PT97263A - Processo para a preparacao de monoamidas de dtpa e de composicoes farmaceuticas que as contem - Google Patents

Processo para a preparacao de monoamidas de dtpa e de composicoes farmaceuticas que as contem

Info

Publication number: PT97263A
Authority: PT; Portugal
Prior art keywords: group; hydrogen atom; radical; alkyl; denote
Prior art date: 1990-04-06

Application number

PT97263A

Other languages

English (en)

Other versions

PT97263B (pt

Inventor

Bernd Raduchel

Heribert Schmitt-Willich

Heinz Gries

Gabriele Schuhmann-Giampieri

Hubert Vogler

Jurgen Conrad

Hans-Joachim Weinmann

Erich Klieger

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-04-06

Filing date

1991-04-05

Publication date

1992-01-31

1991-04-05 Application filed by Schering Ag filed Critical Schering Ag

1992-01-31 Publication of PT97263A publication Critical patent/PT97263A/pt

1998-08-31 Publication of PT97263B publication Critical patent/PT97263B/pt

Links

QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 title 1
239000000178 monomer Substances 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical compound [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 2
-1 C1-C6-alkyl radical Chemical class 0.000 abstract 2
150000001413 amino acids Chemical class 0.000 abstract 2
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
125000006165 cyclic alkyl group Chemical group 0.000 abstract 2
150000003254 radicals Chemical class 0.000 abstract 2
229920006395 saturated elastomer Polymers 0.000 abstract 2
125000001174 sulfone group Chemical group 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
150000007529 inorganic bases Chemical class 0.000 abstract 1
229910021645 metal ion Inorganic materials 0.000 abstract 1
150000007530 organic bases Chemical class 0.000 abstract 1
239000008177 pharmaceutical agent Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/02—Iron compounds
- C07F15/025—Iron compounds without a metal-carbon linkage

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Radiology & Medical Imaging (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Pyrrole Compounds (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PT97263A 1990-04-06 1991-04-05 Processo para a preparacao de monoamidas de dtpa e de composicoes farmaceuticas que as contem PT97263B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4011684A DE4011684A1 (de)	1990-04-06	1990-04-06	Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung

Publications (2)

Publication Number	Publication Date
PT97263A true PT97263A (pt)	1992-01-31
PT97263B PT97263B (pt)	1998-08-31

Family

ID=6404192

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT97263A PT97263B (pt)	1990-04-06	1991-04-05	Processo para a preparacao de monoamidas de dtpa e de composicoes farmaceuticas que as contem

Country Status (16)

Country	Link
US (4)	US5859214A (pt)
EP (1)	EP0450742B1 (pt)
JP (1)	JP2854159B2 (pt)
AT (1)	ATE108179T1 (pt)
AU (1)	AU644639B2 (pt)
CA (1)	CA2039846A1 (pt)
DE (2)	DE4011684A1 (pt)
DK (1)	DK0450742T3 (pt)
ES (1)	ES2057746T3 (pt)
FI (1)	FI911646L (pt)
HU (1)	HUT57180A (pt)
IE (1)	IE65923B1 (pt)
NO (1)	NO180582C (pt)
NZ (1)	NZ237711A (pt)
PT (1)	PT97263B (pt)
ZA (1)	ZA912550B (pt)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4011684A1 (de) *	1990-04-06	1991-10-10	Schering Ag	Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung
WO1994001393A1 (fr) *	1992-07-03	1994-01-20	The Green Cross Corporation	Nouveau chelateur, complexe compose dudit chelateur et d'un atome metallique, et agent diagnostique renfermant ledit complexe
US6875864B2 (en)	1991-08-01	2005-04-05	Bracco International B.V.	Aminocarboxylate ligands having substituted aromatic amide moieties
AU5360994A (en) *	1992-10-13	1994-05-09	Mallinckrodt Medical, Inc.	Novel compositions for magnetic resonance imaging
ES2140469T3 (es) *	1992-10-14	2000-03-01	Nycomed Imaging As	Composiciones y metodos terapeuticos y de diagnostico por obtencion de imagenes.
WO1994009056A1 (en) *	1992-10-14	1994-04-28	Sterling Winthrop Inc.	Chelating polymers
US5817292A (en) *	1992-10-14	1998-10-06	Nycomed Imaging As	MR imaging compositions and methods
DE4317588C2 (de) *	1993-05-24	1998-04-16	Schering Ag	Fluorhaltige makrocyclische Metallkomplexe, Verfahren zu ihrer Herstellung, sowie ihre Verwendung
DE4318369C1 (de) *	1993-05-28	1995-02-09	Schering Ag	Verwendung von makrocyclischen Metallkomplexen als Temperatursonden
JP3878208B2 (ja) *	1994-04-08	2007-02-07	ブラッコインターナショナルベスローテンフェンノートシャップ	芳香族アミド化合物およびそれらのキレート
US5582814A (en) *	1994-04-15	1996-12-10	Metasyn, Inc.	1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging
US5672335A (en) *	1994-11-30	1997-09-30	Schering Aktiengesellschaft	Use of metal complexes as liver and gallbladder X-ray diagnostic agents
AU4173896A (en) *	1994-11-30	1996-06-19	Schering Aktiengesellschaft	Use of chelate compounds as diagnostic agents in the x-ray examination of liver and bile ducts
TW319763B (pt)	1995-02-01	1997-11-11	Epix Medical Inc
DE19507822B4 (de) *	1995-02-21	2006-07-20	Schering Ag	Substituierte DTPA-Monoamide der zentralen Carbonsäure und deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik und Therapie sowie Verfahren zur Herstellung der Komplexe und Mittel
DE19507819A1 (de) *	1995-02-21	1996-08-22	Schering Ag	DTPA-Monoamide der zentralen Carbonsäure und deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik und Therapie sowie Verfahren zur Herstellung der Komplexe und Mittel
DE19507820A1 (de) *	1995-02-21	1996-08-22	Schering Ag	Neuartig substituierte DTPA-Derivate, deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik, sowie Verfahren zur Herstellung der Komplexe und Mittel
IL117200A0 (en) *	1995-02-21	1996-06-18	Schering Ag	Diethylenetriamine-pentaacetic acid monoamide derivatives pharmaceutical compostions containing the same and processes for the preparation thereof
DE19646762B4 (de) *	1996-11-04	2004-05-13	Schering Ag	Verwendung von Metallverbindungen zur Herstellung von Mitteln zur Strahlentherapie von Tumoren
EP0953360B1 (en) *	1998-03-24	2004-05-26	Council of Scientific and Industrial Research	Technetium-99m radiolabelled diethylene triamine pentaacetic acid diester and process for the preparation of technetium-99m diethylene triamine penta-acetic acid diester
GB9806530D0 (en)	1998-03-26	1998-05-27	Glaxo Group Ltd	Inflammatory mediator
GB9823175D0 (en) *	1998-10-22	1998-12-16	Nycomed Imaging As	Compound
CN101010107A (zh) *	2004-08-26	2007-08-01	马林克罗特公司	监测肾功能的发光金属络合物
FI20065030L (fi) *	2006-01-17	2007-07-18	Wallac Oy	Neutraaliset leimausreagenssit ja niistä johdetut konjugaatit
WO2008022263A2 (en) *	2006-08-17	2008-02-21	Epix Pharmaceuticals, Inc.	Methods for lymph system imaging
CN102171384B (zh) *	2008-05-28	2013-12-25	乔治洛德方法研究和开发液化空气有限公司	碳化硅基抗反射涂层
CN102549438B (zh)	2009-09-24	2014-10-29	国家健康与医学研究院	Fkbp52-tau相互作用作为新颖治疗靶点用于治疗涉及tau机能失调的神经障碍
EP2710381A2 (en)	2011-05-16	2014-03-26	Institut National de la Sante et de la Recherche Medicale (INSERM)	Methods for screening substances capable of modulating the replication of an influenza virus
WO2014053871A1 (en)	2012-10-04	2014-04-10	INSERM (Institut National de la Santé et de la Recherche Médicale)	A method for screening a compound capable of inhibiting the notch1 transcriptional activity
US20170051062A1 (en)	2014-02-18	2017-02-23	Inserm (Institut National De La Sante Et De La Recherche Medicale)	Methods and Pharmaceutical Compositions for the Treatment of Diseases Mediated by the NRP-1/OBR Complex Signaling Pathway
ES2796857T3 (es)	2014-04-17	2020-11-30	Inst Nat Sante Rech Med	Polipéptidos y usos de los mismos para reducir la motilidad celular mediada por CD95
KR20190135500A (ko) *	2017-04-27	2019-12-06	더 리젠츠 오브 더 유니버시티 오브 캘리포니아	개질된 mri 조영제 및 이의 용도
US11008354B2 (en) *	2018-05-24	2021-05-18	The Texas A&M University System	Chiral solvating agents
WO2020144324A1 (en)	2019-01-11	2020-07-16	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods for screening inhibitors against chikungunya virus and for determining whether subjects are predisposed to infection by said virus
CN115043747B (zh) *	2022-08-15	2022-11-25	康瑞鑫(天津)药物研究院有限公司	卡洛酸三钠的析晶方法及制备的卡洛酸三钠晶体

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4352751A (en) *	1979-09-10	1982-10-05	Analytical Radiation Corporation	Species-linked diamine triacetic acids and their chelates
US4647447A (en) *	1981-07-24	1987-03-03	Schering Aktiengesellschaft	Diagnostic media
US4957939A (en) *	1981-07-24	1990-09-18	Schering Aktiengesellschaft	Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
DE3324235A1 (de) *	1983-07-01	1985-01-10	Schering AG, 1000 Berlin und 4709 Bergkamen	Neue komplexbildner, komplexe und komplexsalze
US4687659A (en) *	1984-11-13	1987-08-18	Salutar, Inc.	Diamide-DTPA-paramagnetic contrast agents for MR imaging
US4859451A (en) *	1984-10-04	1989-08-22	Salutar, Inc.	Paramagnetic contrast agents for MR imaging
US5087439A (en) *	1984-11-13	1992-02-11	Salutar, Inc.	Paramagnetic metal-diethylenetriamine-pentaacetic acid partial amide complexes for magnetic resonance imaging
US4826673A (en) *	1985-01-09	1989-05-02	Mallinckrodt, Inc.	Methods and compositions for enhancing magnetic resonance imaging
GB8610551D0 (en) *	1986-04-30	1986-06-04	Hoffmann La Roche	Polypeptide & protein derivatives
US5039512A (en) *	1986-08-04	1991-08-13	Salutar, Inc.	NMR imaging with paramagnetic polyvalent metal salts of poly-(acid-alkylene-amino)-alkanes
AU608759B2 (en) *	1986-08-04	1991-04-18	Amersham Health Salutar Inc	NMR imaging with paramagnetic polyvalents metal salts of poly-(acid-alkylene-amido)-alkanes
US5219553A (en) *	1986-08-04	1993-06-15	Salutar, Inc.	Composition of a n-carboxymethylated tetraazacyclododecane chelating agent, a paramagnetic metal and excess calcium ions for MRI
IL83966A (en) *	1986-09-26	1992-03-29	Schering Ag	Amides of aminopolycarboxylic acids and pharmaceutical compositions containing them
DE3640708C2 (de) *	1986-11-28	1995-05-18	Schering Ag	Verbesserte metallhaltige Pharmazeutika
US5693309A (en)	1987-03-31	1997-12-02	Schering Aktiengesellschaft	Substituted complexing agents, complexes, and complex salts, processes for their production, and pharmaceuticals containing same
DE3710730A1 (de) *	1987-03-31	1988-10-20	Schering Ag	Substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
US4994259A (en) *	1987-05-08	1991-02-19	Salutar, Inc.	Improvement in the method of NMR imaging employing a manganese II chelates of N,N'-bis[pyridoxal-alkylene (or cycloalkylene) (or arylene)]-N,N'-diacetic acid derivatives
JP2833766B2 (ja) *	1987-07-16	1998-12-09	ニユコメド・アクシエセルカペト	アミノポリカルボン酸およびその誘導体
US5399340A (en) *	1987-09-24	1995-03-21	Schering Aktiengesellschaft	Use of amide complex compounds
US5137711A (en)	1988-07-19	1992-08-11	Mallickrodt Medical, Inc.	Paramagnetic dtpa and edta alkoxyalkylamide complexes as mri agents
HUT59014A (en)	1988-09-27	1992-04-28	Salutar Inc	Process for producing diagnostic compositions comprising chelates
US5198426A (en)	1988-12-30	1993-03-30	Warner-Lambert Company	Renin inhibitors containing c-terminal dihydroxy amides
GB8900719D0 (en) *	1989-01-13	1989-03-08	Nycomed As	Compounds
US5011925A (en) *	1989-03-09	1991-04-30	Mallinckrodt, Inc.	Morpholinoamido EDTA derivatives
US5384108A (en) *	1989-04-24	1995-01-24	Mallinckrodt Medical, Inc.	Magnetic resonance imaging agents
US6039931A (en)	1989-06-30	2000-03-21	Schering Aktiengesellschaft	Derivatized DTPA complexes, pharmaceutical agents containing these compounds, their use, and processes for their production
DE3922005A1 (de) *	1989-06-30	1991-01-10	Schering Ag	Derivatisierte dtpa-komplexe, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung
US5087440A (en) *	1989-07-31	1992-02-11	Salutar, Inc.	Heterocyclic derivatives of DTPA used for magnetic resonance imaging
GB8923843D0 (en) *	1989-10-23	1989-12-13	Salutar Inc	Compounds
US5843399A (en) *	1990-04-06	1998-12-01	Schering Aktiengesellschaft	DTPA monoamides for MRI
DE4011684A1 (de) *	1990-04-06	1991-10-10	Schering Ag	Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung
US5077037A (en) *	1990-08-03	1991-12-31	Mallinckrodt Medical, Inc.	Novel compositions for magnetic resonance imaging
WO1994001393A1 (fr) *	1992-07-03	1994-01-20	The Green Cross Corporation	Nouveau chelateur, complexe compose dudit chelateur et d'un atome metallique, et agent diagnostique renfermant ledit complexe
JP3215457B2 (ja)	1991-08-05	2001-10-09	株式会社ブリヂストン	氷雪上性能の改善されたゴム製品およびその製造方法
US5330743A (en) *	1992-11-12	1994-07-19	Magnetic Research, Inc.	Aminosaccharide contrast agents for magnetic resonance images

1990
- 1990-04-06 DE DE4011684A patent/DE4011684A1/de not_active Withdrawn
1991
- 1991-04-04 JP JP3097976A patent/JP2854159B2/ja not_active Expired - Lifetime
- 1991-04-05 AT AT91250089T patent/ATE108179T1/de active
- 1991-04-05 FI FI911646A patent/FI911646L/fi unknown
- 1991-04-05 CA CA002039846A patent/CA2039846A1/en not_active Abandoned
- 1991-04-05 EP EP91250089A patent/EP0450742B1/de not_active Expired - Lifetime
- 1991-04-05 PT PT97263A patent/PT97263B/pt not_active IP Right Cessation
- 1991-04-05 ZA ZA912550A patent/ZA912550B/xx unknown
- 1991-04-05 DK DK91250089.9T patent/DK0450742T3/da active
- 1991-04-05 DE DE59102092T patent/DE59102092D1/de not_active Expired - Lifetime
- 1991-04-05 ES ES91250089T patent/ES2057746T3/es not_active Expired - Lifetime
- 1991-04-05 HU HU911126A patent/HUT57180A/hu unknown
- 1991-04-05 NO NO911345A patent/NO180582C/no not_active IP Right Cessation
- 1991-04-05 NZ NZ237711A patent/NZ237711A/en unknown
- 1991-04-08 IE IE115591A patent/IE65923B1/en not_active IP Right Cessation
- 1991-04-08 AU AU74186/91A patent/AU644639B2/en not_active Ceased
1994
- 1994-04-15 US US08/228,524 patent/US5859214A/en not_active Expired - Lifetime
1998
- 1998-04-28 US US09/066,674 patent/US6287538B1/en not_active Expired - Fee Related
2000
- 2000-03-10 US US09/523,310 patent/US6565830B1/en not_active Expired - Fee Related
2003
- 2003-03-25 US US10/395,080 patent/US7074387B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DK0450742T3 (da)	1994-11-07
IE65923B1 (en)	1995-11-29
IE911155A1 (en)	1991-10-09
US20030202943A1 (en)	2003-10-30
EP0450742A1 (de)	1991-10-09
ZA912550B (en)	1992-01-29
DE59102092D1 (de)	1994-08-18
US5859214A (en)	1999-01-12
ES2057746T3 (es)	1994-10-16
FI911646A0 (fi)	1991-04-05
FI911646A7 (fi)	1991-10-07
US7074387B2 (en)	2006-07-11
FI911646L (fi)	1991-10-07
DE4011684A1 (de)	1991-10-10
AU7418691A (en)	1991-10-10
EP0450742B1 (de)	1994-07-06
US6287538B1 (en)	2001-09-11
JPH0665174A (ja)	1994-03-08
NO180582B (no)	1997-02-03
ATE108179T1 (de)	1994-07-15
PT97263B (pt)	1998-08-31
JP2854159B2 (ja)	1999-02-03
US6565830B1 (en)	2003-05-20
NO911345D0 (no)	1991-04-05
CA2039846A1 (en)	1991-10-07
NO911345L (no)	1991-10-07
AU644639B2 (en)	1993-12-16
HU911126D0 (en)	1991-10-28
HUT57180A (en)	1991-11-28
NO180582C (no)	1997-05-14
NZ237711A (en)	1993-12-23

Legal Events

Date

Code

Title

Description

1992-01-31

BB1A

Laying open of patent application

Effective date: 19910911

1998-08-31

FG3A

Patent granted, date of granting

Effective date: 19980506

2000-03-31

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19991130

Publication	Publication Date	Title
PT97263A (pt)	1992-01-31	Processo para a preparacao de monoamidas de dtpa e de composicoes farmaceuticas que as contem
PT94541A (pt)	1991-02-08	Processo para a preparacao de complexos de derivados dtpa e de composicoes farmaceuticas que os contem
PT96505A (pt)	1991-10-15	Processo para preparacao de compostos tetra-aza macrociclicos contendo um anel de 6 elementos e de composicoes farmaceuticas que os contem
RU92016217A (ru)	1995-05-20	Двойные ингибиторы no синтазы и циклооксигеназы, способ их получения и фармацевтическая композиция на их основе
SE7900987L (sv)	1979-08-07	Alkylendiamin-derivat
GR3005807T3 (pt)	1993-06-07
PT84366B (pt)	1989-10-04	Processo para a preparacao de novos derivados de 1,2,5,6-tetra-hidropiridin-3- -carboxaldeido-oxima e de composicoes farmaceuticas que a contem
ATE255880T1 (de)	2003-12-15	Verwendung von kokosölfettsäureacylglutamin in reinigungsmitteln
MX9204622A (es)	1993-04-01	Nuevos derivados de 3,5-di-tert-butil-4-hidroxifenilo, procedimiento para su preparacion y composicion farmaceutica que los contiene.
DE68922405D1 (de)	1995-06-01	Deletionsanaloga von magaininpeptiden.
PT90938A (pt)	1989-12-29	Processo para a preparacao de novas sulfonamidas e de composicoes farmaceuticas que as contem
ES2058670T3 (es)	1994-11-01	Derivados amidicos y preparados dermatologicos que los contienen.
ES8205762A1 (es)	1982-08-16	Procedimiento para la preparacion de oximas de acidos piru- vicos
DK0638072T3 (da)	1997-06-02	N,N-disubstituerede amidsyrer og deres ammoniumsalte og anvendelsen deraf som emulgatorer
PT97001A (pt)	1991-10-31	Processo para a preparacao de fluorbenzenossulfonamidas e de agentes de diagnostico que as contem
DK14389D0 (da)	1989-01-13	Substituerede 3-aminosydnoniminer og farmakologisk acceptable syreadditionssalte deraf, deres fremstilling og anvendelse samt mellemprodukter ved fremstillingen
PT90814A (pt)	1989-12-29	Processo de preparacao de derivados da fenotiazina
KR910000601A (ko)	1991-01-29	아민유도체 및 이의 용도
KR910011287A (ko)	1991-08-07	외과용 필라멘트
PT93675A (pt)	1990-11-20	Processo para a preparacao de derivados de acidos aminodicarboxilicos insaturados, contendo fosforo
PT83920B (pt)	1989-06-30	Processo para a preparacao de novos derivados de 4-morfolini-1h-indol e dos seus sais e de composicoes farmaceuticas que os contem
GB1058947A (pt)	1967-02-15
TH2362A (th)	1985-04-01	สารผสมกำจัดวัชพืชช่วยเสริมฤทธิ์ต่อกัน