PT96021A - Metodo de tratamento de doencas utilizando potenciadores de fluxo transdermico tais como acido e 1-dodecilazacicloheptan-2-ona em combinacao com iontoforese na administracao topica de agentes farmaceuticos - Google Patents
Metodo de tratamento de doencas utilizando potenciadores de fluxo transdermico tais como acido e 1-dodecilazacicloheptan-2-ona em combinacao com iontoforese na administracao topica de agentes farmaceuticosInfo
- Publication number
- PT96021A PT96021A PT96021A PT9602190A PT96021A PT 96021 A PT96021 A PT 96021A PT 96021 A PT96021 A PT 96021A PT 9602190 A PT9602190 A PT 9602190A PT 96021 A PT96021 A PT 96021A
- Authority
- PT
- Portugal
- Prior art keywords
- combination
- iontoforese
- dodecylacyloheptan
- ona
- pharmaceutical agents
- Prior art date
Links
- 239000008177 pharmaceutical agent Substances 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 abstract 1
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 abstract 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 abstract 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 abstract 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000005642 Oleic acid Substances 0.000 abstract 1
- 239000003623 enhancer Substances 0.000 abstract 1
- 230000004907 flux Effects 0.000 abstract 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 abstract 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 abstract 1
- 238000011200 topical administration Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/443,699 US5023085A (en) | 1989-11-29 | 1989-11-29 | Transdermal flux enhancers in combination with iontophoresis in topical administration of pharmaceuticals |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT96021A true PT96021A (pt) | 1991-09-13 |
| PT96021B PT96021B (pt) | 1998-02-27 |
Family
ID=23761854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT96021A PT96021B (pt) | 1989-11-29 | 1990-11-28 | Metodo de tratamento de doencas utilizando potenciadores de fluxo transdermico tais como acido e 1-dodecilazacicloheptan-2-ona em combinacao com iontoforese na administracao topica de agentes farmaceuticos |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5023085A (pt) |
| EP (1) | EP0435436B1 (pt) |
| JP (1) | JPH0688912B2 (pt) |
| KR (1) | KR930007248B1 (pt) |
| AT (1) | ATE99961T1 (pt) |
| AU (1) | AU613281B1 (pt) |
| CA (1) | CA2030943A1 (pt) |
| DE (1) | DE69006000T2 (pt) |
| DK (1) | DK0435436T3 (pt) |
| HU (1) | HUT55629A (pt) |
| IE (1) | IE63597B1 (pt) |
| IL (1) | IL96449A (pt) |
| MY (1) | MY109727A (pt) |
| NZ (1) | NZ236253A (pt) |
| PH (1) | PH27105A (pt) |
| PT (1) | PT96021B (pt) |
| ZA (1) | ZA909512B (pt) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5196410A (en) * | 1986-10-31 | 1993-03-23 | Pfizer Inc. | Transdermal flux enhancing compositions |
| DE3880923T3 (de) * | 1987-02-23 | 1997-12-18 | Shiseido Co Ltd | Perkutaner absorptionspromotor und dermatologische zusammensetzung für externe anwendung. |
| US5080646A (en) * | 1988-10-03 | 1992-01-14 | Alza Corporation | Membrane for electrotransport transdermal drug delivery |
| US5262165A (en) * | 1992-02-04 | 1993-11-16 | Schering Corporation | Transdermal nitroglycerin patch with penetration enhancers |
| US5302172A (en) * | 1990-03-15 | 1994-04-12 | North Carolina State University | Method and composition for iontophoresis |
| US5383848A (en) * | 1990-04-12 | 1995-01-24 | Gensia, Inc. | Iontophoretic administration of drugs |
| US6582416B2 (en) | 1990-11-01 | 2003-06-24 | Robert Tapper | Iontophoretic treatment system |
| US6139537A (en) * | 1990-11-01 | 2000-10-31 | Tapper; Robert | Iontophoretic treatment system |
| US6238381B1 (en) | 1990-11-01 | 2001-05-29 | Robert Tapper | Iontophoretic treatment system |
| US6223076B1 (en) | 1990-11-01 | 2001-04-24 | Robert Tapper | Sweat control system |
| US6235013B1 (en) | 1990-11-01 | 2001-05-22 | Robert Tapper | Iontophoretic treatment system |
| US5224927A (en) * | 1990-11-01 | 1993-07-06 | Robert Tapper | Iontophoretic treatment system |
| US6575957B1 (en) * | 1990-11-01 | 2003-06-10 | Robert Tapper | Iontophoretic treatment system |
| US6600950B1 (en) * | 1990-11-01 | 2003-07-29 | Robert Tapper | Iontophoretic treatment system |
| US5131403A (en) * | 1991-06-05 | 1992-07-21 | Becton Dickinson And Company | Method for obtaining blood using iontophoresis |
| US5356632A (en) * | 1991-09-12 | 1994-10-18 | S.I. Scientific Innovations Ltd. | Transdermal drug delivery device |
| EP0552879B1 (en) * | 1992-01-21 | 1998-08-19 | Macrochem Corporation | Improved iontophoretic administration of drugs |
| DE69407061T2 (de) * | 1992-06-02 | 1998-06-04 | Alza Corp., Palo Alto, Calif. | Abgabevorrichtung zur elektrischen übertragung von arzneimitteln |
| US5580574A (en) * | 1994-04-28 | 1996-12-03 | Hoffmann-La Roche Inc. | Pharmaceutical composition for transdermal delivery |
| US5594015A (en) * | 1994-06-22 | 1997-01-14 | Regents Of The University Of California | Thiazolidine derivatives for the treatment of psoriasis |
| JP4090072B2 (ja) * | 1994-07-13 | 2008-05-28 | アルザ・コーポレーション | 経皮電気的移送式作用剤投与を促進するための組成物と方法 |
| US5540654A (en) * | 1994-09-02 | 1996-07-30 | North Carolina State University | Iontophoretic electrode |
| US5736580A (en) * | 1994-11-14 | 1998-04-07 | Alza Croporation | Composition, device, and method for electrotransport agent delivery |
| US5861439A (en) * | 1994-11-14 | 1999-01-19 | Alza Corporation | Method for enhanced electrotransport agent delivery |
| US5985316A (en) * | 1995-04-28 | 1999-11-16 | Alza Corporation | Composition and method of enhancing electrotransport agent delivery |
| US5990179A (en) * | 1995-04-28 | 1999-11-23 | Alza Corporation | Composition and method of enhancing electrotransport agent delivery |
| US6355025B1 (en) | 1995-06-07 | 2002-03-12 | Alza Corporation | Adjustable electrotransport drug delivery using a fixed output controller |
| WO1997014473A1 (en) * | 1995-10-18 | 1997-04-24 | Novartis Ag | Thermopile powered transdermal drug delivery device |
| US7094422B2 (en) | 1996-02-19 | 2006-08-22 | Acrux Dds Pty Ltd. | Topical delivery of antifungal agents |
| AUPN814496A0 (en) | 1996-02-19 | 1996-03-14 | Monash University | Dermal penetration enhancer |
| EP0849265A1 (de) * | 1996-12-20 | 1998-06-24 | HEUMANN PHARMA GmbH | Neue polymorphe Form von Doxazosin-Mesylat (Form II) |
| AUPO907697A0 (en) * | 1997-09-09 | 1997-10-02 | Day, Robert Edward | Chemical supplementation of bone |
| GB9723669D0 (en) * | 1997-11-07 | 1998-01-07 | Univ Aberdeen | Skin penetration enhancing components |
| AU766913B2 (en) | 1998-11-02 | 2003-10-23 | Alza Corporation | Electrotransport device including a compatible antimicrobial agent |
| JP2001072592A (ja) | 1999-07-01 | 2001-03-21 | Kyowa Hakko Kogyo Co Ltd | テロメラーゼ阻害剤 |
| US6512950B2 (en) | 2000-02-18 | 2003-01-28 | University Of Utah Research Foundation | Methods for delivering agents using alternating current |
| CA2400074A1 (en) | 2000-02-18 | 2001-08-23 | William I. Higuchi | Methods for extracting substances using alternating current |
| US6452014B1 (en) | 2000-12-22 | 2002-09-17 | Geron Corporation | Telomerase inhibitors and methods of their use |
| US7137975B2 (en) * | 2001-02-13 | 2006-11-21 | Aciont, Inc. | Method for increasing the battery life of an alternating current iontophoresis device using a barrier-modifying agent |
| CA2443326A1 (en) * | 2001-04-04 | 2002-10-17 | Alza Corporation | Transdermal electrotransport delivery device including an antimicrobial compatible reservoir composition |
| US7099713B2 (en) | 2002-06-28 | 2006-08-29 | Battelle Memorial Institute | Skin conduction and transport systems |
| US7468428B2 (en) * | 2004-03-17 | 2008-12-23 | App Pharmaceuticals, Llc | Lyophilized azithromycin formulation |
| US20060116336A1 (en) * | 2004-03-17 | 2006-06-01 | American Pharmaceutical Partners, Inc. | Lyophilized azithromycin formulation |
| US20050220439A1 (en) * | 2004-03-19 | 2005-10-06 | Carton Owen A | Interactive multimedia system and method |
| US20060222692A1 (en) * | 2005-03-31 | 2006-10-05 | Fairfield Clinical Trials Llc | Method and compositions for transdermal administration of antimicrobial medications |
| US20080200533A1 (en) * | 2005-07-04 | 2008-08-21 | Ramu Krishnan | Drug or Pharmaceutical Compounds and a Preparation Thereof |
| WO2007147043A2 (en) * | 2006-06-16 | 2007-12-21 | Transport Pharmaceutical, Inc. | Pharmaceutical formulations for iontophoretic tetracycline antibiotic delivery |
| EP2363116A1 (en) | 2008-06-25 | 2011-09-07 | US Worldmeds LLC | Sustained-release formulations comprising lofexidine for oral delivery |
| WO2010054356A1 (en) * | 2008-11-10 | 2010-05-14 | Nitric Biotherapeutics, Inc. | Pharmaceutical formulations for iontophoretic delivery of a corticosteroid |
| US20100331812A1 (en) * | 2009-06-29 | 2010-12-30 | Nitric Biotherapeutics, Inc. | Pharmaceutical Formulations for Iontophoretic Delivery of an Immunomodulator |
| WO2011130455A1 (en) | 2010-04-13 | 2011-10-20 | Najib Babul | Dermal pharmaceutical compositions of 1-methyl-2',6'-pipecoloxylidide and method of use |
| HRP20220112T1 (hr) | 2013-12-24 | 2022-04-15 | Virginia Commonwealth University | Upotreba oksidacijskog sulfata kolesterola (ocs) za liječenje akutne insuficijencije jetre |
| US11564970B2 (en) | 2017-10-09 | 2023-01-31 | The Broad Institute, Inc. | Compositions and methods for combinatorial drug discovery in nanoliter droplets |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3991755A (en) * | 1973-07-27 | 1976-11-16 | Medicon, Inc. | Iontophoresis apparatus for applying local anesthetics |
| US3989816A (en) * | 1975-06-19 | 1976-11-02 | Nelson Research & Development Company | Vehicle composition containing 1-substituted azacycloheptan-2-ones |
| US4316893A (en) * | 1975-06-19 | 1982-02-23 | Nelson Research & Development Co. | Vehicle composition containing 1-substituted azacycloalkan-2-ones |
| US4405616A (en) * | 1975-06-19 | 1983-09-20 | Nelson Research & Development Company | Penetration enhancers for transdermal drug delivery of systemic agents |
| US4954487A (en) * | 1979-01-08 | 1990-09-04 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions |
| JPS6036299B2 (ja) * | 1981-07-02 | 1985-08-20 | タカラベルモント株式会社 | イオン導入器 |
| HU185691B (en) * | 1982-02-09 | 1985-03-28 | Richter Gedeon Vegyeszet | Process for preparing a new analgetic pharmaceutical composition |
| US4557934A (en) * | 1983-06-21 | 1985-12-10 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one |
| US4919648A (en) * | 1983-08-18 | 1990-04-24 | Drug Delivery Systems Inc. | High tack drug patch |
| JPS6222662A (ja) * | 1985-07-19 | 1987-01-30 | 林原 健 | イオン導入電子治療器 |
| MY102980A (en) * | 1986-10-31 | 1993-03-31 | Pfizer | Transdermal flux enhancing compositions |
| US5108363A (en) * | 1988-02-19 | 1992-04-28 | Gensia Pharmaceuticals, Inc. | Diagnosis, evaluation and treatment of coronary artery disease by exercise simulation using closed loop drug delivery of an exercise simulating agent beta agonist |
| ATE80313T1 (de) * | 1988-02-29 | 1992-09-15 | Pfizer | Mittel zur erhoehung des transdermalen penetrationsflusses. |
-
1989
- 1989-11-29 US US07/443,699 patent/US5023085A/en not_active Expired - Fee Related
-
1990
- 1990-11-02 PH PH41182A patent/PH27105A/en unknown
- 1990-11-08 DE DE90312217T patent/DE69006000T2/de not_active Expired - Fee Related
- 1990-11-08 AT AT90312217T patent/ATE99961T1/de not_active IP Right Cessation
- 1990-11-08 DK DK90312217.4T patent/DK0435436T3/da active
- 1990-11-08 EP EP90312217A patent/EP0435436B1/en not_active Expired - Lifetime
- 1990-11-22 IL IL9644990A patent/IL96449A/en not_active IP Right Cessation
- 1990-11-27 ZA ZA909512A patent/ZA909512B/xx unknown
- 1990-11-27 MY MYPI90002098A patent/MY109727A/en unknown
- 1990-11-27 CA CA002030943A patent/CA2030943A1/en not_active Abandoned
- 1990-11-28 HU HU907681A patent/HUT55629A/hu unknown
- 1990-11-28 IE IE428190A patent/IE63597B1/en not_active IP Right Cessation
- 1990-11-28 PT PT96021A patent/PT96021B/pt not_active IP Right Cessation
- 1990-11-28 AU AU67069/90A patent/AU613281B1/en not_active Ceased
- 1990-11-28 NZ NZ236253A patent/NZ236253A/xx unknown
- 1990-11-28 KR KR1019900019334A patent/KR930007248B1/ko not_active Expired - Fee Related
- 1990-11-29 JP JP2333509A patent/JPH0688912B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| IL96449A (en) | 1996-07-23 |
| MY109727A (en) | 1997-05-31 |
| NZ236253A (en) | 1993-05-26 |
| JPH03176426A (ja) | 1991-07-31 |
| IE904281A1 (en) | 1991-06-05 |
| PT96021B (pt) | 1998-02-27 |
| KR930007248B1 (ko) | 1993-08-04 |
| EP0435436A2 (en) | 1991-07-03 |
| ATE99961T1 (de) | 1994-01-15 |
| DK0435436T3 (da) | 1994-02-28 |
| EP0435436A3 (en) | 1992-01-08 |
| DE69006000D1 (de) | 1994-02-24 |
| ZA909512B (en) | 1992-06-24 |
| JPH0688912B2 (ja) | 1994-11-09 |
| CA2030943A1 (en) | 1991-05-30 |
| EP0435436B1 (en) | 1994-01-12 |
| PH27105A (en) | 1993-03-16 |
| IE63597B1 (en) | 1995-05-17 |
| KR910009250A (ko) | 1991-06-28 |
| DE69006000T2 (de) | 1994-05-05 |
| HUT55629A (en) | 1991-06-28 |
| AU613281B1 (en) | 1991-07-25 |
| US5023085A (en) | 1991-06-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB1A | Laying open of patent application |
Effective date: 19910410 |
|
| FG3A | Patent granted, date of granting |
Effective date: 19971111 |
|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19990531 |