PT98590A - Processo de preparacao de (2r)-2-/di(2-propil)fosfonilmetoxi/-3-p-tolueno-sulfoniloxi-1-trimetilacetoxipropano e de derivados (s)-n-(3-hidroxi-2-fosfonilmetoxipropilo de bases heterociclicos puricas e pirimidicas - Google Patents

Processo de preparacao de (2r)-2-/di(2-propil)fosfonilmetoxi/-3-p-tolueno-sulfoniloxi-1-trimetilacetoxipropano e de derivados (s)-n-(3-hidroxi-2-fosfonilmetoxipropilo de bases heterociclicos puricas e pirimidicas

Info

Publication number
PT98590A
PT98590A PT98590A PT9859091A PT98590A PT 98590 A PT98590 A PT 98590A PT 98590 A PT98590 A PT 98590A PT 9859091 A PT9859091 A PT 9859091A PT 98590 A PT98590 A PT 98590A
Authority
PT
Portugal
Prior art keywords
bases
trimethylcetetoxypropane
phosphonymethoxy
pyrimidic
heterocyclics
Prior art date
Application number
PT98590A
Other languages
English (en)
Other versions
PT98590B (pt
Inventor
Antonin Holy
Petr Alexander
Hana Dvorakova
Original Assignee
Ceskoslovenska Akademie Ved
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ceskoslovenska Akademie Ved filed Critical Ceskoslovenska Akademie Ved
Publication of PT98590A publication Critical patent/PT98590A/pt
Publication of PT98590B publication Critical patent/PT98590B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT98590A 1990-08-06 1991-08-06 Processo de preparacao de (2r)-2-/di(2-propil)fosfonilmetoxi/-3-p-tolueno-sulfoniloxi-1-trimetilacetoxipropano e de derivados (s)-n-(3-hidroxi-2-fosfonilmetoxipropilo de bases heterociclicos puricas e pirimidicas PT98590B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CS903871A CS387190A3 (en) 1990-08-06 1990-08-06 (2r)-2-/di(2-propyl)phosphonylmethoxy/-3-p-toluenesulfonyloxy -1- trimethylacetoxypropane and process for preparing thereof

Publications (2)

Publication Number Publication Date
PT98590A true PT98590A (pt) 1992-06-30
PT98590B PT98590B (pt) 1999-04-30

Family

ID=5380072

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98590A PT98590B (pt) 1990-08-06 1991-08-06 Processo de preparacao de (2r)-2-/di(2-propil)fosfonilmetoxi/-3-p-tolueno-sulfoniloxi-1-trimetilacetoxipropano e de derivados (s)-n-(3-hidroxi-2-fosfonilmetoxipropilo de bases heterociclicos puricas e pirimidicas

Country Status (13)

Country Link
US (2) US5130427A (pt)
EP (1) EP0470809A1 (pt)
JP (1) JP2955402B2 (pt)
AU (1) AU8149291A (pt)
CA (1) CA2046755C (pt)
CS (1) CS387190A3 (pt)
FI (1) FI913702L (pt)
IE (1) IE71217B1 (pt)
IL (1) IL98849A0 (pt)
NO (1) NO913035L (pt)
NZ (1) NZ239131A (pt)
PT (1) PT98590B (pt)
ZA (1) ZA915932B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ284678B6 (cs) * 1991-05-20 1999-01-13 Ústav Organické Chemie A Biochemie Avčr Di(2-propyl)estery 1-fluor-2-fosfonomethoxy-3-p -toluensulfonyloxypropanů, způsob jejich přípravy a použití
US6057305A (en) * 1992-08-05 2000-05-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiretroviral enantiomeric nucleotide analogs
JP2532818B2 (ja) 1993-02-01 1996-09-11 松下電器産業株式会社 対物レンズおよび光ヘッド装置
US5502177A (en) * 1993-09-17 1996-03-26 Gilead Sciences, Inc. Pyrimidine derivatives for labeled binding partners
ATE332910T1 (de) * 2000-02-18 2006-08-15 Southern Res Inst Verfahren zur herstellung von 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofura osyl)-9h-purin-6-amin
CZ304734B6 (cs) 2000-07-21 2014-09-10 Gilead Sciences, Inc. Způsob přípravy 9-[2-(fosfonomethoxy)propyl]adeninu a 9-[2-(fosfonomethoxy)ethyl]adeninu
AU2003235501A1 (en) * 2002-05-13 2003-11-11 Metabasis Therapeutics, Inc. PMEA and PMPA cyclic producing synthesis
NZ536328A (en) * 2002-05-13 2007-11-30 Metabasis Therapeutics Inc Novel phosphonic acid based prodrugs of PMEA and its analogues
WO2005123729A1 (en) * 2004-06-08 2005-12-29 Metabasis Therapeutics, Inc. Lewis acid mediated synthesis of cyclic esters
RU2606845C2 (ru) 2010-12-10 2017-01-10 СИГМАФАРМ ЛЭБОРЭТОРИЗ, ЭлЭлСи Высокостабильные композиции перорально активных аналогов нуклеотидов или перорально активных пролекарств аналогов нуклеотидов
ES2874774T3 (es) 2011-12-22 2021-11-05 Geron Corp Análogos de guanina como sustratos de telomerasa y afectores de la longitud de los telómeros
JP2017512183A (ja) 2014-02-13 2017-05-18 リガンド・ファーマシューティカルズ・インコーポレイテッド プロドラッグ化合物およびそれらの使用
CN106687118A (zh) 2014-07-02 2017-05-17 配体药物公司 前药化合物及其用途
RU2020126177A (ru) 2018-01-09 2022-02-10 Лиганд Фармасьютикалз, Инк. Ацетальные соединения и их терапевтическое применение
JP7151348B2 (ja) * 2018-10-03 2022-10-12 日本製鉄株式会社 金属板用塗料およびこれを用いた塗装金属板の製造方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4868187A (en) * 1980-09-16 1989-09-19 Syntex (U.S.A.) Inc. Anti-viral N-substituted pyrimidines
US4816447A (en) * 1981-08-26 1989-03-28 Merck & Co., Inc. Anti-viral guanine compounds
CS233665B1 (en) * 1983-01-06 1985-03-14 Antonin Holy Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene
US5047533A (en) * 1983-05-24 1991-09-10 Sri International Acyclic purine phosphonate nucleotide analogs
CS263951B1 (en) * 1985-04-25 1989-05-12 Antonin Holy 9-(phosponylmethoxyalkyl)adenines and method of their preparation
CS264222B1 (en) * 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
AU8092587A (en) * 1986-11-18 1988-05-19 Bristol-Myers Squibb Company Synthesis of purin-9-ylalkylenoxymethyl phosphonic acids
US4927830A (en) * 1988-04-08 1990-05-22 The Regents Of The University Of Michigan Acyclic pyrrolo[2,3-D]pyrimidine analogs as antiviral agents
US4968686A (en) * 1988-04-08 1990-11-06 The Regents Of The University Of Michigan Acyclic pyrrolo [2,3-d]pyrimidine analogs as antiviral agents
FI930552A7 (fi) * 1990-08-10 1993-02-22 Rega Stichting Uusi menetelmä nukleotidien valmistamiseksi

Also Published As

Publication number Publication date
IL98849A0 (en) 1992-07-15
JPH05230087A (ja) 1993-09-07
IE71217B1 (en) 1997-02-12
CA2046755A1 (en) 1992-02-07
IE912758A1 (en) 1992-02-12
NO913035L (no) 1992-02-07
CS276072B6 (en) 1992-03-18
FI913702A0 (fi) 1991-08-02
AU8149291A (en) 1992-02-13
ZA915932B (en) 1992-04-29
NO913035D0 (no) 1991-08-05
US5130427A (en) 1992-07-14
JP2955402B2 (ja) 1999-10-04
PT98590B (pt) 1999-04-30
CA2046755C (en) 2002-02-12
FI913702A7 (fi) 1992-02-07
EP0470809A1 (en) 1992-02-12
CS387190A3 (en) 1992-03-18
FI913702L (fi) 1992-02-07
USRE35558E (en) 1997-07-08
NZ239131A (en) 1994-04-27

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Legal Events

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BB1A Laying open of patent application

Effective date: 19920214

FG3A Patent granted, date of granting

Effective date: 19990129

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: MAXIMUM VALIDITY LIMIT REACHED

Effective date: 20140129