PT94754A - Processo de obtencao de inibidor de factor de necrose tumoral e de isolamento de genes que codificam o referido inibidor - Google Patents
Processo de obtencao de inibidor de factor de necrose tumoral e de isolamento de genes que codificam o referido inibidorInfo
- Publication number
- PT94754A PT94754A PT94754A PT9475490A PT94754A PT 94754 A PT94754 A PT 94754A PT 94754 A PT94754 A PT 94754A PT 9475490 A PT9475490 A PT 9475490A PT 94754 A PT94754 A PT 94754A
- Authority
- PT
- Portugal
- Prior art keywords
- tnf
- inhibitor
- necrosis factor
- tumor necrosis
- genes
- Prior art date
Links
- 239000002451 tumor necrosis factor inhibitor Substances 0.000 title abstract 8
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title 1
- 229940046728 tumor necrosis factor alpha inhibitor Drugs 0.000 abstract 7
- 108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 6
- 102000003390 tumor necrosis factor Human genes 0.000 abstract 6
- 102000003886 Glycoproteins Human genes 0.000 abstract 1
- 108090000288 Glycoproteins Proteins 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 210000002700 urine Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
- C07K17/06—Peptides being immobilised on, or in, an organic carrier attached to the carrier via a bridging agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38108089A | 1989-07-18 | 1989-07-18 | |
| US45032989A | 1989-12-11 | 1989-12-11 | |
| US47966190A | 1990-02-07 | 1990-02-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT94754A true PT94754A (pt) | 1991-03-20 |
| PT94754B PT94754B (pt) | 1997-04-30 |
Family
ID=27409520
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT94754A PT94754B (pt) | 1989-07-18 | 1990-07-18 | Processo de obtencao de inibidor de factor de necrose tumoral e de isolamento de genes que codificam o referido inibidor |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6541620B1 (pt) |
| EP (2) | EP0422339B1 (pt) |
| JP (1) | JPH03163099A (pt) |
| KR (1) | KR100230156B1 (pt) |
| AT (1) | ATE162801T1 (pt) |
| AU (1) | AU647397B2 (pt) |
| CA (1) | CA2021369A1 (pt) |
| DE (1) | DE69031997T2 (pt) |
| DK (1) | DK0422339T3 (pt) |
| ES (1) | ES2116970T3 (pt) |
| FI (1) | FI114398B (pt) |
| GR (1) | GR3026416T3 (pt) |
| IE (2) | IE990595A1 (pt) |
| IL (2) | IL95031A (pt) |
| NO (1) | NO306728B1 (pt) |
| NZ (1) | NZ234499A (pt) |
| PL (1) | PL168844B1 (pt) |
| PT (1) | PT94754B (pt) |
| SG (1) | SG55131A1 (pt) |
| TW (1) | TW206234B (pt) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5811261A (en) * | 1988-09-12 | 1998-09-22 | Yeda Research And Development Co. Ltd. | Expression of the recombinant tumor necrosis factor binding protein I (TBP-I) |
| US6221675B1 (en) | 1989-04-21 | 2001-04-24 | Amgen, Inc. | TNF receptors, TNF binding proteins and DNAs coding for them |
| US7264944B1 (en) | 1989-04-21 | 2007-09-04 | Amgen Inc. | TNF receptors, TNF binding proteins and DNAs coding for them |
| DE59010941D1 (de) * | 1989-04-21 | 2005-03-24 | Amgen Inc | TNF-Rezeptor, TNF bindende Proteine und dafür kodierende DNAs |
| US6262239B1 (en) | 1989-05-18 | 2001-07-17 | Yeda Research And Development Co., Ltd. | TNF receptor-specific antibodies |
| US6232446B1 (en) | 1989-05-18 | 2001-05-15 | Yeda Research And Development Co. Ltd. | TNF ligands |
| IL95031A (en) | 1989-07-18 | 2007-03-08 | Amgen Inc | Method for the production of a human recombinant tumor necrosis factor inhibitor |
| US6143866A (en) * | 1989-07-18 | 2000-11-07 | Amgen, Inc. | Tumor necrosis factor (TNF) inhibitor and method for obtaining the same |
| US5395760A (en) * | 1989-09-05 | 1995-03-07 | Immunex Corporation | DNA encoding tumor necrosis factor-α and -β receptors |
| US5945397A (en) * | 1989-09-05 | 1999-08-31 | Immunex Corporation | Purified p75 (type II) tumor necrosis factor receptor polypeptides |
| US5605690A (en) * | 1989-09-05 | 1997-02-25 | Immunex Corporation | Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor |
| US6541610B1 (en) | 1989-09-05 | 2003-04-01 | Immunex Corporation | Fusion proteins comprising tumor necrosis factor receptor |
| DE59010908D1 (de) | 1989-09-12 | 2000-08-10 | Hoffmann La Roche | TNF-bindende Proteine |
| US6552170B1 (en) | 1990-04-06 | 2003-04-22 | Amgen Inc. | PEGylation reagents and compounds formed therewith |
| EP0480389A1 (de) * | 1990-10-12 | 1992-04-15 | Hoechst Aktiengesellschaft | Inhibitoren für die Bildung von Tumor Nekrose Faktor, Verfahren zu deren Herstellung und deren Verwendung |
| GB9027917D0 (en) | 1990-12-21 | 1991-02-13 | Ici Plc | Expression systems |
| GEP20002142B (en) * | 1991-01-18 | 2000-06-25 | Amgen Inc | Method for Treatment and Prevention of TNF Mediated Diseases |
| DE69333027T2 (de) * | 1992-03-30 | 2004-05-06 | Immunex Corp., Seattle | Fusionsprotein , das zwei rezeptoren des tumornekrose-faktors enthält |
| CA2118119C (en) * | 1992-04-30 | 2001-07-31 | Robert C. Thompson | Methods for treating interleukin-1 and tumor necrosis factor mediated diseases |
| US6270766B1 (en) | 1992-10-08 | 2001-08-07 | The Kennedy Institute Of Rheumatology | Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease |
| IT1276040B1 (it) * | 1993-07-27 | 1997-10-24 | Angelini Francesco Ist Ricerca | Uso della benzidamina nel trattamento di stati patologici causati dal tnf |
| WO1997028828A1 (en) | 1996-02-09 | 1997-08-14 | Amgen Boulder Inc. | Composition comprising interleukin-1 inhibitor and controlled release polymer |
| US5747639A (en) * | 1996-03-06 | 1998-05-05 | Amgen Boulder Inc. | Use of hydrophobic interaction chromatography to purify polyethylene glycols |
| TW555765B (en) * | 1996-07-09 | 2003-10-01 | Amgen Inc | Low molecular weight soluble tumor necrosis factor type-I and type-II proteins |
| ATE247974T1 (de) | 1996-12-06 | 2003-09-15 | Amgen Inc | Kombinationtherapie mit einem tnf-bindendem protein zür behandlung von durch tnf verursachten erkrangungen |
| CA2273852C (en) | 1996-12-06 | 2009-09-29 | Amgen Inc. | Combination therapy using an il-1 inhibitor for treating il-1 mediated diseases |
| ATE281458T1 (de) * | 1997-09-05 | 2004-11-15 | Glaxo Group Ltd | Pharmazeutische zusammensetzung, enthaltend 2,3- diaryl-pyrazolo(1,5-b)pyridazin derivate |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| US20040220103A1 (en) | 1999-04-19 | 2004-11-04 | Immunex Corporation | Soluble tumor necrosis factor receptor treatment of medical disorders |
| US6808902B1 (en) | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
| WO2001064889A2 (en) | 2000-03-02 | 2001-09-07 | Xencor | Tnf-alpha variants for the treatment of tnf-alpha related disorders |
| TWI322154B (en) | 2000-03-16 | 2010-03-21 | Amgen Inc | Il-17 receptor like molecules and uses thereof |
| US7879448B2 (en) * | 2000-07-11 | 2011-02-01 | Guardian Industires Corp. | Coated article with low-E coating including IR reflecting layer(s) and corresponding method |
| ES2327102T3 (es) | 2000-09-05 | 2009-10-26 | Amgen Inc. | Moleculas analogas al receptor de tnf y usos de las mismas. |
| US7087224B2 (en) | 2000-10-31 | 2006-08-08 | Amgen Inc. | Method of treating anemia by administering IL-1ra |
| TR201809678T4 (tr) | 2001-06-26 | 2018-07-23 | Amgen Fremont Inc | Opgl ye karşi antikorlar. |
| US7084257B2 (en) | 2001-10-05 | 2006-08-01 | Amgen Inc. | Fully human antibody Fab fragments with human interferon-gamma neutralizing activity |
| WO2004060911A2 (en) | 2002-12-30 | 2004-07-22 | Amgen Inc. | Combination therapy with co-stimulatory factors |
| EP1684791A4 (en) | 2003-10-27 | 2009-07-01 | Amgen Inc | COMPOSITIONS AND METHODS FOR MODULATION OF IMMUNE REACTION TO AN IMMUNOGENIC THERAPEUTIC AGENT |
| US7785834B2 (en) * | 2005-11-10 | 2010-08-31 | Ercole Biotech, Inc. | Soluble TNF receptors and their use in treatment of disease |
| WO2007058894A2 (en) * | 2005-11-10 | 2007-05-24 | The University Of North Carolina At Chapel Hill | Splice switching oligomers for tnf superfamily receptors and their use in treatment of disease |
| AR056806A1 (es) | 2005-11-14 | 2007-10-24 | Amgen Inc | Moleculas quimericas de anticuerpo rankl- pth/ pthrp |
| US8795668B2 (en) * | 2005-12-23 | 2014-08-05 | The Regents Of The University Of Michigan | Methods for treating pulmonary fibrosis |
| US7767206B2 (en) | 2006-10-02 | 2010-08-03 | Amgen Inc. | Neutralizing determinants of IL-17 Receptor A and antibodies that bind thereto |
| US20090264353A1 (en) * | 2007-10-19 | 2009-10-22 | Santaris Pharma A/S | Splice Switching Oligomers for TNF Superfamily Receptors and their Use in Treatment of Disease |
| GB0708376D0 (en) | 2007-05-01 | 2007-06-06 | Alligator Bioscience Ab | Novel polypeptides and uses thereof |
| US9052304B2 (en) | 2009-03-13 | 2015-06-09 | Terrasep, Llc | Methods and apparatus for centrifugal liquid chromatography |
| TW201117824A (en) | 2009-10-12 | 2011-06-01 | Amgen Inc | Use of IL-17 receptor a antigen binding proteins |
| SI2523688T1 (en) | 2010-01-15 | 2018-03-30 | Kirin-Amgen, Inc. | Formulation of antibodies and therapeutic regimes |
| US20140234330A1 (en) | 2011-07-22 | 2014-08-21 | Amgen Inc. | Il-17 receptor a is required for il-17c biology |
| KR102530900B1 (ko) | 2014-03-31 | 2023-05-12 | 암젠 케이-에이, 인크. | 손발톱 및 두피 건선의 치료 방법 |
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| US5811261A (en) | 1988-09-12 | 1998-09-22 | Yeda Research And Development Co. Ltd. | Expression of the recombinant tumor necrosis factor binding protein I (TBP-I) |
| US5359037A (en) | 1988-09-12 | 1994-10-25 | Yeda Research And Development Co. Ltd. | Antibodies to TNF binding protein I |
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| DE59010941D1 (de) * | 1989-04-21 | 2005-03-24 | Amgen Inc | TNF-Rezeptor, TNF bindende Proteine und dafür kodierende DNAs |
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-
1990
- 1990-07-10 IL IL95031A patent/IL95031A/en active IP Right Grant
- 1990-07-13 NZ NZ234499A patent/NZ234499A/en unknown
- 1990-07-16 FI FI903591A patent/FI114398B/fi active IP Right Grant
- 1990-07-16 AU AU58976/90A patent/AU647397B2/en not_active Ceased
- 1990-07-17 EP EP90113673A patent/EP0422339B1/en not_active Revoked
- 1990-07-17 PL PL90286089A patent/PL168844B1/pl unknown
- 1990-07-17 IE IE19990595A patent/IE990595A1/en not_active IP Right Cessation
- 1990-07-17 DK DK90113673T patent/DK0422339T3/da active
- 1990-07-17 ES ES90113673T patent/ES2116970T3/es not_active Expired - Lifetime
- 1990-07-17 IE IE260890A patent/IE902608A1/en not_active IP Right Cessation
- 1990-07-17 EP EP97103361A patent/EP0790306A3/en not_active Withdrawn
- 1990-07-17 NO NO903192A patent/NO306728B1/no not_active IP Right Cessation
- 1990-07-17 AT AT90113673T patent/ATE162801T1/de not_active IP Right Cessation
- 1990-07-17 CA CA002021369A patent/CA2021369A1/en not_active Withdrawn
- 1990-07-17 DE DE69031997T patent/DE69031997T2/de not_active Revoked
- 1990-07-17 SG SG1996007310A patent/SG55131A1/en unknown
- 1990-07-18 TW TW079105968A patent/TW206234B/zh active
- 1990-07-18 PT PT94754A patent/PT94754B/pt not_active IP Right Cessation
- 1990-07-18 JP JP2190372A patent/JPH03163099A/ja active Pending
- 1990-07-18 KR KR1019900010841A patent/KR100230156B1/ko not_active Expired - Fee Related
-
1995
- 1995-06-07 US US08/484,337 patent/US6541620B1/en not_active Expired - Lifetime
-
1998
- 1998-03-20 GR GR980400606T patent/GR3026416T3/el unknown
-
1999
- 1999-08-05 IL IL13128199A patent/IL131281A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR910015309A (ko) | 1991-09-30 |
| NZ234499A (en) | 1992-08-26 |
| FI903591A0 (fi) | 1990-07-16 |
| FI114398B (fi) | 2004-10-15 |
| PT94754B (pt) | 1997-04-30 |
| NO306728B1 (no) | 1999-12-13 |
| EP0422339B1 (en) | 1998-01-28 |
| GR3026416T3 (en) | 1998-06-30 |
| EP0422339A1 (en) | 1991-04-17 |
| EP0790306A3 (en) | 1998-07-01 |
| NO306728B3 (pt) | 2003-02-17 |
| AU5897690A (en) | 1991-01-24 |
| PL286089A1 (en) | 1991-07-29 |
| ES2116970T3 (es) | 1998-08-01 |
| IL95031A0 (en) | 1991-06-10 |
| NO903192D0 (no) | 1990-07-17 |
| KR100230156B1 (ko) | 1999-11-15 |
| CA2021369A1 (en) | 1991-01-19 |
| HK1014539A1 (en) | 1999-09-30 |
| NO903192L (no) | 1991-01-21 |
| TW206234B (pt) | 1993-05-21 |
| IL95031A (en) | 2007-03-08 |
| IL131281A0 (en) | 2001-01-28 |
| ATE162801T1 (de) | 1998-02-15 |
| IE902608A1 (en) | 1991-02-27 |
| DE69031997T2 (de) | 1998-05-14 |
| DE69031997D1 (de) | 1998-03-05 |
| PL168844B1 (pl) | 1996-04-30 |
| SG55131A1 (en) | 1998-12-21 |
| IE990595A1 (en) | 2000-11-15 |
| AU647397B2 (en) | 1994-03-24 |
| EP0790306A2 (en) | 1997-08-20 |
| DK0422339T3 (da) | 1998-09-23 |
| JPH03163099A (ja) | 1991-07-15 |
| US6541620B1 (en) | 2003-04-01 |
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Legal Events
| Date | Code | Title | Description |
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| BB1A | Laying open of patent application |
Effective date: 19901018 |
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| PC3A | Transfer or assignment |
Free format text: 20000906 AMGEN INC. US |
|
| PD3A | Change of proprietorship |
Owner name: AMGEN BOULDER INC. Effective date: 20000906 |
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| MM4A | Annulment/lapse due to non-payment of fees, searched and examined patent |
Free format text: MAXIMUM VALIDITY LIMIT REACHED Effective date: 20120109 |