PT94761A - Processo para a preparacao de muteinas da eritropoetina humana e de composicoes farmaceuticas que as contem - Google Patents

Processo para a preparacao de muteinas da eritropoetina humana e de composicoes farmaceuticas que as contem

Info

Publication number: PT94761A
Authority: PT; Portugal
Prior art keywords: human; muteins; eritropoetine; preparation; pharmaceutical compositions
Prior art date: 1989-07-20

Application number

PT94761A

Other languages

English (en)

Other versions

PT94761B (pt

Inventor

Mathias Fibi

Gerd Zettlmeissl

Original Assignee

Behringwerke Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-07-20

Filing date

1990-07-19

Publication date

1991-03-20

1990-07-19 Application filed by Behringwerke Ag filed Critical Behringwerke Ag

1991-03-20 Publication of PT94761A publication Critical patent/PT94761A/pt

1997-03-31 Publication of PT94761B publication Critical patent/PT94761B/pt

Links

238000000034 method Methods 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
102000003951 Erythropoietin Human genes 0.000 abstract 2
108090000394 Erythropoietin Proteins 0.000 abstract 2
229940105423 erythropoietin Drugs 0.000 abstract 2
OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 abstract 2
238000012270 DNA recombination Methods 0.000 abstract 1
101000987586 Homo sapiens Eosinophil peroxidase Proteins 0.000 abstract 1
101000920686 Homo sapiens Erythropoietin Proteins 0.000 abstract 1
102000044890 human EPO Human genes 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Toxicology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Hematology (AREA)
Animal Behavior & Ethology (AREA)
Plant Pathology (AREA)
Diabetes (AREA)
Physics & Mathematics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Microbiology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Saccharide Compounds (AREA)
Enzymes And Modification Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PT94761A 1989-07-20 1990-07-19 Processo para a preparacao de muteinas da eritropoetina humana e de composicoes farmaceuticas que as contem PT94761B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3923963A DE3923963A1 (de)	1989-07-20	1989-07-20	Muteine des menschlichen erythropoetins, ihre herstellung und ihre verwendung

Publications (2)

Publication Number	Publication Date
PT94761A true PT94761A (pt)	1991-03-20
PT94761B PT94761B (pt)	1997-03-31

Family

ID=6385421

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT94761A PT94761B (pt)	1989-07-20	1990-07-19	Processo para a preparacao de muteinas da eritropoetina humana e de composicoes farmaceuticas que as contem

Country Status (13)

Country	Link
US (1)	US5457089A (pt)
EP (1)	EP0409113B1 (pt)
JP (1)	JP3062583B2 (pt)
KR (1)	KR0183981B1 (pt)
AT (1)	ATE139261T1 (pt)
AU (1)	AU638470B2 (pt)
CA (1)	CA2021528C (pt)
DE (2)	DE3923963A1 (pt)
DK (1)	DK0409113T3 (pt)
ES (1)	ES2090061T3 (pt)
GR (1)	GR3020517T3 (pt)
IE (1)	IE902643A1 (pt)
PT (1)	PT94761B (pt)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU646822B2 (en) *	1989-10-13	1994-03-10	Kirin-Amgen Inc.	Erythropoietin isoforms
US7217689B1 (en)	1989-10-13	2007-05-15	Amgen Inc.	Glycosylation analogs of erythropoietin
US5856298A (en) *	1989-10-13	1999-01-05	Amgen Inc.	Erythropoietin isoforms
US6190864B1 (en)	1991-05-08	2001-02-20	Chiron Corporation	HCV genomic sequences for diagnostics and therapeutics
FR2686899B1 (fr)	1992-01-31	1995-09-01	Rhone Poulenc Rorer Sa	Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
WO1994002611A2 (en) *	1992-07-28	1994-02-03	New England Deaconess Hospital	Recombinant human erythropoietin with altered biological activity
US6153407A (en) *	1992-07-28	2000-11-28	Beth Israel Deaconess Medical Center	Erythropoietin DNA having modified 5' and 3' sequences and its use to prepare EPO therapeutics
US5614184A (en) *	1992-07-28	1997-03-25	New England Deaconess Hospital	Recombinant human erythropoietin mutants and therapeutic methods employing them
WO1994024160A2 (en) *	1993-04-21	1994-10-27	Brigham And Women's Hospital	Erythropoietin muteins with enhanced activity
CN1125401A (zh) *	1993-04-29	1996-06-26	艾博特公司	促红细胞生成素类似物组合物和方法
US5773569A (en) *	1993-11-19	1998-06-30	Affymax Technologies N.V.	Compounds and peptides that bind to the erythropoietin receptor
US5830851A (en) *	1993-11-19	1998-11-03	Affymax Technologies N.V.	Methods of administering peptides that bind to the erythropoietin receptor
KR100470180B1 (ko)	1995-06-15	2005-02-04	크루셀 홀란드 비.브이.	유전자 요법에 사용할 수 있는 인간의 재조합아데노바이러스 패키징 시스템
US5952226A (en) *	1996-11-05	1999-09-14	Modex Therapeutiques	Hypoxia responsive EPO producing cells
DE69726571T2 (de) *	1997-09-01	2004-11-04	Aventis Pharma Deutschland Gmbh	Rekombinantes humanes Erythropoietin mit vorteilhaftem Glykosylierungsmuster
US6506595B2 (en) *	1998-03-31	2003-01-14	Itoham Foods Inc.	DNAs encoding new fusion proteins and processes for preparing useful polypeptides through expression of the DNAs
WO1999054486A1 (en) *	1998-04-22	1999-10-28	Cornell Research Foundation, Inc.	Canine erythropoietin gene and recombinant protein
US6696411B1 (en)	1998-04-22	2004-02-24	Cornell Research Foundation, Inc.	Canine erythropoietin gene and recombinant protein
US7304150B1 (en)	1998-10-23	2007-12-04	Amgen Inc.	Methods and compositions for the prevention and treatment of anemia
US7345019B1 (en)	1999-04-13	2008-03-18	The Kenneth S. Warren Institute, Inc.	Modulation of excitable tissue function by peripherally administered erythropoietin
US7410941B1 (en)	1999-04-13	2008-08-12	The Kenneth S. Warren Institute, Inc.	Methods for treatment of neurodegenerative conditions by peripherally administered erythropoietin
US8236561B2 (en) *	1999-04-15	2012-08-07	Crucell Holland B.V.	Efficient production of IgA in recombinant mammalian cells
US6855544B1 (en) *	1999-04-15	2005-02-15	Crucell Holland B.V.	Recombinant protein production in a human cell
US7604960B2 (en) *	1999-04-15	2009-10-20	Crucell Holland B.V.	Transient protein expression methods
US20050170463A1 (en) *	1999-04-15	2005-08-04	Abraham Bout	Recombinant protein production in permanent amniocytic cells that comprise nucleic acid encoding adenovirus E1A and E1B proteins
US7297680B2 (en) *	1999-04-15	2007-11-20	Crucell Holland B.V.	Compositions of erythropoietin isoforms comprising Lewis-X structures and high sialic acid content
US20050164386A1 (en) *	1999-04-15	2005-07-28	Uytdehaag Alphonsus G.	Overexpression of enzymes involved in post-translational protein modifications in human cells
CN100338091C (zh) *	1999-09-25	2007-09-19	伊藤火腿株式会社	编码新的融合蛋白的dna和通过该dna的表达来制备有用的多肽的方法
US6703480B1 (en)	1999-11-24	2004-03-09	Palani Balu	Peptide dimers as agonists of the erythropoientin (EPO) receptor, and associated methods of synthesis and use
US7527961B2 (en) *	1999-11-26	2009-05-05	Crucell Holland B.V.	Production of vaccines
US7192759B1 (en) *	1999-11-26	2007-03-20	Crucell Holland B.V.	Production of vaccines
US7521220B2 (en) *	1999-11-26	2009-04-21	Crucell Holland B.V.	Production of vaccines
US7118737B2 (en) *	2000-09-08	2006-10-10	Amylin Pharmaceuticals, Inc.	Polymer-modified synthetic proteins
ATE500838T1 (de) *	2000-09-08	2011-03-15	Amylin Pharmaceuticals Inc	ßPSEUDOß-NATIVE CHEMISCHE LIGATION
WO2002024899A2 (en)	2000-09-25	2002-03-28	Valentis, Inc.	Improved system for regulation of transgene expression
US20030072737A1 (en) *	2000-12-29	2003-04-17	Michael Brines	Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs
US7767643B2 (en) *	2000-12-29	2010-08-03	The Kenneth S. Warren Institute, Inc.	Protection, restoration, and enhancement of erythropoietin-responsive cells, tissues and organs
PA8536201A1 (es)	2000-12-29	2002-08-29	Kenneth S Warren Inst Inc	Protección y mejoramiento de células, tejidos y órganos que responden a la eritropoyetina
US6531121B2 (en)	2000-12-29	2003-03-11	The Kenneth S. Warren Institute, Inc.	Protection and enhancement of erythropoietin-responsive cells, tissues and organs
US6930086B2 (en) *	2001-09-25	2005-08-16	Hoffmann-La Roche Inc.	Diglycosylated erythropoietin
JP4480398B2 (ja) *	2001-12-07	2010-06-16	クルセルホランドベーヴェー	ウイルス、ウイルス分離株及びワクチンの製造方法
US20040122216A1 (en) *	2002-07-01	2004-06-24	Jacob Nielsen	Recombinant tissue protective cytokines and encoding nucleic acids thereof for protection, restoration, and enhancement of responsive cells, tissues, and organs
CA2498319A1 (en)	2002-09-09	2004-03-18	Nautilus Biotech	Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
KR101183770B1 (ko)	2003-05-09	2012-09-17	크루셀 홀란드 비.브이.	Ｅ1-불멸화된 세포의 배양물 및 이로부터 생성 수율을 증가시키기 위한 동일물의 배양 방법
DE602004027483D1 (de) *	2003-05-23	2010-07-15	Crucell Holland Bv	Herstellung von rekombinanten igm in den per.c6 zellen
KR100632985B1 (ko) *	2003-07-26	2006-10-11	메덱스젠 주식회사	생리활성 조절 단백질의 효능 향상 방법 및 그 예시변이체들
JP2007517769A (ja) *	2003-09-29	2007-07-05	ウォーレンファーマシューティカルズ，インコーポレーテッド	敗血症および癒着形成の治療および予防のための組織保護性サイトカイン
EP1673102A1 (en) *	2003-10-17	2006-06-28	Crucell Holland B.V.	Treatment and prevention of decubitus
US7588745B2 (en) *	2004-04-13	2009-09-15	Si Options, Llc	Silicon-containing products
CA2563874A1 (en) *	2004-04-23	2005-11-03	Cambridge Antibody Technology Limited	Erythropoietin protein variants
AR053416A1 (es)	2005-11-10	2007-05-09	Protech Pharma S A	Combinacion de glicoisoformas para el tratamiento o prevencion de la septicemia, linea celular transgenica productora de glicoformas de eritropoyetina, composicion farmaceutica que comprende a dicha combinacion, procedimientos para obtener la linea celular, procedimiento para producir dicha combinac
EP1966237A2 (en) *	2005-11-24	2008-09-10	Laboratoires Serono SA	Erythropoietin polypeptides and uses thereof
EP2120998B1 (en)	2006-11-28	2013-08-07	HanAll Biopharma Co., Ltd.	Modified erythropoietin polypeptides and uses thereof for treatment
KR100700039B1 (ko) *	2007-01-31	2007-03-26	이수왕	음료용 병
NZ602170A (en)	2008-02-08	2014-03-28	Ambrx Inc	Modified leptin polypeptides and their uses
EP2334699B1 (en)	2008-09-23	2013-09-11	F. Hoffmann-La Roche AG	Purification of erythropoietin
PL2342223T3 (pl)	2008-09-26	2017-09-29	Ambrx, Inc.	Zmodyfikowane polipeptydy zwierzęcej erytropoetyny i ich zastosowania
WO2022159414A1 (en)	2021-01-22	2022-07-28	University Of Rochester	Erythropoietin for gastroinfestinal dysfunction

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4703008A (en) *	1983-12-13	1987-10-27	Kiren-Amgen, Inc.	DNA sequences encoding erythropoietin
NZ210501A (en) *	1983-12-13	1991-08-27	Kirin Amgen Inc	Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
US4835260A (en) *	1987-03-20	1989-05-30	Genetics Institute, Inc.	Erythropoietin composition

1989
- 1989-07-20 DE DE3923963A patent/DE3923963A1/de not_active Withdrawn
1990
- 1990-07-14 EP EP90113505A patent/EP0409113B1/de not_active Expired - Lifetime
- 1990-07-14 DK DK90113505.3T patent/DK0409113T3/da active
- 1990-07-14 AT AT90113505T patent/ATE139261T1/de not_active IP Right Cessation
- 1990-07-14 ES ES90113505T patent/ES2090061T3/es not_active Expired - Lifetime
- 1990-07-14 DE DE59010367T patent/DE59010367D1/de not_active Expired - Lifetime
- 1990-07-19 IE IE264390A patent/IE902643A1/en not_active IP Right Cessation
- 1990-07-19 AU AU59145/90A patent/AU638470B2/en not_active Expired
- 1990-07-19 PT PT94761A patent/PT94761B/pt not_active IP Right Cessation
- 1990-07-19 CA CA002021528A patent/CA2021528C/en not_active Expired - Lifetime
- 1990-07-20 KR KR1019900011049A patent/KR0183981B1/ko not_active Expired - Lifetime
- 1990-07-20 JP JP2192823A patent/JP3062583B2/ja not_active Expired - Lifetime
1994
- 1994-07-06 US US08/272,375 patent/US5457089A/en not_active Expired - Lifetime
1996
- 1996-07-11 GR GR960401877T patent/GR3020517T3/el unknown

Also Published As

Publication number	Publication date
DK0409113T3 (da)	1996-10-07
KR0183981B1 (ko)	1999-04-01
EP0409113B1 (de)	1996-06-12
CA2021528A1 (en)	1991-01-21
US5457089A (en)	1995-10-10
PT94761B (pt)	1997-03-31
AU5914590A (en)	1991-01-24
KR910003102A (ko)	1991-02-26
DE59010367D1 (de)	1996-07-18
JP3062583B2 (ja)	2000-07-10
ATE139261T1 (de)	1996-06-15
GR3020517T3 (en)	1996-10-31
IE902643A1 (en)	1991-02-27
CA2021528C (en)	2001-09-11
ES2090061T3 (es)	1996-10-16
EP0409113A1 (de)	1991-01-23
AU638470B2 (en)	1993-07-01
JPH0372885A (ja)	1991-03-28
DE3923963A1 (de)	1991-01-31

Legal Events

Date

Code

Title

Description

1991-03-20

BB1A

Laying open of patent application

Effective date: 19901019

1997-03-31

FG3A

Patent granted, date of granting

Effective date: 19961216

2011-12-26

MM4A

Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: MAXIMUM VALIDITY LIMIT REACHED

Effective date: 20111216

Publication	Publication Date	Title
ES2090061T3 (es)	1996-10-16	Muteinas de la eritropoyetina humana, su preparacion y su uso.
PT87261A (pt)	1988-05-01	Processo de preparacao de heparinas de baixo peso molecular,com estrutura regular e de composicoes farmaceuticas que as contem
PT95082A (pt)	1991-04-18	Processo para a preparacao de amino acidos isentos de lactamas e de composicoes farmaceuticas que os contem
PT83013B (pt)	1989-01-30	Processo para a preparacao de hidroxialquilxantinas terciarias, e de composicoes farmaceuticas que as contem
PT98102A (pt)	1992-03-31	Processo de preparacao de misturas de polissacaridos de baixo peso molecular e de composicoes farmaceuticas que as contem
ATE91688T1 (de)	1993-08-15	Phospholipidische komplexe aus vitis viniferaextrakten, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische und kosmetische zusammensetzungen.
PT89094A (pt)	1988-12-01	Processo para a preparacao de 1-aril-3-quinolina-e 1-aril-3-isoquinolina-carboxamidas e de composicoes farmaceuticas que as contem
PT93094A (pt)	1990-08-31	Processo para a preparacao de 1,3-oxatiolanos substituidos e de composicoes farmaceuticas que os contem
PT84149B (pt)	1989-07-31	Processo para a preparacao de novas tieno-1,4-diazepinas e de composicoes farmaceuticas que as contem
PT87880A (pt)	1989-06-30	Processo para a preparacao de composicoes farmaceuticas anti-virais que contem ciclo-dextrinas
FI942095L (fi)	1994-11-08	Puhdistettuja hepariinifraktioita, menetelmä niiden valmistamiseksi ja niitä sisältäviä farmaseuttisia koostumuksia
ES2024400T3 (es)	1994-04-16	Extracto de hojas de ginkgo biloba, su metodo de preparacion y productos que contienen el extracto.
ATE81014T1 (de)	1992-10-15	Procyanidol-oligomerische fraktionen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
BR8802852A (pt)	1989-01-03	Processo para a preparacao de compostos,processo para a preparacao de uma composicao,processo e composicoes para combater ou impedir uma infestacao das plantas
PT84702B (pt)	1989-11-30	Processo para a preparacao de 1-hidroxi-2-piridonas, de composicoes farmaceuticas que as contem e dos produtos intermediarios para a sua preparacao
PT89655A (pt)	1989-10-04	Processo para a preparacao de novas lactamas substituidas e de composicoes farmaceuticas que as contem
PT84358B (pt)	1989-11-10	Processo para a preparacao de naftotiazepinonas e de composicoes farmaceuticas que as contem
FI921562A7 (fi)	1992-04-08	Gem-difosfonihapot, menetelmä niiden valmistamiseksi ja farmaseuttiset koostumukset, jotka sisältävät niitä
FI893142A7 (fi)	1989-12-31	Uudet minttutyyppiset aromiöljyt, menetelmä niiden valmistamiseksi ja niitä sisältävät koostumukset
PT98816A (pt)	1992-07-31	Processo para a preparacao de tienodiazepinas e de composicoes farmaceuticas que as contem
PT87895A (pt)	1989-06-30	Processo para a preparacao de esteres e glicosidos derivados de castanospermina ({1s-(1 alfa, 6 beta, 7 alfa, 8 beta, 8a beta)}-octahidro-1,6,7,8-indolizinotetrol) e de composicoes farmaceuticas que os contem
PT90357A (pt)	1989-11-10	Processo para a preparacao de novas anguciclinonas a partir de estreptomicetes e de composicoes farmaceuticas que as contem
PT80920B (pt)	1987-12-30	Processo para a preparacao de imidazo {1,2-a} quinolinas e de composicoes farmaceuticas que as contem
PT94685A (pt)	1991-03-20	Processo para a preparacao de 2-imidazolinas substituidas e de composicoes farmaceuticas que as contem
PT98225A (pt)	1992-05-29	Processo para a preparacao de novas tetra-hidroimidazo{1,4}-benzodiazepina-2-(ti)onas antivirais e de composicoes farmaceuticas que as contem