ATE99961T1 - Verstaerker des transdermalen flusses in kombination mit iontophorese fuer die topische verabreichung von arzneimitteln. - Google Patents

Verstaerker des transdermalen flusses in kombination mit iontophorese fuer die topische verabreichung von arzneimitteln.

Info

Publication number: ATE99961T1
Authority: AT; Austria
Prior art keywords: iontophoresis; combination; drug delivery; topical drug; flow enhancer
Prior art date: 1989-11-29

Application number

AT90312217T

Other languages

English (en)

Inventor

Michael Lee Francoeur

Russell Owen Potts

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-11-29

Filing date

1990-11-08

Publication date

1994-01-15

1990-11-08 Application filed by Pfizer filed Critical Pfizer

1994-01-15 Application granted granted Critical

1994-01-15 Publication of ATE99961T1 publication Critical patent/ATE99961T1/de

Links

239000003623 enhancer Substances 0.000 title abstract 2
238000012377 drug delivery Methods 0.000 title 1
230000000699 topical effect Effects 0.000 title 1
WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 abstract 1
AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 abstract 1
LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 abstract 1
QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 abstract 1
ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 abstract 1
239000005642 Oleic acid Substances 0.000 abstract 1
230000004907 flux Effects 0.000 abstract 1
QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 abstract 1
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 abstract 1
239000008177 pharmaceutical agent Substances 0.000 abstract 1
238000011200 topical administration Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Oil, Petroleum & Natural Gas (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Anesthesiology (AREA)
Hematology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT90312217T 1989-11-29 1990-11-08 Verstaerker des transdermalen flusses in kombination mit iontophorese fuer die topische verabreichung von arzneimitteln. ATE99961T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/443,699 US5023085A (en)	1989-11-29	1989-11-29	Transdermal flux enhancers in combination with iontophoresis in topical administration of pharmaceuticals
EP90312217A EP0435436B1 (de)	1989-11-29	1990-11-08	Verstärker des transdermalen Flusses in Kombination mit Iontophorese für die topische Verabreichung von Arzneimitteln

Publications (1)

Publication Number	Publication Date
ATE99961T1 true ATE99961T1 (de)	1994-01-15

Family

ID=23761854

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90312217T ATE99961T1 (de)	1989-11-29	1990-11-08	Verstaerker des transdermalen flusses in kombination mit iontophorese fuer die topische verabreichung von arzneimitteln.

Country Status (17)

Country	Link
US (1)	US5023085A (de)
EP (1)	EP0435436B1 (de)
JP (1)	JPH0688912B2 (de)
KR (1)	KR930007248B1 (de)
AT (1)	ATE99961T1 (de)
AU (1)	AU613281B1 (de)
CA (1)	CA2030943A1 (de)
DE (1)	DE69006000T2 (de)
DK (1)	DK0435436T3 (de)
HU (1)	HUT55629A (de)
IE (1)	IE63597B1 (de)
IL (1)	IL96449A (de)
MY (1)	MY109727A (de)
NZ (1)	NZ236253A (de)
PH (1)	PH27105A (de)
PT (1)	PT96021B (de)
ZA (1)	ZA909512B (de)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5196410A (en) *	1986-10-31	1993-03-23	Pfizer Inc.	Transdermal flux enhancing compositions
EP0303713B2 (de) *	1987-02-23	1997-07-30	Shiseido Company Limited	Perkutaner absorptionspromotor und dermatologische zusammensetzung für externe anwendung
US5080646A (en) *	1988-10-03	1992-01-14	Alza Corporation	Membrane for electrotransport transdermal drug delivery
US5262165A (en) *	1992-02-04	1993-11-16	Schering Corporation	Transdermal nitroglycerin patch with penetration enhancers
US5302172A (en) *	1990-03-15	1994-04-12	North Carolina State University	Method and composition for iontophoresis
US5383848A (en) *	1990-04-12	1995-01-24	Gensia, Inc.	Iontophoretic administration of drugs
US6600950B1 (en) *	1990-11-01	2003-07-29	Robert Tapper	Iontophoretic treatment system
US6139537A (en) *	1990-11-01	2000-10-31	Tapper; Robert	Iontophoretic treatment system
US6238381B1 (en)	1990-11-01	2001-05-29	Robert Tapper	Iontophoretic treatment system
US5224927A (en) *	1990-11-01	1993-07-06	Robert Tapper	Iontophoretic treatment system
US6575957B1 (en) *	1990-11-01	2003-06-10	Robert Tapper	Iontophoretic treatment system
US6223076B1 (en)	1990-11-01	2001-04-24	Robert Tapper	Sweat control system
US6582416B2 (en)	1990-11-01	2003-06-24	Robert Tapper	Iontophoretic treatment system
US6235013B1 (en)	1990-11-01	2001-05-22	Robert Tapper	Iontophoretic treatment system
US5131403A (en) *	1991-06-05	1992-07-21	Becton Dickinson And Company	Method for obtaining blood using iontophoresis
US5356632A (en) *	1991-09-12	1994-10-18	S.I. Scientific Innovations Ltd.	Transdermal drug delivery device
ATE169826T1 (de) *	1992-01-21	1998-09-15	Macrochem Corp	Iontophoretische verbesserte verabreichung von medikamenten
WO1995025562A1 (en) *	1992-06-02	1995-09-28	Alza Corporation	Electrotransport drug delivery device
US5580574A (en) *	1994-04-28	1996-12-03	Hoffmann-La Roche Inc.	Pharmaceutical composition for transdermal delivery
US5594015A (en) *	1994-06-22	1997-01-14	Regents Of The University Of California	Thiazolidine derivatives for the treatment of psoriasis
ES2153485T3 (es) *	1994-07-13	2001-03-01	Alza Corp	Composicion y procedimiento que incrementa la difusion percutanea por electrotransporte de una substancia.
US5540654A (en) *	1994-09-02	1996-07-30	North Carolina State University	Iontophoretic electrode
US5736580A (en) *	1994-11-14	1998-04-07	Alza Croporation	Composition, device, and method for electrotransport agent delivery
US5861439A (en) *	1994-11-14	1999-01-19	Alza Corporation	Method for enhanced electrotransport agent delivery
US5985316A (en) *	1995-04-28	1999-11-16	Alza Corporation	Composition and method of enhancing electrotransport agent delivery
US5990179A (en) *	1995-04-28	1999-11-23	Alza Corporation	Composition and method of enhancing electrotransport agent delivery
US6355025B1 (en)	1995-06-07	2002-03-12	Alza Corporation	Adjustable electrotransport drug delivery using a fixed output controller
AU7286996A (en) *	1995-10-18	1997-05-07	Ciba-Geigy Ag	Thermopile powered transdermal drug delivery device
US7094422B2 (en)	1996-02-19	2006-08-22	Acrux Dds Pty Ltd.	Topical delivery of antifungal agents
AUPN814496A0 (en)	1996-02-19	1996-03-14	Monash University	Dermal penetration enhancer
EP0849265A1 (de) *	1996-12-20	1998-06-24	HEUMANN PHARMA GmbH	Neue polymorphe Form von Doxazosin-Mesylat (Form II)
AUPO907697A0 (en) *	1997-09-09	1997-10-02	Day, Robert Edward	Chemical supplementation of bone
GB9723669D0 (en) *	1997-11-07	1998-01-07	Univ Aberdeen	Skin penetration enhancing components
JP4321966B2 (ja)	1998-11-02	2009-08-26	アルザ・コーポレーション	適合性抗微生物剤を含有する電気輸送式デバイス
JP2001072592A (ja)	1999-07-01	2001-03-21	Kyowa Hakko Kogyo Co Ltd	テロメラーゼ阻害剤
CA2400074A1 (en)	2000-02-18	2001-08-23	William I. Higuchi	Methods for extracting substances using alternating current
EP1259285A1 (de)	2000-02-18	2002-11-27	University of Utah	Verfahren zur abreichung von medikamenten durch wechselstrom
US6452014B1 (en)	2000-12-22	2002-09-17	Geron Corporation	Telomerase inhibitors and methods of their use
US7137975B2 (en) *	2001-02-13	2006-11-21	Aciont, Inc.	Method for increasing the battery life of an alternating current iontophoresis device using a barrier-modifying agent
RU2290216C2 (ru) *	2001-04-04	2006-12-27	Алза Корпорейшн	Устройство для трансдермального электротранспортного введения, содержащее резервуар с противомикробной совместимой композицией
US7099713B2 (en)	2002-06-28	2006-08-29	Battelle Memorial Institute	Skin conduction and transport systems
US7468428B2 (en) *	2004-03-17	2008-12-23	App Pharmaceuticals, Llc	Lyophilized azithromycin formulation
US20060116336A1 (en) *	2004-03-17	2006-06-01	American Pharmaceutical Partners, Inc.	Lyophilized azithromycin formulation
US20050220439A1 (en) *	2004-03-19	2005-10-06	Carton Owen A	Interactive multimedia system and method
US20060222692A1 (en) *	2005-03-31	2006-10-05	Fairfield Clinical Trials Llc	Method and compositions for transdermal administration of antimicrobial medications
EP1898922A4 (de) *	2005-07-04	2012-03-14	Ramu Krishnan	Verbessertes arzneimittel oder pharmazeutische verbindungen und eine zubereitung davon
EP2040794A4 (de) *	2006-06-16	2010-10-20	Transport Pharmaceuticals Inc	Pharmazeutische formulierungen zur iontophoretischen freisetzung von tetracyclinen
US20110097393A1 (en)	2008-06-25	2011-04-28	US WorldMeade, LLC	Skin Patches and Sustained-Release Formulations Comprising Lofexidine for Transdermal and Oral Delivery
WO2010054356A1 (en) *	2008-11-10	2010-05-14	Nitric Biotherapeutics, Inc.	Pharmaceutical formulations for iontophoretic delivery of a corticosteroid
WO2011002776A1 (en) *	2009-06-29	2011-01-06	Nitric Biotherapeutics, Inc.	Pharmaceutical formulations for iontophoretic delivery of an immunomodulator
WO2011130455A1 (en)	2010-04-13	2011-10-20	Najib Babul	Dermal pharmaceutical compositions of 1-methyl-2',6'-pipecoloxylidide and method of use
EP3086793B1 (de)	2013-12-24	2022-05-11	Virginia Commonwealth University	Verwendung von oxygenierten cholesterinsulfaten (ocs) zur behandlung von nierenstörungen
WO2019074870A1 (en) *	2017-10-09	2019-04-18	The Broad Institute, Inc.	COMPOSITIONS AND METHODS FOR DISCOVERING COMBINATORY DRUG IN DROPLETS OF THE NANOLITRE ORDER

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3991755A (en) *	1973-07-27	1976-11-16	Medicon, Inc.	Iontophoresis apparatus for applying local anesthetics
US4316893A (en) *	1975-06-19	1982-02-23	Nelson Research & Development Co.	Vehicle composition containing 1-substituted azacycloalkan-2-ones
US4405616A (en) *	1975-06-19	1983-09-20	Nelson Research & Development Company	Penetration enhancers for transdermal drug delivery of systemic agents
US3989816A (en) *	1975-06-19	1976-11-02	Nelson Research & Development Company	Vehicle composition containing 1-substituted azacycloheptan-2-ones
US4954487A (en) *	1979-01-08	1990-09-04	The Procter & Gamble Company	Penetrating topical pharmaceutical compositions
JPS6036299B2 (ja) *	1981-07-02	1985-08-20	タカラベルモント株式会社	イオン導入器
HU185691B (en) *	1982-02-09	1985-03-28	Richter Gedeon Vegyeszet	Process for preparing a new analgetic pharmaceutical composition
US4557934A (en) *	1983-06-21	1985-12-10	The Procter & Gamble Company	Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one
US4919648A (en) *	1983-08-18	1990-04-24	Drug Delivery Systems Inc.	High tack drug patch
JPS6222662A (ja) *	1985-07-19	1987-01-30	林原　健	イオン導入電子治療器
MY102980A (en) *	1986-10-31	1993-03-31	Pfizer	Transdermal flux enhancing compositions
US5108363A (en) *	1988-02-19	1992-04-28	Gensia Pharmaceuticals, Inc.	Diagnosis, evaluation and treatment of coronary artery disease by exercise simulation using closed loop drug delivery of an exercise simulating agent beta agonist
DE68902753T2 (de) *	1988-02-29	1993-01-21	Pfizer	Mittel zur erhoehung des transdermalen penetrationsflusses.

1989
- 1989-11-29 US US07/443,699 patent/US5023085A/en not_active Expired - Fee Related
1990
- 1990-11-02 PH PH41182A patent/PH27105A/en unknown
- 1990-11-08 DE DE90312217T patent/DE69006000T2/de not_active Expired - Fee Related
- 1990-11-08 EP EP90312217A patent/EP0435436B1/de not_active Expired - Lifetime
- 1990-11-08 DK DK90312217.4T patent/DK0435436T3/da active
- 1990-11-08 AT AT90312217T patent/ATE99961T1/de not_active IP Right Cessation
- 1990-11-22 IL IL9644990A patent/IL96449A/en not_active IP Right Cessation
- 1990-11-27 ZA ZA909512A patent/ZA909512B/xx unknown
- 1990-11-27 MY MYPI90002098A patent/MY109727A/en unknown
- 1990-11-27 CA CA002030943A patent/CA2030943A1/en not_active Abandoned
- 1990-11-28 IE IE428190A patent/IE63597B1/en not_active IP Right Cessation
- 1990-11-28 NZ NZ236253A patent/NZ236253A/xx unknown
- 1990-11-28 KR KR1019900019334A patent/KR930007248B1/ko not_active Expired - Fee Related
- 1990-11-28 HU HU907681A patent/HUT55629A/hu unknown
- 1990-11-28 AU AU67069/90A patent/AU613281B1/en not_active Ceased
- 1990-11-28 PT PT96021A patent/PT96021B/pt not_active IP Right Cessation
- 1990-11-29 JP JP2333509A patent/JPH0688912B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JPH0688912B2 (ja)	1994-11-09
IE904281A1 (en)	1991-06-05
MY109727A (en)	1997-05-31
HUT55629A (en)	1991-06-28
AU613281B1 (en)	1991-07-25
US5023085A (en)	1991-06-11
CA2030943A1 (en)	1991-05-30
PT96021A (pt)	1991-09-13
DE69006000T2 (de)	1994-05-05
DK0435436T3 (da)	1994-02-28
EP0435436A3 (en)	1992-01-08
NZ236253A (en)	1993-05-26
IL96449A (en)	1996-07-23
JPH03176426A (ja)	1991-07-31
PT96021B (pt)	1998-02-27
EP0435436B1 (de)	1994-01-12
ZA909512B (en)	1992-06-24
IE63597B1 (en)	1995-05-17
KR910009250A (ko)	1991-06-28
PH27105A (en)	1993-03-16
DE69006000D1 (de)	1994-02-24
EP0435436A2 (de)	1991-07-03
KR930007248B1 (ko)	1993-08-04

Legal Events

Date	Code	Title	Description
1994-11-15	UEP	Publication of translation of european patent specification
1999-08-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE99961T1 (de)	1994-01-15	Verstaerker des transdermalen flusses in kombination mit iontophorese fuer die topische verabreichung von arzneimitteln.
DE69401945D1 (de)	1997-04-10	Einarbeitung eines poly-n-vinylamids in ein transdermales system
ATE214946T1 (de)	2002-04-15	Zusammensetzungen zur penetrationsförderung in der haut durch gebrauch von acryllactylaten
DE3751761D1 (de)	1996-05-02	Penetrationsverbesserer für die transdermale Verabreichung von systemisch wirksamen Arzneimitteln
DE3688075D1 (de)	1993-04-22	Transdermales verabreichungssystem.
DE3681570D1 (de)	1991-10-24	Medizinische einrichtung zur pulsatilen transdermalen verabreichung von biologisch aktiven wirkstoffen.
NO307644B1 (no)	2000-05-08	Transdermalt, terapeutisk system med krystalliseringsinhibitor
DE69326848D1 (de)	1999-11-25	Oxybutynin zur transdermalen Verabreichung
MY105121A (en)	1994-08-30	Pharmaceutical composition for systemic transdermal administration.
EP0164998A3 (de)	1987-06-16	Mittel und Verfahren zur Erhöhung der transdermalen und transmembranen Penetration topischer und systemischer Wirkstoffe
DE3587698D1 (de)	1994-02-03	Pharmazeutische Präparate.
ATE56138T1 (de)	1990-09-15	Perfluorkohlenwasserstoffe als vehikel zur verabreichung von arzneimitteln.
ATE50143T1 (de)	1990-02-15	Arzneimittel fuer die behandlung von involutiven gehirnsyndromen und von geistigem verfall.
PT88539A (pt)	1988-10-01	Stabilisierung von therapeutisch wirksamen proteinen in pharmazeutischen zubereitungen
DE3877630D1 (de)	1993-03-04	Transkutane verabreichung von pharmazeutika.
ATE61522T1 (de)	1991-03-15	Pharmazeutische zubereitung zur behandlung von tinea pedis.
DE3863200D1 (de)	1991-07-18	In der krebstherapie verwendbare zusammensetzung auf der basis von aminosaeure und vitaminen.
IT8748116A0 (it)	1987-06-26	Derivati di glicina in qualita' di agenti preventivi e terapeutici del le complicanze diabetiche
DE3771548D1 (de)	1991-08-29	Verwendung von carbonsaeure in fuer topische anwendung vorgesehenen pharmazeutischen zubereitungen.
DK222988A (da)	1988-10-24	Farmaceutiske praeparater indeholdende ornithin-decarboxylase-inhibitorer
ATE94197T1 (de)	1993-09-15	Eindringungserhoehende mittel zur transdermalen verabreichung systemischer mittel.
SE8401907D0 (sv)	1984-04-05	New phenoxypropanol amine salts and pharmaceutical preparations thereof