Ltd Process for producing 3/2h/-pyridazinon derivatives and pharmaceutical compositions containing them as active components
GB8903130D0 (en) * 1989-02-11 1989-03-30 Orion Yhtymae Oy Substituted pyridazinones

Also Published As

Publication number Publication date
FI93956C (fi) 1995-06-26
HUT52094A (en) 1990-06-28
CN1022565C (zh) 1993-10-27
KR900009626A (ko) 1990-07-05
MD383C2 (ro) 1996-06-30
ZA899320B (en) 1991-02-27
US5034391A (en) 1991-07-23
LTIP1808A (en) 1995-08-25
LT3945B (en) 1996-05-27
MD382C2 (ro) 1996-06-30
CA2004298A1 (en) 1990-06-06
IE62890B1 (en) 1995-03-08
MY106282A (en) 1995-04-29
UA19756A1 (uk) 1997-12-25
RU1823874C (ru) 1993-06-23
NO894856L (no) 1990-06-07
DK611789D0 (da) 1989-12-05
DK611789A (da) 1990-06-07
FI93956B (fi) 1995-03-15
DK169102B1 (da) 1994-08-15
PT92488B (pt) 1995-08-09
NZ231625A (en) 1991-02-26
EP0372305A1 (de) 1990-06-13
LTIP1615A (en) 1995-07-25
ES2058449T3 (es) 1994-11-01
DD290885A5 (de) 1991-06-13
YU229289A (en) 1991-10-31
HU203748B (en) 1991-09-30
JPH02200676A (ja) 1990-08-08
NO173441B (no) 1993-09-06
GR3008659T3 (pt) 1993-11-30
AU622501B2 (en) 1992-04-09
RU2024517C1 (ru) 1994-12-15
NO173441C (no) 1993-12-15
EP0372305B1 (de) 1993-08-04
IE893721L (en) 1990-06-06
ATE92487T1 (de) 1993-08-15
AU4589889A (en) 1990-06-14
CN1043129A (zh) 1990-06-20
LV10273A (lv) 1994-10-20
IL92442A0 (en) 1990-08-31
DE58905151D1 (de) 1993-09-09
NO894856D0 (no) 1989-12-05
FI895824A0 (fi) 1989-12-05
LV10273B (en) 1995-04-20

Similar Documents

Publication Publication Date Title
FI895824A0 (fi) Menetelmä uusien piperatsinyylialkyyli-3(2H)-pyridatsinonien valmistamiseksi
HUP0400992A2 (hu) Karbonsavval helyettesített oxazol-származékok, eljárás előállításukra és PPAR-alfa- és -gamma-aktivátorként való alkalmazásuk diabétesz kezelésére felhasználható gyógyszerek készítésére
ID24228A (id) (+)norcisaprida yang berguna untuk gangguan tertular 5-ht3 dan 5-ht4
DK26289A (da) Anvendelse af 1,4-disubstitueret piperidinyl til fremstilling af et farmaceutisk praeparat til behandling af insomnia
NO975094L (no) Vinylpyrrolidoncefalosporinderivater
ATE31921T1 (de) Amidine, verfahren zu ihrer herstellung und deren anwendung in der therapie.
DK527984A (da) 11-substituerede 5h,11h-pyrrolo(2,1-c)(1,4)benzoxazepiner eller farmaceutisk acceptable salte deraf, deres fremstilling og mellemprodukter hertil samt deres anvendelse som antipsychotika og analgetika
ATE173252T1 (de) Arylmorpholine, herstellung und verwendung
DE60013876D1 (de) Nitroxyderivate von (r) und (s)-carnitin
NO162821C (no) Fremgangsmaate for fremstilling av terapeutisk aktive furo-pyridinderivater.
DK461687D0 (da) Benzhydryloxyethylpiperidinderivater og salte deraf samt deres fremstilling og anvendelse.
DK0699198T3 (da) N-benzoylmethyl-substituerede paroxetinderivater
NO951588L (no) 4-kinolinylderivater
RU96117005A (ru) Производные пиперидинилметилоксазолидинона, способ их получения и применение
YU35889A (en) Process for preparing new basically substituted 5-halogen thienoizothiazol-3(2h)-on-1,1-dioxides
DK484684A (da) Derivater af 4-alkyl-2-hydroxy-3-methyl-2-phenylmorpholin, fremgangsmaade til deres fremstilling og deres terapeutiske anvendelse
ES8101045A1 (es) Procedimiento para la preparacion de derivados de acidos pi-rrolidinilsulfamoilbenzoicos sustituidos
FI861328A7 (fi) Nya 1,2-benzioxazol-3-yl- och 1,2-benzisotiazol-3-yl-derivat.
NO831040L (no) Enantiomerer av substituerte fenylazacykloalkaner og fremgangsmaate for deres fremstilling
DK0871611T3 (da) Hidtil ukendte glycylanilidderivater, deres fremstilling og deres terapeutiske anvendelse

Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19950404

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19981031