NO903192L - Tumor necrosis faktor (tnf) inhibitor og fremgangsmaate for oppnaaelse av samme. - Google Patents
Tumor necrosis faktor (tnf) inhibitor og fremgangsmaate for oppnaaelse av samme.Info
- Publication number
- NO903192L NO903192L NO90903192A NO903192A NO903192L NO 903192 L NO903192 L NO 903192L NO 90903192 A NO90903192 A NO 90903192A NO 903192 A NO903192 A NO 903192A NO 903192 L NO903192 L NO 903192L
- Authority
- NO
- Norway
- Prior art keywords
- tnf
- inhibitor
- necrosis factor
- tumor necrosis
- 40kda
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
- C07K17/06—Peptides being immobilised on, or in, an organic carrier attached to the carrier via a bridging agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38108089A | 1989-07-18 | 1989-07-18 | |
| US45032989A | 1989-12-11 | 1989-12-11 | |
| US47966190A | 1990-02-07 | 1990-02-07 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO903192D0 NO903192D0 (no) | 1990-07-17 |
| NO903192L true NO903192L (no) | 1991-01-21 |
| NO306728B1 NO306728B1 (no) | 1999-12-13 |
| NO306728B3 NO306728B3 (no) | 2003-02-17 |
Family
ID=27409520
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO903192A NO306728B1 (no) | 1989-07-18 | 1990-07-17 | Fremgangsmåte for fremstilling av en human rekombinant TNF inhibitor og nukleinsyre |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6541620B1 (no) |
| EP (2) | EP0790306A3 (no) |
| JP (1) | JPH03163099A (no) |
| KR (1) | KR100230156B1 (no) |
| AT (1) | ATE162801T1 (no) |
| AU (1) | AU647397B2 (no) |
| CA (1) | CA2021369A1 (no) |
| DE (1) | DE69031997T2 (no) |
| DK (1) | DK0422339T3 (no) |
| ES (1) | ES2116970T3 (no) |
| FI (1) | FI114398B (no) |
| GR (1) | GR3026416T3 (no) |
| IE (2) | IE902608A1 (no) |
| IL (2) | IL95031A (no) |
| NO (1) | NO306728B1 (no) |
| NZ (1) | NZ234499A (no) |
| PL (1) | PL168844B1 (no) |
| PT (1) | PT94754B (no) |
| SG (1) | SG55131A1 (no) |
| TW (1) | TW206234B (no) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5811261A (en) * | 1988-09-12 | 1998-09-22 | Yeda Research And Development Co. Ltd. | Expression of the recombinant tumor necrosis factor binding protein I (TBP-I) |
| ATE289350T1 (de) * | 1989-04-21 | 2005-03-15 | Amgen Inc | Tnf-rezeptor, tnf bindende proteine und dafür kodierende dnas |
| US6221675B1 (en) | 1989-04-21 | 2001-04-24 | Amgen, Inc. | TNF receptors, TNF binding proteins and DNAs coding for them |
| US7264944B1 (en) | 1989-04-21 | 2007-09-04 | Amgen Inc. | TNF receptors, TNF binding proteins and DNAs coding for them |
| US6262239B1 (en) | 1989-05-18 | 2001-07-17 | Yeda Research And Development Co., Ltd. | TNF receptor-specific antibodies |
| US6232446B1 (en) | 1989-05-18 | 2001-05-15 | Yeda Research And Development Co. Ltd. | TNF ligands |
| IL95031A (en) | 1989-07-18 | 2007-03-08 | Amgen Inc | Method for the production of a human recombinant tumor necrosis factor inhibitor |
| US6143866A (en) * | 1989-07-18 | 2000-11-07 | Amgen, Inc. | Tumor necrosis factor (TNF) inhibitor and method for obtaining the same |
| US5945397A (en) * | 1989-09-05 | 1999-08-31 | Immunex Corporation | Purified p75 (type II) tumor necrosis factor receptor polypeptides |
| US5605690A (en) * | 1989-09-05 | 1997-02-25 | Immunex Corporation | Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor |
| US6541610B1 (en) * | 1989-09-05 | 2003-04-01 | Immunex Corporation | Fusion proteins comprising tumor necrosis factor receptor |
| US5395760A (en) * | 1989-09-05 | 1995-03-07 | Immunex Corporation | DNA encoding tumor necrosis factor-α and -β receptors |
| ATE194384T1 (de) | 1989-09-12 | 2000-07-15 | Hoffmann La Roche | Tnf-bindende proteine |
| US6552170B1 (en) | 1990-04-06 | 2003-04-22 | Amgen Inc. | PEGylation reagents and compounds formed therewith |
| EP0480389A1 (de) * | 1990-10-12 | 1992-04-15 | Hoechst Aktiengesellschaft | Inhibitoren für die Bildung von Tumor Nekrose Faktor, Verfahren zu deren Herstellung und deren Verwendung |
| GB9027917D0 (en) | 1990-12-21 | 1991-02-13 | Ici Plc | Expression systems |
| ATE190629T1 (de) * | 1991-01-18 | 2000-04-15 | Amgen Inc | Methoden zur behandlung von durch den tumor nekrose faktor ausgelösten krankheiten |
| NZ251820A (en) * | 1992-03-30 | 1996-07-26 | Immunex Corp | Fusion proteins with tnf-r (tumour necrosis factor-receptor) peptide linked to another tnf-r or an il-1r (interleukin-1-receptor) peptide |
| JPH07509223A (ja) * | 1992-04-30 | 1995-10-12 | アムジェン インコーポレイテッド | インターロイキン−1媒介疾患および腫瘍壊死因子媒介疾患の治療方法 |
| US6270766B1 (en) | 1992-10-08 | 2001-08-07 | The Kennedy Institute Of Rheumatology | Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease |
| IT1276040B1 (it) * | 1993-07-27 | 1997-10-24 | Angelini Francesco Ist Ricerca | Uso della benzidamina nel trattamento di stati patologici causati dal tnf |
| CA2244664C (en) | 1996-02-09 | 2008-06-03 | Amgen Inc. | Composition comprising interleukin-1 inhibitor and controlled release polymer |
| US5747639A (en) * | 1996-03-06 | 1998-05-05 | Amgen Boulder Inc. | Use of hydrophobic interaction chromatography to purify polyethylene glycols |
| TW555765B (en) | 1996-07-09 | 2003-10-01 | Amgen Inc | Low molecular weight soluble tumor necrosis factor type-I and type-II proteins |
| JP2001513754A (ja) | 1996-12-06 | 2001-09-04 | アムジェン インコーポレイテッド | Tnf媒介疾患を処置するためのtnf結合タンパク質を使用する組み合わせ治療 |
| JP4771563B2 (ja) | 1996-12-06 | 2011-09-14 | アムジエン・インコーポレーテツド | Il−1媒介疾患を処置するためにil−1インヒビターを使用する組合せ療法 |
| ES2256817T3 (es) * | 1997-09-05 | 2006-07-16 | Glaxo Group Limited | Composiciones farmaceuticas que comprenden derivados de 2,3-diaril-pirazolo(1,5-b)piridazina. |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| US20040220103A1 (en) | 1999-04-19 | 2004-11-04 | Immunex Corporation | Soluble tumor necrosis factor receptor treatment of medical disorders |
| US6808902B1 (en) | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
| JP2003525612A (ja) | 2000-03-02 | 2003-09-02 | ゼンコー | TNF−α関連障害の処置のための変種TNF−αタンパク質の設計および発見 |
| TWI322154B (en) | 2000-03-16 | 2010-03-21 | Amgen Inc | Il-17 receptor like molecules and uses thereof |
| US7879448B2 (en) * | 2000-07-11 | 2011-02-01 | Guardian Industires Corp. | Coated article with low-E coating including IR reflecting layer(s) and corresponding method |
| DE60138715D1 (de) | 2000-09-05 | 2009-06-25 | Amgen Inc | Tnf-rezeptor-ähnliche moleküle und deren anwendungen |
| US7087224B2 (en) | 2000-10-31 | 2006-08-08 | Amgen Inc. | Method of treating anemia by administering IL-1ra |
| PH12012502440A1 (en) | 2001-06-26 | 2013-06-17 | Amgen Inc | Antibodies to opgl |
| US7084257B2 (en) | 2001-10-05 | 2006-08-01 | Amgen Inc. | Fully human antibody Fab fragments with human interferon-gamma neutralizing activity |
| AU2003299971A1 (en) | 2002-12-30 | 2004-07-29 | Amgen Inc. | Combination therapy with co-stimulatory factors |
| AU2004287431B2 (en) | 2003-10-27 | 2010-03-11 | Amgen Inc. | Compositions and methods to modulate an immune response to an immunogenic therapeutic agent |
| KR101789603B1 (ko) * | 2005-11-10 | 2017-11-21 | 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 | Tnf 수퍼패밀리 수용체에 대한 스플라이스 스위칭올리고머 및 염증성 질환 치료용 약제학적 조성물 |
| US7785834B2 (en) * | 2005-11-10 | 2010-08-31 | Ercole Biotech, Inc. | Soluble TNF receptors and their use in treatment of disease |
| AR056806A1 (es) | 2005-11-14 | 2007-10-24 | Amgen Inc | Moleculas quimericas de anticuerpo rankl- pth/ pthrp |
| US8795668B2 (en) * | 2005-12-23 | 2014-08-05 | The Regents Of The University Of Michigan | Methods for treating pulmonary fibrosis |
| US7833527B2 (en) | 2006-10-02 | 2010-11-16 | Amgen Inc. | Methods of treating psoriasis using IL-17 Receptor A antibodies |
| US20090264353A1 (en) * | 2007-10-19 | 2009-10-22 | Santaris Pharma A/S | Splice Switching Oligomers for TNF Superfamily Receptors and their Use in Treatment of Disease |
| GB0708376D0 (en) | 2007-05-01 | 2007-06-06 | Alligator Bioscience Ab | Novel polypeptides and uses thereof |
| US8293101B2 (en) | 2009-03-13 | 2012-10-23 | Terrasep, Llc | Methods and apparatus for centrifugal liquid chromatography |
| TW201117824A (en) | 2009-10-12 | 2011-06-01 | Amgen Inc | Use of IL-17 receptor a antigen binding proteins |
| HRP20171939T1 (hr) | 2010-01-15 | 2018-03-23 | Kirin-Amgen, Inc. | Formulacija protutijela i režimi terapije |
| WO2013016220A1 (en) | 2011-07-22 | 2013-01-31 | Amgen Inc. | Il-17 receptor a is required for il-17c biology |
| US20170174772A1 (en) | 2014-03-31 | 2017-06-22 | Kirin-Amgen, Inc. | Methods of treating nail and scalp psoriasis |
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|---|---|---|---|---|
| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| IN150740B (no) | 1978-11-24 | 1982-12-04 | Hoffmann La Roche | |
| US4560649A (en) | 1981-10-15 | 1985-12-24 | Cornell Research Foundation | Assaying for hLH or hCG with immobilized hormone receptors |
| JPH0751511B2 (ja) | 1982-03-15 | 1995-06-05 | 味の素株式会社 | インターロイキン2を含有してなる癌治療剤 |
| US4587046A (en) | 1982-05-18 | 1986-05-06 | The Regents Of The University Of California | Drug-carrier conjugates |
| EP0098110B1 (en) * | 1982-06-24 | 1989-10-18 | NIHON CHEMICAL RESEARCH KABUSHIKI KAISHA also known as JAPAN CHEMICAL RESEARCH CO., LTD | Long-acting composition |
| US4966888A (en) | 1985-07-08 | 1990-10-30 | Cornell Research Foundation, Inc. | hCG-hLH receptor and hCG-hLH receptor-hCG complex as antigens, antibodies thereto and contraceptive vaccine |
| EP0154316B1 (en) | 1984-03-06 | 1989-09-13 | Takeda Chemical Industries, Ltd. | Chemically modified lymphokine and production thereof |
| CA1339269C (en) | 1984-05-21 | 1997-08-12 | Douglas P. Cerretti | Purification of and cloning of the gene for interleukin-2 receptor |
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| US4766106A (en) * | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
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| US4935233A (en) | 1985-12-02 | 1990-06-19 | G. D. Searle And Company | Covalently linked polypeptide cell modulators |
| CA1283046C (en) | 1986-05-29 | 1991-04-16 | Nandini Katre | Tumor necrosis factor formulation |
| IN165717B (no) | 1986-08-07 | 1989-12-23 | Battelle Memorial Institute | |
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| IL80005A (en) | 1986-09-10 | 1992-11-15 | Yeda Res & Dev | Compositions for modulating the effect of tnf and il-1 |
| US5512544A (en) | 1987-09-13 | 1996-04-30 | Yeda Research And Development Co. Ltd. | Pharmaceutical compositions comprising an anticytokine |
| IL98078A0 (en) | 1991-05-07 | 1992-06-21 | Yeda Res & Dev | Pharmaceutical compositions comprising an anticytokyne |
| IL83878A (en) * | 1987-09-13 | 1995-07-31 | Yeda Res & Dev | Soluble protein corresponding to tnf inhibitory protein its preparation and pharmaceutical compositions containing it |
| US4904584A (en) | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
| US4847325A (en) * | 1988-01-20 | 1989-07-11 | Cetus Corporation | Conjugation of polymer to colony stimulating factor-1 |
| US5153265A (en) | 1988-01-20 | 1992-10-06 | Cetus Corporation | Conjugation of polymer to colony stimulating factor-1 |
| GB8806339D0 (en) | 1988-03-17 | 1988-04-13 | Hoffmann La Roche | Monoclonal antibodies |
| GB8807803D0 (en) | 1988-03-31 | 1988-05-05 | Glaxo Group Ltd | Biochemical product |
| US5214131A (en) | 1988-05-06 | 1993-05-25 | Sumitomo Pharmaceuticals Company, Limited | Polyethylene glycol derivatives, modified peptides and production thereof |
| US5811261A (en) | 1988-09-12 | 1998-09-22 | Yeda Research And Development Co. Ltd. | Expression of the recombinant tumor necrosis factor binding protein I (TBP-I) |
| US5359037A (en) | 1988-09-12 | 1994-10-25 | Yeda Research And Development Co. Ltd. | Antibodies to TNF binding protein I |
| US5162430A (en) | 1988-11-21 | 1992-11-10 | Collagen Corporation | Collagen-polymer conjugates |
| US4902502A (en) | 1989-01-23 | 1990-02-20 | Cetus Corporation | Preparation of a polymer/interleukin-2 conjugate |
| US5089261A (en) | 1989-01-23 | 1992-02-18 | Cetus Corporation | Preparation of a polymer/interleukin-2 conjugate |
| US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
| US5166322A (en) | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
| ATE289350T1 (de) * | 1989-04-21 | 2005-03-15 | Amgen Inc | Tnf-rezeptor, tnf bindende proteine und dafür kodierende dnas |
| DE3913101A1 (de) | 1989-04-21 | 1990-10-31 | Boehringer Ingelheim Int | Tnf-(alpha) bindende proteine und dafuer kodierende dnas |
| DE3920282A1 (de) | 1989-06-21 | 1991-01-03 | Boehringer Ingelheim Int | Tnf-rezeptor, tnf bindende proteine und dafuer kodierende dnas |
| JPH03164179A (ja) * | 1989-04-21 | 1991-07-16 | Boehringer Ingelheim Internatl Gmbh | Tnfレセプター、tnf結合たん白質およびこれらをコードするdna |
| DE3922089A1 (de) * | 1989-05-09 | 1990-12-13 | Basf Ag | Neue proteine und ihre herstellung |
| ES2072330T5 (es) * | 1989-05-18 | 2013-06-24 | Yeda Research And Development Co., Ltd. | Proteínas de unión II al Factor de Necrosis Tumoral, su purificación y anticuerpos frente a los mismos |
| IL95031A (en) | 1989-07-18 | 2007-03-08 | Amgen Inc | Method for the production of a human recombinant tumor necrosis factor inhibitor |
| US6143866A (en) * | 1989-07-18 | 2000-11-07 | Amgen, Inc. | Tumor necrosis factor (TNF) inhibitor and method for obtaining the same |
| US5605690A (en) | 1989-09-05 | 1997-02-25 | Immunex Corporation | Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor |
| AU630497B2 (en) | 1989-09-05 | 1992-10-29 | Immunex Corporation | Tumor necrosis factor-alpha and -beta receptors |
| US5395760A (en) | 1989-09-05 | 1995-03-07 | Immunex Corporation | DNA encoding tumor necrosis factor-α and -β receptors |
| NZ235148A (en) * | 1989-09-05 | 1991-12-23 | Immunex Corp | Tumour necrosis factor receptor protein and dna sequences |
| ATE194384T1 (de) | 1989-09-12 | 2000-07-15 | Hoffmann La Roche | Tnf-bindende proteine |
| CA2032191C (en) | 1989-12-13 | 1999-05-18 | David Wallach | Expression of the recombinant tumor necrosis factor binding protein i (tbp-i) |
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| GB2246569A (en) | 1990-06-15 | 1992-02-05 | Charing Cross Sunley Research | Tumour necrosis factor - alpha binding protein |
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| GB9022648D0 (en) | 1990-10-18 | 1990-11-28 | Charing Cross Sunley Research | Polypeptide and its use |
| US5252714A (en) | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
| ATE190629T1 (de) | 1991-01-18 | 2000-04-15 | Amgen Inc | Methoden zur behandlung von durch den tumor nekrose faktor ausgelösten krankheiten |
| ATE241011T1 (de) | 1991-02-27 | 2003-06-15 | Micromet Ag | Serin-reiche peptidlinker |
| DK0575545T3 (da) * | 1991-03-15 | 2003-09-15 | Amgen Inc | Pegylering af polypeptider |
| IL99120A0 (en) | 1991-08-07 | 1992-07-15 | Yeda Res & Dev | Multimers of the soluble forms of tnf receptors,their preparation and pharmaceutical compositions containing them |
| US5382657A (en) | 1992-08-26 | 1995-01-17 | Hoffmann-La Roche Inc. | Peg-interferon conjugates |
| KR100232688B1 (ko) | 1992-09-15 | 1999-12-01 | 스코트 쥐. 홀퀴스트 | 종양 괴사 인자 길항제를 함유하는 tnf-의존성 염증 치료용 제약 조성물 |
| GB9317618D0 (en) | 1993-08-24 | 1993-10-06 | Royal Free Hosp School Med | Polymer modifications |
-
1990
- 1990-07-10 IL IL95031A patent/IL95031A/en active IP Right Grant
- 1990-07-13 NZ NZ234499A patent/NZ234499A/en unknown
- 1990-07-16 AU AU58976/90A patent/AU647397B2/en not_active Ceased
- 1990-07-16 FI FI903591A patent/FI114398B/fi active IP Right Grant
- 1990-07-17 DK DK90113673T patent/DK0422339T3/da active
- 1990-07-17 ES ES90113673T patent/ES2116970T3/es not_active Expired - Lifetime
- 1990-07-17 CA CA002021369A patent/CA2021369A1/en not_active Withdrawn
- 1990-07-17 AT AT90113673T patent/ATE162801T1/de not_active IP Right Cessation
- 1990-07-17 SG SG1996007310A patent/SG55131A1/en unknown
- 1990-07-17 EP EP97103361A patent/EP0790306A3/en not_active Withdrawn
- 1990-07-17 EP EP90113673A patent/EP0422339B1/en not_active Revoked
- 1990-07-17 IE IE260890A patent/IE902608A1/en not_active IP Right Cessation
- 1990-07-17 PL PL90286089A patent/PL168844B1/pl unknown
- 1990-07-17 IE IE19990595A patent/IE990595A1/en not_active IP Right Cessation
- 1990-07-17 DE DE69031997T patent/DE69031997T2/de not_active Revoked
- 1990-07-17 NO NO903192A patent/NO306728B1/no not_active IP Right Cessation
- 1990-07-18 TW TW079105968A patent/TW206234B/zh active
- 1990-07-18 PT PT94754A patent/PT94754B/pt not_active IP Right Cessation
- 1990-07-18 JP JP2190372A patent/JPH03163099A/ja active Pending
- 1990-07-18 KR KR1019900010841A patent/KR100230156B1/ko not_active Expired - Fee Related
-
1995
- 1995-06-07 US US08/484,337 patent/US6541620B1/en not_active Expired - Lifetime
-
1998
- 1998-03-20 GR GR980400606T patent/GR3026416T3/el unknown
-
1999
- 1999-08-05 IL IL13128199A patent/IL131281A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL95031A0 (en) | 1991-06-10 |
| NO306728B1 (no) | 1999-12-13 |
| US6541620B1 (en) | 2003-04-01 |
| HK1014539A1 (en) | 1999-09-30 |
| PT94754A (pt) | 1991-03-20 |
| ES2116970T3 (es) | 1998-08-01 |
| NO306728B3 (no) | 2003-02-17 |
| EP0790306A3 (en) | 1998-07-01 |
| KR100230156B1 (ko) | 1999-11-15 |
| IL95031A (en) | 2007-03-08 |
| PL286089A1 (en) | 1991-07-29 |
| FI114398B (fi) | 2004-10-15 |
| AU647397B2 (en) | 1994-03-24 |
| ATE162801T1 (de) | 1998-02-15 |
| SG55131A1 (en) | 1998-12-21 |
| PT94754B (pt) | 1997-04-30 |
| TW206234B (no) | 1993-05-21 |
| EP0790306A2 (en) | 1997-08-20 |
| DK0422339T3 (da) | 1998-09-23 |
| EP0422339A1 (en) | 1991-04-17 |
| JPH03163099A (ja) | 1991-07-15 |
| EP0422339B1 (en) | 1998-01-28 |
| NO903192D0 (no) | 1990-07-17 |
| AU5897690A (en) | 1991-01-24 |
| GR3026416T3 (en) | 1998-06-30 |
| PL168844B1 (pl) | 1996-04-30 |
| FI903591A0 (fi) | 1990-07-16 |
| KR910015309A (ko) | 1991-09-30 |
| NZ234499A (en) | 1992-08-26 |
| IE990595A1 (en) | 2000-11-15 |
| CA2021369A1 (en) | 1991-01-19 |
| DE69031997D1 (de) | 1998-03-05 |
| DE69031997T2 (de) | 1998-05-14 |
| IE902608A1 (en) | 1991-02-27 |
| IL131281A0 (en) | 2001-01-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LC4 | Limitation of patent rights - b3 (par. 39b patent act) |
Effective date: 20021009 |
|
| MK1K | Patent expired |