PT968194E - Atropisomeros de 3-aril-4(3h)-quinazolinonas e sua utilizacao como antagonistas dos receptores ampa - Google Patents
Atropisomeros de 3-aril-4(3h)-quinazolinonas e sua utilizacao como antagonistas dos receptores ampaInfo
- Publication number
- PT968194E PT968194E PT98900978T PT98900978T PT968194E PT 968194 E PT968194 E PT 968194E PT 98900978 T PT98900978 T PT 98900978T PT 98900978 T PT98900978 T PT 98900978T PT 968194 E PT968194 E PT 968194E
- Authority
- PT
- Portugal
- Prior art keywords
- quinazolinones
- atropisomers
- antagonists
- aryl
- ampa receptors
- Prior art date
Links
- 102000003678 AMPA Receptors Human genes 0.000 title 1
- 108090000078 AMPA Receptors Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3890597P | 1997-02-28 | 1997-02-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT968194E true PT968194E (pt) | 2004-08-31 |
Family
ID=21902563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT98900978T PT968194E (pt) | 1997-02-28 | 1998-02-06 | Atropisomeros de 3-aril-4(3h)-quinazolinonas e sua utilizacao como antagonistas dos receptores ampa |
Country Status (40)
| Country | Link |
|---|---|
| US (1) | US6306864B1 (pt) |
| EP (1) | EP0968194B1 (pt) |
| JP (1) | JP2000509731A (pt) |
| KR (1) | KR100358636B1 (pt) |
| CN (1) | CN1248248A (pt) |
| AP (1) | AP859A (pt) |
| AR (1) | AR011170A1 (pt) |
| AT (1) | ATE267817T1 (pt) |
| AU (1) | AU744028B2 (pt) |
| BG (1) | BG103689A (pt) |
| BR (1) | BR9807872A (pt) |
| CA (1) | CA2282277C (pt) |
| DE (1) | DE69824157T2 (pt) |
| DK (1) | DK0968194T3 (pt) |
| DZ (1) | DZ2440A1 (pt) |
| EA (1) | EA001963B1 (pt) |
| ES (1) | ES2219866T3 (pt) |
| GT (1) | GT199800038A (pt) |
| HR (1) | HRP980106A2 (pt) |
| HU (1) | HUP0000914A3 (pt) |
| ID (1) | ID22711A (pt) |
| IL (1) | IL130900A0 (pt) |
| IS (1) | IS1952B (pt) |
| MA (1) | MA24484A1 (pt) |
| NO (1) | NO313630B1 (pt) |
| NZ (1) | NZ336628A (pt) |
| OA (1) | OA11089A (pt) |
| PA (1) | PA8447001A1 (pt) |
| PE (1) | PE58399A1 (pt) |
| PL (1) | PL335418A1 (pt) |
| PT (1) | PT968194E (pt) |
| SK (1) | SK113299A3 (pt) |
| TN (1) | TNSN98035A1 (pt) |
| TR (1) | TR199902093T2 (pt) |
| TW (1) | TW504508B (pt) |
| UA (1) | UA61097C2 (pt) |
| UY (1) | UY24897A1 (pt) |
| WO (1) | WO1998038173A1 (pt) |
| YU (1) | YU41299A (pt) |
| ZA (1) | ZA981666B (pt) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT901487E (pt) | 1996-05-15 | 2003-08-29 | Pfizer | 4(3h)-quinazolinonas 2,3,6-trissubstituidas |
| US6323208B1 (en) * | 1997-09-05 | 2001-11-27 | Pfizer Inc | Atropisomers of 2,3-disubstituted-(5.6)-heteroaryl fused-pyrimidin-4-ones |
| JPH11279158A (ja) * | 1998-02-09 | 1999-10-12 | Pfizer Prod Inc | キナゾリン―４―オン誘導体の製造方法 |
| DK2223922T3 (en) * | 2000-04-25 | 2016-06-06 | Icos Corp | Inhibitors of HUMANPHOSPHATIDYL-inositol 3-KINASEDELTA |
| US6667300B2 (en) | 2000-04-25 | 2003-12-23 | Icos Corporation | Inhibitors of human phosphatidylinositol 3-kinase delta |
| PT1300396E (pt) | 2000-06-12 | 2009-04-20 | Eisai R&D Man Co Ltd | Compostos de 1,2-di-hidropiridina, processos para a sua preparação e sua utilização |
| ATE497385T1 (de) | 2000-08-18 | 2011-02-15 | Ajinomoto Kk | Neue phenylalanin-derivate |
| GB0129260D0 (en) | 2001-12-06 | 2002-01-23 | Eisai London Res Lab Ltd | Pharmaceutical compositions and their uses |
| US6939968B2 (en) * | 2002-12-23 | 2005-09-06 | Bristol-Myers Squibb Company | Atropisomers of 3-substituted-4-arylquinolin-2-one derivatives |
| EP1660486A4 (en) * | 2003-08-08 | 2006-12-13 | Ulysses Pharmaceutical Product | HALOGENATED CHINAZOLINYL NITROFURANES AS ANTIBACTERIAL AGENTS |
| US20080146562A1 (en) * | 2003-08-08 | 2008-06-19 | Ulysses Pharmaceutical Products Inc., | Halogenated quinazolinyl nitrofurans as antibacterial agents |
| GB0325390D0 (en) * | 2003-10-30 | 2003-12-03 | Novartis Ag | Organic compounds |
| EP1700850B1 (en) | 2003-12-22 | 2015-07-15 | Ajinomoto Co., Inc. | Phenylalanine derivative |
| EP1761540B1 (en) | 2004-05-13 | 2016-09-28 | Icos Corporation | Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta |
| MY148809A (en) | 2004-07-06 | 2013-05-31 | Eisai R&D Man Co Ltd | Crystals of 1,2-dihydropyridine compound and their production process |
| GB0416730D0 (en) * | 2004-07-27 | 2004-09-01 | Novartis Ag | Organic compounds |
| EP1954283A2 (en) | 2005-11-04 | 2008-08-13 | Hydra Biosciences, Inc. | Compounds for modulating trpv3 function |
| CA2663436A1 (en) | 2006-10-04 | 2008-04-10 | Pfizer Products Inc. | Pyrido[4,3-d]pyrimidin-4(3h)-one derivatives as calcium receptor antagonists |
| WO2008140750A1 (en) | 2007-05-10 | 2008-11-20 | Hydra Biosciences Inc. | Compounds for modulating trpv3 function |
| CN101429166B (zh) * | 2007-11-07 | 2013-08-21 | 上海特化医药科技有限公司 | 喹唑啉酮衍生物及其制备方法和用途 |
| KR20160091440A (ko) | 2008-11-13 | 2016-08-02 | 길리아드 칼리스토가 엘엘씨 | 혈액 종양에 대한 요법 |
| US9492449B2 (en) | 2008-11-13 | 2016-11-15 | Gilead Calistoga Llc | Therapies for hematologic malignancies |
| CA2756347A1 (en) | 2009-03-24 | 2010-09-30 | Gilead Calistoga Llc | Atropisomers of 2-purinyl-3-tolyl-quinazolinone derivatives and methods of use |
| AU2010276160A1 (en) | 2009-07-21 | 2012-02-09 | Gilead Calistoga Llc | Treatment of liver disorders with PI3K inhibitors |
| EA025407B1 (ru) | 2012-03-05 | 2016-12-30 | Джилид Калистога Ллс | Полиморфная форма i (s)-2-(1-(9h-пурин-6-иламино)пропил)-5-фтор-3-фенилхиназолин-4(3h)-она |
| CN103275086B (zh) * | 2013-05-30 | 2015-04-15 | 温州大学 | 一种6-取代喹唑啉并喹唑啉酮化合物及其合成方法和用途 |
| NZ720867A (en) | 2013-12-20 | 2018-01-26 | Gilead Calistoga Llc | Process methods for phosphatidylinositol 3-kinase inhibitors |
| WO2015095605A1 (en) | 2013-12-20 | 2015-06-25 | Gilead Calistoga Llc | Polymorphic forms of a hydrochloride salt of (s) -2-(9h-purin-6-ylamino) propyl) -5-fluoro-3-phenylquinazolin-4 (3h) -one |
| US9533909B2 (en) | 2014-03-31 | 2017-01-03 | Corning Incorporated | Methods and apparatus for material processing using atmospheric thermal plasma reactor |
| JP6455995B2 (ja) | 2014-06-13 | 2019-01-23 | ギリアード サイエンシーズ， インコーポレイテッド | ホスファチジルイノシトール３−キナーゼ阻害剤 |
| DE102014217021A1 (de) * | 2014-08-27 | 2016-03-03 | Skf Lubrication Systems Germany Ag | Gehäuse für eine Vorrichtung zum dosierten Verteilen eines Mediums sowie eine Dosiereinrichtung zur Verwendung in dem Gehäuse |
| CN113226286B (zh) | 2018-12-14 | 2024-08-20 | 卫材R&D管理有限公司 | 1,2-二氢吡啶化合物的水基药物制剂 |
| WO2021154966A1 (en) | 2020-01-29 | 2021-08-05 | Kamari Pharma Ltd. | Compounds and compositions for use in treating skin disorders |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1195321B (de) * | 1962-03-16 | 1965-06-24 | Troponwerke Dinklage & Co | Verfahren zur Herstellung von substituierten Chinazolon-(4)-derivaten |
| DE1670416A1 (de) * | 1966-12-30 | 1971-02-11 | Chem Fab Von Heyden Gmbh Muenc | Verfahren zur Herstellung von aminosubstituierten Chinazolinonderivaten |
| GB1298603A (en) * | 1970-04-06 | 1972-12-06 | Karamchand Premchand Private | Quinazolinone derivatives |
| US4183931A (en) * | 1977-09-08 | 1980-01-15 | Research Corporation | 2-Ketoalkyl-4(3H)-quinazolinones |
| GB9022785D0 (en) * | 1990-10-19 | 1990-12-05 | Merck Sharp & Dohme | Therapeutic agents |
| WO1992013535A1 (en) * | 1991-02-06 | 1992-08-20 | Research Corporation Technologies, Inc. | Anticonvulsant substituted quinazolones |
| US5777271A (en) * | 1996-01-18 | 1998-07-07 | Commscope, Inc. | Cable having an at least partially oxidized armor layer |
| PT901487E (pt) * | 1996-05-15 | 2003-08-29 | Pfizer | 4(3h)-quinazolinonas 2,3,6-trissubstituidas |
-
1998
- 1998-02-06 ID IDW990937A patent/ID22711A/id unknown
- 1998-02-06 YU YU41299A patent/YU41299A/sh unknown
- 1998-02-06 EA EA199900693A patent/EA001963B1/ru not_active IP Right Cessation
- 1998-02-06 KR KR1019997007887A patent/KR100358636B1/ko not_active Expired - Fee Related
- 1998-02-06 PL PL98335418A patent/PL335418A1/xx unknown
- 1998-02-06 DE DE69824157T patent/DE69824157T2/de not_active Expired - Fee Related
- 1998-02-06 CN CN98802638A patent/CN1248248A/zh active Pending
- 1998-02-06 TR TR1999/02093T patent/TR199902093T2/xx unknown
- 1998-02-06 NZ NZ336628A patent/NZ336628A/xx unknown
- 1998-02-06 AU AU56768/98A patent/AU744028B2/en not_active Ceased
- 1998-02-06 CA CA002282277A patent/CA2282277C/en not_active Expired - Fee Related
- 1998-02-06 EP EP98900978A patent/EP0968194B1/en not_active Expired - Lifetime
- 1998-02-06 BR BR9807872A patent/BR9807872A/pt not_active Application Discontinuation
- 1998-02-06 PT PT98900978T patent/PT968194E/pt unknown
- 1998-02-06 DK DK98900978T patent/DK0968194T3/da active
- 1998-02-06 AT AT98900978T patent/ATE267817T1/de not_active IP Right Cessation
- 1998-02-06 IL IL13090098A patent/IL130900A0/xx unknown
- 1998-02-06 WO PCT/IB1998/000150 patent/WO1998038173A1/en not_active Ceased
- 1998-02-06 HU HU0000914A patent/HUP0000914A3/hu unknown
- 1998-02-06 ES ES98900978T patent/ES2219866T3/es not_active Expired - Lifetime
- 1998-02-06 SK SK1132-99A patent/SK113299A3/sk unknown
- 1998-02-06 JP JP10537448A patent/JP2000509731A/ja active Pending
- 1998-02-06 US US09/367,960 patent/US6306864B1/en not_active Expired - Fee Related
- 1998-02-17 PA PA19988447001A patent/PA8447001A1/es unknown
- 1998-02-19 GT GT199800038A patent/GT199800038A/es unknown
- 1998-02-20 UY UY24897A patent/UY24897A1/es not_active Application Discontinuation
- 1998-02-23 PE PE1998000126A patent/PE58399A1/es not_active Application Discontinuation
- 1998-02-25 TN TNTNSN98035A patent/TNSN98035A1/fr unknown
- 1998-02-25 TW TW087102714A patent/TW504508B/zh not_active IP Right Cessation
- 1998-02-25 MA MA24978A patent/MA24484A1/fr unknown
- 1998-02-25 DZ DZ980050A patent/DZ2440A1/xx active
- 1998-02-26 AR ARP980100871A patent/AR011170A1/es not_active Application Discontinuation
- 1998-02-26 AP APAP/P/1998/001199A patent/AP859A/en active
- 1998-02-27 HR HR60/038,905A patent/HRP980106A2/hr not_active Application Discontinuation
- 1998-02-27 ZA ZA9801666A patent/ZA981666B/xx unknown
- 1998-06-02 UA UA99084849A patent/UA61097C2/uk unknown
-
1999
- 1999-07-30 IS IS5140A patent/IS1952B/is unknown
- 1999-08-20 OA OA9900187A patent/OA11089A/en unknown
- 1999-08-24 BG BG103689A patent/BG103689A/bg unknown
- 1999-08-27 NO NO19994177A patent/NO313630B1/no not_active IP Right Cessation
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