PT97009A - Processo apeefeicoado para a preparacao de hexa-hidrato de fosfonoformato de trissodio (foscarnet) - Google Patents

Processo apeefeicoado para a preparacao de hexa-hidrato de fosfonoformato de trissodio (foscarnet)

Info

Publication number: PT97009A
Authority: PT; Portugal
Prior art keywords: foscarnet; trisode; phosphonomethate; hexa; hydrate
Prior art date: 1990-03-12

Application number

PT97009A

Other languages

English (en)

Other versions

PT97009B (pt

Inventor

Edib Jakupovic

Urban Stenhede

Original Assignee

Astra Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-03-12

Filing date

1991-03-11

Publication date

1991-10-31

1991-03-11 Application filed by Astra Ab filed Critical Astra Ab

1991-10-31 Publication of PT97009A publication Critical patent/PT97009A/pt

1998-07-31 Publication of PT97009B publication Critical patent/PT97009B/pt

Links

ZJAOAACCNHFJAH-UHFFFAOYSA-N phosphonoformic acid Chemical compound OC(=O)P(O)(O)=O ZJAOAACCNHFJAH-UHFFFAOYSA-N 0.000 title abstract 4
229960005102 foscarnet Drugs 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
150000004687 hexahydrates Chemical class 0.000 title 1
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 6
238000010438 heat treatment Methods 0.000 abstract 2
239000011541 reaction mixture Substances 0.000 abstract 2
230000015572 biosynthetic process Effects 0.000 abstract 1
238000001816 cooling Methods 0.000 abstract 1
NOJFJZZMRDSOLM-UHFFFAOYSA-N ethyl diethoxyphosphorylformate Chemical compound CCOC(=O)P(=O)(OCC)OCC NOJFJZZMRDSOLM-UHFFFAOYSA-N 0.000 abstract 1
238000010992 reflux Methods 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
JTFHKOYORZAXSV-UHFFFAOYSA-K trisodium phosphonoformate hexahydrate Chemical compound O.O.O.O.O.O.[Na+].[Na+].[Na+].OP(O)(=O)C([O-])=O.OP(O)(=O)C([O-])=O.OP(O)(=O)C([O-])=O JTFHKOYORZAXSV-UHFFFAOYSA-K 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3886—Acids containing the structure -C(=X)-P(=X)(XH)2 or NC-P(=X)(XH)2, (X = O, S, Se)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Crystallography & Structural Chemistry (AREA)
Catalysts (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Glass Compositions (AREA)
Saccharide Compounds (AREA)
Inorganic Compounds Of Heavy Metals (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Steroid Compounds (AREA)
Crystals, And After-Treatments Of Crystals (AREA)
Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Treating Waste Gases (AREA)

PT97009A 1990-03-12 1991-03-11 Processo apeefeicoado para a preparacao de hexa-hidrato de fosfonoformato de trissodio (foscarnet) PT97009B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB9005534A GB2241954A (en)	1990-03-12	1990-03-12	Preparation of trisodium phosphonoformate hexahydrate

Publications (2)

Publication Number	Publication Date
PT97009A true PT97009A (pt)	1991-10-31
PT97009B PT97009B (pt)	1998-07-31

Family

ID=10672476

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT97009A PT97009B (pt)	1990-03-12	1991-03-11	Processo apeefeicoado para a preparacao de hexa-hidrato de fosfonoformato de trissodio (foscarnet)

Country Status (29)

Country	Link
EP (1)	EP0479960B1 (pt)
JP (1)	JP2568341B2 (pt)
KR (1)	KR920701214A (pt)
AT (1)	ATE129249T1 (pt)
AU (1)	AU635413B2 (pt)
BG (1)	BG61650B1 (pt)
CA (1)	CA2053270C (pt)
DE (2)	DE69113949T2 (pt)
DK (1)	DK0479960T3 (pt)
ES (1)	ES2055681T3 (pt)
FI (1)	FI101540B1 (pt)
GB (1)	GB2241954A (pt)
GR (2)	GR920300063T1 (pt)
HK (1)	HK7297A (pt)
HU (1)	HU212621B (pt)
ID (1)	ID853B (pt)
IE (1)	IE71021B1 (pt)
IS (1)	IS1635B (pt)
LT (1)	LT3585B (pt)
LV (1)	LV10869B (pt)
MY (1)	MY135300A (pt)
NO (1)	NO179793C (pt)
NZ (1)	NZ237386A (pt)
PL (1)	PL166798B1 (pt)
PT (1)	PT97009B (pt)
RO (1)	RO111574B1 (pt)
RU (1)	RU2043993C1 (pt)
UA (1)	UA25900A1 (pt)
WO (1)	WO1991013894A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3590579B2 (ja) *	2000-12-11	2004-11-17	オーエスジー株式会社	ダイヤモンド被覆部材およびその製造方法
RU2228336C1 (ru) *	2002-12-23	2004-05-10	Бондаренко Наталья Александровна	Способ получения тринатриевой соли фосфонмуравьиной кислоты гексагидрата

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4018854A (en) *	1973-07-23	1977-04-19	E. I. Du Pont De Nemours And Company	Carboxyphosphonates
DD243500A1 (de) *	1985-12-17	1987-03-04	Univ Halle Wittenberg	Verfahren zur herstellung von phosphonoformiaten
DE3607445A1 (de) *	1986-03-07	1987-09-10	Hoechst Ag	Verfahren zur herstellung von alkali-phosphonoformiaten
CS253848B1 (cs) *	1986-07-18	1987-12-17	Viktor Zikan	Způsob výroby hexahydrátu trojsodné soli kyseliny fosfonomravenčí

1990
- 1990-03-12 GB GB9005534A patent/GB2241954A/en not_active Withdrawn
1991
- 1991-03-06 DK DK91905856.0T patent/DK0479960T3/da active
- 1991-03-06 AT AT91905856T patent/ATE129249T1/de not_active IP Right Cessation
- 1991-03-06 EP EP91905856A patent/EP0479960B1/en not_active Expired - Lifetime
- 1991-03-06 UA UA5010100A patent/UA25900A1/uk unknown
- 1991-03-06 HU HU913521A patent/HU212621B/hu unknown
- 1991-03-06 DE DE69113949T patent/DE69113949T2/de not_active Expired - Lifetime
- 1991-03-06 WO PCT/SE1991/000172 patent/WO1991013894A1/en not_active Ceased
- 1991-03-06 ES ES91905856T patent/ES2055681T3/es not_active Expired - Lifetime
- 1991-03-06 RO RO148727A patent/RO111574B1/ro unknown
- 1991-03-06 PL PL91293014A patent/PL166798B1/pl unknown
- 1991-03-06 DE DE199191905856T patent/DE479960T1/de active Pending
- 1991-03-06 KR KR1019910701581A patent/KR920701214A/ko not_active Ceased
- 1991-03-06 CA CA002053270A patent/CA2053270C/en not_active Expired - Lifetime
- 1991-03-06 AU AU74921/91A patent/AU635413B2/en not_active Expired
- 1991-03-06 JP JP3505894A patent/JP2568341B2/ja not_active Expired - Lifetime
- 1991-03-11 IE IE78891A patent/IE71021B1/en not_active IP Right Cessation
- 1991-03-11 IS IS3682A patent/IS1635B/is unknown
- 1991-03-11 NZ NZ237386A patent/NZ237386A/en unknown
- 1991-03-11 PT PT97009A patent/PT97009B/pt not_active IP Right Cessation
- 1991-03-12 MY MYPI91000403A patent/MY135300A/en unknown
- 1991-11-01 NO NO914291A patent/NO179793C/no not_active IP Right Cessation
- 1991-11-11 RU SU915010100A patent/RU2043993C1/ru active
- 1991-11-11 FI FI915313A patent/FI101540B1/fi active
- 1991-11-12 BG BG95452A patent/BG61650B1/bg unknown
1992
- 1992-01-27 ID IDP174892A patent/ID853B/id unknown
- 1992-08-31 GR GR92300063T patent/GR920300063T1/el unknown
1993
- 1993-06-30 LV LVP-93-817A patent/LV10869B/en unknown
- 1993-12-30 LT LTIP1737A patent/LT3585B/lt not_active IP Right Cessation
1995
- 1995-12-15 GR GR950403569T patent/GR3018439T3/el unknown
1997
- 1997-01-16 HK HK7297A patent/HK7297A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2053270C (en)	1995-10-03
HU212621B (en)	1996-09-30
RU2043993C1 (ru)	1995-09-20
IS1635B (is)	1996-09-20
PL166798B1 (pl)	1995-06-30
DK0479960T3 (da)	1996-03-04
GB2241954A (en)	1991-09-18
EP0479960A1 (en)	1992-04-15
JP2568341B2 (ja)	1997-01-08
UA25900A1 (uk)	1999-02-26
DE479960T1 (de)	1992-08-13
NO179793B (no)	1996-09-09
FI101540B (sv)	1998-07-15
LV10869A (lv)	1995-10-20
NO914291D0 (no)	1991-11-01
HUT58750A (en)	1992-03-30
NO179793C (no)	1996-12-18
BG95452A (bg)	1993-12-24
LTIP1737A (en)	1995-07-25
IS3682A7 (is)	1991-09-13
GR920300063T1 (en)	1992-08-31
ES2055681T3 (es)	1995-12-16
AU635413B2 (en)	1993-03-18
BG61650B1 (bg)	1998-02-27
WO1991013894A1 (en)	1991-09-19
AU7492191A (en)	1991-10-10
IE910788A1 (en)	1991-09-25
PT97009B (pt)	1998-07-31
NO914291L (no)	1991-11-01
HK7297A (en)	1997-01-24
EP0479960B1 (en)	1995-10-18
GB9005534D0 (en)	1990-05-09
IE71021B1 (en)	1997-01-15
ATE129249T1 (de)	1995-11-15
GR3018439T3 (en)	1996-03-31
LT3585B (en)	1995-12-27
PL293014A1 (en)	1992-06-15
NZ237386A (en)	1992-03-26
ID853B (id)	1996-08-02
LV10869B (en)	1996-08-20
MY135300A (en)	2008-03-31
FI915313A0 (fi)	1991-11-11
DE69113949T2 (de)	1996-03-21
DE69113949D1 (de)	1995-11-23
ES2055681T1 (es)	1994-09-01
CA2053270A1 (en)	1991-09-13
HU913521D0 (en)	1992-01-28
KR920701214A (ko)	1992-08-11
FI101540B1 (fi)	1998-07-15
JPH04503822A (ja)	1992-07-09
RO111574B1 (ro)	1996-11-29

Legal Events

Date	Code	Title	Description
1991-10-31	BB1A	Laying open of patent application	Effective date: 19910710
1998-07-31	FG3A	Patent granted, date of granting	Effective date: 19980414
2011-10-12	PC4A	Transfer of assignment	Owner name: CLINIGEN HEALTHCARE LIMITED, GB Effective date: 20110805
2013-04-23	MM4A	Annulment/lapse due to non-payment of fees, searched and examined patent	Free format text: MAXIMUM VALIDITY LIMIT REACHED Effective date: 20130415

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DE69108401D1 (de)	1995-04-27	Verfahren zur herstellung von bisphenol-fluorenverbindungen.
JPS56140949A (en)	1981-11-04	3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenic acid
PT97009A (pt)	1991-10-31	Processo apeefeicoado para a preparacao de hexa-hidrato de fosfonoformato de trissodio (foscarnet)
ES532278A0 (es)	1985-08-01	Un procedimiento para la preparacion de nuevos indonaftoles.
ATE59943T1 (de)	1991-02-15	Verfahren zum herstellen eines brausegranulates, danach hergestelltes brausegranulat sowie dessen verwendung.
DK434989A (da)	1990-03-04	Fremgangsmaade til kontinuerlig fremstilling af 2-phosphonobutan-1,2,4-tricarboxylsyre eller dennes alkalimetalsalte
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ES2118845T3 (es)	1998-10-01	Proceso para la preparacion de trimetilaluminio por reaccion de cloruros de metilaluminio con sodio en reactores de estado solido.
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US2478834A (en)	1949-08-09	Process of making the disodium salt of 2-carboxy-phenyl-sulfuric acid
DK0437567T3 (da)	1995-02-13	Phenylglycin-derivater
DE69826394D1 (de)	2004-10-28	Verfahren zur herstellung von c-glykosiden der ulosonsäure
JPS57171958A (en)	1982-10-22	Preparation of 1-hydroxypropane derivative
ATE164825T1 (de)	1998-04-15	Verfahren zur herstellung von hydroxyphenylessigsäuren
JPS6327463A (ja)	1988-02-05	デアセチルモキシシリトの製法
YU5693A (sh)	1996-05-20	Postupak za sintezu 3-alfa-fenil-beta-acetiletil-4-hidroksikumarina i dobijanje njegove natrijumove soli