ES2112268T3 - Nuevos 19-nor-esteroides que tienen en posicion 11beta una cadena carbonada que comprende una funcion amida, su preparacion, su aplicacion como medicamentos y composiciones farmaceuticas que los contienen. - Google Patents

Nuevos 19-nor-esteroides que tienen en posicion 11beta una cadena carbonada que comprende una funcion amida, su preparacion, su aplicacion como medicamentos y composiciones farmaceuticas que los contienen.

Info

Publication number
ES2112268T3
ES2112268T3 ES91402214T ES91402214T ES2112268T3 ES 2112268 T3 ES2112268 T3 ES 2112268T3 ES 91402214 T ES91402214 T ES 91402214T ES 91402214 T ES91402214 T ES 91402214T ES 2112268 T3 ES2112268 T3 ES 2112268T3
Authority
ES
Spain
Prior art keywords
preparation
hydrogen
pharmaceutical compositions
application
amida
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91402214T
Other languages
English (en)
Inventor
Andre Claussner
Francois Nique
Jean-Georges Teutsch
De Velde Patrick Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Marion Roussel
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9010323A external-priority patent/FR2665901B2/fr
Application filed by Hoechst Marion Roussel, Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel
Application granted granted Critical
Publication of ES2112268T3 publication Critical patent/ES2112268T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A COMPUESTOS: O N = 1, K = OXIGENO, R SUB 17 = HIDROXILO, R'' SUB 17 = HIDROGENO, ETINILO, R SUB A = METILO, R'' SUB A = ISOPROPILO, BUTILO, HEPTAFLUOROBUTILO, X = METILENO, FENILENO O FENILOXI, Y = -(CH SUB 2) SUB 7; -(CH SUB 2) SUB 8; -(CH SUB 2) SUB 5-C (EQUIVALE) C -; -(CH SUB 2) SUB Q-O-CH SUB 2-Q = 5 A 7 Y -(CH SUB 2) SUB 5-S-CH SUB 2-, 0 N = 1 O 2, K = OXIGENO O AZUFRE, R SUB 17 Y R SUB 17'' = CETONA O R SUB 17 = HIDROXILO, ACILOXI Y R SUB 17'' = HIDROGENO, ALQUILO, ALCENILO, ALCINILO, X = METILENO, ARILENO, CH SUB 2-O, ARILENOXI O ARILENETIO, Y = ENLACE O CADENA ALIFATICA EVENTUALMENTE INTERRUMPIDA POR ARILENO, OXIGENO O AZUFRE EVENTUALMENTE OXIDADO Y EVENTUALMENTE TERMINADO POR ARILENO, Z = ENLACE Y SI Y Y Z = ENLACE, X CH SUB 2 O CH SUB 2-O, R SUB A O R SUB A'' = HIDROGENO, ALQUILO, HETEROCICLO, (5 O 6 ESLABONES) EVENTUALMENTE SUSTITUIDO CON R SUB A O R SUB A'' HIDROGENO, K = AZUFRE, O X = ARILENETIO, O R SUB A Y R SUB A'' = HETEROCICLO SUSTITUIDO POR ARILO OAROALQUILO, SU PREPARACION COMO MEDICAMENTOS Y LAS COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN
ES91402214T 1990-08-14 1991-08-09 Nuevos 19-nor-esteroides que tienen en posicion 11beta una cadena carbonada que comprende una funcion amida, su preparacion, su aplicacion como medicamentos y composiciones farmaceuticas que los contienen. Expired - Lifetime ES2112268T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9010323A FR2665901B2 (fr) 1989-02-24 1990-08-14 Nouveaux 19-nor sterouides ayant en position 11beta une chaine carbonee comportant une fonction amide, leur preparation, leur application comme medicaments.

Publications (1)

Publication Number Publication Date
ES2112268T3 true ES2112268T3 (es) 1998-04-01

Family

ID=9399655

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91402214T Expired - Lifetime ES2112268T3 (es) 1990-08-14 1991-08-09 Nuevos 19-nor-esteroides que tienen en posicion 11beta una cadena carbonada que comprende una funcion amida, su preparacion, su aplicacion como medicamentos y composiciones farmaceuticas que los contienen.

Country Status (15)

Country Link
EP (1) EP0471612B1 (es)
JP (1) JP3073803B2 (es)
KR (1) KR920004408A (es)
AT (1) ATE162797T1 (es)
AU (1) AU644671B2 (es)
CA (1) CA2049102A1 (es)
DE (1) DE69128820T2 (es)
DK (1) DK0471612T3 (es)
ES (1) ES2112268T3 (es)
GR (1) GR3026315T3 (es)
HU (1) HUT59416A (es)
IE (1) IE912863A1 (es)
MX (1) MX9100647A (es)
PT (1) PT98681B (es)
ZA (1) ZA916420B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2685332A1 (fr) * 1991-12-20 1993-06-25 Roussel Uclaf Nouveaux 19-nor sterouides ayant en position 11beta une chaine thiocarbonee, leur procede de preparation et les intermediaires et leur application a titre de medicaments.
NZ261414A (en) * 1993-01-21 1997-06-24 Merrell Dow Pharma N-acyl-2-(diphenylalkyl)piperidine derivatives and pharmaceutical compositions
FR2706454B1 (fr) * 1993-06-17 1995-09-15 Roussel Uclaf Nouveaux 19-Nor stéroïdes, procédé et intermédiaires de préparation, application comme médicaments et compositions pharmaceutiques les contenant.
US5670521A (en) * 1994-08-05 1997-09-23 Merrell Pharmaceuticals Inc. Reversal of multi-drug resistance by triphenyl-azacycloalkane derivatives
DE19724187A1 (de) * 1997-06-02 1998-12-03 Schering Ag 11beta-Arylsubstituierte 14,17-Ethanoestratriene, Verfahren zur Herstellung dieser Verbindungen, sowie ihre Verwendung zur Herstellung von Arzneimitteln
US6054446A (en) * 1997-12-24 2000-04-25 Sri International Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
AU6228299A (en) * 1998-10-29 2000-05-22 Teikoku Hormone Mfg. Co., Ltd. 2-substituted-d-homooxasteroid derivatives
DE19929715A1 (de) * 1999-06-24 2000-12-28 Schering Ag 11ß-langkettig-substituierte Estratriene, Verfahren zur Herstellung , pharmazeutische Präparate, die diese 11ß-langkettig-substituierten Estratriene enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
DE102009034526A1 (de) * 2009-07-21 2011-02-10 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-ethinylphenyl-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
CN103201279A (zh) 2010-11-05 2013-07-10 赛诺米克斯公司 作为trpm8的调节剂有用的化合物
CN108473484B (zh) 2015-10-01 2021-06-29 弗门尼舍公司 可用作trpm8调节剂的化合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2235949B1 (es) * 1973-06-18 1978-03-17 Roussel Uclaf
AU580843B2 (en) * 1985-02-07 1989-02-02 Schering Aktiengesellschaft 11``-phenyl-gonanes, their manufacture and pharmaceutical preparations containing them
DE3621024C2 (de) * 1986-06-20 1999-10-28 Schering Ag 11beta-Phenylestradiene, deren Herstellung und diese enthaltende pharmazeutische Präparate
FR2620707B1 (fr) * 1987-09-18 1989-12-08 Roussel Uclaf Nouveaux steroides comportant un cycle spirannique a 3, 4 ou 6 chainons en position 17, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
FR2643638B1 (fr) * 1989-02-24 1991-06-14 Roussel Uclaf Nouveaux 19-nor steroides ayant en position 11beta une chaine carbonee comportant une fonction amide ou carbamate, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
PT98681A (pt) 1992-07-31
DE69128820T2 (de) 1998-06-10
EP0471612A3 (en) 1992-05-13
JPH06340688A (ja) 1994-12-13
HUT59416A (en) 1992-05-28
AU644671B2 (en) 1993-12-16
CA2049102A1 (fr) 1992-02-15
PT98681B (pt) 1999-01-29
HU912690D0 (en) 1992-01-28
IE912863A1 (en) 1992-02-26
ATE162797T1 (de) 1998-02-15
DE69128820D1 (de) 1998-03-05
JP3073803B2 (ja) 2000-08-07
DK0471612T3 (da) 1999-02-22
ZA916420B (en) 1992-10-28
AU8242291A (en) 1992-02-20
EP0471612A2 (fr) 1992-02-19
GR3026315T3 (en) 1998-06-30
MX9100647A (es) 1992-04-01
KR920004408A (ko) 1992-03-27
EP0471612B1 (fr) 1998-01-28

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