RU2012122334A - Композиция полисахаридного геля, обладающего многоступенчатой доставкой биоактивных веществ - Google Patents

Композиция полисахаридного геля, обладающего многоступенчатой доставкой биоактивных веществ Download PDF

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RU2012122334A
RU2012122334A RU2012122334/15A RU2012122334A RU2012122334A RU 2012122334 A RU2012122334 A RU 2012122334A RU 2012122334/15 A RU2012122334/15 A RU 2012122334/15A RU 2012122334 A RU2012122334 A RU 2012122334A RU 2012122334 A RU2012122334 A RU 2012122334A
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polysaccharide
sulfate
inhibitor
glycosaminoglycan
composition
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RU2012122334/15A
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Димитриос СТРОУМПОУЛИС
Дастин Б. ЛЕСЛИ
Кристофер С. МАДД
Ахмет ТЕЗЕЛ
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Аллерган, Инк.
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Abstract

1. Композиция полисахаридного геля, содержащая:(a) по меньшей мере один полисахарид, выбранный из группы, состоящей из гиалуроновой кислоты, целлюлозы, хитозана, о-сульфатированной ГК, декстрана, сульфата декстрана, хондроитин сульфата, дерматан сульфата, кератин сульфата, гепарина, сульфата гепарина и альгината:(b) по меньшей мере один ингибитор разрушения полисахарида, выбранный из группы, состоящей из гликозаминогликана, антиоксиданта, флавоноида, белка, жирной кислоты и их комбинации: и(c) маннитол.2. Композиция по п.1, отличающаяся тем, что указанный полисахарид представляет собой поперечно сшитую гиалуроновую кислоту.3. Композиция по п.1, отличающаяся тем, что по меньшей мере один указанный ингибитор представляет собой гликозаминогликан.4. Композиция по п.1, отличающаяся тем, что указанный гликозаминогликан представляет собой хондроитин сульфат.5. Композиция по п.1, отличающаяся тем, что по меньшей мере один указанный ингибитор представляет собой дубильную кислоту.6. Композиция по п.1, отличающаяся тем, что дополнительно содержит биосовместимый или биоразлагаемый сосуд, отличающаяся тем, что указанный ингибитор находится внутри или является частью этого сосуда, где указанный сосуд представляет собой липосому, мицеллу или полимеризованную везикулу.7. Композиция полисахаридного геля, содержащая:(a) гиалуроновую кислоту;(b) по меньшей мере один ингибитор разрушения полисахарида, выбранный из группы, состоящей из гликозаминогликана, антиоксиданта, флавоноида, белка, жирной кислоты и их комбинации; и(с) маннитол.8. Способ получения композиции полисахаридного геля, обладающей удлиненным временем разрушения, включающ

Claims (15)

1. Композиция полисахаридного геля, содержащая:
(a) по меньшей мере один полисахарид, выбранный из группы, состоящей из гиалуроновой кислоты, целлюлозы, хитозана, о-сульфатированной ГК, декстрана, сульфата декстрана, хондроитин сульфата, дерматан сульфата, кератин сульфата, гепарина, сульфата гепарина и альгината:
(b) по меньшей мере один ингибитор разрушения полисахарида, выбранный из группы, состоящей из гликозаминогликана, антиоксиданта, флавоноида, белка, жирной кислоты и их комбинации: и
(c) маннитол.
2. Композиция по п.1, отличающаяся тем, что указанный полисахарид представляет собой поперечно сшитую гиалуроновую кислоту.
3. Композиция по п.1, отличающаяся тем, что по меньшей мере один указанный ингибитор представляет собой гликозаминогликан.
4. Композиция по п.1, отличающаяся тем, что указанный гликозаминогликан представляет собой хондроитин сульфат.
5. Композиция по п.1, отличающаяся тем, что по меньшей мере один указанный ингибитор представляет собой дубильную кислоту.
6. Композиция по п.1, отличающаяся тем, что дополнительно содержит биосовместимый или биоразлагаемый сосуд, отличающаяся тем, что указанный ингибитор находится внутри или является частью этого сосуда, где указанный сосуд представляет собой липосому, мицеллу или полимеризованную везикулу.
7. Композиция полисахаридного геля, содержащая:
(a) гиалуроновую кислоту;
(b) по меньшей мере один ингибитор разрушения полисахарида, выбранный из группы, состоящей из гликозаминогликана, антиоксиданта, флавоноида, белка, жирной кислоты и их комбинации; и
(с) маннитол.
8. Способ получения композиции полисахаридного геля, обладающей удлиненным временем разрушения, включающий этап:
предоставления по меньшей мере одного полисахарида, выбранного из группы, состоящей из гиалуроновой кислоты, целлюлозы, хитозана, о-сульфатированной ГК, декстрана, сульфата декстрана, хондроитин сульфата, дерматан сульфата, кератин сульфата, гепарина, сульфата гепарина и альгината, и включение в указанный полисахарид по меньшей мере одного ингибитора разрушения полисахарида, выбранного из группы, состоящей из гликозаминогликана, антиоксиданта, флавоноида, белка и жирной кислоты, и маннитола.
9. Способ по п.8, отличающийся тем, что указанный этап включения состоит из 1) смешивания по меньшей мере одного указанного ингибитора с по меньшей мере одним указанным полисахаридом при высоко гидратированном состоянии, таким образом, инкапсулируя по меньшей мере один указанный ингибитор в полисахаридную сеть, и 2) дегидратации указанной полисахаридной сети и, посредством этого контроля, кинетики высвобождения или конечного коэффициента набухания.
10. Способ по п.8, отличающийся тем, что указанный этап включения состоит из 1) инкапсуляции по меньшей мере одного ингибитора в биосовместимый или биоразлагаемый сосуд и 2) объединения по меньшей мере одного указанного полисахарида и указанного сосуда в гелевую композицию.
11. Система увеличения мягких тканей, содержащая полисахаридный матрикс, имеющий полисахаридные частицы, диспергированные в нем, при этом матрикс и/или частицы дополнительно содержат по меньшей мере одно биологически активное вещество и матрикс и/или частицы контролируют высвобождение по меньшей мере одного биологически активного вещества из матрикса и/или частиц в мягкие ткани.
12. Система увеличения мягких тканей по п.11, отличающаяся тем, что указанный матрикс высвобождает биологически активные вещества с одной скоростью, а указанные частицы высвобождают биологически активные вещества с другой скоростью.
13. Система увеличения мягких тканей по п.11, отличающаяся тем, что указанный матрикс и указанные частицы высвобождают разные биологически активные вещества.
14. Система увеличения мягких тканей по п.11 отличающаяся тем, что указанные частицы содержат хитозан, физически поперечно сшитый с триполифосфатом и покрытый альгинатом.
15. Система увеличения мягких тканей по п.11, отличающаяся тем, что указанные частицы содержат альгинат, физически поперечно сшитый с кальцием и стабилизированный хитозаном.
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