PT97100A - Processo para a preparacao de derivados de indol - Google Patents

Processo para a preparacao de derivados de indol Download PDF

Info

Publication number: PT97100A
Authority: PT; Portugal
Prior art keywords: compound; carbon atoms; formula; quinuclidinyl; ind
Prior art date: 1990-03-24

Application number

PT97100A

Other languages

English (en)

Portuguese (pt)

Inventor

Klaus-Otto Minck

Henning Bottcher

Christoph Seyfried

Hans-Peter Wolf

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-03-24

Filing date

1991-03-21

Publication date

1991-11-29

1991-03-21 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

1991-11-29 Publication of PT97100A publication Critical patent/PT97100A/pt

Links

238000000034 method Methods 0.000 title claims 4
229940054051 antipsychotic indole derivative Drugs 0.000 title claims 2
SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
-1 3-indolyl group Chemical group 0.000 claims abstract 8
150000003839 salts Chemical class 0.000 claims abstract 6
CJTOFAIRBFMRTI-UHFFFAOYSA-N 3-(1-azabicyclo[2.2.2]octan-3-yl)-1h-indole Chemical class C1=CC=C2C(C3C4CCN(C3)CC4)=CNC2=C1 CJTOFAIRBFMRTI-UHFFFAOYSA-N 0.000 claims abstract 2
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims abstract 2
229910052731 fluorine Inorganic materials 0.000 claims abstract 2
239000011737 fluorine Substances 0.000 claims abstract 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract 2
125000004432 carbon atom Chemical group C* 0.000 claims 9
150000001875 compounds Chemical class 0.000 claims 7
239000007788 liquid Substances 0.000 claims 2
QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 claims 2
ZKMZPXWMMSBLNO-UHFFFAOYSA-N 1-azabicyclo[2.2.2]octan-3-one Chemical compound C1CC2C(=O)CN1CC2 ZKMZPXWMMSBLNO-UHFFFAOYSA-N 0.000 claims 1
239000002253 acid Substances 0.000 claims 1
125000004423 acyloxy group Chemical group 0.000 claims 1
125000003545 alkoxy group Chemical group 0.000 claims 1
125000000217 alkyl group Chemical group 0.000 claims 1
125000005278 alkyl sulfonyloxy group Chemical group 0.000 claims 1
125000004414 alkyl thio group Chemical group 0.000 claims 1
125000005333 aroyloxy group Chemical group 0.000 claims 1
125000002102 aryl alkyloxo group Chemical group 0.000 claims 1
125000005279 aryl sulfonyloxy group Chemical group 0.000 claims 1
125000004104 aryloxy group Chemical group 0.000 claims 1
230000037396 body weight Effects 0.000 claims 1
239000003795 chemical substances by application Substances 0.000 claims 1
201000010099 disease Diseases 0.000 claims 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
150000002475 indoles Chemical class 0.000 claims 1
239000000203 mixture Substances 0.000 claims 1
239000008194 pharmaceutical composition Substances 0.000 claims 1
125000006239 protecting group Chemical class 0.000 claims 1
229940076279 serotonin Drugs 0.000 claims 1
239000007787 solid Substances 0.000 claims 1
239000000126 substance Substances 0.000 claims 1
230000001225 therapeutic effect Effects 0.000 claims 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
239000000460 chlorine Substances 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
Public Health (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Anesthesiology (AREA)
Addiction (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

PT97100A 1990-03-24 1991-03-21 Processo para a preparacao de derivados de indol PT97100A (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4009565A DE4009565A1 (de)	1990-03-24	1990-03-24	Indolderivate

Publications (1)

Publication Number	Publication Date
PT97100A true PT97100A (pt)	1991-11-29

Family

ID=6403022

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT97100A PT97100A (pt)	1990-03-24	1991-03-21	Processo para a preparacao de derivados de indol

Country Status (15)

Country	Link
US (1)	US5227386A (de)
EP (1)	EP0450345B1 (de)
JP (1)	JPH04235184A (de)
KR (1)	KR910016747A (de)
AT (1)	ATE123031T1 (de)
AU (1)	AU631303B2 (de)
CA (1)	CA2038908A1 (de)
DE (2)	DE4009565A1 (de)
DK (1)	DK0450345T3 (de)
ES (1)	ES2072467T3 (de)
HU (1)	HU207069B (de)
IE (1)	IE70661B1 (de)
PT (1)	PT97100A (de)
TW (1)	TW217411B (de)
ZA (1)	ZA912198B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9201038D0 (en) *	1992-01-16	1992-03-11	Glaxo Group Ltd	Chemical compounds
SE9201478D0 (sv) *	1992-05-11	1992-05-11	Kabi Pharmacia Ab	Heteroaromatic quinuclidinenes, their use and preparation
GB9314174D0 (en) *	1993-07-08	1993-08-18	American Home Prod	5-ht3-antagonists
EP1315493A4 (de) *	2000-08-21	2007-12-05	Univ Georgetown	2,3-Disubstituierte Chinuklidine as Monoamin-Transportermodulatoren und therapeutische und diagnostische Methoden, die darauf basieren.
DE10045112A1 (de) *	2000-09-11	2002-03-21	Merck Patent Gmbh	Verwendung von Indolderivaten zur Behandlung von Erkrankungen des zentralen Nervensystems
ATE385497T1 (de) *	2000-12-01	2008-02-15	Neurosearch As	3-substituierte quinuclidin-derivate und deren verwendung als nikotinischen agonisten
DE10121215A1 (de)	2001-04-30	2002-10-31	Merck Patent Gmbh	Dihydro-imidazo[4,5-e]indol- und 7H-Pyrrolo[3,2-f]chinoxalin Derivate als nikotinische Acetylcholinrezeptor Liganden und/oder serotonerge Liganden
CN1656093A (zh) *	2002-05-30	2005-08-17	神经研究公司	3－取代的奎宁环及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4605652A (en) *	1985-02-04	1986-08-12	A. H. Robins Company, Inc.	Method of enhancing memory or correcting memory deficiency with arylamido (and arylthioamido)-azabicycloalkanes
AU611976B2 (en) *	1987-12-24	1991-06-27	John Wyeth & Brother Limited	Aroyl urea and carbamic acid derivatives of azabicyclo compounds
DE3810552A1 (de) *	1988-03-29	1989-10-19	Sandoz Ag	Ester und amide von indol-, benzo(b)thiopen-, benzo(b)furancarbonsaeuren oder 4-amino-2-methoxy-benzolsaeuren mit n-heterocyclischen oder n-heterobicyclischen alkoholen oder aminen, verfahren zu deren herstellung sie enthaltende pharmazeutische zusammensetzungen sowie applikator zur verabreichung derselben
WO1990014347A1 (fr) *	1989-05-24	1990-11-29	Nippon Shinyaku Co., Ltd.	Derives d'indole et medicament

1990
- 1990-03-24 DE DE4009565A patent/DE4009565A1/de not_active Withdrawn
1991
- 1991-03-09 ES ES91103628T patent/ES2072467T3/es not_active Expired - Lifetime
- 1991-03-09 DK DK91103628.3T patent/DK0450345T3/da active
- 1991-03-09 AT AT91103628T patent/ATE123031T1/de not_active IP Right Cessation
- 1991-03-09 EP EP91103628A patent/EP0450345B1/de not_active Expired - Lifetime
- 1991-03-09 DE DE59105550T patent/DE59105550D1/de not_active Expired - Fee Related
- 1991-03-19 AU AU73609/91A patent/AU631303B2/en not_active Ceased
- 1991-03-21 TW TW080102231A patent/TW217411B/zh active
- 1991-03-21 PT PT97100A patent/PT97100A/pt not_active Application Discontinuation
- 1991-03-22 HU HU91972A patent/HU207069B/hu not_active IP Right Cessation
- 1991-03-22 JP JP3130776A patent/JPH04235184A/ja active Pending
- 1991-03-22 ZA ZA912198A patent/ZA912198B/xx unknown
- 1991-03-22 KR KR1019910004550A patent/KR910016747A/ko not_active Ceased
- 1991-03-22 US US07/673,544 patent/US5227386A/en not_active Expired - Fee Related
- 1991-03-22 IE IE96391A patent/IE70661B1/en not_active IP Right Cessation
- 1991-03-22 CA CA002038908A patent/CA2038908A1/en not_active Abandoned

Also Published As

Publication number	Publication date
DK0450345T3 (da)	1995-08-07
IE70661B1 (en)	1996-12-11
CA2038908A1 (en)	1991-09-25
AU631303B2 (en)	1992-11-19
IE910963A1 (en)	1991-09-25
TW217411B (de)	1993-12-11
EP0450345B1 (de)	1995-05-24
HU207069B (en)	1993-03-01
US5227386A (en)	1993-07-13
DE59105550D1 (de)	1995-06-29
ES2072467T3 (es)	1995-07-16
KR910016747A (ko)	1991-11-05
DE4009565A1 (de)	1991-09-26
AU7360991A (en)	1991-10-03
ATE123031T1 (de)	1995-06-15
HU910972D0 (en)	1991-10-28
JPH04235184A (ja)	1992-08-24
EP0450345A1 (de)	1991-10-09
ZA912198B (en)	1992-01-29
HUT57761A (en)	1991-12-30

Legal Events

Date	Code	Title	Description
1991-11-29	BB1A	Laying open of patent application	Effective date: 19910724
1999-03-31	FC3A	Refusal	Effective date: 19981207

Publication	Publication Date	Title
PT87542B (pt)	1992-09-30	Processo de preparacao de um medicamento a base de derivados da indolona para o tratamento da doenca de parkinson
CA2492081A1 (en)	2004-01-22	Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders
AR031680A1 (es)	2003-10-01	Utilizacion de acrilamidas de quinuclidina para la preparacion de medicamentos, compuestos y composicion farmaceutica
KR890011592A (ko)	1989-08-21	기관내 허혈병의 치료용 조성물
KR910009699A (ko)	1991-06-28	신규 삼환식 화합물
PT95827A (pt)	1991-09-13	Processo para a preparacao de composicoes farmaceuticas para combater retrovirus, contendo como ingredientes activos acidos carboxilicos com enxofre
AU2003236364C1 (en)	2009-12-24	Medicinal compositions improving brain function and method for improving brain function
KR880006193A (ko)	1988-07-22	피페리딘 화합물 및 그의 제조 및 용도
PT97100A (pt)	1991-11-29	Processo para a preparacao de derivados de indol
ATE257704T1 (de)	2004-01-15	Pharmazeutische zusammensetzungen enthaltend norastemizol.
KR970025615A (ko)	1997-06-24	암 전이 억제제
DE69031340D1 (de)	1997-10-02	3'-azido-2',3'-dideoxy-5-methylcytidin enthaltende antivirale zusammensetzungen
BRPI0411344A (pt)	2006-07-11	composições farmacêuticas granuladas de atorvastatina, forma de dosagem unitária, método para preparar as mesmas, uso e kit
KR950701922A (ko)	1995-05-17	치환된 트리아졸의 설페이트 염, 이를 포함하는 약제학적 조성물 및 치료요법에서의 이의 용도(The sulphate salt of a substituted triazole, pharmaceutical compositions thereof and their use in therapy)
KR920019350A (ko)	1992-11-19	자기면역질환요법을 위한 약제조성물
HUT52376A (en)	1990-07-28	Process for producing pharmaceutical compositions comprising 3-substituted-2-oxindole-1-carboxamide derivatives as active ingredient
KR970701191A (ko)	1997-03-17	복소환 화합물
IL68916A (en)	1986-11-30	5-(2-chlorobenzyl)-5,6,7,7a-tetrahydro-3-hydroxythieno(3,2-c)pyridin-2(4h)-one,its preparation and therapeutic compositions containing it
KR927002224A (ko)	1992-09-03	항종양효과증강제 및 항종양제
KR930002322A (ko)	1993-02-22	피라졸 유도체
KR930017882A (ko)	1993-09-20	아미노 벤조산 유도체
KR910011787A (ko)	1991-08-07	항혈전성 화합물
KR890014111A (ko)	1989-10-21	뇌활성제로서의 이소옥사졸리논의 용도
BR0009846A (pt)	2002-02-13	Composição para o tratamento ou profilaxia, de doenças tratáveis ou evitáveis pela potencialização do efeito de uma neurotrofina e, de uma doença neurodegenerativa, e, usos de um derivado de 6(5h)fenantridinona, e de um composto
NO20000055L (no)	2000-01-06	Polyhydroksyalkylpyrazinderivater, deres fremstilling samt medikamenter inneholdende forbindelsene