PT97062A - Metodo para a utilizacao de tenidap como inibidor da libertacao de elastase por neutrofilos - Google Patents

Metodo para a utilizacao de tenidap como inibidor da libertacao de elastase por neutrofilos

Info

Publication number: PT97062A
Authority: PT; Portugal
Prior art keywords: tenidap; elastase; neutrophilos; libertacation; inhibitor
Prior art date: 1990-03-19

Application number

PT97062A

Other languages

English (en)

Other versions

PT97062B (pt

Inventor

Leland David Loose

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-03-19

Filing date

1991-03-18

Publication date

1991-10-31

1991-03-18 Application filed by Pfizer filed Critical Pfizer

1991-10-31 Publication of PT97062A publication Critical patent/PT97062A/pt

1998-07-31 Publication of PT97062B publication Critical patent/PT97062B/pt

Links

LXIKEPCNDFVJKC-QXMHVHEDSA-N tenidap Chemical compound C12=CC(Cl)=CC=C2N(C(=O)N)C(=O)\C1=C(/O)C1=CC=CS1 LXIKEPCNDFVJKC-QXMHVHEDSA-N 0.000 title abstract 4
229960003676 tenidap Drugs 0.000 title abstract 4
102000016387 Pancreatic elastase Human genes 0.000 title abstract 3
108010067372 Pancreatic elastase Proteins 0.000 title abstract 3
239000003112 inhibitor Substances 0.000 title 1
241000124008 Mammalia Species 0.000 abstract 3
150000003839 salts Chemical class 0.000 abstract 3
IGPDWKCUDHIIRL-UHFFFAOYSA-N 5-chloro-2-oxo-3-[oxo(thiophen-2-yl)methyl]-3H-indole-1-carboxamide Chemical compound C12=CC(Cl)=CC=C2N(C(=O)N)C(=O)C1C(=O)C1=CC=CS1 IGPDWKCUDHIIRL-UHFFFAOYSA-N 0.000 abstract 1
206010014561 Emphysema Diseases 0.000 abstract 1
206010003230 arteritis Diseases 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000004064 dysfunction Effects 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
210000000440 neutrophil Anatomy 0.000 abstract 1
201000001474 proteinuria Diseases 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Pulmonology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines Containing Plant Substances (AREA)

PT97062A 1990-03-19 1991-03-18 Metodo para a utilizacao de tenidap como inibidor da libertacao de elastase por neutrofilos PT97062B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/495,888 US5006547A (en)	1990-03-19	1990-03-19	Tenidap as an inhibitor of the release of elastase by neutrophils

Publications (2)

Publication Number	Publication Date
PT97062A true PT97062A (pt)	1991-10-31
PT97062B PT97062B (pt)	1998-07-31

Family

ID=23970396

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT97062A PT97062B (pt)	1990-03-19	1991-03-18	Metodo para a utilizacao de tenidap como inibidor da libertacao de elastase por neutrofilos

Country Status (17)

Country	Link
US (1)	US5006547A (pt)
EP (1)	EP0448261B1 (pt)
JP (1)	JPH0678230B2 (pt)
KR (1)	KR960016511B1 (pt)
AT (1)	ATE133071T1 (pt)
AU (1)	AU629109B2 (pt)
CA (1)	CA2038410C (pt)
DE (1)	DE69116404T2 (pt)
DK (1)	DK0448261T3 (pt)
HU (1)	HU212492B (pt)
IE (1)	IE70732B1 (pt)
IL (1)	IL97520A (pt)
MY (1)	MY107227A (pt)
NZ (1)	NZ237450A (pt)
PH (1)	PH27229A (pt)
PT (1)	PT97062B (pt)
ZA (1)	ZA911980B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5008283A (en) *	1990-03-19	1991-04-16	Pfizer Inc.	Use of tenidap to inhibit activation of collagenase and to inhibit the activity of myeloperoxidase
US5122534A (en) *	1991-02-08	1992-06-16	Pfizer Inc.	Use of tenidap to reduce total serum cholesterol, ldl cholesterol and triglycerides
US5545656A (en) *	1995-04-05	1996-08-13	Pfizer Inc.	2-Oxidole-1-carboxamide pharmaceutical agents for the treatment of alzheimer's disease
US6544556B1 (en)	2000-09-11	2003-04-08	Andrx Corporation	Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and a proton pump inhibitor
EP1390062A4 (en) *	2001-05-02	2005-09-14	Blood Res Center	MODULATORS OF ELASTASE INHIBITOR SECRETION
DK2026651T3 (da)	2006-03-08	2013-07-08	Cortria Corp	Kombinationsterapi med ikke-selektive COX-inhibitorer til forebyggelse af COX-relaterede maveskader
EP2886541A1 (en) *	2013-12-19	2015-06-24	Sanofi	Oxindole derivatives, preparation thereof and therapeutic use in the treatment of AMPK-related diseases

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4556672A (en) *	1984-03-19	1985-12-03	Pfizer Inc.	3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
US4678802A (en) *	1985-07-09	1987-07-07	Pfizer Inc.	1-acylcarbamoyloxindole-3-carboxamides as antiinflammatory agents
RO105052B1 (en) *	1987-02-02	1994-12-01	Pfizer	Producing process for the crystalline sodium salt, anhydre, of 5-chlorine-3-(2-tenoil)-2-oxindol-1-carboxamide
DE3852145T2 (de) *	1987-02-18	1995-04-06	Beecham Group Plc	Indolderivate, Verfahren zu deren Herstellung und pharmazeutische Präparate, die diese enthalten.
US4861794A (en) *	1988-04-13	1989-08-29	Pfizer Inc.	3-substituted-2-oxindole-1-carboxamides as inhibitors of interleukin-1 biosynthesis
US4853409A (en) *	1988-04-13	1989-08-01	Pfizer Inc.	3-substituted-2-oxindole-1-carboxamides for suppressing T-cell function
DE3814504A1 (de) *	1988-04-29	1989-11-09	Bayer Ag	(alpha)-substituierte 4-(chinolin-2-yl-methoxy)phenylessigsaeuren und -ester, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln

1990
- 1990-03-19 US US07/495,888 patent/US5006547A/en not_active Expired - Lifetime
1991
- 1991-03-08 AT AT91301963T patent/ATE133071T1/de not_active IP Right Cessation
- 1991-03-08 DK DK91301963.4T patent/DK0448261T3/da active
- 1991-03-08 PH PH42109A patent/PH27229A/en unknown
- 1991-03-08 DE DE69116404T patent/DE69116404T2/de not_active Expired - Fee Related
- 1991-03-08 EP EP91301963A patent/EP0448261B1/en not_active Expired - Lifetime
- 1991-03-12 IL IL9752091A patent/IL97520A/en not_active IP Right Cessation
- 1991-03-15 IE IE86191A patent/IE70732B1/en not_active IP Right Cessation
- 1991-03-15 NZ NZ237450A patent/NZ237450A/en unknown
- 1991-03-15 CA CA002038410A patent/CA2038410C/en not_active Expired - Fee Related
- 1991-03-18 PT PT97062A patent/PT97062B/pt not_active IP Right Cessation
- 1991-03-18 ZA ZA911980A patent/ZA911980B/xx unknown
- 1991-03-18 KR KR1019910004237A patent/KR960016511B1/ko not_active Expired - Fee Related
- 1991-03-18 HU HU91871A patent/HU212492B/hu not_active IP Right Cessation
- 1991-03-18 AU AU73586/91A patent/AU629109B2/en not_active Ceased
- 1991-03-18 MY MYPI91000439A patent/MY107227A/en unknown
- 1991-03-19 JP JP3130751A patent/JPH0678230B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JPH04234814A (ja)	1992-08-24
EP0448261A3 (en)	1992-04-08
JPH0678230B2 (ja)	1994-10-05
NZ237450A (en)	1997-02-24
ZA911980B (en)	1992-10-28
CA2038410C (en)	1995-01-24
KR910016327A (ko)	1991-11-05
US5006547A (en)	1991-04-09
IL97520A (en)	1995-12-31
PT97062B (pt)	1998-07-31
EP0448261B1 (en)	1996-01-17
HUT60622A (en)	1992-10-28
DK0448261T3 (da)	1996-02-12
DE69116404T2 (de)	1996-05-30
HU212492B (en)	1996-07-29
IL97520A0 (en)	1992-06-21
AU7358691A (en)	1992-08-06
DE69116404D1 (de)	1996-02-29
IE70732B1 (en)	1996-12-11
ATE133071T1 (de)	1996-02-15
PH27229A (en)	1993-05-04
MY107227A (en)	1995-10-31
KR960016511B1 (ko)	1996-12-14
EP0448261A2 (en)	1991-09-25
IE910861A1 (en)	1991-09-25
AU629109B2 (en)	1992-09-24
HU910871D0 (en)	1991-09-30

Legal Events

Date

Code

Title

Description

1991-10-31

BB1A

Laying open of patent application

Effective date: 19910710

1998-07-31

FG3A

Patent granted, date of granting

Effective date: 19980417

2000-02-29

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19991031

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DE69435118D1 (de)	2008-08-28	Gereinigte Zusammensetzungen von Newcastle-Krankheitvirus
PT627221E (pt)	2002-04-29	Substancias antagonistas p para o tratamento de emese
ATE148130T1 (de)	1997-02-15	Typ-iv-dipeptidyl-aminopeptidase-inhibitoren
ATE225341T1 (de)	2002-10-15	In 6-position durch thio substituierte paclitaxele
FI901085A0 (fi)	1990-03-02	Biosidisia koostumuksia ja menetelmiä, joissa niitä käytetään
DE69010162D1 (de)	1994-07-28	Zusammensetzung zur Behandlung von Entzündung.
BR9205142A (pt)	1993-07-06	Composicao inseticida,e,processo para produzi-la
AR244492A1 (es)	1993-11-30	Composicion fungicida mejorada para el tratamiento de la madera.
RU94031161A (ru)	1996-03-27	Фармацевтическая композиция и способ ее получения, способ лечения нарушений, развивающихся вследствие нейродегенеративных процессов
NO900612L (no)	1990-08-13	Preservativ for vandige sammensetninger.
DK0448261T3 (da)	1996-02-12	Tenidap som inhibitor for neutrofilers frigørelse af elastase
CO5221050A1 (es)	2002-11-28	Composicion limpiadora que comprende un depurados de radicales, para limpieza eficaz y estabilidad mejorada en almacenamiento
BR9102635A (pt)	1992-01-21	Derivado de pirazolcarboxamida,composicao fungicida e acaricida e processo para produzir derivado de pirazolcarboxamida
BR9813357A (pt)	2000-10-10	Composição de barra, e, processo para fornecer atividade bacteriostática
MX9205257A (es)	1993-03-01	Dihidropiridinas substituidas por indolsulfonamida y procedimiento para su fabricacion.
DK0471040T3 (da)	1997-04-01	Anvendelse af cromakalim/BRL 38227 til behandling af hyperreaktivitet i luftveje
SE9202434D0 (sv)	1992-08-25	Skatolinaktiverande komposition
AR013096A1 (es)	2000-12-13	Sal de adicion de acido maleico de 5-(2-etil-2-h-tetrazol-5-il)-1-metil- 1,2,3,6-tetrahidropiridina, composicion farmaceutica que la contiene, su usoen terapia y metodo de preparacion de la misma.
ES1022616Y (es)	1993-11-16	Dado para juegos.
ES521091A0 (es)	1984-06-01	Mejoras en el objeto de la patente principal no 513.956 por procedimiento para la carbonilacion de olefinas y esteres organicos.
ES1014974Y (es)	1991-11-01	Punta de anclaje para varillas en taladros practicados en tableros o piezas de madera.
ES512654A0 (es)	1983-06-01	"mejoras introducidas en el objeto de la patente principal n 497.716, por: perfeccionamientos introducidos en las correderas sencillas o de giro para lama verticales".
BR6900022U (pt)	1990-09-11	Piano de reforma tecnica e financeira para o futebol
ITVC970001U4 (it)	1994-07-28	Regolo di calcolo per il gioco del lotto.
ES2025787T3 (es)	1992-04-01	Procedimiento de tratamiento de madera.