PT97583A - Processo para a preparacao de peptidamidas e de composicoes farmaceuticas que as contem uteis como inibidores da coagulacao por fibrina/trombina - Google Patents

Processo para a preparacao de peptidamidas e de composicoes farmaceuticas que as contem uteis como inibidores da coagulacao por fibrina/trombina

Info

Publication number: PT97583A
Authority: PT; Portugal
Prior art keywords: amino acid; peptidamides; trombin; fibrin; preparing
Prior art date: 1990-05-08

Application number

PT97583A

Other languages

English (en)

Other versions

PT97583B (pt

Inventor

Werner Stueber

Karl Fickenscher

Original Assignee

Behringwerke Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-05-08

Filing date

1991-05-07

Publication date

1992-02-28

1991-05-07 Application filed by Behringwerke Ag filed Critical Behringwerke Ag

1992-02-28 Publication of PT97583A publication Critical patent/PT97583A/pt

1998-08-31 Publication of PT97583B publication Critical patent/PT97583B/pt

Links

238000000034 method Methods 0.000 title abstract 2
102000009123 Fibrin Human genes 0.000 title 1
108010073385 Fibrin Proteins 0.000 title 1
BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 title 1
239000003130 blood coagulation factor inhibitor Substances 0.000 title 1
229950003499 fibrin Drugs 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
229940024606 amino acid Drugs 0.000 abstract 5
235000001014 amino acid Nutrition 0.000 abstract 5
150000001413 amino acids Chemical class 0.000 abstract 5
ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 3
229960002429 proline Drugs 0.000 abstract 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 abstract 2
108010016626 Dipeptides Proteins 0.000 abstract 1
239000004471 Glycine Substances 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 abstract 1
229930064664 L-arginine Natural products 0.000 abstract 1
235000014852 L-arginine Nutrition 0.000 abstract 1
229930182821 L-proline Natural products 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
-1 proline Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Hematology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Diabetes (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Investigating Or Analysing Biological Materials (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

PT97583A 1990-05-08 1991-05-07 Processo para a preparacao de peptidamidas e de composicoes farmaceuticas que as contem uteis como inibidores da coagulacao por fibrina/trombina PT97583B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4014655A DE4014655A1 (de)	1990-05-08	1990-05-08	Peptidamide, verfahren zu deren herstellung und diese enthaltende mittel als fibrin/thrombin-gerinnungsinhibitoren

Publications (2)

Publication Number	Publication Date
PT97583A true PT97583A (pt)	1992-02-28
PT97583B PT97583B (pt)	1998-08-31

Family

ID=6405908

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT97583A PT97583B (pt)	1990-05-08	1991-05-07	Processo para a preparacao de peptidamidas e de composicoes farmaceuticas que as contem uteis como inibidores da coagulacao por fibrina/trombina

Country Status (13)

Country	Link
US (2)	US5478810A (pt)
EP (1)	EP0456152B1 (pt)
JP (1)	JP3090495B2 (pt)
KR (1)	KR0181512B1 (pt)
AT (1)	ATE172987T1 (pt)
AU (1)	AU642733B2 (pt)
CA (1)	CA2042001C (pt)
DE (2)	DE4014655A1 (pt)
DK (1)	DK0456152T3 (pt)
ES (1)	ES2125225T3 (pt)
IE (1)	IE911548A1 (pt)
NO (1)	NO911787L (pt)
PT (1)	PT97583B (pt)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4014655A1 (de) *	1990-05-08	1991-11-14	Behringwerke Ag	Peptidamide, verfahren zu deren herstellung und diese enthaltende mittel als fibrin/thrombin-gerinnungsinhibitoren
DE4133946A1 (de) *	1991-10-14	1993-04-15	Behringwerke Ag	Funktioneller test und reagenz zur bestimmung von fibrinogen
DE4242736A1 (de)	1992-12-17	1994-06-23	Behringwerke Ag	Synthetische Peptide, Antikörper dagegen und ihre Verwendung
WO2000018895A1 (en) *	1998-09-25	2000-04-06	The Children's Medical Center Corporation	Short peptides which selectively modulate the activity of protein kinases
CN1377276A (zh) *	1999-08-09	2002-10-30	特里帕普股份公司	含有三肽的药用组合物
US6258932B1 (en) *	1999-08-09	2001-07-10	Tripep Ab	Peptides that block viral infectivity and methods of use thereof
WO2001017953A1 (en)	1999-09-08	2001-03-15	Guilford Pharmaceuticals Inc.	Non-peptidic cyclophilin binding compounds and their use
MXPA03006666A (es)	2001-01-25	2004-05-31	Guilford Pharm Inc	Compuestos de union de ciclofilina carbociclicos trisubstituidos y su uso.
US6593362B2 (en)	2001-05-21	2003-07-15	Guilford Pharmaceuticals Inc.	Non-peptidic cyclophilin binding compounds and their use
US6908899B2 (en) *	2001-08-17	2005-06-21	U.S. Dept. Of Veterans Affairs	Pro-inflammatory fibrinopeptide
US6593455B2 (en) *	2001-08-24	2003-07-15	Tripep Ab	Tripeptide amides that block viral infectivity and methods of use thereof
US6455670B1 (en) *	2001-09-06	2002-09-24	Tripep Ab	Pentamer peptide amide, ALGPG-NH2, that inhibits viral infectivity and methods of use thereof
EP1425296B1 (de) *	2001-09-10	2011-04-13	Novel Science International GmbH	Organische verbindungen mit biologischer wirkung als thrombinhemmer und ihre verwendung
EP1436317A1 (en) *	2001-09-19	2004-07-14	Tripep Ab	Molecules that block viral infectivity and methods of use thereof
PL378163A1 (pl) *	2003-02-21	2006-03-06	Tripep Ab	Pochodna glicynoamidu do hamowania replikacji HIV
US20050096319A1 (en) *	2003-02-21	2005-05-05	Balzarini Jan M.R.	Identification of compounds that inhibit replication of human immunodeficiency virus
DE102004059055A1 (de)	2004-12-07	2006-06-08	Dade Behring Marburg Gmbh	Verfahren zur automatischen Bestimmung des endogenen Thrombinpotenzials
CA2588560A1 (en) *	2004-12-29	2006-07-06	Labo Cosprophar Ag	Cosmetic composition for skin application suitable for relaxing expression wrinkles
DE102005003145B4 (de)	2005-01-21	2006-10-19	Dade Behring Marburg Gmbh	Stablies, chromogenes Flüssigreagenz und dessen Verwendung in gerinnungsdiagnostischen Tests
US7442323B2 (en) *	2006-06-02	2008-10-28	E. I. Du Pont De Nemours And Company	Potassium monopersulfate solutions
AU2007305268A1 (en) *	2006-10-02	2008-04-10	The Board Of Trustees Of The Leland Stanford Junior University	Peptides derived from the C2 domain of epsilon PKC, and use thereof
DE102009048198A1 (de)	2009-10-05	2011-04-21	Siemens Healthcare Diagnostics Products Gmbh	Verfahren zur Bestimmung von Faktor XIII mittels NAD(P)H-Analoga
DE102009048199A1 (de)	2009-10-05	2011-04-21	Siemens Healthcare Diagnostics Products Gmbh	Verfahren zur Bestimmung von Faktor XIII mit Hilfe von Referenzmaterial auf Plasmabasis
EP2333555A1 (de)	2009-12-09	2011-06-15	Siemens Healthcare Diagnostics Products GmbH	Heterogener Gerinnungstest
EP2395354A1 (de)	2010-06-10	2011-12-14	Siemens Healthcare Diagnostics Products GmbH	Homogener Aktivitätstest zur Bestimmung von enzymatischen Reaktionen
EP2465941A1 (de)	2010-12-20	2012-06-20	Siemens Healthcare Diagnostics Products GmbH	Verfahren zur simultanen Bestimmung mehrerer Gerinnungsproteasen
EP2471945A1 (de)	2010-12-30	2012-07-04	Siemens Healthcare Diagnostics Products GmbH	Verfahren zur Bestimmung von Inhibitoren der Gerinnung
US10450343B2 (en)	2013-03-21	2019-10-22	Sanofi-Aventis Deutschland Gmbh	Synthesis of cyclic imide containing peptide products
HUE034308T2 (en)	2013-03-21	2018-02-28	Sanofi Aventis Deutschland	Preparation of hydantoin-containing peptide products
IL230151A0 (en)	2013-12-24	2014-09-30	Omrix Biopharmaceuticals Ltd	One-component fibrin glue containing a polymerization inhibitor
IL231792A0 (en)	2014-03-27	2014-08-31	Omrix Biopharmaceuticals Ltd	Device and method for the preparation and administration of one-component fibrin glue
JP7410652B2 (ja) *	2019-04-12	2024-01-10	株式会社エイアンドティー	フィブリノゲンの定量方法
JP7359538B2 (ja) *	2018-12-07	2023-10-11	株式会社エイアンドティー	フィブリノゲン測定試薬
WO2020116556A1 (ja) *	2018-12-07	2020-06-11	株式会社エイアンドティー	フィブリノゲン測定試薬
CN110669126B (zh) *	2019-10-23	2022-08-16	广州领晟医疗科技有限公司	多肽gpr5及其促进肝细胞增殖和抑制肝细胞凋亡的用途
CN112206307B (zh) *	2020-09-15	2023-12-05	广州领晟医疗科技有限公司	一种可注射的温敏型水凝胶及其制备方法与应用
EP4239338A1 (de)	2022-03-03	2023-09-06	Siemens Healthcare Diagnostics Products GmbH	Globaltest zur feststellung des status des blutgerinnungssystems

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3811647A1 (de) *	1988-04-07	1989-10-26	Behringwerke Ag	Verfahren und verpackung enthaltend mittel zur kinetischen bestimmung von faktor xiii
DE4014655A1 (de) *	1990-05-08	1991-11-14	Behringwerke Ag	Peptidamide, verfahren zu deren herstellung und diese enthaltende mittel als fibrin/thrombin-gerinnungsinhibitoren

1990
- 1990-05-08 DE DE4014655A patent/DE4014655A1/de not_active Withdrawn
1991
- 1991-04-26 AU AU76222/91A patent/AU642733B2/en not_active Expired
- 1991-05-06 DE DE59109067T patent/DE59109067D1/de not_active Expired - Lifetime
- 1991-05-06 DK DK91107307T patent/DK0456152T3/da active
- 1991-05-06 EP EP91107307A patent/EP0456152B1/de not_active Expired - Lifetime
- 1991-05-06 AT AT91107307T patent/ATE172987T1/de not_active IP Right Cessation
- 1991-05-06 ES ES91107307T patent/ES2125225T3/es not_active Expired - Lifetime
- 1991-05-06 KR KR1019910007287A patent/KR0181512B1/ko not_active Expired - Fee Related
- 1991-05-07 IE IE154891A patent/IE911548A1/en not_active Application Discontinuation
- 1991-05-07 JP JP03130229A patent/JP3090495B2/ja not_active Expired - Lifetime
- 1991-05-07 CA CA002042001A patent/CA2042001C/en not_active Expired - Lifetime
- 1991-05-07 PT PT97583A patent/PT97583B/pt not_active IP Right Cessation
- 1991-05-07 NO NO91911787A patent/NO911787L/no not_active Application Discontinuation
1993
- 1993-02-24 US US08/022,381 patent/US5478810A/en not_active Expired - Lifetime
1995
- 1995-06-07 US US08/475,827 patent/US5607858A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0456152A2 (de)	1991-11-13
NO911787L (no)	1991-11-11
ES2125225T3 (es)	1999-03-01
CA2042001C (en)	2002-01-08
PT97583B (pt)	1998-08-31
AU642733B2 (en)	1993-10-28
KR910020031A (ko)	1991-12-19
CA2042001A1 (en)	1991-11-09
ATE172987T1 (de)	1998-11-15
NO911787D0 (no)	1991-05-07
DK0456152T3 (da)	1999-07-19
JP3090495B2 (ja)	2000-09-18
US5607858A (en)	1997-03-04
IE911548A1 (en)	1991-11-20
KR0181512B1 (ko)	1999-04-01
EP0456152A3 (en)	1992-07-22
EP0456152B1 (de)	1998-11-04
AU7622291A (en)	1991-11-14
US5478810A (en)	1995-12-26
DE59109067D1 (de)	1998-12-10
JPH0789990A (ja)	1995-04-04
DE4014655A1 (de)	1991-11-14

Legal Events

Date	Code	Title	Description
1992-02-28	BB1A	Laying open of patent application	Effective date: 19911009
1998-08-31	FG3A	Patent granted, date of granting	Effective date: 19980519
1999-02-26	PC3A	Transfer or assignment	Free format text: 19981125 BEHRING DIAGNOSTICS GMBH DE
1999-02-26	PD3A	Change of proprietorship	Owner name: DADE BEHRING MARBURG GMBH Effective date: 19981125
2002-03-28	MM3A	Annulment or lapse	Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20011130

Publication	Publication Date	Title
ES2125225T3 (es)	1999-03-01	Amidas de peptidos, procedimiento para su preparacion y agentes que las contienen como inhibidores de la coagulacion de fibrina/trombina.
MY137301A (en)	2009-01-30	Peptide analogs as irreversible interleukin-1b protease inhibitors
IT1196500B (it)	1988-11-16	Derivati dell'acido malonico e metodi per la loro sintesi
GEP20012413B (en)	2001-04-25	Novel Substituted Cyclic Amino Acids as Pharmaceutical Agents
ES2113606T3 (es)	1998-05-01	Cetonas peptidicas como inhibidores de la enzima convertidora de la interleuquina-1beta.
NO982976L (no)	1998-08-26	N-acylaminoalkylhydrazinkarboksimidamider
EA200300678A1 (ru)	2003-10-30	Пептиды и/или белки, а также их применение для получения терапевтической и/или профилактической фармацевтической композиции
DE3862006D1 (de)	1991-04-18	Verfahren zur herstellung von n-alkylierten aminosaeuren und deren estern, verwendung zur synthese von carboxyalkyldipeptiden.
MX9302327A (es)	1993-10-01	Aminoacidos ciclicos novedosos y derivados de los mismos.
BR9803914A (pt)	2000-03-28	Lantibióticos relacionados a actagardina e processos para sua preparação e uso.
BG88028A (bg)	1993-12-24	Амиди на циклометилен-1,2-дикарбоксилни киселини с терапевтична активност,методи за получаването им и фармацевтични състави, които ги съдържат
DE3854266D1 (de)	1995-09-07	Verfahren zur Modifizierung eines Molekularsiebes.
ATA298086A (de)	1997-02-15	Verfahren zur herstellung von neuen cystinverbindungen und deren verwendung
ES506192A0 (es)	1982-09-01	Procedimiento de preparacion de nuevos hexapeptidos
NO178325C (no)	1996-03-06	Fremgangsmåte for fremstilling av et t-PA injeksjonspreparat
ATE80380T1 (de)	1992-09-15	Diastereoselektives verfahren zur herstellung von zwischenprodukten verwendbar zur peptidderivatensynthese.
DE69526462D1 (de)	2002-05-23	Verfahren zur Herstellung von Peptiden aus N-Carboxyanhydridaminosäuren
FR2622578B1 (fr)	1990-03-16	Nouveaux derives de l'acide aminopimelique, leur procede de preparation et leur application comme medicaments
ATE119913T1 (de)	1995-04-15	Thymopentin-analoge mit allen umgekehrten verbindungen, verfahren zur deren herstellung und deren verwendung zur herstellung von pharmazeutischen zusammensetzungen.
ES2115535B1 (es)	1999-02-01	Procedimiento para la preparacion de amidas de d-(-)-aminoacidos.
DE3586752D1 (de)	1992-11-19	Verfahren zur herstellung wundheilungsfoerdernder praeparationen und solche praeparationen.
DE69428401D1 (de)	2001-10-31	Verfahren zur Herstellung von alpha-Aminosäureamiden zur Verwendung in der Peptidsynthese
DE69711553D1 (de)	2002-05-08	Verfahren zur Herstellung von alpha-Aminosäureamide, alpha-Aminosäuren und ihre Derivaten
DE68909451D1 (de)	1993-11-04	Peptide mit inhibitorischer wirkung auf enzymatische systeme, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
PT82422B (pt)	1988-03-03	Processo para a preparacao de sais de l-fosfosserina e de composicoes farmaceuticas que os contem