PT98955A - Processo de preparacao de composicoes quimicas secas estabilizadas contendo um sal de adicao de acido soluvel em agua de um composto basico pouco soluvel, e de aumento da insensibilidade de um procedimento de granulacao - Google Patents

Processo de preparacao de composicoes quimicas secas estabilizadas contendo um sal de adicao de acido soluvel em agua de um composto basico pouco soluvel, e de aumento da insensibilidade de um procedimento de granulacao

Info

Publication number: PT98955A
Authority: PT; Portugal
Prior art keywords: compositions containing; basic compound; insensibility; soluable; increasing
Prior art date: 1990-09-13

Application number

PT98955A

Other languages

English (en)

Other versions

PT98955B (pt

Inventor

Pieter De Haan

Cornelus Josephus Maria Va Ven

Original Assignee

Akzo Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-09-13

Filing date

1991-09-12

Publication date

1992-08-31

1991-09-12 Application filed by Akzo Nv filed Critical Akzo Nv

1992-08-31 Publication of PT98955A publication Critical patent/PT98955A/pt

1999-02-26 Publication of PT98955B publication Critical patent/PT98955B/pt

Links

239000000203 mixture Substances 0.000 title abstract 5
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title abstract 5
239000002253 acid Substances 0.000 title abstract 2
150000007514 bases Chemical class 0.000 title abstract 2
238000005469 granulation Methods 0.000 title abstract 2
230000003179 granulation Effects 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
150000003839 salts Chemical class 0.000 title abstract 2
239000000126 substance Substances 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title 1
239000003381 stabilizer Substances 0.000 abstract 3
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 abstract 1
PWWVAXIEGOYWEE-UHFFFAOYSA-N Isophenergan Chemical compound C1=CC=C2N(CC(C)N(C)C)C3=CC=CC=C3SC2=C1 PWWVAXIEGOYWEE-UHFFFAOYSA-N 0.000 abstract 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract 1
UEQUQVLFIPOEMF-UHFFFAOYSA-N Mianserin Chemical compound C1C2=CC=CC=C2N2CCN(C)CC2C2=CC=CC=C21 UEQUQVLFIPOEMF-UHFFFAOYSA-N 0.000 abstract 1
229920000168 Microcrystalline cellulose Polymers 0.000 abstract 1
VMWNQDUVQKEIOC-CYBMUJFWSA-N apomorphine Chemical compound C([C@H]1N(C)CC2)C3=CC=C(O)C(O)=C3C3=C1C2=CC=C3 VMWNQDUVQKEIOC-CYBMUJFWSA-N 0.000 abstract 1
229960004046 apomorphine Drugs 0.000 abstract 1
FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 abstract 1
ZPEIMTDSQAKGNT-UHFFFAOYSA-N chlorpromazine Chemical compound C1=C(Cl)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 ZPEIMTDSQAKGNT-UHFFFAOYSA-N 0.000 abstract 1
229960001076 chlorpromazine Drugs 0.000 abstract 1
235000019700 dicalcium phosphate Nutrition 0.000 abstract 1
BCGWQEUPMDMJNV-UHFFFAOYSA-N imipramine Chemical compound C1CC2=CC=CC=C2N(CCCN(C)C)C2=CC=CC=C21 BCGWQEUPMDMJNV-UHFFFAOYSA-N 0.000 abstract 1
229960004801 imipramine Drugs 0.000 abstract 1
239000008101 lactose Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
229960003955 mianserin Drugs 0.000 abstract 1
235000019813 microcrystalline cellulose Nutrition 0.000 abstract 1
239000008108 microcrystalline cellulose Substances 0.000 abstract 1
229940016286 microcrystalline cellulose Drugs 0.000 abstract 1
239000000546 pharmaceutical excipient Substances 0.000 abstract 1
229960003910 promethazine Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Inorganic Chemistry (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Lubricants (AREA)
Developing Agents For Electrophotography (AREA)

PT98955A 1990-09-13 1991-09-12 Processo de preparacao de composicoes quimicas secas estabilizadas contendo um sal de adicao de acido soluvel em agua de um composto basico pouco soluvel, e de aumento da insensibilidade de um procedimento de granulacao PT98955B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US58185990A	1990-09-13	1990-09-13

Publications (2)

Publication Number	Publication Date
PT98955A true PT98955A (pt)	1992-08-31
PT98955B PT98955B (pt)	1999-02-26

Family

ID=24326864

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT98955A PT98955B (pt)	1990-09-13	1991-09-12	Processo de preparacao de composicoes quimicas secas estabilizadas contendo um sal de adicao de acido soluvel em agua de um composto basico pouco soluvel, e de aumento da insensibilidade de um procedimento de granulacao

Country Status (14)

Country	Link
EP (1)	EP0475482B1 (pt)
JP (1)	JP3153577B2 (pt)
KR (1)	KR100196209B1 (pt)
AT (1)	ATE112491T1 (pt)
AU (1)	AU643920B2 (pt)
CA (1)	CA2049811C (pt)
DE (1)	DE69104453T2 (pt)
DK (1)	DK0475482T3 (pt)
ES (1)	ES2064887T3 (pt)
FI (1)	FI104361B (pt)
IE (1)	IE65274B1 (pt)
NZ (1)	NZ239753A (pt)
PT (1)	PT98955B (pt)
ZA (1)	ZA916661B (pt)

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ATE290864T1 (de) *	1993-03-26	2005-04-15	Franciscus Wilhelmus He Merkus	Pharmazeutische zusammensetzungen zur intranasalen verabreichung von dihydroergotamin
JP2001518923A (ja) *	1997-03-26	2001-10-16	ダブリュエイチエムマーカス，フランシスカス	鼻腔用メラトニン組成物
GB0001621D0 (en)	2000-01-26	2000-03-15	Astrazeneca Ab	Pharmaceutical compositions
US6691057B2 (en)	2001-02-26	2004-02-10	L.U.M. Gesellschaft Fur Labor- Umweltdiagnostic & Medizintechnik Mbh	Method and device for accelerated stability analysis
US7407955B2 (en)	2002-08-21	2008-08-05	Boehringer Ingelheim Pharma Gmbh & Co., Kg	8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
DE102004054054A1 (de)	2004-11-05	2006-05-11	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
CA2491665A1 (fr) *	2004-12-24	2006-06-24	Louis Cartilier	Formulation de comprime pour liberation soutenue de principe actif
PE20080251A1 (es)	2006-05-04	2008-04-25	Boehringer Ingelheim Int	Usos de inhibidores de dpp iv
EP2540725A1 (de)	2006-05-04	2013-01-02	Boehringer Ingelheim International GmbH	Polymorphe von 1-((4-Methyl-chinazolin-2-yl)methyl)-3-methyl-7-(2-butin-1-yl)-8-(3-(R)-amino-piperidin-1-yl)xanthin
EP1852108A1 (en)	2006-05-04	2007-11-07	Boehringer Ingelheim Pharma GmbH & Co.KG	DPP IV inhibitor formulations
PE20091730A1 (es)	2008-04-03	2009-12-10	Boehringer Ingelheim Int	Formulaciones que comprenden un inhibidor de dpp4
BRPI0916997A2 (pt)	2008-08-06	2020-12-15	Boehringer Ingelheim International Gmbh	Inibidor de dpp-4 e seu uso
UY32030A (es)	2008-08-06	2010-03-26	Boehringer Ingelheim Int	"tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
US20200155558A1 (en)	2018-11-20	2020-05-21	Boehringer Ingelheim International Gmbh	Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
CN102256976A (zh)	2008-12-23	2011-11-23	贝林格尔.英格海姆国际有限公司	有机化合物的盐形式
AR074990A1 (es)	2009-01-07	2011-03-02	Boehringer Ingelheim Int	Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
KR20240090632A (ko)	2009-11-27	2024-06-21	베링거 인겔하임 인터내셔날 게엠베하	리나글립틴과 같은 ｄｐｐ－ｉｖ 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료
CN102946875A (zh)	2010-05-05	2013-02-27	贝林格尔.英格海姆国际有限公司	组合疗法
WO2011161161A1 (en)	2010-06-24	2011-12-29	Boehringer Ingelheim International Gmbh	Diabetes therapy
AR083878A1 (es)	2010-11-15	2013-03-27	Boehringer Ingelheim Int	Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
US8883800B2 (en)	2011-07-15	2014-11-11	Boehringer Ingelheim International Gmbh	Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions
US9555001B2 (en)	2012-03-07	2017-01-31	Boehringer Ingelheim International Gmbh	Pharmaceutical composition and uses thereof
JP6218811B2 (ja)	2012-05-14	2017-10-25	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	Ｓｉｒｓ及び／又は敗血症の治療に用いるｄｐｐ−４阻害薬としてのキサンチン誘導体
JP6224084B2 (ja)	2012-05-14	2017-11-01	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	糸球体上皮細胞関連障害及び／又はネフローゼ症候群の治療に用いるｄｐｐ−４阻害薬としてのキサンチン誘導体
WO2013174767A1 (en)	2012-05-24	2013-11-28	Boehringer Ingelheim International Gmbh	A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
EP3110449B1 (en)	2014-02-28	2023-06-28	Boehringer Ingelheim International GmbH	Medical use of a dpp-4 inhibitor
RU2609198C1 (ru) *	2016-01-25	2017-01-30	Закрытое Акционерное Общество "БИОКОМ"	Твердая лекарственная форма имипрамина немедленного высвобождения и способ ее получения
CN109310697A (zh)	2016-06-10	2019-02-05	勃林格殷格翰国际有限公司	利格列汀和二甲双胍的组合
KR102416406B1 (ko) *	2019-09-24	2022-07-04	주식회사 종근당	티카그렐러의 산 부가염을 포함하는 안정화된 약학 조성물
CN117820319A (zh) *	2023-12-27	2024-04-05	仁和堂药业有限公司	一种盐酸米安色林的新晶型及其制备方法

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1991
- 1991-08-13 EP EP91202070A patent/EP0475482B1/en not_active Expired - Lifetime
- 1991-08-13 DE DE69104453T patent/DE69104453T2/de not_active Expired - Lifetime
- 1991-08-13 AT AT91202070T patent/ATE112491T1/de not_active IP Right Cessation
- 1991-08-13 ES ES91202070T patent/ES2064887T3/es not_active Expired - Lifetime
- 1991-08-13 DK DK91202070.8T patent/DK0475482T3/da active
- 1991-08-22 ZA ZA916661A patent/ZA916661B/xx unknown
- 1991-08-23 CA CA002049811A patent/CA2049811C/en not_active Expired - Fee Related
- 1991-08-27 AU AU83416/91A patent/AU643920B2/en not_active Expired
- 1991-08-29 IE IE305491A patent/IE65274B1/en not_active IP Right Cessation
- 1991-09-03 FI FI914147A patent/FI104361B/fi not_active IP Right Cessation
- 1991-09-11 NZ NZ239753A patent/NZ239753A/en not_active IP Right Cessation
- 1991-09-12 JP JP23322491A patent/JP3153577B2/ja not_active Expired - Fee Related
- 1991-09-12 PT PT98955A patent/PT98955B/pt not_active IP Right Cessation
- 1991-09-12 KR KR1019910015896A patent/KR100196209B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
KR100196209B1 (ko)	1999-06-15
JPH0578236A (ja)	1993-03-30
ATE112491T1 (de)	1994-10-15
DE69104453D1 (de)	1994-11-10
NZ239753A (en)	1992-10-28
PT98955B (pt)	1999-02-26
IE65274B1 (en)	1995-10-18
DE69104453T2 (de)	1995-03-16
ES2064887T3 (es)	1995-02-01
EP0475482B1 (en)	1994-10-05
FI914147L (fi)	1992-03-14
KR920005978A (ko)	1992-04-27
ZA916661B (en)	1992-06-24
AU643920B2 (en)	1993-11-25
FI104361B (fi)	2000-01-14
EP0475482A1 (en)	1992-03-18
CA2049811A1 (en)	1992-03-14
IE913054A1 (en)	1992-02-25
FI914147A0 (fi)	1991-09-03
JP3153577B2 (ja)	2001-04-09
DK0475482T3 (da)	1995-04-03
AU8341691A (en)	1992-03-19
CA2049811C (en)	2002-11-05

Legal Events

Date	Code	Title	Description
1992-08-31	BB1A	Laying open of patent application	Effective date: 19920511
1999-02-26	FG3A	Patent granted, date of granting	Effective date: 19981109
2007-01-31	PC4A	Transfer of assignment	Owner name: N.V. ORGANON, NL Effective date: 20061124
2007-01-31	PD4A	Change of proprietorship	Owner name: AKZO NOBEL N.V., NL Effective date: 20061124
2011-12-20	PC4A	Transfer of assignment	Owner name: MSD OSS B.V., NL Effective date: 20111209
2013-05-27	PC4A	Transfer of assignment	Owner name: ORGANON BIOSCIENCES NEDERLAND B.V., NL Effective date: 20130517
2013-06-11	PC4A	Transfer of assignment	Owner name: MERCK SHARP & DOHME B.V., NL Effective date: 20130604
2013-11-19	MM4A	Annulment/lapse due to non-payment of fees, searched and examined patent	Free format text: MAXIMUM VALIDITY LIMIT REACHED Effective date: 20131111

Publication	Publication Date	Title
PT98955A (pt)	1992-08-31	Processo de preparacao de composicoes quimicas secas estabilizadas contendo um sal de adicao de acido soluvel em agua de um composto basico pouco soluvel, e de aumento da insensibilidade de um procedimento de granulacao
PT90466A (pt)	1989-11-30	Processo de preparacao de composicoes farmaceuticas compreendendo um excipiente extragranular, higroscopio insoluvel em agua e um ingrediente activo, em particular a cimetidina
DE69606840D1 (de)	2000-04-06	Monohydrate von Aminobenzensulfonsäurederivaten und Verfahren zu ihrer Herstellung
MX9706062A (es)	1997-10-31	FORMAS DE DOSIFICACION ORAL CONTENIENDO UN ANTIBIOTICO DE beta -LACTAMA.
HUT59832A (en)	1992-07-28	Process for producing pharmaceutical compositions containing calcitonin
CZ65296A3 (en)	1996-06-12	Effervescent granulate and process for preparing thereof
PT76219A (en)	1983-03-01	Process for the preparation of a fabric softening composition including an aqueous base a cationic lanoline softener and a viscosity control agent
EP0264259A1 (en)	1988-04-20	Stabilized pharmaceutical compositions
ES8703278A1 (es)	1987-02-16	Un procedimiento para cargar un polimero insoluble en agua yesponjable en agua con acetato de metilhidroxiprogesterona
HUT53664A (en)	1990-11-28	Process for producing enzyme inhibiting amino acid derivatives and pharmaceutical compositions comprising such compounds as active ingredient
NO941036L (no)	1994-03-22	Sparfloxacinsalter og opplösninger inneholdende saltene
KR880001154B1 (ko)	1988-07-02	항생물질의 안정화 방법
NO177484C (no)	1995-09-27	Fremgangsmåte for fremstilling av et farmasöytisk preparat i form av myke kapsler
CA1070299A (en)	1980-01-22	Stabilized solid form choline salicylate compositions
CA1136550A (en)	1982-11-30	Pharmaceutical composition containing thymidine
MY101266A (en)	1991-08-17	Pharmaceutical formulations
ZA793720B (en)	1981-03-25	Substituted 2-phenylamino-imidazoline-(2)derivatives,acid addition salts thereof,processes for their preparation,and pharmaceutical compositions thereof
FI900469A0 (fi)	1990-01-30	Aktivaemnen avgivande system med kontrollerad erosion och foerfarande foer dess framstaellning.
DE68903017D1 (de)	1992-11-05	Aktives derivat von zirkonium und seine herstellung.
JPS565412A (en)	1981-01-20	Pharmaceutical composition
HUT53096A (en)	1990-09-28	Process for producing thienylacetic acid derivatives and pharmaceutical compositions comprising same
ZA897713B (en)	1990-06-27	Stabel aqueous solution of primycin,pharmaceutical and cosmetic compositions containing these solutions and process for preparing same
ZA793541B (en)	1981-03-25	Substituted 2-phenylamino-imidazoline-(2)derivatives and their acid addition salts,processes for their preparation and pharmaceutical compositions containing these compounds
JPS54154729A (en)	1979-12-06	Aminobenzoic acid derivative and drug preparation containing the same
HYUN et al.	1989	Study of Fluorescein Pharmacokinetics