PT99028A - Processo para a preparacao de compostos azabiciclicos - Google Patents

Processo para a preparacao de compostos azabiciclicos

Info

Publication number: PT99028A
Authority: PT; Portugal
Prior art keywords: alkyl; phenyl; naphthyl; preparation; group
Prior art date: 1990-09-26

Application number

PT99028A

Other languages

English (en)

Other versions

PT99028B (pt

Inventor

Francis David King

Julian Anthony Gregory

Original Assignee

Beecham Group Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-09-26

Filing date

1991-09-24

Publication date

1993-10-29

1991-09-24 Application filed by Beecham Group Plc filed Critical Beecham Group Plc

1993-10-29 Publication of PT99028A publication Critical patent/PT99028A/pt

1999-02-26 Publication of PT99028B publication Critical patent/PT99028B/pt

Links

150000001875 compounds Chemical class 0.000 title abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
125000001624 naphthyl group Chemical group 0.000 abstract 2
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
125000006570 (C5-C6) heteroaryl group Chemical group 0.000 abstract 1
229940113081 5 Hydroxytryptamine 3 receptor antagonist Drugs 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000005647 linker group Chemical group 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000002950 monocyclic group Chemical group 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
239000003369 serotonin 5-HT3 receptor antagonist Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PT99028A 1990-09-26 1991-09-24 Processo para a preparacao de compostos azabiciclicos PT99028B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB909020927A GB9020927D0 (en)	1990-09-26	1990-09-26	Pharmaceuticals

Publications (2)

Publication Number	Publication Date
PT99028A true PT99028A (pt)	1993-10-29
PT99028B PT99028B (pt)	1999-02-26

Family

ID=10682769

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT99028A PT99028B (pt)	1990-09-26	1991-09-24	Processo para a preparacao de compostos azabiciclicos

Country Status (18)

Country	Link
EP (1)	EP0550550B1 (pt)
JP (1)	JP2831464B2 (pt)
KR (1)	KR100200438B1 (pt)
AT (1)	ATE245157T1 (pt)
AU (1)	AU652187B2 (pt)
CA (1)	CA2092431C (pt)
CY (1)	CY2387B1 (pt)
DE (1)	DE69133295T2 (pt)
DK (1)	DK0550550T3 (pt)
ES (1)	ES2203609T3 (pt)
GB (1)	GB9020927D0 (pt)
IE (1)	IE913352A1 (pt)
MX (1)	MX9101236A (pt)
NZ (1)	NZ239915A (pt)
PT (1)	PT99028B (pt)
TW (1)	TW240227B (pt)
WO (1)	WO1992005174A1 (pt)
ZA (1)	ZA917606B (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9121170D0 (en) *	1991-10-05	1991-11-20	Smithkline Beecham Plc	Pharmaceuticals
US5344831A (en) *	1992-01-31	1994-09-06	Nisshin Flour Milling Co., Ltd.	Diazabicyclo derivatives
GB9214184D0 (en) *	1992-07-03	1992-08-12	Smithkline Beecham Plc	Pharmaceuticals
US5514690A (en) *	1992-11-17	1996-05-07	E. R. Squibb & Sons, Inc.	Aminocarbonyl (thiocarbonyl) and cyanoguanidine derivatives of quinoline and indoline
US5612323A (en) *	1995-06-07	1997-03-18	Bristol-Myers Squibb Company	Phosphinic ester substituted benzopyran derivatives
US5869478A (en) *	1995-06-07	1999-02-09	Bristol-Myers Squibb Company	Sulfonamido substituted benzopyran derivatives
US5629429A (en) *	1995-06-07	1997-05-13	Bristol-Myers Squibb Company	Process for preparing 4-arylamino-benzopyran and related compounds
US5612370A (en) *	1995-06-07	1997-03-18	Bristol-Myers Squibb Company	Phenylglycine and phenylalaninen amido benzopyran derivatives
GB9721139D0 (en)	1997-10-07	1997-12-03	Glaxo Group Ltd	Medicaments
KR100783863B1 (ko)	2002-04-29	2007-12-10	액테리온 파마슈티칼 리미티드	7-아릴-3,9-디아자바이사이클로(3.3.1)논-6-엔 유도체 및고혈압, 심혈관 질환 또는 신장 질환의 치료에서 레닌저해물질로써 이들의 용도
JP2007508262A (ja) *	2003-10-13	2007-04-05	アクテリオン　ファマシューティカルズ　リミテッド	新規ジアザビシクロノネン誘導体およびその使用
EA200801607A1 (ru)	2004-06-15	2008-10-30	Пфайзер Инк.	Производные бензимидазолонкарбоновой кислоты
US7737163B2 (en)	2004-06-15	2010-06-15	Pfizer Inc.	Benzimidazolone carboxylic acid derivatives
AU2006217534B8 (en)	2005-02-22	2011-12-08	Pfizer Inc.	Oxyindole derivatives as 5HT4 receptor agonists
US8129538B1 (en)	2007-03-28	2012-03-06	Takeda Pharmaceutical Company Limited	Renin inhibitors
GB201511382D0 (en)	2015-06-29	2015-08-12	Imp Innovations Ltd	Novel compounds and their use in therapy
CN119997982A (zh)	2022-09-09	2025-05-13	迈里克斯制药有限公司	包含nmt抑制剂的抗体药物偶联物及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3687080T2 (de) *	1985-04-27	1993-03-25	Beecham Group Plc	Azabicyclononyl-indazol-carboxamid mit 5-ht-antagonistischer wirkung.
HU202108B (en) *	1986-07-30	1991-02-28	Sandoz Ag	Process for producing pharmaceutical compositions containing serotonine antqgonistic derivatives of indol-carboxylic acid or imidazolyl-methyl-carbazol
US4920219A (en) *	1988-11-29	1990-04-24	Rorer Pharmaceutical Corp.	Substituted saturated and unsaturated indole quinoline and benzazepine carboxamides and their use as pharmacological agents
US4920227A (en) *	1988-11-29	1990-04-24	Rorer Pharmaceutical Corp.	Benzobicyclic carboxamide 5-HT3 antagonists

1990
- 1990-09-26 GB GB909020927A patent/GB9020927D0/en active Pending
1991
- 1991-09-23 DE DE69133295T patent/DE69133295T2/de not_active Expired - Lifetime
- 1991-09-23 ES ES91916973T patent/ES2203609T3/es not_active Expired - Lifetime
- 1991-09-23 AT AT91916973T patent/ATE245157T1/de not_active IP Right Cessation
- 1991-09-23 EP EP91916973A patent/EP0550550B1/en not_active Expired - Lifetime
- 1991-09-23 DK DK91916973T patent/DK0550550T3/da active
- 1991-09-23 JP JP3515796A patent/JP2831464B2/ja not_active Expired - Lifetime
- 1991-09-23 AU AU86244/91A patent/AU652187B2/en not_active Expired
- 1991-09-23 CA CA002092431A patent/CA2092431C/en not_active Expired - Lifetime
- 1991-09-23 WO PCT/GB1991/001629 patent/WO1992005174A1/en not_active Ceased
- 1991-09-24 NZ NZ239915A patent/NZ239915A/xx not_active IP Right Cessation
- 1991-09-24 PT PT99028A patent/PT99028B/pt not_active IP Right Cessation
- 1991-09-24 ZA ZA917606A patent/ZA917606B/xx unknown
- 1991-09-24 MX MX9101236A patent/MX9101236A/es unknown
- 1991-09-24 IE IE335291A patent/IE913352A1/en not_active Application Discontinuation
- 1991-09-26 TW TW080107616A patent/TW240227B/zh active
1993
- 1993-03-26 KR KR1019930700921A patent/KR100200438B1/ko not_active Expired - Lifetime
2003
- 2003-10-17 CY CY0300069A patent/CY2387B1/xx unknown

Also Published As

Publication number	Publication date
KR930702345A (ko)	1993-09-08
JP2831464B2 (ja)	1998-12-02
MX9101236A (es)	1992-05-04
DK0550550T3 (da)	2003-09-08
CY2387B1 (en)	2004-09-10
PT99028B (pt)	1999-02-26
GB9020927D0 (en)	1990-11-07
HK1012356A1 (en)	1999-07-30
CA2092431C (en)	2002-12-10
EP0550550B1 (en)	2003-07-16
TW240227B (pt)	1995-02-11
ZA917606B (en)	1992-09-30
IE913352A1 (en)	1992-04-08
KR100200438B1 (ko)	1999-06-15
WO1992005174A1 (en)	1992-04-02
JPH06501256A (ja)	1994-02-10
EP0550550A1 (en)	1993-07-14
NZ239915A (en)	1993-11-25
DE69133295T2 (de)	2004-03-18
ES2203609T3 (es)	2004-04-16
ATE245157T1 (de)	2003-08-15
DE69133295D1 (de)	2003-08-21
AU8624491A (en)	1992-04-15
CA2092431A1 (en)	1992-03-27
AU652187B2 (en)	1994-08-18

Legal Events

Date

Code

Title

Description

1993-10-29

BB1A

Laying open of patent application

Effective date: 19930526

1999-02-26

FG3A

Patent granted, date of granting

Effective date: 19981111

2013-11-19

MM4A

Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: MAXIMUM VALIDITY LIMIT REACHED

Effective date: 20131111

Publication	Publication Date	Title
MX9101236A (es)	1992-05-04	Procedimiento para la preparacion de compuestos azabiciclicos
DK633088A (da)	1989-05-15	Kollagenaseinhibitorer
MX9200817A (es)	1992-08-01	Derivados de piranil cianoguanidina y proceso para su preparacion.
ATE126219T1 (de)	1995-08-15	Benzimidazolderivate, verfahren zu deren herstellung und anwendung.
IT1171880B (it)	1987-06-10	Derivati di 2-ammino-3-acilammino-6-benzilammino-piridina aventi azione antiepilettica e procedimento per la loro produzione
ES2074594T3 (es)	1995-09-16	Derivados de 4-(4-alcoxifenil)-2-butilamina y su procedimiento de preparacion.
SE8106125L (sv)	1982-04-18	4,5-polymetylen-4-isotiazolin-3-oner, sett for framstellning derav och anvendning derav som baktericida och fungicida medel
BR9503536A (pt)	1996-06-04	Composto processo para sua preparação seu uso e composição farmacêutica
SE8604950L (sv)	1987-05-20	Demensforbettrande och terapeutiska medel
PT83725B (pt)	1989-05-12	Processo para preparacao de novos derivados da 3-oxadiol-beta-carbolina e 3-carboxilato-beta-carbolina e de composicoes farmaceuticas que os contem
DE69828284D1 (de)	2005-01-27	Naphthyridinderivate oder salze davon
MX9300875A (es)	1993-08-31	Procedimiento para la preparacion de compuestos azabiciclicos.
DE69214827D1 (de)	1996-11-28	Tetrazolamide als acat inhibitoren
FI812804L (fi)	1982-03-11	2-(1,4-bensodioxan-2-ylalkyl)-imidazoler anvaendbara som antidepressiva laekemedel
SE8008555L (sv)	1981-06-08	Tioetylamidderivat
ATE57702T1 (de)	1990-11-15	Neue tetraoxoverbindungen.
SE8207294L (sv)	1982-12-21	1,4-tiazankarboxylsyraderivat, deras framstellning och anvendning och kompositioner vari dessa derivat ingar
EA199800931A1 (ru)	1999-04-29	Способ получения ингибиторов фосфодиэстеразы iv
DE3469527D1 (en)	1988-04-07	Nortropine derivative, process for its preparation and its use
ATE188470T1 (de)	2000-01-15	Chinolondisulfide als zwischenverbindungen
ES2092714T3 (es)	1996-12-01	Derivados de indol.
DK128892A (da)	1992-10-22	Benzyletherderivater
ES2052613T3 (es)	1994-07-16	Un procedimiento para preparar un nuevo derivado de acido 2-anilinofenilacetico.
FI863897L (fi)	1988-03-27	Kemiskt foerfarande.
PT100104A (pt)	1993-04-30	Processo para a preparacao de aminoalcanos substituidos