PT98681A - Processo para a preparacao de novos 19-nor esteroides que tem na posicao 11b uma cadeia de atomos de carbono com uma funcao amida e de composicoes farmaceuticas que os contem - Google Patents

Processo para a preparacao de novos 19-nor esteroides que tem na posicao 11b uma cadeia de atomos de carbono com uma funcao amida e de composicoes farmaceuticas que os contem

Info

Publication number: PT98681A
Authority: PT; Portugal
Prior art keywords: hydrogen; pharmaceutical compositions; amida; steroids; chain
Prior art date: 1990-08-14

Application number

PT98681A

Other languages

English (en)

Other versions

PT98681B (pt

Inventor

Francois Nique

Jean-Georges Teutsch

Patrick Van De Velde

Andre Claussner

Original Assignee

Roussel Uclaf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-08-14

Filing date

1991-08-14

Publication date

1992-07-31

1990-08-14 Priority claimed from FR9010323A external-priority patent/FR2665901B2/fr

1991-08-14 Application filed by Roussel Uclaf filed Critical Roussel Uclaf

1992-07-31 Publication of PT98681A publication Critical patent/PT98681A/pt

1999-01-29 Publication of PT98681B publication Critical patent/PT98681B/pt

Links

239000008194 pharmaceutical composition Substances 0.000 title abstract 2
VVUQRXPUVKXAIO-XFUVECHXSA-N 19-nor-5-androstenediol Chemical compound C1[C@@H](O)CC[C@@H]2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC=C21 VVUQRXPUVKXAIO-XFUVECHXSA-N 0.000 title 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 title 1
229910052799 carbon Inorganic materials 0.000 title 1
239000001257 hydrogen Substances 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
229910052760 oxygen Inorganic materials 0.000 abstract 4
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 3
239000005864 Sulphur Chemical group 0.000 abstract 3
125000000732 arylene group Chemical group 0.000 abstract 3
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 3
-1 heptafluorobutyl Chemical group 0.000 abstract 3
150000002431 hydrogen Chemical class 0.000 abstract 3
239000001301 oxygen Substances 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
125000000623 heterocyclic group Chemical group 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000001931 aliphatic group Chemical group 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
KCNKJCHARANTIP-SNAWJCMRSA-N allyl-{4-[3-(4-bromo-phenyl)-benzofuran-6-yloxy]-but-2-enyl}-methyl-amine Chemical group C=1OC2=CC(OC/C=C/CN(CC=C)C)=CC=C2C=1C1=CC=C(Br)C=C1 KCNKJCHARANTIP-SNAWJCMRSA-N 0.000 abstract 1
HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000002534 ethynyl group Chemical group [H]C#C* 0.000 abstract 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
150000002576 ketones Chemical class 0.000 abstract 1
229940126601 medicinal product Drugs 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PT98681A 1990-08-14 1991-08-14 Processo para a preparacao de novos 19-nor esteroides que tem na posicao 11b uma cadeia de atomos de carbono com uma funcao amida e de composicoes farmaceuticas que os contem PT98681B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9010323A FR2665901B2 (fr)	1989-02-24	1990-08-14	Nouveaux 19-nor sterouides ayant en position 11beta une chaine carbonee comportant une fonction amide, leur preparation, leur application comme medicaments.

Publications (2)

Publication Number	Publication Date
PT98681A true PT98681A (pt)	1992-07-31
PT98681B PT98681B (pt)	1999-01-29

Family

ID=9399655

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT98681A PT98681B (pt)	1990-08-14	1991-08-14	Processo para a preparacao de novos 19-nor esteroides que tem na posicao 11b uma cadeia de atomos de carbono com uma funcao amida e de composicoes farmaceuticas que os contem

Country Status (15)

Country	Link
EP (1)	EP0471612B1 (pt)
JP (1)	JP3073803B2 (pt)
KR (1)	KR920004408A (pt)
AT (1)	ATE162797T1 (pt)
AU (1)	AU644671B2 (pt)
CA (1)	CA2049102A1 (pt)
DE (1)	DE69128820T2 (pt)
DK (1)	DK0471612T3 (pt)
ES (1)	ES2112268T3 (pt)
GR (1)	GR3026315T3 (pt)
HU (1)	HUT59416A (pt)
IE (1)	IE912863A1 (pt)
MX (1)	MX9100647A (pt)
PT (1)	PT98681B (pt)
ZA (1)	ZA916420B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2685332A1 (fr) *	1991-12-20	1993-06-25	Roussel Uclaf	Nouveaux 19-nor sterouides ayant en position 11beta une chaine thiocarbonee, leur procede de preparation et les intermediaires et leur application a titre de medicaments.
DK0680470T3 (pt) *	1993-01-21	1997-04-28	Merrell Pharma Inc
FR2706454B1 (fr) *	1993-06-17	1995-09-15	Roussel Uclaf	Nouveaux 19-Nor stéroïdes, procédé et intermédiaires de préparation, application comme médicaments et compositions pharmaceutiques les contenant.
US5670521A (en) *	1994-08-05	1997-09-23	Merrell Pharmaceuticals Inc.	Reversal of multi-drug resistance by triphenyl-azacycloalkane derivatives
DE19724187A1 (de) *	1997-06-02	1998-12-03	Schering Ag	11beta-Arylsubstituierte 14,17-Ethanoestratriene, Verfahren zur Herstellung dieser Verbindungen, sowie ihre Verwendung zur Herstellung von Arzneimitteln
US6054446A (en) *	1997-12-24	2000-04-25	Sri International	Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
AU6228299A (en) *	1998-10-29	2000-05-22	Teikoku Hormone Mfg. Co., Ltd.	2-substituted-d-homooxasteroid derivatives
DE19929715A1 (de) *	1999-06-24	2000-12-28	Schering Ag	11ß-langkettig-substituierte Estratriene, Verfahren zur Herstellung , pharmazeutische Präparate, die diese 11ß-langkettig-substituierten Estratriene enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
DE102009034526A1 (de) *	2009-07-21	2011-02-10	Bayer Schering Pharma Aktiengesellschaft	17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-ethinylphenyl-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
PH12013500907A1 (en)	2010-11-05	2013-07-08	Firmenich Incorporated	Compounds useful as modulators of trpm8
EP3356356B1 (en)	2015-10-01	2021-05-26	Firmenich Incorporated	Compounds useful as modulators of trpm8

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2235949B1 (pt) *	1973-06-18	1978-03-17	Roussel Uclaf
AU580843B2 (en) *	1985-02-07	1989-02-02	Schering Aktiengesellschaft	11``-phenyl-gonanes, their manufacture and pharmaceutical preparations containing them
DE3621024C2 (de) *	1986-06-20	1999-10-28	Schering Ag	11beta-Phenylestradiene, deren Herstellung und diese enthaltende pharmazeutische Präparate
FR2620707B1 (fr) *	1987-09-18	1989-12-08	Roussel Uclaf	Nouveaux steroides comportant un cycle spirannique a 3, 4 ou 6 chainons en position 17, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
FR2643638B1 (fr) *	1989-02-24	1991-06-14	Roussel Uclaf	Nouveaux 19-nor steroides ayant en position 11beta une chaine carbonee comportant une fonction amide ou carbamate, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant

1991
- 1991-08-09 EP EP91402214A patent/EP0471612B1/fr not_active Expired - Lifetime
- 1991-08-09 DE DE69128820T patent/DE69128820T2/de not_active Expired - Fee Related
- 1991-08-09 AT AT91402214T patent/ATE162797T1/de not_active IP Right Cessation
- 1991-08-09 DK DK91402214T patent/DK0471612T3/da active
- 1991-08-09 ES ES91402214T patent/ES2112268T3/es not_active Expired - Lifetime
- 1991-08-13 MX MX9100647A patent/MX9100647A/es unknown
- 1991-08-13 CA CA002049102A patent/CA2049102A1/fr not_active Abandoned
- 1991-08-13 JP JP03226410A patent/JP3073803B2/ja not_active Expired - Fee Related
- 1991-08-13 IE IE286391A patent/IE912863A1/en not_active IP Right Cessation
- 1991-08-13 KR KR1019910013914A patent/KR920004408A/ko not_active Withdrawn
- 1991-08-13 HU HU912690A patent/HUT59416A/hu unknown
- 1991-08-14 ZA ZA916420A patent/ZA916420B/xx unknown
- 1991-08-14 PT PT98681A patent/PT98681B/pt not_active IP Right Cessation
- 1991-08-14 AU AU82422/91A patent/AU644671B2/en not_active Ceased
1998
- 1998-03-11 GR GR970402371T patent/GR3026315T3/el unknown

Also Published As

Publication number	Publication date
AU8242291A (en)	1992-02-20
EP0471612B1 (fr)	1998-01-28
ZA916420B (en)	1992-10-28
HU912690D0 (en)	1992-01-28
DE69128820T2 (de)	1998-06-10
EP0471612A3 (en)	1992-05-13
JP3073803B2 (ja)	2000-08-07
ES2112268T3 (es)	1998-04-01
EP0471612A2 (fr)	1992-02-19
JPH06340688A (ja)	1994-12-13
DK0471612T3 (da)	1999-02-22
GR3026315T3 (en)	1998-06-30
HUT59416A (en)	1992-05-28
MX9100647A (es)	1992-04-01
ATE162797T1 (de)	1998-02-15
CA2049102A1 (fr)	1992-02-15
IE912863A1 (en)	1992-02-26
AU644671B2 (en)	1993-12-16
KR920004408A (ko)	1992-03-27
DE69128820D1 (de)	1998-03-05
PT98681B (pt)	1999-01-29

Legal Events

Date	Code	Title	Description
1992-07-31	BB1A	Laying open of patent application	Effective date: 19920310
1999-01-29	FG3A	Patent granted, date of granting	Effective date: 19981022
2000-01-31	PC3A	Transfer or assignment	Free format text: 19991011 HOECHST MARION ROUSSEL FR
2000-01-31	PD3A	Change of proprietorship	Owner name: ROUSSEL UCLAF Effective date: 19991011
2000-01-31	TE3A	Change of address (patent)	Owner name: ROUSSEL UCLAF Effective date: 19991011
2003-03-31	PC3A	Transfer or assignment	Free format text: AVENTIS PHARMA S.A. FR Effective date: 20030110
2004-07-30	MM3A	Annulment or lapse	Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20040430

Publication	Publication Date	Title
PT98102A (pt)	1992-03-31	Processo de preparacao de misturas de polissacaridos de baixo peso molecular e de composicoes farmaceuticas que as contem
PT93263A (pt)	1990-08-31	Processo para a preparacao de 19-nor esteroides contendo na posicao 11-beta umacadeia carbonada possuindo uma funcao amida ou carbamato
DK509088D0 (da)	1988-09-13	17-spiro-steroider, deres fremstilling samt laegemidler med indhold deraf
BR9007950A (pt)	1992-10-27	Metodo para tratamento ou prevencao da manifestacao de uma doenca auto-imune em um mamifero,formulacao farmaceutica,metodo para tratamento de uma doenca auto-imune,e metodo para tratamento de um mamifero acometido de doenca auto-imune
KR860005636A (ko)	1986-08-11	활성성분으로 스페르구알린(Spergualin)을 함유하는 주사제 조성물과 그 제조방법.
KR870000072A (ko)	1987-02-16	아졸 유도체를 함유하는 제제물 및 외상없이 손톱을 제거하기 위한 그 용도
KR830000911A (ko)	1983-04-28	X-선 콘트라스트제제의 살균된 주사용의 생리적으로 가능한 용액의 제조방법 및 x-선콘트라스트 제제 및 완충액
DE69402114D1 (de)	1997-04-24	Neue 19-Nor-Steroide mit einer 11-Beta-Phenoxysulfonamid- oder 11-Beta-Phenoxysulfonylurea-Gruppe, Verfahren und Zwischenprodukte zu ihrer Herstellung sowie Medikamenten und pharmazeutische Präparate davon
DK0471612T3 (da)	1999-02-22	Nye 19-nor steroider med carbonkæde omfattende en amidgruppe i 11-beta-stillingen, fremgangsmåde til deres fremstilling, de
ATE28752T1 (de)	1987-08-15	1-alkyl-androsta-1,4-dien-3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate.
DE68917885D1 (de)	1994-10-06	Phosphonsäure-Derivate von Steroiden als Hemmstoffe der 5-alpha-Reduktase.
KR860000867A (ko)	1986-02-20	급성 방사선 증후군 발현억제 및 패혈증 발현억제의 방법 및 그 조성물
ATE39388T1 (de)	1989-01-15	Verfahren zur herstellung von truebgasarmen eich- oder kontrollseren.
KR900700448A (ko)	1990-08-13	불포화 측쇄를 갖는 1α-히드로시비타민 D동족체
PT97286A (pt)	1992-01-31	Processo para a preparacao de novos derivados do 3-aminocromano e de composicoes farmaceuticas que os contem
PT93915A (pt)	1990-11-20	Processo para a preparacao de novos derivados de 4-fenil-metil-1h-indol e de composicoes farmaceuticas que os contem
PT91362A (pt)	1990-03-08	Processo para a preparacao de novos acidos 6-fluor-3,5-di-hidroxi-carboxilicos e seus derivados, e de composicoes farmaceuticas que os contem e de produtos intermediarios
ATE90095T1 (de)	1993-06-15	Optisch aktive produkte von 20,21dinoreburnamenin-derivaten,verfahren zur herstellung, ihre verwendung als arzneimittel und diese enthaltende pharmazeutische zusammenstellungen.
ATE14727T1 (de)	1985-08-15	(3,6-pyridazindiylbis(thio))bis-(2,2dimethylalkans\|uren) und deren derivate, geeignet als antiarteriosklerotische mittel, verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische zusammenstellungen.
PT75900A (de)	1982-12-01	Neue oxyme von 3'''-dehydro-cardenolid-trididitoxosiden verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
SE7907353L (sv)	1981-03-05	Radioopaka kompositioner for tandrestauration