PT937041E - Utilizacao de um sal farmaceuticamente aceitavel de (3r,2'r)-3-¬(ciclopentil-hidroxifenilacetil)oxi|-1,1-dimetil-pirrolidinio para a preparacao de um medicamento - Google Patents

Utilizacao de um sal farmaceuticamente aceitavel de (3r,2'r)-3-¬(ciclopentil-hidroxifenilacetil)oxi|-1,1-dimetil-pirrolidinio para a preparacao de um medicamento

Info

Publication number
PT937041E
PT937041E PT97911049T PT97911049T PT937041E PT 937041 E PT937041 E PT 937041E PT 97911049 T PT97911049 T PT 97911049T PT 97911049 T PT97911049 T PT 97911049T PT 937041 E PT937041 E PT 937041E
Authority
PT
Portugal
Prior art keywords
pharmaceutically acceptable
cyclopentil
hydroxyphenylethyl
pyrrolidines
medication
Prior art date
Application number
PT97911049T
Other languages
English (en)
Inventor
Christian R Noe
Ernst Mutschler
Gunter Lambrecht
Michael Elgert
Sittah Czeche
Magali Waelbroeck
Original Assignee
Christian R Noe
Ernst Mutschler
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Christian R Noe, Ernst Mutschler filed Critical Christian R Noe
Publication of PT937041E publication Critical patent/PT937041E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
PT97911049T 1996-11-11 1997-11-11 Utilizacao de um sal farmaceuticamente aceitavel de (3r,2'r)-3-¬(ciclopentil-hidroxifenilacetil)oxi|-1,1-dimetil-pirrolidinio para a preparacao de um medicamento PT937041E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT197396 1996-11-11

Publications (1)

Publication Number Publication Date
PT937041E true PT937041E (pt) 2003-09-30

Family

ID=3525062

Family Applications (2)

Application Number Title Priority Date Filing Date
PT3005232T PT1371645E (pt) 1996-11-11 1997-11-11 Utilização de (3s,2¿r)-glicopirrónio como produto farmacêutico
PT97911049T PT937041E (pt) 1996-11-11 1997-11-11 Utilizacao de um sal farmaceuticamente aceitavel de (3r,2'r)-3-¬(ciclopentil-hidroxifenilacetil)oxi|-1,1-dimetil-pirrolidinio para a preparacao de um medicamento

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT3005232T PT1371645E (pt) 1996-11-11 1997-11-11 Utilização de (3s,2¿r)-glicopirrónio como produto farmacêutico

Country Status (18)

Country Link
US (1) US6307060B1 (pt)
EP (3) EP0937041B1 (pt)
JP (1) JP2001504459A (pt)
CN (1) CN100391942C (pt)
AT (1) ATE238280T1 (pt)
AU (1) AU745331B2 (pt)
CA (1) CA2271276C (pt)
DE (1) DE59709927D1 (pt)
DK (2) DK1371645T3 (pt)
ES (2) ES2195121T3 (pt)
HU (1) HU228273B1 (pt)
NO (1) NO314354B1 (pt)
NZ (1) NZ336202A (pt)
PL (1) PL195520B1 (pt)
PT (2) PT1371645E (pt)
RU (1) RU2238936C2 (pt)
SI (2) SI0937041T1 (pt)
WO (1) WO1998021183A1 (pt)

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GB0428418D0 (en) * 2004-12-24 2005-02-02 Novartis Ag Organic compounds
GB0428416D0 (en) 2004-12-24 2005-02-02 Novartis Ag Organic compounds
GB0504463D0 (en) 2005-03-03 2005-04-13 Arakis Ltd Method of crystallisation and purification
SI1863476T1 (sl) * 2005-03-16 2016-05-31 Meda Pharma Gmbh & Co. Kg Kombinacija antiholinergikov in antagonistov receptorja levkotriena za zdravljenje respiratornih bolezni
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EP1879571A1 (de) * 2005-04-23 2008-01-23 Boehringer Ingelheim International GmbH Arzneimittelkombination für die inhalation enthaltend neben einem anticholinergikum ein betamimetikum und ein steroid
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WO2011157536A1 (en) * 2010-06-14 2011-12-22 Chiesi Farmaceutici S.P.A. Process for the preparation of glycopyrronium chloride
CN102939280B (zh) * 2010-06-14 2014-11-19 奇斯药制品公司 格隆氯铵的晶型
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CN102627595A (zh) * 2012-03-09 2012-08-08 徐奎 一种制备格隆溴铵的方法
US8558008B2 (en) 2013-02-28 2013-10-15 Dermira, Inc. Crystalline glycopyrrolate tosylate
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WO2014141069A1 (en) 2013-03-14 2014-09-18 Novartis Ag Deamorphization of spray-dried formulations via spray-blending
US9452139B2 (en) 2013-03-14 2016-09-27 Novartis Ag Respirable agglomerates of porous carrier particles and micronized drug
CN104586841A (zh) * 2013-10-30 2015-05-06 中国药科大学 (3r,2’r)-格隆溴铵作为m3毒蕈碱性受体拮抗剂在制药中的用途
US9926270B2 (en) 2014-08-20 2018-03-27 Dermira, Inc. Process for production of glycopyrronium tosylate
US10131630B2 (en) 2014-12-24 2018-11-20 Laboratorios Lesvi, S.L. Process for preparing (3RS)-3-[(2SR)-(2-cyclopentyl-2-hydroxy-2-phenylacetyl)oxy]-1,1-dimethylpyrrolidinium bromide
CN107304178B (zh) * 2016-04-21 2020-03-27 辽宁药联制药有限公司 一种毒蕈碱受体拮抗剂格隆溴铵手性对映体的制备方法
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Also Published As

Publication number Publication date
HK1061023A1 (en) 2004-09-03
DK0937041T3 (da) 2003-08-11
AU4856097A (en) 1998-06-03
ES2407135T3 (es) 2013-06-11
PL195520B1 (pl) 2007-09-28
AU745331B2 (en) 2002-03-21
NO314354B1 (no) 2003-03-10
RU2238936C2 (ru) 2004-10-27
CA2271276A1 (en) 1998-05-22
HUP9903791A2 (hu) 2000-03-28
CN1237159A (zh) 1999-12-01
SI0937041T1 (en) 2003-10-31
EP0937041A1 (de) 1999-08-25
NZ336202A (en) 2000-10-27
NO991056L (no) 1999-05-11
SI1371645T1 (sl) 2013-07-31
EP0937041B1 (de) 2003-04-23
ATE238280T1 (de) 2003-05-15
HU228273B1 (en) 2013-02-28
EP1371645A1 (de) 2003-12-17
US6307060B1 (en) 2001-10-23
NO991056D0 (no) 1999-03-03
PL332595A1 (en) 1999-09-27
DK1371645T3 (da) 2013-06-03
JP2001504459A (ja) 2001-04-03
DE59709927D1 (de) 2003-05-28
EP1371645B1 (de) 2013-02-20
WO1998021183A1 (de) 1998-05-22
HUP9903791A3 (en) 2001-10-29
CA2271276C (en) 2009-01-13
PT1371645E (pt) 2013-05-21
EP1369414A1 (de) 2003-12-10
ES2195121T3 (es) 2003-12-01
CN100391942C (zh) 2008-06-04

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