RO127465A8 - Complecşi metalici ai clorhexidinei şi procedeu de obţinere a acestora - Google Patents
Complecşi metalici ai clorhexidinei şi procedeu de obţinere a acestora Download PDFInfo
- Publication number
- RO127465A8 RO127465A8 ROA201001220A RO201001220A RO127465A8 RO 127465 A8 RO127465 A8 RO 127465A8 RO A201001220 A ROA201001220 A RO A201001220A RO 201001220 A RO201001220 A RO 201001220A RO 127465 A8 RO127465 A8 RO 127465A8
- Authority
- RO
- Romania
- Prior art keywords
- metal
- chlorhexidine
- preparing
- salts
- complexes
- Prior art date
Links
- 239000002184 metal Substances 0.000 title abstract 6
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical class C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 title abstract 5
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 229960003260 chlorhexidine Drugs 0.000 abstract 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 3
- -1 chlorhexidine metal compounds Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 235000019441 ethanol Nutrition 0.000 abstract 2
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 abstract 1
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 238000000354 decomposition reaction Methods 0.000 abstract 1
- 230000000249 desinfective effect Effects 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 229910021645 metal ion Inorganic materials 0.000 abstract 1
- 238000002156 mixing Methods 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 230000007928 solubilization Effects 0.000 abstract 1
- 238000005063 solubilization Methods 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Prezenta invenţie se referă la compuşi complecşi metalici ai clorhexidinei, cu acţiune dezinfectantă, şi la un procedeu de obţinere a acestora. Compuşii sunt complecşii metalici ai clorhexidinei sau ai sărurilor sale cu Cu(II) sau Zn(II) şi/sau Ag(I), sub formă de pulberi microcristaline stabile, intens colorate, cu puncte de topire cuprinse între 100 şi 230°C (descompunere). Procedeul de obţinere a compuşilor complecşi metalici constă din următoarele etape: solubilizarea în alcool etilic a clorhexidinei, respectiv, a sărurilor acesteia, ajustarea pH-ului la 6,5 şi aducerea în soluţie a sărurilor metalice, în raport molar de amestec metal:clorhexidină de 2:1 şi 1:1, iar în cazul complecşilor cu ioni metalici, în rapoarte molare metal 1:metal 2:clorhexidină de 1:1:1, amestecarea soluţiilor de reactanţi cu agitare la 40...50°C, concentrarea soluţiei, filtrarea şi spălarea precipitatului cu alcool etilic, şi uscarea compusului.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ROA201001220A RO127465B1 (ro) | 2010-11-29 | 2010-11-29 | Complecşi metalici ai clorhexidinei şi procedeu de obţinere a acestora |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ROA201001220A RO127465B1 (ro) | 2010-11-29 | 2010-11-29 | Complecşi metalici ai clorhexidinei şi procedeu de obţinere a acestora |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RO127465A2 RO127465A2 (ro) | 2012-06-29 |
| RO127465A8 true RO127465A8 (ro) | 2012-07-30 |
| RO127465B1 RO127465B1 (ro) | 2013-11-29 |
Family
ID=46319338
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ROA201001220A RO127465B1 (ro) | 2010-11-29 | 2010-11-29 | Complecşi metalici ai clorhexidinei şi procedeu de obţinere a acestora |
Country Status (1)
| Country | Link |
|---|---|
| RO (1) | RO127465B1 (ro) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3727601B1 (en) * | 2017-12-19 | 2024-05-08 | Colgate-Palmolive Company | Oral care compositions |
| BR112020012007B1 (pt) * | 2017-12-19 | 2023-12-26 | Colgate-Palmolive Company | Complexo compreendendo um agente antibacteriano e composição para higiene pessoal |
-
2010
- 2010-11-29 RO ROA201001220A patent/RO127465B1/ro unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RO127465A2 (ro) | 2012-06-29 |
| RO127465B1 (ro) | 2013-11-29 |
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