PT99503A - Processo para a preparacao de novos derivados da n-benzoil-prolina e de composicoes farmaceuticas que os contem - Google Patents
Processo para a preparacao de novos derivados da n-benzoil-prolina e de composicoes farmaceuticas que os contemInfo
- Publication number
- PT99503A PT99503A PT99503A PT9950391A PT99503A PT 99503 A PT99503 A PT 99503A PT 99503 A PT99503 A PT 99503A PT 9950391 A PT9950391 A PT 9950391A PT 99503 A PT99503 A PT 99503A
- Authority
- PT
- Portugal
- Prior art keywords
- benzoyl
- derivatives
- prolina
- compositions
- proline
- Prior art date
Links
- RQYKQWFHJOBBAO-JTQLQIEISA-N (2s)-1-benzoylpyrrolidine-2-carboxylic acid Chemical class OC(=O)[C@@H]1CCCN1C(=O)C1=CC=CC=C1 RQYKQWFHJOBBAO-JTQLQIEISA-N 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR909014087A FR2669029B1 (fr) | 1990-11-14 | 1990-11-14 | Nouveaux derives de la n-benzoyl proline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT99503A true PT99503A (pt) | 1992-09-30 |
| PT99503B PT99503B (pt) | 1999-04-30 |
Family
ID=9402135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT99503A PT99503B (pt) | 1990-11-14 | 1991-11-13 | Processo para a preparacao de novos derivados da n-benzoil-prolina e de composicoes farmaceuticas que os contem |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5332735A (pt) |
| EP (1) | EP0486386B1 (pt) |
| JP (1) | JPH078856B2 (pt) |
| AT (1) | ATE140450T1 (pt) |
| AU (1) | AU642053B2 (pt) |
| CA (1) | CA2055326A1 (pt) |
| DE (1) | DE69120899T2 (pt) |
| DK (1) | DK0486386T3 (pt) |
| ES (1) | ES2091310T3 (pt) |
| FR (1) | FR2669029B1 (pt) |
| GR (1) | GR3021196T3 (pt) |
| IE (1) | IE913963A1 (pt) |
| NZ (1) | NZ240575A (pt) |
| PT (1) | PT99503B (pt) |
| ZA (1) | ZA919030B (pt) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1245712B (it) * | 1991-04-09 | 1994-10-14 | Boehringer Mannheim Italia | Ammine eterocicliche utili terapia dell'asma e dell'infiammazione delle vie aeree |
| FR2680508B1 (fr) * | 1991-08-20 | 1995-03-03 | Adir | Nouveaux composes amidiques des 1-(alcoxybenzyl)piperazines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
| EP1156043B1 (en) * | 1992-07-24 | 2003-11-12 | The Regents Of The University Of California | Drugs that enhance synaptic responses mediated by ampa receptors |
| WO1997005105A1 (en) * | 1995-07-26 | 1997-02-13 | Pfizer Inc. | N-(aroyl)glycine hydroxamic acid derivatives and related compounds |
| US6376514B1 (en) | 2000-10-17 | 2002-04-23 | The Procter & Gamble Co. | Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof |
| EP1524265A1 (en) * | 2003-10-15 | 2005-04-20 | Newron Pharmaceuticals S.p.A. | Prolinamide derivatives as sodium and/or calcium channel blockers or selective MAO-B inhibitors |
| MX2007001337A (es) * | 2004-08-02 | 2008-03-13 | Genmedica Therapeutics Sl | Compuestos para inhibir amina-oxidasas que contienen cobre y usos de los mismos. |
| DK1856102T3 (da) * | 2005-02-28 | 2009-08-31 | Tseti Ioulia | Medikamenter til Alzheimers sygdom |
| US20080306054A1 (en) | 2005-04-13 | 2008-12-11 | Astex Therapeutics Limited | Pharmaceutical Compounds |
| US7754725B2 (en) | 2006-03-01 | 2010-07-13 | Astex Therapeutics Ltd. | Dihydroxyphenyl isoindolymethanones |
| GB0620259D0 (en) | 2006-10-12 | 2006-11-22 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| WO2008044045A1 (en) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Pharmaceutical combinations |
| WO2008044041A1 (en) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Pharmaceutical combinations |
| JP5721949B2 (ja) * | 2006-10-12 | 2015-05-20 | アステックス、セラピューティックス、リミテッドＡｓｔｅｘ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ | 複合薬剤 |
| WO2008044027A2 (en) * | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Pharmaceutical compounds having hsp90 inhibitory or modulating activity |
| JP5518478B2 (ja) | 2006-10-12 | 2014-06-11 | アステックス、セラピューティックス、リミテッド | 医薬化合物 |
| GB0806527D0 (en) * | 2008-04-11 | 2008-05-14 | Astex Therapeutics Ltd | Pharmaceutical compounds |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3524849A (en) * | 1967-10-27 | 1970-08-18 | Hoffmann La Roche | Process for the preparation of pyrrolo-benzodiazepine acrylamides and intermediates useful therein |
| JPS5015793B2 (pt) * | 1972-06-07 | 1975-06-07 | ||
| US3763183A (en) * | 1972-07-10 | 1973-10-02 | Sterling Drug Inc | 1,2,3,10,11,11a-hexahydro-5h-pyrrolo (2,1-c)(1,4)benzodiazepines |
| US4123544A (en) * | 1977-03-02 | 1978-10-31 | Merrell Toraude S. A. | Acetylsalicylic acid derivatives |
| JPS5419969A (en) * | 1977-07-15 | 1979-02-15 | Yoshitomi Pharmaceut Ind Ltd | Proline derivative and its preparation |
| US4427587A (en) * | 1982-11-10 | 1984-01-24 | Bristol-Myers Company | Total synthesis of antitumor antibiotics BBM-2040A and BBM-2040B |
| JPS6137764A (ja) * | 1984-07-31 | 1986-02-22 | Suntory Ltd | 抗プロリルエンドペプチダ−ゼ活性を有する新規生理活性化合物 |
| JPH0623190B2 (ja) * | 1985-04-16 | 1994-03-30 | サントリー株式会社 | インヒビタ−活性を有するｎ−アシルピロリジン誘導体及びその製法並びに用途 |
| US4880827A (en) * | 1986-03-18 | 1989-11-14 | Sumitomo Pharmaceuticals Company, Ltd. | Pyrrolidine derivatives having inhibitory action for proline specific endopepidase |
| US4833155A (en) * | 1986-11-25 | 1989-05-23 | Syntex (U.S.A.) Inc. | 3-(ω-(3,5,-di-t-butyl-4-hydroxyphenyl)-alkanoyl)pyrroles, and anti-inflammatory uses thereof |
| US4912231A (en) * | 1987-06-15 | 1990-03-27 | E. R. Squibb & Sons, Inc. | Process for preparing (trans)-4-phenyl-L-proline derivatives |
| NZ228329A (en) * | 1988-03-18 | 1991-12-23 | Mitsui Toatsu Chemicals | Catechol derivatives and pharmaceutical compositions thereof |
| US5053414A (en) * | 1988-04-08 | 1991-10-01 | Ono Pharmaceutical Co., Ltd. | Heterocyclic compounds |
| US5142065A (en) * | 1988-08-20 | 1992-08-25 | Bayer Aktiengesellschaft | 3-aryl-pyrrolidine-2,4-diones |
-
1990
- 1990-11-14 FR FR909014087A patent/FR2669029B1/fr not_active Expired - Fee Related
-
1991
- 1991-11-13 AU AU87776/91A patent/AU642053B2/en not_active Ceased
- 1991-11-13 NZ NZ240575A patent/NZ240575A/xx unknown
- 1991-11-13 CA CA002055326A patent/CA2055326A1/fr not_active Abandoned
- 1991-11-13 PT PT99503A patent/PT99503B/pt not_active IP Right Cessation
- 1991-11-14 AT AT91403044T patent/ATE140450T1/de not_active IP Right Cessation
- 1991-11-14 EP EP91403044A patent/EP0486386B1/fr not_active Expired - Lifetime
- 1991-11-14 ZA ZA919030A patent/ZA919030B/xx unknown
- 1991-11-14 DE DE69120899T patent/DE69120899T2/de not_active Expired - Fee Related
- 1991-11-14 ES ES91403044T patent/ES2091310T3/es not_active Expired - Lifetime
- 1991-11-14 DK DK91403044.0T patent/DK0486386T3/da active
- 1991-11-14 IE IE396391A patent/IE913963A1/en unknown
- 1991-11-14 US US07/792,238 patent/US5332735A/en not_active Expired - Fee Related
- 1991-11-14 JP JP3299228A patent/JPH078856B2/ja not_active Expired - Lifetime
-
1996
- 1996-09-30 GR GR960402551T patent/GR3021196T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2091310T3 (es) | 1996-11-01 |
| FR2669029A1 (fr) | 1992-05-15 |
| NZ240575A (en) | 1993-07-27 |
| US5332735A (en) | 1994-07-26 |
| AU8777691A (en) | 1992-05-21 |
| DK0486386T3 (da) | 1996-11-25 |
| FR2669029B1 (fr) | 1994-09-02 |
| ZA919030B (en) | 1992-08-26 |
| DE69120899D1 (de) | 1996-08-22 |
| PT99503B (pt) | 1999-04-30 |
| CA2055326A1 (fr) | 1992-05-15 |
| AU642053B2 (en) | 1993-10-07 |
| JPH078856B2 (ja) | 1995-02-01 |
| ATE140450T1 (de) | 1996-08-15 |
| IE913963A1 (en) | 1992-05-20 |
| EP0486386A2 (fr) | 1992-05-20 |
| DE69120899T2 (de) | 1997-02-27 |
| EP0486386B1 (fr) | 1996-07-17 |
| GR3021196T3 (en) | 1996-12-31 |
| EP0486386A3 (en) | 1992-10-14 |
| JPH04283561A (ja) | 1992-10-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB1A | Laying open of patent application |
Effective date: 19920525 |
|
| FG3A | Patent granted, date of granting |
Effective date: 19990126 |
|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20000731 |