RS64681B1 - Heterociklični imunomodulatori kao inhibitor kontrolne tačke pdl1 - Google Patents
Heterociklični imunomodulatori kao inhibitor kontrolne tačke pdl1Info
- Publication number
- RS64681B1 RS64681B1 RS20230805A RSP20230805A RS64681B1 RS 64681 B1 RS64681 B1 RS 64681B1 RS 20230805 A RS20230805 A RS 20230805A RS P20230805 A RSP20230805 A RS P20230805A RS 64681 B1 RS64681 B1 RS 64681B1
- Authority
- RS
- Serbia
- Prior art keywords
- 6alkyl
- compound
- inhibitors
- hbv
- cancer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19179072 | 2019-06-07 | ||
| EP20730279.5A EP3980413B1 (en) | 2019-06-07 | 2020-06-05 | Heterocyclic immunomodulators as pdl1 checkpoint inhibitor |
| PCT/EP2020/065646 WO2020245372A1 (en) | 2019-06-07 | 2020-06-05 | Heterocyclic immunomodulators as pdl1 checkpoint inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS64681B1 true RS64681B1 (sr) | 2023-11-30 |
Family
ID=66793871
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20230805A RS64681B1 (sr) | 2019-06-07 | 2020-06-05 | Heterociklični imunomodulatori kao inhibitor kontrolne tačke pdl1 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US12624022B2 (pl) |
| EP (1) | EP3980413B1 (pl) |
| JP (1) | JP7768770B2 (pl) |
| KR (1) | KR102939670B1 (pl) |
| CN (1) | CN113966329B (pl) |
| AU (1) | AU2020286962B2 (pl) |
| BR (1) | BR112021023780A2 (pl) |
| CA (1) | CA3138494A1 (pl) |
| ES (1) | ES2956866T3 (pl) |
| HR (1) | HRP20230873T1 (pl) |
| HU (1) | HUE063236T2 (pl) |
| MA (1) | MA56098B1 (pl) |
| MD (1) | MD3980413T2 (pl) |
| MX (1) | MX2021015048A (pl) |
| PL (1) | PL3980413T3 (pl) |
| RS (1) | RS64681B1 (pl) |
| SM (1) | SMT202300280T1 (pl) |
| WO (1) | WO2020245372A1 (pl) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4815773B2 (ja) | 2003-09-17 | 2011-11-16 | 住友化学株式会社 | シンナモイル化合物及びその用途 |
| MX2016002544A (es) * | 2013-09-04 | 2016-06-17 | Squibb Bristol Myers Co | Compuestos utiles como inmunomoduladores. |
| US9850225B2 (en) * | 2014-04-14 | 2017-12-26 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
| EP3474845B1 (en) | 2016-06-27 | 2024-03-20 | ChemoCentryx, Inc. | Immunomodulator compounds |
| CN109689640B (zh) | 2016-07-08 | 2022-01-04 | 百时美施贵宝公司 | 可用作免疫调节剂的化合物 |
| JP7150745B2 (ja) * | 2017-03-27 | 2022-10-11 | ブリストル－マイヤーズ スクイブ カンパニー | 免疫調節剤としての置換イソキノリン誘導体 |
-
2020
- 2020-06-05 PL PL20730279.5T patent/PL3980413T3/pl unknown
- 2020-06-05 CA CA3138494A patent/CA3138494A1/en active Pending
- 2020-06-05 AU AU2020286962A patent/AU2020286962B2/en active Active
- 2020-06-05 MD MDE20220403T patent/MD3980413T2/ro not_active IP Right Cessation
- 2020-06-05 RS RS20230805A patent/RS64681B1/sr unknown
- 2020-06-05 HR HRP20230873TT patent/HRP20230873T1/hr unknown
- 2020-06-05 SM SM20230280T patent/SMT202300280T1/it unknown
- 2020-06-05 MX MX2021015048A patent/MX2021015048A/es unknown
- 2020-06-05 KR KR1020217042602A patent/KR102939670B1/ko active Active
- 2020-06-05 HU HUE20730279A patent/HUE063236T2/hu unknown
- 2020-06-05 US US17/595,711 patent/US12624022B2/en active Active
- 2020-06-05 CN CN202080041699.XA patent/CN113966329B/zh active Active
- 2020-06-05 EP EP20730279.5A patent/EP3980413B1/en active Active
- 2020-06-05 ES ES20730279T patent/ES2956866T3/es active Active
- 2020-06-05 WO PCT/EP2020/065646 patent/WO2020245372A1/en not_active Ceased
- 2020-06-05 MA MA56098A patent/MA56098B1/fr unknown
- 2020-06-05 JP JP2021572339A patent/JP7768770B2/ja active Active
- 2020-06-05 BR BR112021023780A patent/BR112021023780A2/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2020286962B2 (en) | 2025-10-16 |
| HRP20230873T1 (hr) | 2024-02-16 |
| EP3980413A1 (en) | 2022-04-13 |
| EP3980413B1 (en) | 2023-07-19 |
| JP7768770B2 (ja) | 2025-11-12 |
| US20220259186A1 (en) | 2022-08-18 |
| US12624022B2 (en) | 2026-05-12 |
| EP3980413C0 (en) | 2023-07-19 |
| ES2956866T3 (es) | 2023-12-29 |
| MD3980413T2 (ro) | 2023-12-31 |
| PL3980413T3 (pl) | 2023-12-27 |
| WO2020245372A1 (en) | 2020-12-10 |
| KR102939670B1 (ko) | 2026-03-13 |
| CN113966329B (zh) | 2024-08-13 |
| CN113966329A (zh) | 2022-01-21 |
| SMT202300280T1 (it) | 2023-11-13 |
| MA56098A (fr) | 2022-04-13 |
| CA3138494A1 (en) | 2020-12-10 |
| HUE063236T2 (hu) | 2024-01-28 |
| MX2021015048A (es) | 2022-01-18 |
| MA56098B1 (fr) | 2023-10-31 |
| BR112021023780A2 (pt) | 2022-01-11 |
| JP2022535879A (ja) | 2022-08-10 |
| KR20220017942A (ko) | 2022-02-14 |
| AU2020286962A1 (en) | 2022-02-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7241810B2 (ja) | Ｈｐｋ１阻害剤およびそれを用いる方法 | |
| JP7295169B2 (ja) | Ｂｔｋ阻害活性を有するピリミジン及びピリジン化合物を用いた癌の治療方法 | |
| JP7217752B2 (ja) | Ａｃｓｓ２阻害剤およびその使用方法 | |
| KR101990605B1 (ko) | 아미노피리미딘 키나아제 억제제 | |
| ES2988739T3 (es) | Compuestos de fenil-2-hidroxiacetilamino-2-metilfenilo. | |
| JP2012193188A (ja) | 二環式複素環誘導体およびステアロイル−ＣｏＡデサチュラーゼ（ＳＣＤ）のインヒビターとしてのそれらの使用 | |
| JP2026503211A (ja) | １，２，４－チアジアゾリジン－３－オン１，１－ジオキシドのタンパク質チロシンホスファターゼ阻害剤、組成物、および使用方法 | |
| JP2025538169A (ja) | がん疾患を治療するための、タンパク質チロシンホスファターゼ（ｐｔｐｎ２）の阻害剤としての、インダゾール置換１，２，５－チアジアゾリジン誘導体 | |
| EP3980413B1 (en) | Heterocyclic immunomodulators as pdl1 checkpoint inhibitor | |
| RU2824127C2 (ru) | Гетероциклические иммуномодуляторы в качестве ингибитора контрольных точек иммунного ответа pdl1 | |
| HK40067662A (en) | Heterocyclic immunomodulators as pdl1 checkpoint inhibitor | |
| WO2025240238A1 (en) | Thieno[3,4-d]pyrimidin-4-amine inhibitors of hck | |
| HK40057478A (en) | Hpk1 inhibitors and methods of using same | |
| CN121240859A (zh) | 用于治疗健康状况的组合物和制备和使用小分子的方法 | |
| HK1255833B (en) | Hpk1 inhibitors and methods of using same | |
| BR122018071494B1 (pt) | Composto de indol carboxamida útil como inibidor de cinase, seu uso e composição farmacêutica compreendendo o mesmo |