RS56599B1 - Konjugati humanog antitela sa lekom protiv tkivnog faktora - Google Patents

Konjugati humanog antitela sa lekom protiv tkivnog faktora

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Publication number
RS56599B1
RS56599B1 RS20171169A RSP20171169A RS56599B1 RS 56599 B1 RS56599 B1 RS 56599B1 RS 20171169 A RS20171169 A RS 20171169A RS P20171169 A RSP20171169 A RS P20171169A RS 56599 B1 RS56599 B1 RS 56599B1
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lever
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sitting
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RS20171169A
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English (en)
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David Satijn
Sandra Verploegen
Wim Bleeker
Steen Lisby
Jan Van De Winkel
Patrick Van Berkel
Paul Parren
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Genmab As
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Publication of RS56599B1 publication Critical patent/RS56599B1/sr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6817—Toxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Mycology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Invalid Beds And Related Equipment (AREA)

Description

UNIVERZALNA FOTELJA
Pronalazak pripada oblasti proizvodnje sobnog i kancelarijskog nameštaja, a odnosi se na UNIVERZALNU FOTELJU koja zauzima dva položaja : položaj za sedenje i položaj za spavanje.
Po međunarodnoj klasifikaciji patenata (MKP) oznaka je A 47C 17/00 SOFE I LEŽAJI.
TEHNIČKI PROBLEM
Pronalazak rešava problem dužinskih parametara fotelje kada je u položaju za sedenje i u drugom slučaju, kada je fotelja u položaju za spavanje, pri čemu je dušek iz jednog dela.
U prvom slučaju, kada je fotelja u položaju za sedenje, anatomski je pilagođena položaju tela i ima dovoljnu dužinu za sedenje kao i odgovarajuću visinu naslona za leđa.
U drugom slučaju, kada je fotelja u položaju za spavanje, ima dovoljnu dužinu prema potrebnim zahtevima slika 1.1 i slika 1.2.
Problem odnosa dužina fotelje, kada je u položaju za sedenje i u drugom slučaju kada je u položaju za spavanje, rešen je ubacivanjem pokretnog mosta, koji se postavlja čvrsto uz dušek na tačno određenom položaju.
U položaju fotelje za sedenje, pokretni most zauzima položaj na naslonu leđa. U položaju fotelje za spavanje, pokretni most premošćava dva dela fotelje, nepokretni i pokretni, tako da se dobije dovoljna dužina u razvučenom položaju za spavanje.
Ubacivanjem pokretnog mosta, fotelja ima sve parametre anatomske fotelje, a u položaju za spavanje sve parametre anatomskog ležaja.
Postavljanje fotelje u položaj za sedenje ili u položaj za spavanje rešeno je na dva načina : ručno ili pomoću elektromotornog pogona.
STANJE TEHNIKE
Na tržištu se uočavaju rešenja koja ne ispunjavaju željene rezultate iz napred navedenog.
SUŠTINA PRONALASKA
Suština pronalaska sastoji se u tome da se definišu sve dobre karakteristike fotelje, a to su : da ima dovoljnu dužinu za ležanje, latofleks letvice raspoređene adekvatno po celoj dužini rama, da ima dovoljnu debljinu dušeka, uzglavlje za glavu i jastuk, da nema suvišnih delova koji se odlažu kada je fotelja u položaju za spavanje.
Fotelja treba biti definisana na sledeći način : da ima odgovarajuću dužinu dela za sedenje, da nije suviše dugačka, da ima naslone za ruke, anatomski oblikovano sedište i da je dizajnirana tako da zadovoljava nameni.
Ovako definisana fotelja i ležaj integrisani su u jednu celinu u ovom slučaju UNIVERZALNA FOTELJA i nastao jedinstven nov proizvod koji je svrsishodan i neprevaziđen.
KRATAK OPIS SLIKA
Slika 1.1 Bočni izgled fotelje u položaju za sedenje
Slika 1.2 Izgled odozgo u položaju za spavanje
Slika 1.3 Elektromotorni pogon za postavljanje fotelje u položaj za sedenje ili ležanje Slika 1.4 Spojnica za ručni ili elektromotorni pogon
DETALJNI OPIS PRONALASKA
Slike 1.1 i 1.2 pokazuju UNIVERZALNU FOTELJU koja se sastoji od nepokretnog rama 1, koji je preko poluga 11 i 12 vezan za ram 2, tako da poluge omogućavaju da se ramovi razvlače ili skupljaju u položaju fotelje za sedenje ili spavanje. Za ramove 1 i 2 vezan je dušek 6 u tačkama 3 i 8, tako da se u tački 3 može zakretati za ugao od 90°. Za dušek je čvrsto spojen most 5, a sve se uravnotežava oprugama 10 i oslanja na podlogu preko nogu 9 i uzglavlja 4. Na polugu fotelje 1 (slika 1.1) postavljen je elektromotorni pogon (slika 1.3) za postavljanje fotelje u položaj za sedenje ili u položaj za spavanje, a sastoji se od pužnog reduktora 13 na koji je postavljen elektromotor 14 spojen za osovinu 16 čivijom 17 i nosačem 15, a sve je učvršćeno na nosaču 18 i vezano za ram 1 vijcima 19, pri čemu izbor elektromotora može biti različit, s tim što mora biti dvosmerni, a ograničavanje krajnjih položaja rama 2 vrši se pomoću dva mikroprekidača 20 koji su postavljeni na odgovarajućem položaju. Prebacivanje elektromotronog pogona na ručni ili obratno, ostvareno je spojnicom (slika 1.4) koja se sastoji od podloške 22 učvršćene za polugu 11 kroz koju prolaze čivije 24 čvrsto postavljene na podlošku 23, koja se klizno kreće po poluzi 11 i ostvaruju vezu ša vratilom pužnog prenosnika 13, pritiskom opruge 26 oslonjene na podlošku 25, čvrsto vezane za polugu 11, a sa suprotne strane pužnog prenosnika postavljena je podloška 21 čvrsto vezana za polugu 11.

Claims (1)

  1. Anatomska fotelja naznačena time da ima nepokretni ram 1 koji je preko poluga 11 i 12 vezan za ram 2 tako da poluge omogućavaju da se ramovi razvlače ili skupljaju u položaju fotelje za sedenje ili spavanje. Za ramove 1 i 2 vezan je dušek 6 u tačkama 3 i 8, tako da se u tački 3 može zakretati za ugao od 90°. Za dušek je čvrsto spojen most 5, a sve se uravnotežava oprugama i oslanja na podlogu preko nogu 9 i uzglavlja 10. Na polugu fotelje (slika 1.1). postavljen je elektromotorni pogon (slika 1.3) za postavljanje fotelje u položaj za sedenje ili u položaj za spavanje. Sastoji se od pužnog reduktora 13 na koji je postavljen elektromotor 14 spojen za osovinu 16 čivijom 17 i nosačem 15, a sve je učvršćeno na nosaču 18 i vezano za ram 1 vijcima 19, pri čemu izbor elektromotora može biti različit s tim što mora biti dvosmerni, a ograničavanje krajnjih položaja rama 2 vrši se pomoću dva mikroprekidača 20 koji su postavljeni na odgovarajućem položaju. Prebacivanje elektromotronog pogona na ručni ili obratno ostvareno je spojnicom (slika 1.4) koja se sastoji od podloške 22 učvršćene za polugu 11 kroz koju prolaze čivije 24 čvrsto vezane na podlošku 23 koja se klizno kreće po poluzi 11 i ostvaruje vezu sa vratilom pužnog prenosnika 13, pritiskom opruge 26 oslonjene na podlošku 25, čvrsto vezane za polugu 11, a sa suprotne strane pužnog prenosnika postavljena je podloška 21 čvrsto vezana za polugu 11.
RS20171169A 2010-06-15 2011-06-15 Konjugati humanog antitela sa lekom protiv tkivnog faktora RS56599B1 (sr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US35497010P 2010-06-15 2010-06-15
DKPA201000529 2010-06-15
US201161434776P 2011-01-20 2011-01-20
DKPA201100039 2011-01-20
EP11725095.1A EP2582728B1 (en) 2010-06-15 2011-06-15 Human antibody drug conjugates against tissue factor
PCT/EP2011/059917 WO2011157741A2 (en) 2010-06-15 2011-06-15 Human antibody drug conjugates against tissue factor

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RS56599B1 true RS56599B1 (sr) 2018-02-28

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