DK0456152T3 - Peptidamider, fremgangsmåde til deres fremstilling og midler indeholdende disse som fibrin/thrombin-koagulationsinhibitorer - Google Patents

Peptidamider, fremgangsmåde til deres fremstilling og midler indeholdende disse som fibrin/thrombin-koagulationsinhibitorer

Info

Publication number: DK0456152T3
Authority: DK; Denmark
Prior art keywords: preparation; amino acid; peptidamides; fibrin; methods
Prior art date: 1990-05-08

Application number

DK91107307T

Other languages

English (en)

Inventor

Karl Dr Fickenscher

Werner Dr Stueber

Original Assignee

Dade Behring Marburg Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-05-08

Filing date

1991-05-06

Publication date

1999-07-19

1991-05-06 Application filed by Dade Behring Marburg Gmbh filed Critical Dade Behring Marburg Gmbh

1999-07-19 Application granted granted Critical

1999-07-19 Publication of DK0456152T3 publication Critical patent/DK0456152T3/da

Links

238000000034 method Methods 0.000 title abstract 2
102000009123 Fibrin Human genes 0.000 title 1
108010073385 Fibrin Proteins 0.000 title 1
BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 title 1
108090000190 Thrombin Proteins 0.000 title 1
239000003130 blood coagulation factor inhibitor Substances 0.000 title 1
239000003795 chemical substances by application Substances 0.000 title 1
229950003499 fibrin Drugs 0.000 title 1
229960004072 thrombin Drugs 0.000 title 1
229940024606 amino acid Drugs 0.000 abstract 5
235000001014 amino acid Nutrition 0.000 abstract 5
150000001413 amino acids Chemical class 0.000 abstract 5
ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 3
229960002429 proline Drugs 0.000 abstract 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 abstract 2
108010016626 Dipeptides Proteins 0.000 abstract 1
239000004471 Glycine Substances 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 abstract 1
229930064664 L-arginine Natural products 0.000 abstract 1
235000014852 L-arginine Nutrition 0.000 abstract 1
229930182821 L-proline Natural products 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
-1 proline Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Hematology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Toxicology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Gastroenterology & Hepatology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Zoology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Investigating Or Analysing Biological Materials (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

DK91107307T 1990-05-08 1991-05-06 Peptidamider, fremgangsmåde til deres fremstilling og midler indeholdende disse som fibrin/thrombin-koagulationsinhibitorer DK0456152T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4014655A DE4014655A1 (de)	1990-05-08	1990-05-08	Peptidamide, verfahren zu deren herstellung und diese enthaltende mittel als fibrin/thrombin-gerinnungsinhibitoren

Publications (1)

Publication Number	Publication Date
DK0456152T3 true DK0456152T3 (da)	1999-07-19

Family

ID=6405908

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91107307T DK0456152T3 (da)	1990-05-08	1991-05-06	Peptidamider, fremgangsmåde til deres fremstilling og midler indeholdende disse som fibrin/thrombin-koagulationsinhibitorer

Country Status (13)

Country	Link
US (2)	US5478810A (da)
EP (1)	EP0456152B1 (da)
JP (1)	JP3090495B2 (da)
KR (1)	KR0181512B1 (da)
AT (1)	ATE172987T1 (da)
AU (1)	AU642733B2 (da)
CA (1)	CA2042001C (da)
DE (2)	DE4014655A1 (da)
DK (1)	DK0456152T3 (da)
ES (1)	ES2125225T3 (da)
IE (1)	IE911548A1 (da)
NO (1)	NO911787L (da)
PT (1)	PT97583B (da)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4014655A1 (de) *	1990-05-08	1991-11-14	Behringwerke Ag	Peptidamide, verfahren zu deren herstellung und diese enthaltende mittel als fibrin/thrombin-gerinnungsinhibitoren
DE4133946A1 (de) *	1991-10-14	1993-04-15	Behringwerke Ag	Funktioneller test und reagenz zur bestimmung von fibrinogen
DE4242736A1 (de) *	1992-12-17	1994-06-23	Behringwerke Ag	Synthetische Peptide, Antikörper dagegen und ihre Verwendung
JP2002525382A (ja)	1998-09-25	2002-08-13	ザチルドレンズメディカルセンターコーポレイション	プロテインキナーゼの活性を選択的に調節するショートペプチド
HUP0202512A2 (hu) *	1999-08-09	2002-11-28	Tripep Ab	Fehérjék polimerizációját gátló anyagok és eljárások ezek alkalmazására
US6258932B1 (en) *	1999-08-09	2001-07-10	Tripep Ab	Peptides that block viral infectivity and methods of use thereof
AU7353300A (en)	1999-09-08	2001-04-10	Guilford Pharmaceuticals Inc.	Non-peptidic cyclophilin binding compounds and their use
MXPA03006666A (es)	2001-01-25	2004-05-31	Guilford Pharm Inc	Compuestos de union de ciclofilina carbociclicos trisubstituidos y su uso.
US6593362B2 (en)	2001-05-21	2003-07-15	Guilford Pharmaceuticals Inc.	Non-peptidic cyclophilin binding compounds and their use
US6908899B2 (en) *	2001-08-17	2005-06-21	U.S. Dept. Of Veterans Affairs	Pro-inflammatory fibrinopeptide
US6593455B2 (en) *	2001-08-24	2003-07-15	Tripep Ab	Tripeptide amides that block viral infectivity and methods of use thereof
US6455670B1 (en) *	2001-09-06	2002-09-24	Tripep Ab	Pentamer peptide amide, ALGPG-NH2, that inhibits viral infectivity and methods of use thereof
WO2003022873A1 (de)	2001-09-10	2003-03-20	Novel Science International Gmbh	Organische verbindungen mit biologischer wirkung als thrombinhemmer und ihre verwendung
WO2003024995A1 (en) *	2001-09-19	2003-03-27	Tripep Ab	Molecules that block viral infectivity and methods of use thereof
NZ541883A (en) *	2003-02-21	2008-12-24	Tripep Ab	Glycinamide derivative for inhibiting HIV replication
US20050096319A1 (en) *	2003-02-21	2005-05-05	Balzarini Jan M.R.	Identification of compounds that inhibit replication of human immunodeficiency virus
DE102004059055A1 (de)	2004-12-07	2006-06-08	Dade Behring Marburg Gmbh	Verfahren zur automatischen Bestimmung des endogenen Thrombinpotenzials
CA2588560A1 (en) *	2004-12-29	2006-07-06	Labo Cosprophar Ag	Cosmetic composition for skin application suitable for relaxing expression wrinkles
DE102005003145B4 (de)	2005-01-21	2006-10-19	Dade Behring Marburg Gmbh	Stablies, chromogenes Flüssigreagenz und dessen Verwendung in gerinnungsdiagnostischen Tests
US7442323B2 (en) *	2006-06-02	2008-10-28	E. I. Du Pont De Nemours And Company	Potassium monopersulfate solutions
WO2008042421A2 (en) *	2006-10-02	2008-04-10	The Board Of Trustees Of The Leland Stanford Junior University	Peptides derived from the c2 domain of epsilon pkc, and use thereof
DE102009048198A1 (de)	2009-10-05	2011-04-21	Siemens Healthcare Diagnostics Products Gmbh	Verfahren zur Bestimmung von Faktor XIII mittels NAD(P)H-Analoga
DE102009048199A1 (de)	2009-10-05	2011-04-21	Siemens Healthcare Diagnostics Products Gmbh	Verfahren zur Bestimmung von Faktor XIII mit Hilfe von Referenzmaterial auf Plasmabasis
EP2333555A1 (de)	2009-12-09	2011-06-15	Siemens Healthcare Diagnostics Products GmbH	Heterogener Gerinnungstest
EP2395354A1 (de)	2010-06-10	2011-12-14	Siemens Healthcare Diagnostics Products GmbH	Homogener Aktivitätstest zur Bestimmung von enzymatischen Reaktionen
EP2465941A1 (de)	2010-12-20	2012-06-20	Siemens Healthcare Diagnostics Products GmbH	Verfahren zur simultanen Bestimmung mehrerer Gerinnungsproteasen
EP2471945A1 (de)	2010-12-30	2012-07-04	Siemens Healthcare Diagnostics Products GmbH	Verfahren zur Bestimmung von Inhibitoren der Gerinnung
HUE034308T2 (en)	2013-03-21	2018-02-28	Sanofi Aventis Deutschland	Preparation of hydantoin-containing peptide products
CN105102427B (zh)	2013-03-21	2018-09-07	赛诺菲-安万特德国有限公司	含有环状酰亚胺的肽产物的合成
IL230151A0 (en)	2013-12-24	2014-09-30	Omrix Biopharmaceuticals Ltd	One-component fibrin glue containing a polymerization inhibitor
IL231792A0 (en)	2014-03-27	2014-08-31	Omrix Biopharmaceuticals Ltd	Device and method for the preparation and administration of one-component fibrin glue
JP7410652B2 (ja) *	2019-04-12	2024-01-10	株式会社エイアンドティー	フィブリノゲンの定量方法
JP7359538B2 (ja) *	2018-12-07	2023-10-11	株式会社エイアンドティー	フィブリノゲン測定試薬
WO2020116556A1 (ja) *	2018-12-07	2020-06-11	株式会社エイアンドティー	フィブリノゲン測定試薬
CN110669126B (zh) *	2019-10-23	2022-08-16	广州领晟医疗科技有限公司	多肽gpr5及其促进肝细胞增殖和抑制肝细胞凋亡的用途
CN112206307B (zh) *	2020-09-15	2023-12-05	广州领晟医疗科技有限公司	一种可注射的温敏型水凝胶及其制备方法与应用
EP4239338A1 (de)	2022-03-03	2023-09-06	Siemens Healthcare Diagnostics Products GmbH	Globaltest zur feststellung des status des blutgerinnungssystems

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3811647A1 (de) *	1988-04-07	1989-10-26	Behringwerke Ag	Verfahren und verpackung enthaltend mittel zur kinetischen bestimmung von faktor xiii
DE4014655A1 (de) *	1990-05-08	1991-11-14	Behringwerke Ag	Peptidamide, verfahren zu deren herstellung und diese enthaltende mittel als fibrin/thrombin-gerinnungsinhibitoren

1990
- 1990-05-08 DE DE4014655A patent/DE4014655A1/de not_active Withdrawn
1991
- 1991-04-26 AU AU76222/91A patent/AU642733B2/en not_active Expired
- 1991-05-06 KR KR1019910007287A patent/KR0181512B1/ko not_active Expired - Fee Related
- 1991-05-06 ES ES91107307T patent/ES2125225T3/es not_active Expired - Lifetime
- 1991-05-06 EP EP91107307A patent/EP0456152B1/de not_active Expired - Lifetime
- 1991-05-06 AT AT91107307T patent/ATE172987T1/de not_active IP Right Cessation
- 1991-05-06 DE DE59109067T patent/DE59109067D1/de not_active Expired - Lifetime
- 1991-05-06 DK DK91107307T patent/DK0456152T3/da active
- 1991-05-07 JP JP03130229A patent/JP3090495B2/ja not_active Expired - Lifetime
- 1991-05-07 CA CA002042001A patent/CA2042001C/en not_active Expired - Lifetime
- 1991-05-07 PT PT97583A patent/PT97583B/pt not_active IP Right Cessation
- 1991-05-07 IE IE154891A patent/IE911548A1/en not_active Application Discontinuation
- 1991-05-07 NO NO91911787A patent/NO911787L/no not_active Application Discontinuation
1993
- 1993-02-24 US US08/022,381 patent/US5478810A/en not_active Expired - Lifetime
1995
- 1995-06-07 US US08/475,827 patent/US5607858A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
AU7622291A (en)	1991-11-14
US5478810A (en)	1995-12-26
NO911787L (no)	1991-11-11
PT97583A (pt)	1992-02-28
CA2042001A1 (en)	1991-11-09
JPH0789990A (ja)	1995-04-04
CA2042001C (en)	2002-01-08
ES2125225T3 (es)	1999-03-01
DE59109067D1 (de)	1998-12-10
KR0181512B1 (ko)	1999-04-01
ATE172987T1 (de)	1998-11-15
PT97583B (pt)	1998-08-31
US5607858A (en)	1997-03-04
EP0456152A2 (de)	1991-11-13
JP3090495B2 (ja)	2000-09-18
EP0456152A3 (en)	1992-07-22
IE911548A1 (en)	1991-11-20
EP0456152B1 (de)	1998-11-04
NO911787D0 (no)	1991-05-07
KR910020031A (ko)	1991-12-19
AU642733B2 (en)	1993-10-28
DE4014655A1 (de)	1991-11-14

Publication	Publication Date	Title
NO911787L (no)	1991-11-11	Peptidaminer samt fremgangsmaate for fremstilling derav ogmidler som inneholder disse som fibrin/-trombin-koaguleringsinhibitorer
Meister	1974	22. Glutathione Synthesis
MY137301A (en)	2009-01-30	Peptide analogs as irreversible interleukin-1b protease inhibitors
TW377350B (en)	1999-12-21	Peptidic ketones as interleukin-1beta-converting enzyme inhibitors
ATE102629T1 (de)	1994-03-15	Peptidderivate des blutplaettchen-aggregationsinhibitors.
EA199700239A1 (ru)	1998-02-26	Ингибиторы тромбина, основанные на аминокислотной последовательности гирудина
RU94032284A (ru)	1996-07-20	Карбоксамиды, способ их получения, фармацевтическая композиция, применение
NZ336116A (en)	2000-10-27	Diagnostic agent comprising an amino acid or peptide containing at least one 13C or 14C for pancreatic exocrine function
NO903952D0 (no)	1990-09-11	Fremgangsmaate for fremstilling av aminosyrederivater med reninhemmende egenskaper, og anvendelse av midler som inneholder disse.
DK0679631T3 (da)	1998-10-07	Biaromatiske adamantylgruppeholdige acetylenforbindelser,farmaceutiske og kosmetiske sammensætninger, der indeholder disse,
ATE357456T1 (de)	2007-04-15	Mittel zur förderung von knochenbildung
US5714499A (en)	1998-02-03	3-amino-2-oxo-1-piperidineacetic derivatives containing an arginine mimic as enzyme inhibitors
Wiley et al.	1995	Serine protease selectivity of the thrombin inhibitor D-Phe-Pro-agmatine and its homologs
ITRM910189A1 (it)	1992-09-22	Derivati amminoacilici e oligopeptidici dell'allopurinolo dotati di attivita' immunostimolante e composizioni farmaceutiche che li contengono
DK515288A (da)	1989-03-18	Fremgangsmaade til syntese af alpha-n-alkylerede aminosyrer og estere deraf
BR9803914A (pt)	2000-03-28	Lantibióticos relacionados a actagardina e processos para sua preparação e uso.
ATE60788T1 (de)	1991-02-15	Derivat von p-aminophenol mit mucrosekretolytischer fluessiger und antipyretischer wirksamkeit, dessen verfahren zur herstellung und dessen pharmazeutische zusammensetzungen.
NO984206L (no)	1998-09-11	Fremgangsmaate for fremstilling av N-beskyttende D-prolinderivater
DK1041082T3 (da)	2002-06-17	Fremgangsmåde til peptidsyntese ud fra N-carboxyandridaminosyrer
BR9813595A (pt)	2000-10-17	Cristal misto, processo para produzir o mesmo, e, adoçante
Midura-Nowaczek et al.	2003	Synthesis of benzylamides of dipeptides as potential inhibitors of plasmin
Midura-Nowaczek et al.	2006	Synthesis of alkylamides of dipeptides as potential plasmin inhibitors
DE69428401D1 (de)	2001-10-31	Verfahren zur Herstellung von alpha-Aminosäureamiden zur Verwendung in der Peptidsynthese
ATE101616T1 (de)	1994-03-15	Verfahren zur herstellung von dipeptiden.
JPS6485996A (en)	1989-03-30	Peptide derivative and method for using said derivative