RU2007145444A - Способы и композиции для оценки функции легких и их заболеваний - Google Patents
Способы и композиции для оценки функции легких и их заболеваний Download PDFInfo
- Publication number
- RU2007145444A RU2007145444A RU2007145444/13A RU2007145444A RU2007145444A RU 2007145444 A RU2007145444 A RU 2007145444A RU 2007145444/13 A RU2007145444/13 A RU 2007145444/13A RU 2007145444 A RU2007145444 A RU 2007145444A RU 2007145444 A RU2007145444 A RU 2007145444A
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- Prior art keywords
- gene encoding
- promoter
- genotype
- gene
- emphysema
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 29
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 210000004072 lung Anatomy 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 claims abstract 229
- 102000054765 polymorphisms of proteins Human genes 0.000 claims abstract 26
- 102000003810 Interleukin-18 Human genes 0.000 claims abstract 19
- 108090000171 Interleukin-18 Proteins 0.000 claims abstract 19
- 102000000380 Matrix Metalloproteinase 1 Human genes 0.000 claims abstract 16
- 108010016113 Matrix Metalloproteinase 1 Proteins 0.000 claims abstract 16
- 102100022364 Polyunsaturated fatty acid 5-lipoxygenase Human genes 0.000 claims abstract 15
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims abstract 15
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims abstract 15
- 102100038110 Arylamine N-acetyltransferase 2 Human genes 0.000 claims abstract 13
- 102000003858 Chymases Human genes 0.000 claims abstract 13
- 108090000227 Chymases Proteins 0.000 claims abstract 13
- 102000010907 Cyclooxygenase 2 Human genes 0.000 claims abstract 13
- 108010037462 Cyclooxygenase 2 Proteins 0.000 claims abstract 13
- 101000884399 Homo sapiens Arylamine N-acetyltransferase 2 Proteins 0.000 claims abstract 13
- 101001056128 Homo sapiens Mannose-binding protein C Proteins 0.000 claims abstract 13
- 102100026553 Mannose-binding protein C Human genes 0.000 claims abstract 13
- 102100037850 Interferon gamma Human genes 0.000 claims abstract 12
- 108010074328 Interferon-gamma Proteins 0.000 claims abstract 12
- 108010022233 Plasminogen Activator Inhibitor 1 Proteins 0.000 claims abstract 12
- CDKIEBFIMCSCBB-UHFFFAOYSA-N 1-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)-3-(1-methyl-2-phenylpyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one;hydrochloride Chemical compound Cl.C1C=2C=C(OC)C(OC)=CC=2CCN1C(=O)C=CC(C1=CC=CN=C1N1C)=C1C1=CC=CC=C1 CDKIEBFIMCSCBB-UHFFFAOYSA-N 0.000 claims abstract 10
- 101000839464 Leishmania braziliensis Heat shock 70 kDa protein Proteins 0.000 claims abstract 10
- 102100025748 Mothers against decapentaplegic homolog 3 Human genes 0.000 claims abstract 10
- 101710143111 Mothers against decapentaplegic homolog 3 Proteins 0.000 claims abstract 10
- 102200037608 rs875989894 Human genes 0.000 claims abstract 10
- 108700028369 Alleles Proteins 0.000 claims abstract 8
- 102100023795 Elafin Human genes 0.000 claims abstract 8
- 108010015972 Elafin Proteins 0.000 claims abstract 8
- MDCUNMLZLNGCQA-HWOAGHQOSA-N elafin Chemical compound N([C@H](C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H]1C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]2CSSC[C@H]3C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CSSC[C@H]4C(=O)N5CCC[C@H]5C(=O)NCC(=O)N[C@H](C(N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]5N(CCC5)C(=O)[C@H]5N(CCC5)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@H](C)NC2=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N4)C(=O)N[C@@H](CSSC1)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N3)=O)[C@@H](C)CC)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(N)=O)C(O)=O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(C)C)C(C)C)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)N MDCUNMLZLNGCQA-HWOAGHQOSA-N 0.000 claims abstract 8
- 101001125026 Homo sapiens Nucleotide-binding oligomerization domain-containing protein 2 Proteins 0.000 claims abstract 7
- 102100029441 Nucleotide-binding oligomerization domain-containing protein 2 Human genes 0.000 claims abstract 7
- 208000011623 Obstructive Lung disease Diseases 0.000 claims abstract 6
- 229960003130 interferon gamma Drugs 0.000 claims abstract 6
- KZMAWJRXKGLWGS-UHFFFAOYSA-N 2-chloro-n-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-n-(3-methoxypropyl)acetamide Chemical compound S1C(N(C(=O)CCl)CCCOC)=NC(C=2C=CC(OC)=CC=2)=C1 KZMAWJRXKGLWGS-UHFFFAOYSA-N 0.000 claims abstract 5
- 108010093579 Arachidonate 5-lipoxygenase Proteins 0.000 claims abstract 5
- 102000011727 Caspases Human genes 0.000 claims abstract 5
- 108010076667 Caspases Proteins 0.000 claims abstract 5
- 108010062745 Chloride Channels Proteins 0.000 claims abstract 5
- 102000011045 Chloride Channels Human genes 0.000 claims abstract 5
- 102000018932 HSP70 Heat-Shock Proteins Human genes 0.000 claims abstract 5
- 108010027992 HSP70 Heat-Shock Proteins Proteins 0.000 claims abstract 5
- 239000011575 calcium Substances 0.000 claims abstract 5
- 229910052791 calcium Inorganic materials 0.000 claims abstract 5
- -1 calcium activated chlorine Chemical class 0.000 claims abstract 5
- 239000003669 enzymatically hydrolysed carboxymethyl cellulose Substances 0.000 claims abstract 5
- 230000003834 intracellular effect Effects 0.000 claims abstract 5
- 230000017074 necrotic cell death Effects 0.000 claims abstract 5
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 claims abstract 4
- 101710095845 Monocyte differentiation antigen CD14 Proteins 0.000 claims abstract 4
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 26
- 206010014561 Emphysema Diseases 0.000 claims 26
- 230000014509 gene expression Effects 0.000 claims 15
- 230000001681 protective effect Effects 0.000 claims 13
- 102100039418 Plasminogen activator inhibitor 1 Human genes 0.000 claims 10
- 102000050760 Vitamin D-binding protein Human genes 0.000 claims 9
- 101710179590 Vitamin D-binding protein Proteins 0.000 claims 9
- 102100022712 Alpha-1-antitrypsin Human genes 0.000 claims 8
- 102000005486 Epoxide hydrolase Human genes 0.000 claims 8
- 108020002908 Epoxide hydrolase Proteins 0.000 claims 8
- 102000003816 Interleukin-13 Human genes 0.000 claims 8
- 108090000176 Interleukin-13 Proteins 0.000 claims 8
- 108010050122 alpha 1-Antitrypsin Proteins 0.000 claims 8
- 229940024142 alpha 1-antitrypsin Drugs 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 8
- 239000003795 chemical substances by application Substances 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 6
- 239000000523 sample Substances 0.000 claims 6
- 101001124309 Homo sapiens Nitric oxide synthase, endothelial Proteins 0.000 claims 5
- 125000002059 L-arginyl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H] 0.000 claims 5
- 102100028452 Nitric oxide synthase, endothelial Human genes 0.000 claims 5
- 238000012216 screening Methods 0.000 claims 5
- 125000000570 L-alpha-aspartyl group Chemical group [H]OC(=O)C([H])([H])[C@]([H])(N([H])[H])C(*)=O 0.000 claims 4
- 230000035772 mutation Effects 0.000 claims 4
- 108020004705 Codon Proteins 0.000 claims 3
- 102100027186 Extracellular superoxide dismutase [Cu-Zn] Human genes 0.000 claims 3
- 101000836222 Homo sapiens Extracellular superoxide dismutase [Cu-Zn] Proteins 0.000 claims 3
- 101000577881 Homo sapiens Macrophage metalloelastase Proteins 0.000 claims 3
- 101000990902 Homo sapiens Matrix metalloproteinase-9 Proteins 0.000 claims 3
- 102100027998 Macrophage metalloelastase Human genes 0.000 claims 3
- 102100030412 Matrix metalloproteinase-9 Human genes 0.000 claims 3
- 102100026261 Metalloproteinase inhibitor 3 Human genes 0.000 claims 3
- 108010031429 Tissue Inhibitor of Metalloproteinase-3 Proteins 0.000 claims 3
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 3
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 3
- 230000003828 downregulation Effects 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 102100038782 Carbohydrate sulfotransferase 1 Human genes 0.000 claims 2
- 101710158459 Carbohydrate sulfotransferase 1 Proteins 0.000 claims 2
- 102000005720 Glutathione transferase Human genes 0.000 claims 2
- 108010070675 Glutathione transferase Proteins 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
- 102100036534 Glutathione S-transferase Mu 1 Human genes 0.000 claims 1
- 102100030943 Glutathione S-transferase P Human genes 0.000 claims 1
- 101001071694 Homo sapiens Glutathione S-transferase Mu 1 Proteins 0.000 claims 1
- 101001010139 Homo sapiens Glutathione S-transferase P Proteins 0.000 claims 1
- 102000015696 Interleukins Human genes 0.000 claims 1
- 108010063738 Interleukins Proteins 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 102000016966 beta-2 Adrenergic Receptors Human genes 0.000 claims 1
- 108010014499 beta-2 Adrenergic Receptors Proteins 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 210000005265 lung cell Anatomy 0.000 claims 1
- 210000001616 monocyte Anatomy 0.000 claims 1
- 230000017239 negative regulation of gene expression Effects 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 230000019532 positive regulation of gene expression Effects 0.000 claims 1
- 230000003827 upregulation Effects 0.000 claims 1
- 102000012335 Plasminogen Activator Inhibitor 1 Human genes 0.000 abstract 2
- 230000001684 chronic effect Effects 0.000 abstract 1
Landscapes
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ539934 | 2005-05-10 | ||
| NZ53993405 | 2005-05-10 | ||
| NZ541935 | 2005-08-19 | ||
| NZ54193505 | 2005-08-19 | ||
| JP2005-360523 | 2005-12-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2007145444A true RU2007145444A (ru) | 2009-06-20 |
Family
ID=37535560
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2007145444/13A RU2007145444A (ru) | 2005-05-10 | 2006-05-10 | Способы и композиции для оценки функции легких и их заболеваний |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP2006314315A (pt) |
| BR (1) | BRPI0608794A2 (pt) |
| MX (1) | MX2007013926A (pt) |
| RU (1) | RU2007145444A (pt) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3513344A1 (en) * | 2016-09-14 | 2019-07-24 | Philip Morris Products S.a.s. | Systems, methods, and gene signatures for predicting a biological status of an individual |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1801240A1 (en) * | 2001-06-05 | 2007-06-27 | Auckland Uniservices Limited | Methods and compositions for assessment of pulmonary function and disorders |
-
2005
- 2005-12-14 JP JP2005360523A patent/JP2006314315A/ja active Pending
-
2006
- 2006-05-10 MX MX2007013926A patent/MX2007013926A/es not_active Application Discontinuation
- 2006-05-10 BR BRPI0608794-9A patent/BRPI0608794A2/pt not_active Application Discontinuation
- 2006-05-10 RU RU2007145444/13A patent/RU2007145444A/ru not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0608794A2 (pt) | 2010-01-26 |
| JP2006314315A (ja) | 2006-11-24 |
| MX2007013926A (es) | 2008-03-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20090805 |