RS57200B1 - Sintetičke imitacije apelina u terapiji srčane insuficijencije - Google Patents
Sintetičke imitacije apelina u terapiji srčane insuficijencijeInfo
- Publication number
- RS57200B1 RS57200B1 RS20180546A RSP20180546A RS57200B1 RS 57200 B1 RS57200 B1 RS 57200B1 RS 20180546 A RS20180546 A RS 20180546A RS P20180546 A RSP20180546 A RS P20180546A RS 57200 B1 RS57200 B1 RS 57200B1
- Authority
- RS
- Serbia
- Prior art keywords
- press
- gear
- circular guide
- large gear
- move
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/08—Bellows; Connecting tubes ; Water traps; Patient circuits
- A61M16/0816—Joints or connectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/0057—Pumps therefor
- A61M16/0066—Blowers or centrifugal pumps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/20—Valves specially adapted to medical respiratory devices
- A61M16/201—Controlled valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/0027—Accessories therefor, e.g. sensors, vibrators, negative pressure pressure meter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/003—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/35—Communication
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
- A61M2205/502—User interfaces, e.g. screens or keyboards
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Diabetes (AREA)
- Anesthesiology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Toxicology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
Description
NAPRAVA ZA IZNENADNO KOČENJE PRESE
Oblasttehnike pronalaska
Ovaj pronalazak se odnosi na motornu presu, posebno na napravu za iznenadno koče-nje motorne prese, sa ciljem sprečavanja nesreća tokom rada prese, omogućavanjem trenurnog zaustavljanja rada iste.
Stanje tehnike
Opšte uzev, presa je tipično opasna mašina, koja prouzrokuje industrijske nesreće u oblasti proizvodnje. Mada se u sadašnje vreme broj industrijskih nesreća smanjuje, broj nesreća od presa se ne smanjuje i stoga je potrebna protivmera radi rešavanja ovog problema.
Osim toga, pošto su uobičajene prese u najvećem broju slučajeva tipa sa kandžastim kvačilima, čak i u uslovima kada prst radnika na presi dospe u kalup iste usled nepa-žnje radnika, rad uobičajene prese ne može se brzo zaustaviti. Presa, koja sadrži pneu-matsko kvačilo, koje omogućava da se presa zaustavi trenutno uz korišćenje senzora, kao na pr., prekidač sa infracrvenim zrakom, široko je poznata da se koristi sa ciljem sprečavanja nesreća u slučaju opasnih situacija. Medjutim, cena ovakve prese je visoka, pa je malim kompanijama teško da ih kupe.
Potred toga, osnovna struktura pneumatskog kvačila je vrlo složena, pošto ima mnogo delova, koji mora da se prepravljaju kada se presa oprema pneumatskim kvačilom. Dalje, pošto je cena pneumatskog kvačila visoka, ako bi se uobičajeni model prepravljao u tip sa pneumatskim kvačilom, to mogu da obavljaju samo specijalisti. Stoga, usled fi-nansijskih gubitaka zbog vremena čekanja tokom prepravke i visoke cene iste, uobi-čajene prese se i dalje koriste, a opasnost pojava nesreća se toleriše.
Kratak opis pronalaska
Ovaj pronalazak se objavljuje sa ciljem rešavanja problema spomenutog gore, pa je predmet ovog pronalaska da se ostvari naparava za iznenadno kočenje, ugradjena na laktasto vratilo prese, čijim dejstvom se rad pritiskača (bata prese) može trenutno zakočiti, čime bi se sprečila nesreća radnika, smanjili proizvodni troškovi i postiglo lako prepravljanje, kao i brz ponovni rad, jer se tom napravom upravlja direktno a ne preko složenog prenosa.
Da bi se postigao postavljeni cilj, ovaj pronalazak obuhvata jedan kružni sklop oko kolenastog vratil, sa kočionim oblogama na bočnom ramu prese, jedan običan zupčanik na drugom kraju i jedan konusni žljeb, izradjen po obimu središnog dela vodećeg tela, pri čemu ploča kvačila sadrži takodje jedan obični zupčanik, koji odgovara onom, pričvr-šćenom za veliki pogonski zupčanik ; i jednu viljušku sa parom valjaka, ugradjenih na oba kraja viljuške sa ciljem slobodnog obrtanja i pričvršene za noseći ram, radi omo-gućavanja da viljuška pomeri kružnu vodjicu pomoću hidrauličkog cilindra preko jedne radne poluge. Na taj način kružna vodjica se može pomerati, što omogućava da se kretanje pritiskača (bata prese) gore-dole naglo zaustavi.
Kratak opis crteža
51.1 je šematski izgled poprečnog preseka, koji prikazuje napravu za iznenadno kočenje prese prema ovom pronalasku ;
51.2 je izgled glavnog dela u perspektivi, sa ciljem objašnjavanja principa kočenja prema ovom pronalasku.
Detaljan opis pronalaska
U daljem tekstu će ovaj pronalazak biti opisan sa pozivom na priložene crteže.
Kako je prikazano na sl.1, ovaj pronalazak obuhvata jedan noseći ram 2, vertikalno pričvršćen za osnovu 1, obrtnu osovinu 3 koja je u horizontalnom položaju unutar
nosećeg rama 2, zamajac 5 sa remenicom 7, pričvršćenim za jedan kraj obrtne osovine 3 i spojenim za obrtnu osovinu (nije prikazana) pogonskog motora 6 preko remenice 4 i remena 8. Mali zupčanik 9 je ugradjen na drugi kraj obrtne osovine 3 i nalazi se u zahvatu sa velikim zupčanikom 10, koji će biti opisan niže, tako da se obrtni momenat prenosi sa zamajca 5 na veliki zupčanik 10.
Dalje, kolenasto vratilo, koje se nalazi ispod obrtne osovine, podeljeno je na dva dela, 11a,11b, koji su mnogouglog i kružnog preseka, respektivno. Kolenasto vratilo 11a,11b ugradjeno je paralelno sa obrtnom osom 3 pomoću ležišta (nisu prikazana).
Pored toga, kolenasto vratilo 11a,11b spojeno je bregom 14, ugradjenim za klipnjaču 13, čime je omogućeno da se pritiskač {bat prese) podiže. Kružna vodjica 19 postavljena je na mnogougli deo kolenastog vratila 11a, kako je prikazano na si.2, pri. Zljeb konusnog preseka 15 izradjen je po obimu, po sredini kružne vodjice 19, kočiona obloga 16 je pričvršćena za jednu stranu kružne vopdjice 19, a sa druge strane u odnosu na ovo pričvršćen je radijalno (čeono) nazubljeni zupčanik 18, pomoču, na pr., svornjaka 17.
Dalje, veliki zupčanik 10 sa pločom kvačila 22, za koju je pričvršćen radijalno nazubljeni zupčanik 21 pomoću, na pr., svornjaka 20, oblika koji odgoavara zupčaniku 18, po-stavljenom na kružnu vodjicu 19 , može se slobodno obrtati na slobodnom kraju kolenastog vratila 11b pri čemu je veliki zupčanik u zahvatu sa malim zupčanikom 9.
Pored toga, viljuška 24 smeštena je preko kružne vodjice 19, pri čemu se viljuška 24 kreće unazad (u levo) i unapred (u desno), prema hodu hidrauličkog cilindra, ugradjenog na gornji deo nosećeg rama 2. Viljuška 24 ugradjena je izjedna sa klipnjačom 26, čije telo 25 ima oblik potkovice, i postavljena je vertikalno u odnosu na klipnjaču 29 cilindra. Za oba kraja tela 25, pričvršen je par vaoljaka 28, pomoću osovine 27, i ti valjci 28 predstavljaju deo kružnog konusnog oblika, istog nagiba kao i kosi deo žljeba 15.
Na si. 1, deo sa valjcima (A,A') dat je u položaju zakrenutom za 90°, sa ciljem prikazi-vanja svih delova.
Dalje, na ulaznom delu kalupa naprave za iznenadno kočenje prese prema ovom pronalasku, ugradjen je senzor, kao na pr. foto-senzor (nije prikazan) koji je električno spo-jen sa cilindrom 23. Shodno tome, tokom podizanja bata prese 12, u slučaju opasnih situacija, kao kada se šaka zadrži unutar kalupa usled nepažnje radnika itd., senzor zapaža ovu situaciju i učini da se klipnjača 29 pomeri unazad, unošenjem upravljačke sile u cilindar 23. Kao radni fluid može se koristiti bilo hidraulički, bilo pneumatski.
Rad i dejstvo prema ovom pronalasku su sledeći.
Naprava za iznenadno kočenje prese prema ovom pronalasku naznačena je time, što senzor otkriva opasnu situaciju i daje komandu za pogon cilindra 23, a zatim viljuška 24 omogućava kretanje kružne vodjice 19, čime se sprečava obrtanje velikog zupčanika 10 i, prema tome, prouzrokuje trenutno zaustavljanje kretanje bata 11, ugradjenog na kolenasto vratilo 11a,11b.
To znači, ako se presa uključi, pogonski motor 6 radi i prenosi svoj obrtni momenat na zamajac 5 preko remena 6, što omogućava da mali zupčanik 9, ugradjen na obrtnu osovinu 3 i veliki zupčanik 10, rade istovremeno.
Dalje, pod tim uslovima, ako se izazove kretanje cilindra napred (u desno), prebacivan-jem jednog prekidača, kao što je nožni, ugradjenog na presi 29, viljuška 24 biva potis-nuta klipnjačom 26, i kružna vodjica 19 pokreće u smeru naznačenom crtkano na si.2, što znači u smeru velikog zupčanika 10.
Prema tome, obrtna sila velikog zupčanika 10 prenosi se na kolenasto vratilo 11b, usled činjenice da su radijalni zupčanici 18,21 u zahvatu medjusobno i tako se bat prese 12 pokreće na dole pomoću kolena 14, što omogućava da presa obradi radni predmet.
Dalje, tokom rada prese, ako se pojavi opasna situacija, kao što je zadržavanje šake radnika unutar kalupa, onda usled toga što senzor otkriva tu situaciju, potrebna uprav-ljačka snaga se unosi u cilindar 23, koji pokreće klipnjaču 29 unazad. Posle toga, vi-ljuška 24 se pomera ka nosećem ramu 2, prikazano na si.2 punom linijom strelice, i to pomoću klipnjače 26, što uzrokuje odvajanje radijalnih zuba 18,21, i, kao rezultat tog odvajanja, inercija zamajca 5 ne može da se prenese na kolenasto vratilo. Pored toga, obloga 16 ugradjena na kružnu vodjicu 19, pritiska se uz bočni zid nosečeg rama 2, ta-ko da upravlja obrtanjem kolenastog vratila 11b. U rezultatu, obrtanje kružne vodjice 19 i kolenastog vratila se može iznenada zaustaviti. Prema tome, moguće je iznenada zaustaviti kretanje bata prese 12.
U medjuvremenu, valjci 28 u viljušci 24, koja se kreće napred - nazad pomoću klipnjače 26, sadrži i deo kružnog konusnog oblika, istog nagiba kao i odgovarajući deo konusnog žljeba 15 na kružnoj vodjici 19, tako da je moguće da se na minimum smanji tro-šenje usled trenja žljeba 15 u slučaju kretanja napred - nazad. Stoga, viljuška se može kretati glatko, bez trenja sa kružnom vodjicom 19.
Ovaj pronalazak se može ostvariti na različite načine, polazeći od ideje i obima pronalaska. Pored toga, ovaj pronalazak nije ograničen na prikazana i objašnjena izvodjenja. Sve varijacije u okviru gornjeg opisa i sledećih zahteva nalaze se i unutar obima ovog pronalaska.
Claims (2)
1. Naprava za iznenadno kočenje prese, koja se sastoji od zamajca (5), malog zupčanika (9), vezanim preko remenice i remena sa pogonskim motorom, ugradjenim na obrtnu osovinu (3), ugradjenu horizontalno u odnosu na noseći ram, jednog pritis-kača (bata prese) (12) i jednog velikog zupčanika,'ugradjenog na kolenastu osovinu, koja je postavljena ispod obrtne osovine (3) i, pored toga, malog zupčanika (9) i velikog zupčanika, u medjusobnom zahvatu, tako da se veliki zupčanik (10) obrće i prenosi svoju obimnu silu na zamajac (5), čime se izaziva kretanje bata prese gore-dole, naznačena time, što
naprava sadrži kružnu vodjicu (19), postavljenu na kolenasto vratilo (11b) sa kočionom oblogom (16), radijalno nazubljeni zupčanik (18) i konusni žljeb (15) duž obima sre-dišnog dela tela ;
ploča kvačila (22), sa radijalno nazubjenim zupčanikom, koji odgovara istom takvom (18), pričvršćenom za veliki zupčanik (10) ; i
napravu za pomeranje, koja omogućava da kružna vodjica (19) može da se kreće horizontalno, ugradjenu na noseći ram (2).
2. Naprava za iznenadno kočenje prema Zahtevu 1,naznačena time, što naprava za pomeranje poseduje jednu viljušku (24), ugradjenu na kružnu vodjicu (19) preko klipnjače (26) i cilinder (23), koji omogućava rad klipnjače (26) u cilju pomeranja.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261591557P | 2012-01-27 | 2012-01-27 | |
| US201261717760P | 2012-10-24 | 2012-10-24 | |
| US201261731697P | 2012-11-30 | 2012-11-30 | |
| EP13711953.3A EP2807183B1 (en) | 2012-01-27 | 2013-01-25 | Synthetic apelin mimetics for the treatment of heart failure |
| PCT/IB2013/050666 WO2013111110A2 (en) | 2012-01-27 | 2013-01-25 | Synthetic apelin mimetics for the treatment of heart failure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS57200B1 true RS57200B1 (sr) | 2018-07-31 |
Family
ID=47997598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20180546A RS57200B1 (sr) | 2012-01-27 | 2013-01-25 | Sintetičke imitacije apelina u terapiji srčane insuficijencije |
Country Status (42)
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8673848B2 (en) | 2012-01-27 | 2014-03-18 | Novartis Ag | Synthetic apelin mimetics for the treatment of heart failure |
| UY35144A (es) * | 2012-11-20 | 2014-06-30 | Novartis Ag | Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca |
| US8921307B2 (en) * | 2012-11-20 | 2014-12-30 | Novartis Ag | Synthetic linear apelin mimetics for the treatment of heart failure |
| EP2925368B1 (en) | 2012-11-30 | 2019-03-27 | Novartis AG | Methods for making conjugates from disulfide-containing proteins |
| JP6426107B2 (ja) * | 2012-12-20 | 2018-11-21 | アムジエン・インコーポレーテツド | Ａｐｊ受容体アゴニストおよびその使用 |
| WO2014152955A1 (en) | 2013-03-14 | 2014-09-25 | Regeneron Pharmaceuticals, Inc. | Apelin fusion proteins and uses thereof |
| CN105612173A (zh) * | 2013-07-25 | 2016-05-25 | 诺华股份有限公司 | 用于治疗心力衰竭的环状apelin衍生物 |
| US9266925B2 (en) * | 2013-07-25 | 2016-02-23 | Novartis Ag | Cyclic polypeptides for the treatment of heart failure |
| BR112016001376A2 (pt) | 2013-07-25 | 2017-10-24 | Novartis Ag | bioconjugados de polipeptídeos de apelin sintéticos |
| WO2015013167A1 (en) * | 2013-07-25 | 2015-01-29 | Novartis Ag | Disulfide cyclic polypeptides for the treatment of heart failure |
| UA119247C2 (uk) | 2013-09-06 | 2019-05-27 | РОЙВЕНТ САЙЕНСИЗ ҐмбГ | Спіроциклічні сполуки як інгібітори триптофангідроксилази |
| WO2015077491A1 (en) * | 2013-11-20 | 2015-05-28 | Regeneron Pharmaceuticals, Inc. | Aplnr modulators and uses thereof |
| JP6609563B2 (ja) * | 2013-11-26 | 2019-11-20 | ノバルティス アーゲー | ケトンで修飾されたポリペプチドをオキシム複合化する方法 |
| WO2015089137A1 (en) | 2013-12-11 | 2015-06-18 | Karos Pharmaceuticals, Inc. | Acylguanidines as tryptophan hydroxylase inhibitors |
| WO2015147641A1 (en) * | 2014-03-25 | 2015-10-01 | Lanthiopep B.V. | Cyclic apelin analogs |
| GB201407532D0 (en) * | 2014-04-29 | 2014-06-11 | Univ Ulster | Apelin analogues |
| EP3145552B1 (en) | 2014-05-23 | 2020-03-04 | Novartis AG | Methods for making conjugates from disulfide-containing proteins |
| SG11201609706VA (en) | 2014-06-23 | 2017-01-27 | Novartis Ag | Site specific protein modifications |
| US10588980B2 (en) | 2014-06-23 | 2020-03-17 | Novartis Ag | Fatty acids and their use in conjugation to biomolecules |
| WO2016109501A1 (en) | 2014-12-30 | 2016-07-07 | Karos Pharmaceuticals, Inc. | Amide compounds as tryptophan hydroxylase inhibitors |
| CA2972871A1 (en) * | 2015-01-23 | 2016-07-28 | Novartis Ag | Synthetic apelin fatty acid conjugates with improved half-life |
| US9611201B2 (en) | 2015-03-05 | 2017-04-04 | Karos Pharmaceuticals, Inc. | Processes for preparing (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone |
| WO2016151018A1 (en) * | 2015-03-24 | 2016-09-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method and pharmaceutical composition for use in the treatment of diabetes |
| AU2016263564B2 (en) | 2015-05-20 | 2019-12-05 | Amgen Inc. | Triazole agonists of the APJ receptor |
| US11484577B2 (en) | 2016-02-15 | 2022-11-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for the treatment of post-operative cognitive dysfunction |
| US9988369B2 (en) | 2016-05-03 | 2018-06-05 | Amgen Inc. | Heterocyclic triazole compounds as agonists of the APJ receptor |
| EP3528820B1 (en) | 2016-10-19 | 2023-10-04 | Avive, Inc. | Novel pegylated liposomal formulations of apelin for treatment of cardiovascular-related diseases |
| WO2018093577A1 (en) | 2016-11-16 | 2018-05-24 | Amgen Inc. | Cycloalkyl substituted triazole compounds as agonists of the apj receptor |
| US10689367B2 (en) | 2016-11-16 | 2020-06-23 | Amgen Inc. | Triazole pyridyl compounds as agonists of the APJ receptor |
| US11191762B2 (en) | 2016-11-16 | 2021-12-07 | Amgen Inc. | Alkyl substituted triazole compounds as agonists of the APJ Receptor |
| US11046680B1 (en) | 2016-11-16 | 2021-06-29 | Amgen Inc. | Heteroaryl-substituted triazoles as APJ receptor agonists |
| WO2018097944A1 (en) | 2016-11-16 | 2018-05-31 | Amgen Inc. | Triazole furan compounds as agonists of the apj receptor |
| US10906890B2 (en) | 2016-11-16 | 2021-02-02 | Amgen Inc. | Triazole phenyl compounds as agonists of the APJ receptor |
| JOP20190245A1 (ar) | 2017-04-20 | 2019-10-15 | Novartis Ag | أنظمة توصيل إطلاق مستدام تتضمن روابط بلا أثر لنقطة الربط |
| US10278957B2 (en) | 2017-09-11 | 2019-05-07 | Protagonist Therapeutics, Inc. | Opioid agonist peptides and uses thereof |
| MA50509A (fr) | 2017-11-03 | 2021-06-02 | Amgen Inc | Agonistes de triazole fusionnés du récepteur apj |
| MA52487A (fr) | 2018-05-01 | 2021-03-10 | Amgen Inc | Pyrimidinones substituées en tant qu'agonistes du récepteur apj |
| CA3109082A1 (en) | 2018-08-16 | 2020-02-20 | Isolere Bio, Inc. | Genetically encoded polypeptide for affinity capture and purification of biologics |
| KR20210102887A (ko) | 2018-11-14 | 2021-08-20 | 알타반트 사이언시스 게엠베하 | 말초 세로토닌과 관련된 질병 또는 장애를 치료하기 위한 트립토판 하이드록실라제 1 (tph1)의 결정질 스피로사이클릭 화합물 억제제 |
| CN112007027B (zh) * | 2020-09-14 | 2022-07-15 | 长春金赛药业有限责任公司 | 含酯基芳香丙酰胺类化合物及其代谢产物在制备治疗心衰药物中的应用 |
| CN119101143A (zh) * | 2023-05-31 | 2024-12-10 | 浙江大学 | 一种G蛋白偏向的apelin-13多肽突变体及应用 |
| WO2026007693A1 (zh) * | 2024-07-05 | 2026-01-08 | 浙江大学 | Apelin-13多肽突变体 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE164884T1 (de) | 1992-11-17 | 1998-04-15 | Icos Corp | Neue sieben-transmembran-rezeptor v28 |
| US6555339B1 (en) | 1997-04-14 | 2003-04-29 | Arena Pharmaceuticals, Inc. | Non-endogenous, constitutively activated human protein-coupled receptors |
| AU1685499A (en) | 1997-12-24 | 1999-07-19 | Takeda Chemical Industries Ltd. | Polypeptide, their production and use |
| AU5759399A (en) | 1998-09-25 | 2000-04-17 | Takeda Chemical Industries Ltd. | Peptide derivative |
| CA2346064A1 (en) | 1998-10-05 | 2000-04-13 | Takeda Chemical Industries, Ltd. | Method for removing n-terminal methionine |
| US7045532B2 (en) | 1999-04-30 | 2006-05-16 | Millennium Pharmaceuticals, Inc. | ACE-2 modulating compounds and methods of use thereof |
| AU2001242749A1 (en) | 2000-03-23 | 2001-10-03 | Takeda Chemical Industries Ltd. | Peptide derivative |
| AU2001264937A1 (en) | 2000-05-23 | 2001-12-03 | Genaissance Pharmaceuticals, Inc. | Haplotypes of the agtrl1 gene |
| DE60230927D1 (de) | 2001-07-16 | 2009-03-05 | Caprotec Bioanalytics Gmbh | Fangverbindungen, ihre entnahme und verfahren zur analysierung des proteoms und von komplexen zusammensetzungen |
| WO2003063892A1 (en) | 2002-01-29 | 2003-08-07 | Takeda Chemical Industries, Ltd. | Use of apelin |
| EP1613348B1 (en) | 2003-03-12 | 2010-06-23 | The Arizona Board of Regents on Behalf of the University of Arizona | Methods for modulating angiogenesis with apelin compositions |
| WO2005029066A2 (en) | 2003-05-22 | 2005-03-31 | Agilent Technologies, Inc. | Diagnostic markers and pharmacological targets in heart failure and related reagents and methods of use thereof |
| US7947280B2 (en) | 2003-05-22 | 2011-05-24 | The Board Of Trustees Of The Leland Stanford Junior University | Apelin and uses thereof |
| EP1520861A1 (en) | 2003-09-11 | 2005-04-06 | Aventis Pharma Deutschland GmbH | Test system for the identification of APJ receptor ligands |
| WO2005106493A1 (en) | 2004-04-30 | 2005-11-10 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with g protein-coupled apelin receptor (apj) |
| EP1768951A4 (en) | 2004-06-17 | 2011-06-15 | Musc Found For Res Dev | NON-NATURAL AMINO ACIDS |
| US20060045880A1 (en) | 2004-08-23 | 2006-03-02 | Krieg Paul A | Methods for modulating angiogenesis and apoptosis with apelin compositions |
| JP2008013436A (ja) | 2004-10-14 | 2008-01-24 | Kanazawa Univ | 血管形成促進剤 |
| US20110097710A1 (en) | 2004-10-26 | 2011-04-28 | Macrae Calum A | Methods for detecting atrial fibrillation and related conditions |
| WO2006076736A2 (en) | 2005-01-14 | 2006-07-20 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Methods for modulating angiogenesis, lymphangiogenesis, and apoptosis with apelin compositions |
| BRPI0614649A2 (pt) | 2005-08-11 | 2011-04-12 | Amylin Pharmaceuticals Inc | polipeptìdeos hìbridos com propriedades selecionáveis |
| US8673848B2 (en) * | 2012-01-27 | 2014-03-18 | Novartis Ag | Synthetic apelin mimetics for the treatment of heart failure |
| EP1876448A1 (en) | 2005-09-30 | 2008-01-09 | DIGILAB BioVisioN GmbH | Method and analytical reagents for identifying therapeutics using biomarkers responsive to thiazolidinediones. |
| US7736346B2 (en) | 2005-10-18 | 2010-06-15 | Biocardia, Inc. | Bio-interventional therapeutic treatments for cardiovascular diseases |
| US20080031871A1 (en) | 2006-02-21 | 2008-02-07 | Allen Margaret L | Memory and learning impairments associated with disruption of Ephrin receptor A6 (EphA6) gene |
| US20090324610A1 (en) | 2006-04-25 | 2009-12-31 | Kyushu Univeristy, National University Corporation | Gene associated with arteriosclerotic disease, and use thereof |
| WO2009033819A2 (en) | 2007-09-11 | 2009-03-19 | Mondobiotech Laboratories Ag | Use of a peptide as a therapeutic agent |
| AU2008297885A1 (en) | 2007-09-11 | 2009-03-19 | Mondobiotech Laboratories Ag | Use of GLP-1 as a therapeutic agent |
| WO2009075566A1 (en) | 2007-12-12 | 2009-06-18 | Erasmus University Medical Center Rotterdam | Biomarkers for cardiovascular disease |
| US20110123534A1 (en) | 2007-12-12 | 2011-05-26 | Erasmus University Medical Center Rotterdam | Novel compounds for modulating neovascularisation and methods of treatment using these compounds |
| CN102203117A (zh) | 2008-11-04 | 2011-09-28 | 安科治疗公司 | Apj受体化合物 |
| WO2010115874A1 (en) | 2009-04-07 | 2010-10-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment and the diagnosis ofpulmonary arterial hypertension |
| US20120277144A1 (en) | 2009-11-04 | 2012-11-01 | Henricus Johannes Duckers | Novel compounds for modulating neovascularisation and methods of treatment using these compounds |
| US9782454B2 (en) | 2010-04-22 | 2017-10-10 | Longevity Biotech, Inc. | Highly active polypeptides and methods of making and using the same |
| TW201138808A (en) | 2010-05-03 | 2011-11-16 | Bristol Myers Squibb Co | Serum albumin binding molecules |
| RU2457216C1 (ru) | 2010-12-21 | 2012-07-27 | Федеральное государственное учреждение "Российский кардиологический научно-производственный комплекс" Министерства здравоохранения и социального развития Российской Федерации (ФГУ "РКНПК" Минздравсоцразвития России) | Додекапептиды, обладающие кардиопротекторными свойствами |
| EP2802596A1 (en) | 2012-01-09 | 2014-11-19 | Anchor Therapeutics, Inc. | Apj receptor compounds |
| CN105612173A (zh) | 2013-07-25 | 2016-05-25 | 诺华股份有限公司 | 用于治疗心力衰竭的环状apelin衍生物 |
| WO2015013167A1 (en) | 2013-07-25 | 2015-01-29 | Novartis Ag | Disulfide cyclic polypeptides for the treatment of heart failure |
| US9266925B2 (en) | 2013-07-25 | 2016-02-23 | Novartis Ag | Cyclic polypeptides for the treatment of heart failure |
| BR112016001376A2 (pt) | 2013-07-25 | 2017-10-24 | Novartis Ag | bioconjugados de polipeptídeos de apelin sintéticos |
-
2013
- 2013-01-23 US US13/747,621 patent/US8673848B2/en not_active Expired - Fee Related
- 2013-01-24 UY UY0001034593A patent/UY34593A/es not_active Application Discontinuation
- 2013-01-24 JO JOP/2013/0027A patent/JO3380B1/ar active
- 2013-01-25 DK DK13711953.3T patent/DK2807183T3/en active
- 2013-01-25 EP EP13711953.3A patent/EP2807183B1/en active Active
- 2013-01-25 TR TR2018/07309T patent/TR201807309T4/tr unknown
- 2013-01-25 MX MX2014009085A patent/MX351569B/es active IP Right Grant
- 2013-01-25 PL PL13711953T patent/PL2807183T3/pl unknown
- 2013-01-25 AU AU2013213265A patent/AU2013213265C1/en not_active Ceased
- 2013-01-25 PE PE2014001176A patent/PE20142194A1/es active IP Right Grant
- 2013-01-25 HU HUE13711953A patent/HUE039137T2/hu unknown
- 2013-01-25 SG SG11201404369PA patent/SG11201404369PA/en unknown
- 2013-01-25 NZ NZ627772A patent/NZ627772A/en not_active IP Right Cessation
- 2013-01-25 EA EA201491433A patent/EA027853B1/ru not_active IP Right Cessation
- 2013-01-25 ES ES13711953.3T patent/ES2670832T3/es active Active
- 2013-01-25 RS RS20180546A patent/RS57200B1/sr unknown
- 2013-01-25 CA CA2862240A patent/CA2862240A1/en active Pending
- 2013-01-25 AR ARP130100228A patent/AR089808A1/es unknown
- 2013-01-25 AP AP2014007846A patent/AP2014007846A0/xx unknown
- 2013-01-25 TW TW102103025A patent/TWI576356B/zh not_active IP Right Cessation
- 2013-01-25 PT PT137119533T patent/PT2807183T/pt unknown
- 2013-01-25 WO PCT/IB2013/050666 patent/WO2013111110A2/en not_active Ceased
- 2013-01-25 SI SI201330999T patent/SI2807183T1/en unknown
- 2013-01-25 JP JP2014553847A patent/JP6313222B2/ja not_active Expired - Fee Related
- 2013-01-25 MY MYPI2014002154A patent/MY172268A/en unknown
- 2013-01-25 LT LTEP13711953.3T patent/LT2807183T/lt unknown
- 2013-01-25 CU CUP2014000097A patent/CU24266B1/xx unknown
- 2013-01-25 BR BR112014018306A patent/BR112014018306A8/pt not_active IP Right Cessation
- 2013-01-25 HR HRP20180806TT patent/HRP20180806T1/hr unknown
- 2013-01-25 CN CN201380016261.6A patent/CN104220452B/zh not_active Expired - Fee Related
- 2013-01-25 UA UAA201408328A patent/UA116196C2/uk unknown
- 2013-01-25 KR KR1020197037887A patent/KR20200003229A/ko not_active Ceased
- 2013-01-25 KR KR1020147023505A patent/KR102068370B1/ko not_active Expired - Fee Related
-
2014
- 2014-01-28 US US14/165,680 patent/US9067971B2/en active Active
- 2014-07-22 ZA ZA2014/05400A patent/ZA201405400B/en unknown
- 2014-07-23 TN TNP2014000318A patent/TN2014000318A1/fr unknown
- 2014-07-24 IL IL233792A patent/IL233792B/en active IP Right Grant
- 2014-07-25 GT GT201400166A patent/GT201400166A/es unknown
- 2014-07-25 CL CL2014001994A patent/CL2014001994A1/es unknown
- 2014-07-25 PH PH12014501701A patent/PH12014501701A1/en unknown
- 2014-07-28 CR CR20140364A patent/CR20140364A/es unknown
- 2014-07-31 CO CO14167109A patent/CO7020879A2/es unknown
- 2014-08-27 EC ECIEPI201416014A patent/ECSP14016014A/es unknown
-
2015
- 2015-05-18 US US14/714,914 patent/US9982017B2/en active Active
-
2017
- 2017-10-06 JP JP2017195815A patent/JP6595553B2/ja not_active Expired - Fee Related
-
2018
- 2018-05-24 CY CY20181100556T patent/CY1120239T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105626722A (zh) | 机器手臂的刹车装置 | |
| US6543345B1 (en) | Sudden braking apparatus for press | |
| US8657091B2 (en) | Clutch device | |
| CN103185093A (zh) | 一种液压盘式制动器用闸瓦磨损自动补偿装置 | |
| WO2014111065A2 (en) | An apparatus for opening and closing a lid pivotally connected to a frame, especially a car boot lid | |
| JP5862583B2 (ja) | 増力機構、それを備えた加圧装置および圧入装置 | |
| US5048410A (en) | Apparatus for securely clamping a transmission shaft of a transfer feed press during its shutdown | |
| US1013339A (en) | Inclinable punching-press. | |
| JP2775326B2 (ja) | 油圧作動型クラッチレリーズ軸受装置 | |
| CN203214726U (zh) | 一种液压盘式制动器用闸瓦磨损自动补偿装置 | |
| US9080549B2 (en) | Hydrostatic axial piston machine | |
| US20070277683A1 (en) | Electrically driven mechanical servo press machine | |
| JP4031580B2 (ja) | スクリュー式プレス機械 | |
| CN104080625B (zh) | 复位设备 | |
| CN114033812A (zh) | 一种用于控制凸轮车床离合的装置 | |
| US8146452B2 (en) | Apparatus for driving a roller of a printing press and printing press having the apparatus | |
| US10501057B2 (en) | Parking lock pre-selection system | |
| US2428337A (en) | Sleeve clutch and brake | |
| RU2283233C1 (ru) | Привод ползуна механического пресса | |
| US2499954A (en) | Clutch and brake mechanism | |
| JP4939111B2 (ja) | 機械式プレス機からの改造サーボプレス | |
| MXPA00009720A (en) | Sudden braking apparatus for press | |
| CZ20003598A3 (cs) | Zařízení pro náhlé zastavení lisu | |
| US212584A (en) | Improvement in self-acting brakes or friction-couplings | |
| RU2310540C2 (ru) | Горизонтально-ковочная машина |